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Protein Page:
PACT (human)

Overview
PACT a double strand RNA binding protein (dsRBP). Interacts with TRBP and Dicer to stimulate the cleavage of double-stranded or short hairpin RNA to siRNA. Appears to have a pro-apoptotic function that may be suppressed in the presence of growth factor. Activates the interferon-induced protein kinase PKR. Three alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: RNA binding protein; RNA processing; Activator protein
Cellular Component: membrane; perinuclear region of cytoplasm; cytoplasm; cytosol
Molecular Function: protein binding; protein homodimerization activity; enzyme activator activity
Biological Process: positive regulation of catalytic activity; negative regulation of cell proliferation; skeletal morphogenesis; response to virus; outer ear morphogenesis; immune response; gene expression; middle ear morphogenesis; protein amino acid phosphorylation; RNA interference, production of siRNA
Reference #:  O75569 (UniProtKB)
Alt. Names/Synonyms: DYT16; HSD14; Interferon-inducible double stranded RNA-dependent protein kinase activator A; PACT; PKR-associated protein X; PKR-associating protein X; PRKRA; Protein activator of the interferon-induced protein kinase; protein kinase, interferon-inducible double stranded RNA dependent activator; Protein kinase, interferon-inducible double stranded RNA-dependent activator; RAX
Gene Symbols: PRKRA
Molecular weight: 34,404 Da
Basal Isoelectric point: 8.68  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

PACT

Protein Structure Not Found.


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Sites Implicated In
apoptosis, altered: S246‑p, S287‑p

Modification Sites and Domains  

Modification Sites in Parent Protein, Orthologs, and Isoforms  
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
3 154 S18-p PPLEREDsGtFsLGK
0 16 T20-p LEREDsGtFsLGKMI
0 5 S22-p REDsGtFsLGKMITA
0 1 T71-p PTFTFRVtVGDITCT
0 4 S130-p NQLNPIGsLQELAIH
0 1 Y159-p GPAHKREytTICRLE
0 2 T160-p PAHKREytTICRLEs
0 90 S167-p tTICRLEsFMETGKG
0 1 S217-p SLGCTWHsLRNSPGE
0 1 S235-p LLKRSLLsIPNTDYI
3 1 S246-p TDYIQLLsEIAKEQG
0 1 Y270-p ELSANGQyQCLAELS
3 0 S287-p PITVCHGsGISCGNA
  mouse

 
S18-p PPLQREDsGtFsLGK
T20-p LQREDsGtFsLGKMI
S22-p REDsGtFsLGKMITA
T71 PTFTFRVTVGDITCT
S130-p NQLNPIGsLQELAIH
Y159 GPAHKREYTTICRLE
T160 PAHKREYTTICRLEs
S167-p TTICRLEsFMETGKG
S217 SLGCTWHSLRNSPGE
S235 LLKRSLLSLPNTDYI
S246 TDYIQLLSEIASEQG
Y270 ELSANGQYQCLAELS
S287 PITVCHGSGISCGNA
  rat

 
S18-p PPLQREDsGTFSLGK
T20 LQREDsGTFSLGKMI
S22 REDsGTFSLGKMITA
T71 PTFTFRVTVGDITCT
S130 NQLNPIGSLQELAIH
Y159 GPAHKREYTTICRLE
T160 PAHKREYTTICRLES
S167 TTICRLESFMETGKG
S217 SLGCTWHSLRNSPGE
S235 LLKRSLLSLPNTDYI
S246 TDYIQLLSEIAKEQG
Y270 ELSANGQYQCLAELS
S287 PITVCHGSGISCGNA
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