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Protein Page:
ATRX (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
ATRX a global transcriptional regulator. Belongs to the SNF2 family of proteins, many of which modify gene expression via chromatin remodeling activity. Involved in the developmental silencing of imprinted genes in the brain. Contains one PxVxL motif, which is required for interaction with chromoshadow domains. This motif requires additional residues at -7, -6, +4 and +5 relative to the central V which contact the chromoshadow domain. Constitutive mutations in ATRX are associated with brain, facial, and genital abnormalities, and alpha thalassemia. Acquired mutations in ATRX have been observed in preleukemic conditions. Six alternatively spliced human isoforms have been described. Note: This description may include information from UniProtKB.
Protein type: EC 3.6.4.12; EC 3.6.1.-; Helicase; DNA repair, damage; Ubiquitin conjugating system
Cellular Component: PML body; mitochondrion; cytoplasm; nucleolus; nuclear heterochromatin; nucleus
Molecular Function: DNA helicase activity; protein binding; DNA binding; histone binding; zinc ion binding; chromatin binding; DNA translocase activity; helicase activity; ATP binding; methylated histone residue binding
Biological Process: ATP catabolic process; transcription, DNA-dependent; DNA damage response, signal transduction by p53 class mediator; positive regulation of telomere maintenance; DNA repair; DNA duplex unwinding; DNA recombination; replication fork processing; chromatin remodeling; nucleosome assembly; regulation of transcription, DNA-dependent; DNA replication-independent nucleosome assembly; forebrain development; DNA methylation; positive regulation of transcription from RNA polymerase II promoter
Reference #:  P46100 (UniProtKB)
Alt. Names/Synonyms: alpha thalassemia/mental retardation syndrome X-linked (RAD54 homolog, S. cerevisiae); ATP-dependent helicase ATRX; ATR2; ATRX; DNA dependent ATPase and helicase; helicase 2, X-linked; MGC2094; MRXHF1; RAD54; RAD54L; SFM1; SHS; Transcriptional regulator ATRX; X-linked helicase II; X-linked nuclear protein; XH2; XNP; Zinc finger helicase; Znf-HX
