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Protein Page:
ILK (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
ILK a tyrosine kinase-like kinase of the MLK family. Couples integrins and growth factors to downstream pathways involved in cell survival, cell cycle control, cell-cell adhesion and cell motility. Functions as a scaffold bridging the extra-cellular matrix and growth factor receptors to the actin cytoskeleton through interactions with the ILK-PINCH complex. This complex, which includes integrin, PINCH (which links ILK to receptor tyrosine kinases via Nck2), PARVA and affixin, is considered to be one of the convergence points of integrin- and growth factor-signaling pathways. May be implicated in mediating cell architecture, adhesion to integrin substrates and anchorage-dependent growth in epithelial cells. Stimulated downstream of PI3 kinase. Increased expression is correlated with progression of several tumor types, including breast, prostate, and colon carcinomas. Overexpression drives anchorage-independent growth and faster cell cycle. Note: This description may include information from UniProtKB.
Protein type: Protein kinase, Ser/Thr (non-receptor); Kinase, protein; EC 2.7.11.1; Protein kinase, TKL; TKL group; MLK family; ILK subfamily
Cellular Component: focal adhesion; costamere; protein complex; terminal button; intercellular junction; cytosol; sarcomere; membrane; cell soma; lamellipodium; cytoplasm; nucleolus; plasma membrane; dendritic shaft; cell junction; nucleus
Molecular Function: integrin binding; protein serine/threonine kinase activity; signal transducer activity; protein binding; SH3 domain binding; protein kinase binding; ATP binding
Biological Process: protein heterooligomerization; negative regulation of smooth muscle cell proliferation; cell-matrix adhesion; positive regulation of axon extension; positive regulation of transcription, DNA-dependent; negative regulation of smooth muscle cell migration; protein amino acid phosphorylation; myelin formation; positive regulation of MAP kinase activity; positive regulation of cell proliferation; fibril organization and biogenesis; protein kinase B signaling cascade; negative regulation of neuron apoptosis; positive regulation of cell-matrix adhesion; cell cycle arrest; positive regulation of BMP signaling pathway; integrin-mediated signaling pathway; cell aging; positive regulation of dendrite morphogenesis; positive regulation of myoblast differentiation; myelination in the peripheral nervous system; establishment and/or maintenance of epithelial cell polarity; positive regulation of osteoblast differentiation; cell proliferation; positive regulation of protein kinase B signaling cascade; peptidyl-serine phosphorylation; ureteric bud branching; regulation of actin cytoskeleton organization and biogenesis; negative regulation of protein kinase activity; nerve development; positive regulation of phosphorylation; neurite morphogenesis; positive regulation of cell migration
Reference #:  Q13418 (UniProtKB)
Alt. Names/Synonyms: 59 kDa serine/threonine-protein kinase; DKFZp686F1765; ILK; ILK-1; ILK-2; ILK1; ILK2; integrin-linked kinase; Integrin-linked protein kinase; P59; p59ILK
Gene Symbols: ILK
Molecular weight: 51,419 Da
Basal Isoelectric point: 8.3  Predict pI for various phosphorylation states
CST Pathways:  PI3K/Akt Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

ILK

Protein Structure Not Found.


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Sites Implicated In
cell motility, altered: T173‑p, S246‑p
intracellular localization: T173‑p, S246‑p
molecular association, regulation: S343‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 T69-p VMNRGDDtPLHLAAs
0 1 S76-p tPLHLAAsHGHRDIV
0 3 K85-ub GHRDIVQkLLQYKAD
0 2 K139-ub YGEMPVDkAKAPLRE
0 3 K154 LLRERAEKMGQNLNR
0 4 K165-ub NLNRIPYkDTFWkGt
0 1 T167 NRIPYkDTFWkGttR
0 3 K170-ub PYkDTFWkGttRTRP
0 10 T172-p kDTFWkGttRTRPRN
2 1 T173-p DTFWkGttRTRPRNG
0 5 T175 FWkGttRTRPRNGtL
1 20 T181-p RTRPRNGtLNKHsGI
0 3 S186-p NGtLNKHsGIDFkQL
0 3 K191-ub KHsGIDFkQLNFLTk
0 1 K198-ub kQLNFLTkLNENHSG
0 3 K209-ub NHSGELWkGRWQGND
0 5 K220-ub QGNDIVVkVLKVRDW
0 2 S232-p RDWSTRKsRDFNEEC
2 0 S246-p CPRLRIFsHPNVLPV
4 1 S343-p SMADVKFsFQCPGRM
0 1 K426-ac PHVCKLMkICMNEDP
0 2 K438-ub EDPAKRPkFDMIVPI
0 1 K448-ub MIVPILEkMQDK___
  mouse

 
T69 VMNRGDDTPLHLAAS
S76 TPLHLAASHGHRDIV
K85-ub GHRDIVQkLLQYKAD
K139-ub YGEMPVDkAKAPLRE
K154-ub LLRERAEkMGQNLNR
K165-ub NLNRIPYkDtFWkGt
T167-p NRIPYkDtFWkGttR
K170-ub PYkDtFWkGttRtRP
T172-p kDtFWkGttRtRPRN
T173-p DtFWkGttRtRPRNG
T175-p FWkGttRtRPRNGtL
T181-p RtRPRNGtLNKHsGI
S186-p NGtLNKHsGIDFkQL
K191-ub KHsGIDFkQLNFLAK
K198 kQLNFLAKLNENHSG
K209-ub NHSGELWkGRWQGND
K220-ub QGNDIVVkVLKVRDW
S232-p RDWSTRKsRDFNEEC
S246-p CPRLRIFsHPNVLPV
S343-p SMADVKFsFQCPGRM
K426 PHVCKLMKICMNEDP
K438 EDPAKRPKFDMIVPI
K448 MIVPILEKMQDK___
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