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Protein Page:
IGF1R (human)
p Phosphorylation
a Acetylation
m Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
u Ubiquitination
s Sumoylation
n Neddylation
gl O-GlcNAc
ga O-GalNAc
h Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage

Overview
IGF1R a receptor tyrosine kinase that binds insulin-like growth factor 1 (IGF1) with a high affinity and IGF2 with a lower affinity. Functions as an anti-apoptotic agent by enhancing cell survival. Can play a critical role in transformation events. Cleavage of the precursor generates alpha and beta subunits. Tetramer of 2 alpha and 2 beta chains linked by disulfide bonds. The alpha chains contribute to the formation of the ligand- binding domain, while the beta chain carries the kinase domain. Interacts with PIK3R1 and with the PTB/PID domains of IRS1 and SHC1 in vitro when autophosphorylated on tyrosine residues. Mutated in rare cases of pre- and post-natal growth retardation. One SNP associated with increased human longevity. Increased expression of IGF1R and other pathway members associated with progression and malignancy in a range of cancers. Inhibitors: AG1024, AEW541. Note: This description may include information from UniProtKB.
Protein type: EC 2.7.10.1; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor); TK group; InsR family
Cellular Component: neuron projection; membrane; intracellular membrane-bound organelle; integral to plasma membrane; plasma membrane; caveola; receptor complex
Molecular Function: insulin binding; identical protein binding; insulin-like growth factor binding; protein binding; insulin-like growth factor I binding; protein-tyrosine kinase activity; insulin receptor substrate binding; G-protein alpha-subunit binding; phosphoinositide 3-kinase binding; insulin receptor binding; ATP binding; insulin-like growth factor receptor activity
Biological Process: phosphoinositide 3-kinase cascade; peptidyl-tyrosine phosphorylation; inactivation of MAPKK activity; protein heterooligomerization; protein amino acid autophosphorylation; exocrine pancreas development; signal transduction; regulation of JNK cascade; response to vitamin E; positive regulation of MAPKKK cascade; mammary gland development; male sex determination; positive regulation of cell proliferation; protein tetramerization; positive regulation of cytokinesis; phosphoinositide-mediated signaling; negative regulation of protein kinase B signaling cascade; positive regulation of protein kinase B signaling cascade; insulin-like growth factor receptor signaling pathway; axonogenesis; establishment of cell polarity; insulin receptor signaling pathway; immune response; brain development; positive regulation of DNA replication; positive regulation of cell migration; negative regulation of apoptosis
Reference #:  P08069 (UniProtKB)
Alt. Names/Synonyms: CD221; IGF-I receptor; IGF1R; IGFIR; IGFR; Insulin-like growth factor 1 receptor; Insulin-like growth factor 1 receptor alpha chain; Insulin-like growth factor 1 receptor beta chain; Insulin-like growth factor I receptor; JTK13; MGC142170; MGC142172; MGC18216; soluble IGF1R variant 1; soluble IGF1R variant 2
Gene Symbols: IGF1R
Molecular weight: 154,793 Da
Basal Isoelectric point: 5.58  Predict pI for various phosphorylation states
CST Pathways:  Angiogenesis  |  ESC Pluripotency and Differentiation  |  Tyrosine Kinases & Substrates
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

IGF1R

Protein Structure Not Found.