Gene Symbols: ATRX
Molecular weight: 282,586 Da
Basal Isoelectric point: 6.2  Predict pI for various phosphorylation states
Select Structure to View Below

ATRX

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 6 S25-p LHDFLAHssEEsEET
0 5 S26-p HDFLAHssEEsEETS
0 3 S29-p LAHssEEsEETSsPP
0 6 S34-p EEsEETSsPPRLAMN
0 1 P35 EsEETSsPPRLAMNQ
0 1 S50-p NTDKISGsGsNsDMM
0 1 S50 NTDKISGSGsNsDMM
0 1 S52-p DKISGsGsNsDMMEN
0 3 S54-p ISGsGsNsDMMENSK
0 1 T65-p ENSKEEGtsssEKsK
0 1 S66-p NSKEEGtsssEKsKS
0 2 S67-p SKEEGtsssEKsKSs
0 1 S68-p KEEGtsssEKsKSsG
0 1 S71-p GtsssEKsKSsGSSR
0 1 S74-p ssEKsKSsGSSRSKR
0 18 S84-p SRSKRKPsIVtKyVE
0 1 T87-p KRKPsIVtKyVEsDD
0 7 Y89-p KPsIVtKyVEsDDEK
0 28 S92-p IVtKyVEsDDEKPLD
0 2 D99 sDDEKPLDDETVNED
0 1 S108-p ETVNEDAsNENsEND
0 7 S112-p EDAsNENsENDITMQ
0 1 S191-p DSIYRHPsLQVLICK
0 1 K202-ub LICKNCFkyyMSDDI
0 1 Y203-p ICKNCFkyyMSDDIs
0 1 Y204-p CKNCFkyyMSDDIsR
0 1 S210-p yyMSDDIsRDsDGMD
0 3 S213-p SDDIsRDsDGMDEQC
0 5 Y309-p SEKSNKVyEHTSRFs
0 26 S316-p yEHTSRFsPKKTSSN
0 1 T320 SRFsPKKTSSNCNGE
0 1 S321 RFsPKKTSSNCNGEE
0 1 S322 FsPKKTSSNCNGEEk
0 1 N323 sPKKTSSNCNGEEkK
0 1 K329-ac SNCNGEEkKLDDsCS
0 2 S334-p EEkKLDDsCSGsVTy
0 1 S336 kKLDDsCSGsVTySY
0 2 S338-p LDDsCSGsVTySYSA
0 1 T340 DsCSGsVTySYSALI
0 1 Y341-p sCSGsVTySYSALIV
0 2 A356 PKEMIKKAKKLIETT
0 1 S384-p ATDNSEIssAtKLRQ
0 1 S385-p TDNSEIssAtKLRQL
0 1 T387-p NSEIssAtKLRQLKA
0 1 S458-p ALEKKDIsKsEAKLs
0 1 S460-p EKKDIsKsEAKLsRK
0 1 S465-p sKsEAKLsRKQVDSE
0 1 S549-p VDHQGDGssGTEQEV
0 1 S550-p DHQGDGssGTEQEVE
0 1 S566-p SSVKLNIsSKDNRGG
0 5 K575-ac KDNRGGIkSkTTAkV
0 5 K577-ac NRGGIkSkTTAkVTK
0 5 K581-ac IkSkTTAkVTKELyV
0 1 Y587-p AkVTKELyVKLtPVs
0 5 T591-p KELyVKLtPVsLsNs
0 14 S594-p yVKLtPVsLsNsPIK
0 7 S596-p KLtPVsLsNsPIKGA
0 19 S598-p tPVsLsNsPIKGADC
0 2 K623-ac KSCGLNPkLEKCGLG
0 10 S634-p CGLGQENsDNEHLVE
0 2 S645-p HLVENEVsLLLEESD
0 1 S651 VsLLLEESDLRRSPR
0 3 T661-p RRSPRVKttPLRRPt
0 2 T662-p RSPRVKttPLRRPtE
0 20 T668-p ttPLRRPtEtNPVts
0 9 T670-p PLRRPtEtNPVtsNs
0 9 T674-p PtEtNPVtsNsDEEC
0 17 S675-p tEtNPVtsNsDEECN
0 50 S677-p tNPVtsNsDEECNEt
