a receptor tyrosine kinase that binds insulin-like growth factor 1 (IGF1) with a high affinity and IGF2 with a lower affinity. Functions as an anti-apoptotic agent by enhancing cell survival. Can play a critical role in transformation events. Cleavage of the precursor generates alpha and beta subunits. Tetramer of 2 alpha and 2 beta chains linked by disulfide bonds. The alpha chains contribute to the formation of the ligand- binding domain, while the beta chain carries the kinase domain. Interacts with PIK3R1 and with the PTB/PID domains of IRS1 and SHC1 in vitro when autophosphorylated on tyrosine residues. Mutated in rare cases of pre- and post-natal growth retardation. One SNP associated with increased human longevity. Increased expression of IGF1R and other pathway members associated with progression and malignancy in a range of cancers. Inhibitors: AG1024, AEW541. Note: This description may include information from UniProtKB.
Protein type: Protein kinase, tyrosine (receptor); Protein kinase, TK; EC 188.8.131.52; Membrane protein, integral; Kinase, protein; TK group; InsR family
Chromosomal Location of Human Ortholog: 15q26.3
Cellular Component: neuron projection; membrane; intracellular membrane-bound organelle; integral to plasma membrane; plasma membrane; caveola; receptor complex
Biological Process: positive regulation of cytokinesis; phosphoinositide 3-kinase cascade; phosphoinositide-mediated signaling; negative regulation of protein kinase B signaling cascade; inactivation of MAPKK activity; protein heterooligomerization; protein amino acid autophosphorylation; exocrine pancreas development; signal transduction; regulation of JNK cascade; positive regulation of protein kinase B signaling cascade; response to vitamin E; positive regulation of MAPKKK cascade; insulin-like growth factor receptor signaling pathway; mammary gland development; axonogenesis; establishment of cell polarity; male sex determination; positive regulation of cell proliferation; insulin receptor signaling pathway; immune response; brain development; protein tetramerization; positive regulation of DNA replication; positive regulation of cell migration; negative regulation of apoptosis
SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.