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Protein Page:
VAMP2 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
VAMP2 a member of the vesicle-associated membrane protein (VAMP)/synaptobrevin family. Synaptobrevins/VAMPs, syntaxins, and the 25-kD synaptosomal-associated protein SNAP25 are the main components of a protein complex involved in the docking and/or fusion of synaptic vesicles with the presynaptic membrane. Thought to participate in neurotransmitter release at a step between docking and fusion. The protein forms a stable complex with syntaxin, synaptosomal-associated protein, 25 kD, and synaptotagmin. It also forms a distinct complex with synaptophysin. Note: This description may include information from UniProtKB.
Protein type: Motility/polarity/chemotaxis; Membrane protein, integral; Vesicle protein
Cellular Component: SNARE complex; synaptic vesicle; synaptic vesicle membrane; clathrin-coated vesicle; membrane; secretory granule membrane; integral to plasma membrane; plasma membrane; cell junction
Molecular Function: protein binding
Biological Process: synaptic transmission; cellular protein metabolic process; glutamate secretion; neurotransmitter secretion; energy reserve metabolic process; post-Golgi vesicle-mediated transport; regulation of insulin secretion
Reference #:  P63027 (UniProtKB)
Alt. Names/Synonyms: FLJ11460; SYB2; synaptobrevin 2; Synaptobrevin-2; VAMP-2; VAMP2; vesicle associated membrane protein 2; Vesicle-associated membrane protein 2; vesicle-associated membrane protein 2 (synaptobrevin 2)
Gene Symbols: VAMP2
Molecular weight: 12,663 Da
Basal Isoelectric point: 7.84  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

VAMP2

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
1 0 T35 SNRRLQQTQAQVDEV
0 101 K52-ub IMRVNVDkVLERDQk
0 98 K59-ub kVLERDQkLsELDDR
1 23 S61-p LERDQkLsELDDRAD
0 43 S75-p DALQAGAsQFEtsAA
0 2 T79-p AGAsQFEtsAAkLkR
0 7 S80-p GAsQFEtsAAkLkRK
0 16 K83-ub QFEtsAAkLkRKYWW
0 6 K85-ub EtsAAkLkRKYWWKN
  mouse

 
T35-p SNRRLQQtQAQVDEV
K52-ub IMRVNVDkVLERDQk
K59-ub kVLERDQkLsELDDR
S61-p LERDQkLsELDDRAD
S75-p DALQAGAsQFEtsAA
T79-p AGAsQFEtsAAkLKR
S80-p GAsQFEtsAAkLKRK
K83-ub QFEtsAAkLKRKYWW
K85 EtsAAkLKRKYWWKN
  rat

 
T35 SNRRLQQTQAQVDEV
K52-ub IMRVNVDkVLERDQk
K59-ub kVLERDQkLSELDDR
S61 LERDQkLSELDDRAD
S75 DALQAGASQFETSAA
T79 AGASQFETSAAKLkR
S80 GASQFETSAAKLkRK
K83 QFETSAAKLkRKYWW
K85-ub ETSAAKLkRKYWWKN
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