0 1 C681 tsNsDEECNEtVKEK
0 4 T684-p sDEECNEtVKEKQKL
0 1 S692-p VKEKQKLsVPVRKKD
0 7 S703-p RKKDKRNssDsAIDN
0 3 S704-p KKDKRNssDsAIDNP
0 1 S706-p DKRNssDsAIDNPKP
0 1 S719-p KPNKLPKsKQsEtVD
0 2 S722-p KLPKsKQsEtVDQNs
0 1 T724-p PKsKQsEtVDQNsDs
0 25 S729-p sEtVDQNsDsDEMLA
0 22 S731-p tVDQNsDsDEMLAIL
0 1 S748-p VSRMSHSsssDtDIN
0 1 S749-p SRMSHSsssDtDINE
0 2 S750-p RMSHSsssDtDINEI
0 1 T752-p SHSsssDtDINEIHT
0 2 S783-p KGKRKRKsstsGsDF
1 39 S784-p GKRKRKsstsGsDFD
0 12 T785-p KRKRKsstsGsDFDT
0 8 S786-p RKRKsstsGsDFDTK
0 21 S788-p RKsstsGsDFDTKKG
0 1 T792 tsGsDFDTKKGKSAK
0 1 T810-p ISKKKRQtQsEssNY
0 7 S812-p KKKRQtQsEssNYDs
0 2 S814-p KRQtQsEssNYDsEL
0 3 S815-p RQtQsEssNYDsELE
0 24 S819-p sEssNYDsELEKEIK
0 9 S849-p PNTKDFDssEDEKHS
0 8 S850-p NTKDFDssEDEKHSK
0 5 S871-p GHKNLKTsQEGssDD
0 10 S875-p LKTsQEGssDDAERK
0 13 S876-p KTsQEGssDDAERKQ
0 1 T887 ERKQERETFssAEGt
0 8 S889-p KQERETFssAEGtVD
0 2 S890-p QERETFssAEGtVDK
0 1 T894-p TFssAEGtVDKDttI
0 1 T899-p EGtVDKDttIMELRD
0 1 T900-p GtVDKDttIMELRDR
0 2 S925-p TDGVDKLsGKEQSFT
0 3 S933 GKEQSFTSLEVRKVA
0 1 L961 CKKVQDGLsDIAEkF
0 1 S962-p KKVQDGLsDIAEkFL
0 10 K967-ac GLsDIAEkFLKkDQs
0 1 K967-ub GLsDIAEkFLKkDQs
0 1 K971-ac IAEkFLKkDQsDEts
0 3 S974-p kFLKkDQsDEtsEDD
0 3 T977-p KkDQsDEtsEDDKKQ
0 3 S978-p kDQsDEtsEDDKKQS
0 12 S1011-p KMEQQYEsssDGTEK
0 8 S1012-p MEQQYEsssDGTEKL
0 8 S1013-p EQQYEsssDGTEKLP
0 4 T1016 YEsssDGTEKLPERE
0 17 S1061-p SKKKDELsDyAEKSt
0 1 Y1063-p KKDELsDyAEKStGK
0 1 T1068-p sDyAEKStGKGDsCD
0 2 S1073-p KStGKGDsCDssEDK
0 1 S1076-p GKGDsCDssEDKKSK
0 2 S1077-p KGDsCDssEDKKSKN
0 1 Y1087 KKSKNGAYGREKKRC
0 1 K1095 GREKKRCKLLGKSSR
0 1 S1108 SRKRQDCSSSDTEKY
0 1 S1109 RKRQDCSSSDTEKYS
0 56 L1140 ELRERRNLssKRNTK
0 9 S1141-p LRERRNLssKRNTKE
0 1 S1142-p RERRNLssKRNTKEI
0 1 S1153 TKEIQSGSsSSDAEE
0 1 S1154-p KEIQSGSsSSDAEEs
0 2 S1161-p sSSDAEEsSEDNKKK
0 3 T1239-p NLVLSSHtGFCQssG
0 11 S1244-p SHtGFCQssGDEALs
0 12 S1245-p HtGFCQssGDEALsK
0 2 S1251-p ssGDEALsKsVPVtV
0 3 S1253-p GDEALsKsVPVtVDD
0 2 T1257-p LsKsVPVtVDDDDDD
0 5 S1285-p EEIKANLssDEDGss
0 5 S1286-p EIKANLssDEDGssD
0 5 S1291-p LssDEDGssDDEPEE
0 5 S1292-p ssDEDGssDDEPEEG
0 4 N1307 KKRTGKQNEENPGDE
