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VAMP2 (human)

Overview VAMP2 a member of the vesicle-associated membrane protein (VAMP)/synaptobrevin family. Synaptobrevins/VAMPs, syntaxins, and the 25-kD synaptosomal-associated protein SNAP25 are the main components of a protein complex involved in the docking and/or fusion of synaptic vesicles with the presynaptic membrane. Thought to participate in neurotransmitter release at a step between docking and fusion. The protein forms a stable complex with syntaxin, synaptosomal-associated protein, 25 kD, and synaptotagmin. It also forms a distinct complex with synaptophysin. Note: This description may include information from UniProtKB. Protein type: Membrane protein, integral; Motility/polarity/chemotaxis; Vesicle protein Cellular Component: SNARE complex; neuron projection; clathrin-coated vesicle; synaptic vesicle membrane; integral to plasma membrane; secretory granule membrane; plasma membrane; cell junction Molecular Function: protein binding Biological Process: synaptic transmission; glutamate secretion; neurotransmitter secretion; energy reserve metabolic process; post-Golgi vesicle-mediated transport; regulation of insulin secretion; membrane organization and biogenesis Reference #:  P63027 (UniProtKB) Alt. Names/Synonyms: FLJ11460; SYB2; synaptobrevin 2; Synaptobrevin-2; VAMP-2; VAMP2; vesicle associated membrane protein 2; Vesicle-associated membrane protein 2; vesicle-associated membrane protein 2 (synaptobrevin 2) Gene Symbols: VAMP2 Molecular weight: 12,663 Da Basal Isoelectric point: 7.84  Predict pI for various phosphorylation states Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below VAMP2 1F83 - B=53-76, C=77-88 (human) 3FIE - D/C=22-58 (human) 3FII - B=22-53 (human) 3RK2 - A/E=28-60 (human) 3RK3 - A=28-60 (human) 3RL0 - A/Y/E/Q/c/M/I/U=28-60 (human) 1KIL - A=28-92 (rat) 1N7S - A=28-89 (rat) 1SFC - A/E/I=1-96 (rat) 2BU0 - A=25-88 (rat) 2KOG - A=1-116 (rat) 3HD7 - A/E=30-116 (rat) 3IPD - A/E=30-116 (rat)

STRING  |  Scansite  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  RCSB PDB 1F83 3FIE 3FII 3RK2 3RK3 3RL0  |  Phospho3D  |  DISEASE  |  Source  |  UCSD-Nature  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
1	0		T35	SNRRLQQTQAQVDEV
0	101		K52-u	IMRVNVDkVLERDQk
0	98		K59-u	kVLERDQkLsELDDR
1	17		S61-p	LERDQkLsELDDRAD
0	36		S75-p	DALQAGAsQFETsAA
0	1		T79	AGAsQFETsAAkLkR
0	6		S80-p	GAsQFETsAAkLkRK
0	16		K83-u	QFETsAAkLkRKYWW
0	6		K85-u	ETsAAkLkRKYWWKN

	mouse
T35-p	SNRRLQQtQAQVDEV
K52-u	IMRVNVDkVLERDQk
K59-u	kVLERDQkLsELDDR
S61-p	LERDQkLsELDDRAD
S75-p	DALQAGAsQFEtsAA
T79-p	AGAsQFEtsAAkLKR
S80-p	GAsQFEtsAAkLKRK
K83-u	QFEtsAAkLKRKYWW
K85	EtsAAkLKRKYWWKN

	rat
T35	SNRRLQQTQAQVDEV
K52-u	IMRVNVDkVLERDQk
K59-u	kVLERDQkLSELDDR
S61	LERDQkLSELDDRAD
S75	DALQAGASQFETSAA
T79	AGASQFETSAAKLkR
S80	GASQFETSAAKLkRK
K83	QFETSAAKLkRKYWW
K85-u	ETSAAKLkRKYWWKN

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