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Sites Implicated In
apoptosis, altered: Y980‑p, Y1281‑p, S1310‑p, S1311‑p, S1312‑p, S1313‑p
cell cycle regulation: Y980‑p
cell differentiation, altered: Y980‑p, Y1280‑p, Y1281‑p, S1310‑p, S1311‑p, S1312‑p, S1313‑p, Y1346‑p
cell growth, altered: Y980‑p, Y1166‑p, Y1280‑p, Y1281‑p, S1310‑p, S1311‑p, S1312‑p, S1313‑p, Y1346‑p
activity, induced: Y980‑p, S1310‑p, S1311‑p, S1312‑p, S1313‑p
enzymatic activity, induced: Y1161‑p, Y1165‑p, Y1166‑p, Y1346‑p
molecular association, regulation: Y1161‑p, Y1346‑p
phosphorylation: Y980‑p, Y1166‑p, S1310‑p, S1311‑p, S1312‑p, S1313‑p
protein conformation: Y1161‑p, Y1165‑p, Y1166‑p
receptor internalization, altered: Y1161‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 Y131-p NLKDIGLyNLRNITR
0 1 Y577-p GLKPWTQyAVyVKAV
0 1 Y580-p PWTQyAVyVKAVTLT
2 1 Y973-p RLGNGVLyASVNPEy
6 1 Y980-p yASVNPEyFsAADVY
1 0 S982-p SVNPEyFsAADVYVP
0 1 Y1014-p QGSFGMVyEGVAKGV
0 4 K1033-u PETRVAIkTVNEAAS
1 0 K1055-s LNEASVMkEFNCHHV
1 0 K1130-s MAYLNANkFVHRDLA
1 0 K1150-s VAEDFTVkIGDFGMT
16 467 Y1161-p FGMTRDIyEtDyyRK
0 43 T1163-p MTRDIyEtDyyRKGG
12 721 Y1165-p RDIyEtDyyRKGGKG
10 118 Y1166-p DIyEtDyyRKGGKGL
1 0 S1278-p EPGFREVsFyySEEN
5 0 Y1280-p GFREVsFyySEENKL
5 0 Y1281-p FREVsFyySEENKLP
2 0 S1310-p VPLDPSAssssLPLP
2 0 S1311-p PLDPSAssssLPLPD
2 0 S1312-p LDPSAssssLPLPDR
2 0 S1313-p DPSAssssLPLPDRH
1 0 S1321-p LPLPDRHsGHKAENG
0 4 S1339-p GVLVLRAsFDERQPy
3 27 Y1346-p sFDERQPyAHMNGGR
0 7 T1366-p LPLPQSStC______
4568 : Phospho-IGF-I Receptor beta (Tyr980) (C14A11) Rabbit mAb
3021 : Phospho-IGF-I Receptor beta (Tyr1131)/Insulin Receptor beta (Tyr1146) Antibody
2969 : Phospho-IGF-I Receptor beta (Tyr1135/1136)/Insulin Receptor beta (Tyr1150/1151) (19H7) Rabbit mAb (Biotinylated)
3024 : Phospho-IGF-I Receptor beta (Tyr1135/1136)/Insulin Receptor beta (Tyr1150/1151) (19H7) Rabbit mAb
3918 : Phospho-IGF-1 Receptor beta (Tyr1135) (DA7A8) Rabbit mAb
2969 : Phospho-IGF-I Receptor beta (Tyr1135/1136)/Insulin Receptor beta (Tyr1150/1151) (19H7) Rabbit mAb (Biotinylated)
3024 : Phospho-IGF-I Receptor beta (Tyr1135/1136)/Insulin Receptor beta (Tyr1150/1151) (19H7) Rabbit mAb
6113 : Phospho-IGF-I Receptor beta (Tyr1316) Antibody
  mouse

 
Y131 NLKDIGLYNLRNITR
Y578 GLKPWTQYAVYVKAV
Y581 PWTQYAVYVKAVTLT
Y974-p RLGNGVLyASVNPEy
Y981-p yASVNPEyFSAADVY
S983 SVNPEyFSAADVYVP
Y1015 QGSFGMVYEGVAKGV
K1034-u PETRVAIkTVNEAAS
K1056 LNEASVMKEFNCHHV
K1132 MAYLNANKFVHRDLA
K1152 VAEDFTVKIGDFGMT
Y1163-p FGMTRDIyEtDyyRK
T1165-p MTRDIyEtDyyRKGG
Y1167-p RDIyEtDyyRKGGKG
Y1168-p DIyEtDyyRKGGKGL
S1280 EPSFQEVSFyySEEN
Y1282-p SFQEVSFyySEENKP
Y1283-p FQEVSFyySEENKPP
S1316 VPLDPSASSASLPLP
S1317 PLDPSASSASLPLPE
A1318 LDPSASSASLPLPER
S1319 DPSASSASLPLPERH
S1327 LPLPERHSGHKAENG
S1345-p GVLVLRAsFDERQPy
Y1352-p sFDERQPyAHMNGGR
T1372-p LPLPQSStC______
4568 : Phospho-IGF-I Receptor beta (Tyr980) (C14A11) Rabbit mAb
3021 : Phospho-IGF-I Receptor beta (Tyr1131)/Insulin Receptor beta (Tyr1146) Antibody
2969 : Phospho-IGF-I Receptor beta (Tyr1135/1136)/Insulin Receptor beta (Tyr1150/1151) (19H7) Rabbit mAb (Biotinylated)
3024 : Phospho-IGF-I Receptor beta (Tyr1135/1136)/Insulin Receptor beta (Tyr1150/1151) (19H7) Rabbit mAb
3918 : Phospho-IGF-1 Receptor beta (Tyr1135) (DA7A8) Rabbit mAb
2969 : Phospho-IGF-I Receptor beta (Tyr1135/1136)/Insulin Receptor beta (Tyr1150/1151) (19H7) Rabbit mAb (Biotinylated)
3024 : Phospho-IGF-I Receptor beta (Tyr1135/1136)/Insulin Receptor beta (Tyr1150/1151) (19H7) Rabbit mAb
6113 : Phospho-IGF-I Receptor beta (Tyr1316) Antibody
  rat