0 13 N1310 TGKQNEENPGDEEAK
0 9 S1322-p EAKNQVNsEsDsDSE
0 9 S1324-p KNQVNsEsDsDSEES
0 6 S1326-p QVNsEsDsDSEESKK
0 5 T1346-p RLLRHKLtVsDGEsG
0 24 S1348-p LRHKLtVsDGEsGEE
0 27 S1352-p LtVsDGEsGEEKkTk
0 2 K1357-ub GEsGEEKkTkPkEHK
0 2 T1358 EsGEEKkTkPkEHKE
0 2 K1359-ub sGEEKkTkPkEHKEV
0 2 K1361-ub EEKkTkPkEHKEVKG
0 1 K1429-ub KKKRRRIkVQEDsss
0 1 S1434-p RIkVQEDsssENKsN
0 2 S1435-p IkVQEDsssENKsNs
0 1 S1436-p kVQEDsssENKsNsE
0 1 S1440-p DsssENKsNsEEEEE
0 6 S1442-p ssENKsNsEEEEEEK
0 1 T1491-p LKDDKLRtEtQNALK
0 2 T1493-p DDKLRtEtQNALKEE
0 16 S1527-p VIEIEDAsPtKCPIT
0 4 T1529-p EIEDAsPtKCPITTK
0 1 S1654-p DDEKLEVsELATVKR
0 1 S1772-p IKENLLGsIkEFRNR
0 2 K1774-ub ENLLGsIkEFRNRFI
0 1 K1845 RMTSIQCKLYQyYLD
0 1 Y1849-p IQCKLYQyYLDHLTG
0 1 K1896 LQLDYISKENKGYFD
0 3 S1906-p KGYFDEDsMDEFIAs
0 3 S1913-p sMDEFIAsDSDEtSM
0 2 T1918-p IAsDSDEtSMsLssD
0 2 S1921-p DSDEtSMsLssDDYT
0 1 S1923-p DEtSMsLssDDYTKk
0 1 S1924-p EtSMsLssDDYTKkK
0 6 K1930-ac ssDDYTKkKKkGkkG
0 32 K1933-ac DYTKkKKkGkkGKkD
0 34 K1935-ac TKkKKkGkkGKkDSS
0 34 K1936-ac KkKKkGkkGKkDSSS
0 10 K1939-ac KkGkkGKkDSSSSGS
0 1 S1948 SSSSGSGSDNDVEVI
0 2 S1980-p TGNNPSVsLkLEESk
0 1 K1982-ub NNPSVsLkLEESkAt
0 1 K1987-ub sLkLEESkAtsssNP
0 2 T1989-p kLEESkAtsssNPss
0 3 S1990-p LEESkAtsssNPssP
0 3 S1991-p EESkAtsssNPssPA
0 12 S1992-p ESkAtsssNPssPAP
0 5 S1995-p AtsssNPssPAPDWy
0 23 S1996-p tsssNPssPAPDWyK
0 5 Y2002-p ssPAPDWyKDFVTDA
0 2 S2017-p DAEVLEHsGKMVLLF
0 2 K2076-ac LIYKGEGkWLRNIDY
0 1 S2089-p DYYRLDGsttAQsRK
0 1 T2090-p YYRLDGsttAQsRKK
0 1 T2091-p YRLDGsttAQsRKKW
0 1 S2094-p DGsttAQsRKKWAEE
0 2 S2220-p DLLDDPNsEKKKKRD
0 1 K2233-ub RDTPMLPkDTILAEL
0 1 K2282-ub WAEYEAEkKGLTMRF
0 1 T2293 TMRFNIPTGTNLPPV
0 1 T2295 RFNIPTGTNLPPVSF
0 1 S2301 GTNLPPVSFNSQTPY
0 1 N2303 NLPPVSFNSQTPYIP
0 1 S2317 PFNLGALSAMSNQQL
0 1 S2320 LGALSAMSNQQLEDL
0 1 T2339-p REKVVEAtNSVTAVR
0 1 S2355-p QPLEDIIsAVWKENM
0 11 S2379-p LALSRQAsQELDVKR
0 2 R2474-m2 MQPPPLQrAPPPMrS
0 1 R2474 MQPPPLQRAPPPMrS
0 2 R2480-m2 QrAPPPMrSKNPGPs
0 1 R2480 QrAPPPMRSKNPGPs
0 4 S2487-p rSKNPGPsQGkSM__
0 2 K2490-ac NPGPsQGkSM_____
  mouse

 
S25 LHDFLAHSSEESEET
S26 HDFLAHSSEESEETC
S29 LAHSSEESEETCSsP
S34 EESEETCSsPRLVMN
