a member of the vesicle-associated membrane protein (VAMP)/synaptobrevin family. Synaptobrevins/VAMPs, syntaxins, and the 25-kD synaptosomal-associated protein SNAP25 are the main components of a protein complex involved in the docking and/or fusion of synaptic vesicles with the presynaptic membrane. Thought to participate in neurotransmitter release at a step between docking and fusion. The protein forms a stable complex with syntaxin, synaptosomal-associated protein, 25 kD, and synaptotagmin. It also forms a distinct complex with synaptophysin. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral; Vesicle protein; Motility/polarity/chemotaxis
Cellular Component: SNARE complex; neuron projection; zymogen granule membrane; clathrin-coated vesicle; synaptic vesicle membrane; membrane; secretory granule membrane; perinuclear region of cytoplasm; integral to plasma membrane; plasma membrane; trans-Golgi network; cell junction
Molecular Function: calmodulin binding; protein C-terminus binding; protein binding; myosin binding; syntaxin-1 binding; protein complex binding; phospholipid binding
Biological Process: regulation of exocytosis; synaptic transmission; synaptic vesicle exocytosis; cellular protein metabolic process; glutamate secretion; cellular response to insulin stimulus; neurotransmitter secretion; Golgi to plasma membrane protein transport; energy reserve metabolic process; response to glucose stimulus; protein complex assembly; post-Golgi vesicle-mediated transport; regulation of insulin secretion; calcium ion-dependent exocytosis
SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.