 
Y131 NLKDIGLYNLRNITR
Y578 GLKPWTQYAVYVKAV
Y581 PWTQYAVYVKAVTLT
Y974 RLGNGVLYASVNPEY
Y981 YASVNPEYFSAADVY
S983 SVNPEYFSAADVYVP
Y1015 QGSFGMVYEGVAKGV
K1034 PETRVAIKTVNEAAS
K1056 LNEASVMKEFNCHHV
K1131 MAYLNANKFVHRDLA
K1151 VAEDFTVKIGDFGMT
Y1162-p FGMTRDIyETDyyRK
T1164 MTRDIyETDyyRKGG
Y1166-p RDIyETDyyRKGGKG
Y1167-p DIyETDyyRKGGKGL
S1279 EPSFQEVSFYYSEEN
Y1281 SFQEVSFYYSEENKP
Y1282 FQEVSFYYSEENKPP
S1315 VPLDPSASSASLPLP
S1316 PLDPSASSASLPLPE
A1317 LDPSASSASLPLPER
S1318 DPSASSASLPLPERH
S1326 LPLPERHSGHKAENG
S1342 GVLVLRASFDERQPY
Y1349 SFDERQPYAHMNGGR
T1369 LPLPQSSTC______
4568 : Phospho-IGF-I Receptor beta (Tyr980) (C14A11) Rabbit mAb
3021 : Phospho-IGF-I Receptor beta (Tyr1131)/Insulin Receptor beta (Tyr1146) Antibody
2969 : Phospho-IGF-I Receptor beta (Tyr1135/1136)/Insulin Receptor beta (Tyr1150/1151) (19H7) Rabbit mAb (Biotinylated)
3024 : Phospho-IGF-I Receptor beta (Tyr1135/1136)/Insulin Receptor beta (Tyr1150/1151) (19H7) Rabbit mAb
3918 : Phospho-IGF-1 Receptor beta (Tyr1135) (DA7A8) Rabbit mAb
2969 : Phospho-IGF-I Receptor beta (Tyr1135/1136)/Insulin Receptor beta (Tyr1150/1151) (19H7) Rabbit mAb (Biotinylated)
3024 : Phospho-IGF-I Receptor beta (Tyr1135/1136)/Insulin Receptor beta (Tyr1150/1151) (19H7) Rabbit mAb
6113 : Phospho-IGF-I Receptor beta (Tyr1316) Antibody
  pig

 
Y131 NLKDIGLYNLRNITR
Y577 GLKPWTQYAVYVKAV
Y580 PWTQYAVYVKAVTLT
Y973 RLGNGVLYASVNPEY
Y980 YASVNPEYFSAADVY
S982 SVNPEYFSAADVYVP
Y1014 QGSFGMVYEGVAKGV
K1033 PETRVAIKTVNEAAS
K1055 LNEASVMKEFNCHHV
K1130 MAYLNANKFVHRDLA
K1150 VAEDFTVKIGDFGMT
Y1161-p FGMTRDIyETDYYRK
T1163 MTRDIyETDYYRKGG
Y1165 RDIyETDYYRKGGKG
Y1166 DIyETDYYRKGGKGL
S1278 EPGFREVSFYYSEEN
Y1280 GFREVSFYYSEENKP
Y1281 FREVSFYYSEENKPP
S1310 VPLDPSASSSSLPLP
S1311 PLDPSASSSSLPLPD
S1312 LDPSASSSSLPLPDR
S1313 DPSASSSSLPLPDRH
S1321 LPLPDRHSGHKAENG
S1339 GVLVLRASFDERQPY
Y1346 SFDERQPYAHMNGGR
T1366 LPLPQSSTC______
2969 : Phospho-IGF-I Receptor beta (Tyr1135/1136)/Insulin Receptor beta (Tyr1150/1151) (19H7) Rabbit mAb (Biotinylated)
3918 : Phospho-IGF-1 Receptor beta (Tyr1135) (DA7A8) Rabbit mAb
2969 : Phospho-IGF-I Receptor beta (Tyr1135/1136)/Insulin Receptor beta (Tyr1150/1151) (19H7) Rabbit mAb (Biotinylated)
6113 : Phospho-IGF-I Receptor beta (Tyr1316) Antibody
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