S35-p ESEETCSsPRLVMNQ
S50 STDKICGSGLNsDMM
S50-gl STDKICGsGLNsDMM
L52 DKICGsGLNsDMMEN
S54-p ICGsGLNsDMMENNK
A65 ENNKEEGASTSEKSR
S66 NNKEEGASTSEKSRS
T67 NKEEGASTSEKSRSS
S68 KEEGASTSEKSRSSG
S71 GASTSEKSRSSGSSR
S74 TSEKSRSSGSSRSKR
S84-p SRSKRKPsIVTKyVE
T87 KRKPsIVTKyVEsDD
Y89-p KPsIVTKyVEsDDEK
S92-p IVTKyVEsDDEKPtD
T98-p EsDDEKPtDENVNEK
A107 ENVNEKAATENsEND
S111-p EKAATENsENDITMQ
S190 DSIYRHPSLKVLICK
K201 LICKNCFKYYMSDDI
Y202 ICKNCFKYYMSDDIS
Y203 CKNCFKYYMSDDISR
S209 YYMSDDISRDsDGMD
S212-p SDDISRDsDGMDEQC
C308 SEKTSKVCDQTSKFs
S315-p CDQTSKFsPKKssss
S319-p SKFsPKKssssCNGE
S320-p KFsPKKssssCNGEE
S321-p FsPKKssssCNGEEK
S322-p sPKKssssCNGEEKK
K328 ssCNGEEKKLEEsCs
S333-p EEKKLEEsCsGsVsS
S335-p KKLEEsCsGsVsSTY
S337-p LEEsCsGsVsSTYSH
S339-p EsCsGsVsSTYSHSA
Y342 sGsVsSTYSHSALSV
T357-p PKEMIKKtTKLIETT
T385 AADNSEMTSAMKLCQ
S386 ADNSEMTSAMKLCQL
M388 NSEMTSAMKLCQLKS
L459 STEKREFLKLDARSS
L461 EKREFLKLDARSSVK
S466 LKLDARSSVKAIDGE
N541 ADYQGDGNSGTEPEL
S542 DYQGDGNSGTEPELE
S558 SSVKLNVSSKDSRGN
K567 KDSRGNIKSKVTAKV
K569 SRGNIKSKVTAKVRK
K573 IKSKVTAKVRKELFV
F579 AKVRKELFVKLtPVs
T583-p KELFVKLtPVsLsNs
S586-p FVKLtPVsLsNsPIK
S588-p KLtPVsLsNsPIKGV
S590-p tPVsLsNsPIKGVDC
S615 KSSGVARSSEKCRPR
S626-p CRPREEIsDHENNVt
T633-p sDHENNVtILLEDsD
S639-p VtILLEDsDLRRSPR
T649 RRSPRVKTtPLRRQt
T650-p RSPRVKTtPLRRQtE
T656-p TtPLRRQtEsNPAMs
S658-p PLRRQtEsNPAMsNs
M662 QtEsNPAMsNsDEEs
S663-p tEsNPAMsNsDEEsN
S665-p sNPAMsNsDEEsNGt
S669-p MsNsDEEsNGtMKEK
T672-p sDEEsNGtMKEKQKM
S680 MKEKQKMSGPIRKKD
S691-p RKKDKRNsADCATDN
A692 KKDKRNsADCATDNP
C694 DKRNsADCATDNPKP
A707 KPHKVPKAKQPVIGD
P710 KVPKAKQPVIGDQNs
I712 PKAKQPVIGDQNsDs
S717-p PVIGDQNsDsDEMLA
S719-p IGDQNsDsDEMLAVL
S736 ASQMGHSSSSDTDIN
S737 SQMGHSSSSDTDINE
S738 QMGHSSSSDTDINEP
T740 GHSSSSDTDINEPQM
N765 NGKRKRKNstsGsDF
S766-p GKRKRKNstsGsDFD
T767-p KRKRKNstsGsDFDt
S768-p RKRKNstsGsDFDtK
S770-p RKNstsGsDFDtKKG
T774-p tsGsDFDtKKGKSTE
N792 ISKKKRQNYsEssNY
S794-p KKKRQNYsEssNYDs
S796-p KRQNYsEssNYDsEL
S797-p RQNYsEssNYDsELE
S801-p sEssNYDsELEREIK
S828-p PEKKEEDssEDEKQG
S829-p EKKEEDssEDEKQGK
T850 GHERAKTTQEGssAD
S854-p AKTTQEGssADDTGD
S855-p KTTQEGssADDTGDT
S869-p TEGRQGGsCsIAGGS
