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ILK
a tyrosine kinase-like kinase of the MLK family. Couples integrins and growth factors to downstream pathways involved in cell survival, cell cycle control, cell-cell adhesion and cell motility. Functions as a scaffold bridging the extra-cellular matrix and growth factor receptors to the actin cytoskeleton through interactions with the ILK-PINCH complex. This complex, which includes integrin, PINCH (which links ILK to receptor tyrosine kinases via Nck2), PARVA and affixin, is considered to be one of the convergence points of integrin- and growth factor-signaling pathways. May be implicated in mediating cell architecture, adhesion to integrin substrates and anchorage-dependent growth in epithelial cells. Stimulated downstream of PI3 kinase. Increased expression is correlated with progression of several tumor types, including breast, prostate, and colon carcinomas. Overexpression drives anchorage-independent growth and faster cell cycle. Note: This description may include information from UniProtKB.
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| Protein type: EC 2.7.11.1; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL; TKL group; MLK family; ILK subfamily |
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Cellular Component: focal adhesion; protein complex; costamere; cell soma; cytoplasm; plasma membrane; stress fiber; terminal button; intercellular junction; dendritic shaft; cytosol
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Molecular Function: integrin binding; protein serine/threonine kinase activity; protein binding; signal transducer activity; SH3 domain binding; protein kinase binding; ATP binding
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Biological Process: protein heterooligomerization; negative regulation of smooth muscle cell proliferation; positive regulation of axon extension; positive regulation of transcription, DNA-dependent; cell-matrix adhesion; negative regulation of smooth muscle cell migration; protein amino acid phosphorylation; myelin formation; positive regulation of MAP kinase activity; positive regulation of MAPKKK cascade; positive regulation of cell proliferation; fibril organization and biogenesis; negative regulation of neuron apoptosis; cell cycle arrest; positive regulation of cell-matrix adhesion; positive regulation of BMP signaling pathway; integrin-mediated signaling pathway; cell aging; positive regulation of dendrite morphogenesis; positive regulation of myoblast differentiation; establishment and/or maintenance of epithelial cell polarity; positive regulation of osteoblast differentiation; cell proliferation; positive regulation of protein kinase B signaling cascade; peptidyl-serine phosphorylation; ureteric bud branching; regulation of actin cytoskeleton organization and biogenesis; negative regulation of protein kinase activity; positive regulation of phosphorylation; neurite morphogenesis; positive regulation of cell migration
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Reference #:
Q13418 (UniProtKB)
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| Alt. Names/Synonyms: 59 kDa serine/threonine-protein kinase; DKFZp686F1765; ILK; ILK-1; ILK-2; ILK1; ILK2; integrin-linked kinase; Integrin-linked protein kinase; P59; p59ILK |
| Gene Symbols: ILK |
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Molecular weight: 51,419 Da
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Basal Isoelectric point: 8.3
Predict pI for various phosphorylation states
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CST Pathways:
PI3K/Akt Signaling
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Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®
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