S871-p GRQGGsCsIAGGSIE
I872 RQGGsCsIAGGSIEK
A873 QGGsCsIAGGSIEKV
R881 GGSIEKVRSGVEFRE
S882 GSIEKVRSGVEFREM
S904 SDGAEKPSVKEENVN
S912-p VKEENVNsPEDKRVS
S940-p SRKGKGGsSDGTDRF
S941 RKGKGGsSDGTDRFP
R946 GsSDGTDRFPKKEQs
R946 GsSDGTDRFPKKEQs
K950 GTDRFPKKEQsDEss
S953-p RFPKKEQsDEssEGE
S956-p KKEQsDEssEGEKKQ
S957-p KEQsDEssEGEKKQS
S991-p KREQEWDsssDGtER
S992-p REQEWDsssDGtERL
S993-p EQEWDsssDGtERLP
T996-p WDsssDGtERLPEEE
S1041-p CEKKEELsDSVDKLP
S1043 KKEELsDSVDKLPGK
P1048 sDSVDKLPGKGDsCD
S1053-p KLPGKGDsCDssEDK
S1056-p GKGDsCDssEDKKTR
S1057-p KGDsCDssEDKKTRN
S1067-p KKTRNRVsLREKKRF
S1075-p LREKKRFsLPAKSPG
S1088-p PGKRPECssSDTEKS
S1089-p GKRPECssSDTEKSL
S1119-p DLRERRNssSKRNTK
S1120-p LRERRNssSKRNTKE
S1121 RERRNssSKRNTKEV
S1132-p TKEVKSAsSSSDAEG
S1133 KEVKSAsSSSDAEGS
S1140 SSSDAEGSSEDNKKQ
T1218-p NLVLPSHtGFCQssG
S1223-p SHtGFCQssGDEALs
S1224-p HtGFCQssGDEALsK
S1230-p ssGDEALsKsVPAtV
S1232-p GDEALsKsVPAtVDD
T1236-p LsKsVPAtVDDDDDD
S1264-p EEIKANLssDEDGss
S1265-p EIKANLssDEDGssD
S1270-p LssDEDGssDDEPDG
S1271-p ssDEDGssDDEPDGG
S1287-p KKRIGKQsEEsPADD
S1290-p IGKQsEEsPADDGEL
S1309-p LAVNQVNsEsDsDSE
S1311-p VNQVNsEsDsDSEES
S1313-p QVNsEsDsDSEESKK
T1333-p RLLRHKLtLsDGEsG
S1335-p LRHKLtLsDGEsGEE
S1339-p LtLsDGEsGEEKPtK
P1344 GEsGEEKPtKPKEHK
T1345-p EsGEEKPtKPKEHKE
K1346 sGEEKPtKPKEHKEA
K1348 EEKPtKPKEHKEAKG
K1416 KKKRRRIKVQEDSSS
S1421 RIKVQEDSSSENKSH
S1422 IKVQEDSSSENKSHS
S1423 KVQEDSSSENKSHSE
S1427 DSSSENKSHSEEDKK
S1429 SSENKSHSEEDKKEG
T1476 LKDDKLRTETQNALK
T1478 DDKLRTETQNALKEE
S1512-p VIEIEDAsPtKCPIT
T1514-p EIEDAsPtKCPITTK
S1639 DNEKLEVSELATVKR
S1757 IKENLLGSIKEFRNR
K1759 ENLLGSIKEFRNRFI
K1830-ub RMTAIQCkLYQYYLD
Y1834 IQCkLYQYYLDHLTG
K1881-ub LQLDYISkENKGYFD
S1891-p KGYFDEDsMDEFIAs
S1898-p sMDEFIAsDSDEtSK
T1903-p IAsDSDEtSKSLSSD
S1906 DSDEtSKSLSSDEKK
S1908 DEtSKSLSSDEKKKP
S1909 EtSKSLSSDEKKKPK
K1913 SLSSDEKKKPKGKKG
K1916 SDEKKKPKGKKGKKD
K1918 EKKKPKGKKGKKDSS
K1919 KKKPKGKKGKKDSSS
K1922 PKGKKGKKDSSSSGS
S1931-p SSSSGSGsDNDVEVI
S1963 TGNNPSVSLKLDESK
K1965 NNPSVSLKLDESKTt
K1970 SLKLDESKTtstsNP
T1972-p KLDESKTtstsNPss
S1973-p LDESKTtstsNPssP
T1974-p DESKTtstsNPssPA
S1975-p ESKTtstsNPssPAP
S1978-p TtstsNPssPAPDWy
S1979-p tstsNPssPAPDWyK
Y1985-p ssPAPDWyKDFVTDT
S2000 DAEVLEHSGKMVLLF
K2059 LIYKGEGKWIRNIDY
S2072 DYYRLDGSTNAQSRK
T2073 YYRLDGSTNAQSRKK
N2074 YRLDGSTNAQSRKKW
S2077 DGSTNAQSRKKWAEE
S2203 DLLDDPNSEKKKKRD
K2216 RDTPMLPKDTILAEL
K2265 WAEYEAEKKGLTMRF
T2276-p TMRFNIPtGtNLPPV
T2278-p RFNIPtGtNLPPVtF
T2284-p GtNLPPVtFtSQTPY
T2286-p NLPPVtFtSQTPYIP
S2300-p PFNLGALsAMsNQQL
S2303-p LGALsAMsNQQLEDL
T2322 REKVVEATNSMTAVR
S2338 QPLEDIISTVWKENM
S2362-p LALSRQAsQELDVKR
R2457 MQPPPLQRAPPPTVr
R2457-m1 MQPPPLQrAPPPTVr
R2464 rAPPPTVRSKNPGPs
R2464-m1 rAPPPTVrSKNPGPs
S2471-p rSKNPGPsPGKSM__
K2474 NPGPsPGKSM_____
  rat

 
S20 LHDFLAHSSEESEET
S21 HDFLAHSSEESEETC
S24 LAHSSEESEETCSSP
S29 EESEETCSSPRLVMN
S30 ESEETCSSPRLVMNQ
S45 STDKISASGLNSDMM
S45 STDKISASGLNSDMM
L47 DKISASGLNSDMMEN
S49 ISASGLNSDMMENSK
T60 ENSKEEGTSTSEKSK
S61 NSKEEGTSTSEKSKS
T62 SKEEGTSTSEKSKSS
S63 KEEGTSTSEKSKSSG
S66 GTSTSEKSKSSGSSR
S69 TSEKSKSSGSSRSKR
S79-p SRSKRKPsIVTKyVE
T82 KRKPsIVTKyVEsDD
Y84-p KPsIVTKyVEsDDEK
S87-p IVTKyVEsDDEKPTD
T93 EsDDEKPTDENVNEK
A102 ENVNEKAATENsEND
S106-p EKAATENsENDITMQ
S185 DSIYRHPSLKVLICK
K196 LICKNCFKYYMSDDI
Y197 ICKNCFKYYMSDDIS
Y198 CKNCFKYYMSDDISR
S204 YYMSDDISRDSDGMD
S207 SDDISRDSDGMDEQC
C303 SEKTSKVCDQTSKFs
S310-p CDQTSKFsPKKNSSS
N314 SKFsPKKNSSSCNGE
S315 KFsPKKNSSSCNGEE
S316 FsPKKNSSSCNGEEK
S317 sPKKNSSSCNGEEKK
K323 SSCNGEEKKLEESGS
S328 EEKKLEESGSSSVTS
S330 KKLEESGSSSVTSTS
S332 LEESGSSSVTSTSSA
T334 ESGSSSVTSTSSALI
S335 SGSSSVTSTSSALIV
T350 PKELIKKTKKLIETT
S378 AADNSEMSPAMKLRQ
P379 ADNSEMSPAMKLRQL
M381 NSEMSPAMKLRQLKA
F452 NTEKKDFFKLDARSS
L454 EKKDFFKLDARSSVK
S459 FKLDARSSVKAVDRE
N532 ADYQGDGNSANEAEL
S533 DYQGDGNSANEAELE
S549 SSLKLNTSKGSKGNV
K557 KGSKGNVKSKVTAKV
K559 SKGNVKSKVTAKVRK
K563 VKSKVTAKVRKELYV
Y569 AKVRKELYVKLTPVS
T573 KELYVKLTPVSLSNS
S576 YVKLTPVSLSNSPLK
S578 KLTPVSLSNSPLKGV
S580 TPVSLSNSPLKGVDC
S605 KSSGVARSSEKCRPR
S616 CRPREESSDNEHSVE
T627 HSVEHDVTILLEDSD
S633 VTILLEDSDLRRSPR
T643 RRSPRVKTTPLRRQt
T644 RSPRVKTTPLRRQtE
T650-p TTPLRRQtEsNPAVS
S652-p PLRRQtEsNPAVSNS
V656 QtEsNPAVSNSDEEG
S657 tEsNPAVSNSDEEGN
S659 sNPAVSNSDEEGNEt
G663 VSNSDEEGNEtIKEK
T666-p SDEEGNEtIKEKQKL
S674 IKEKQKLSVPVRKKD
S685 RKKDKRNSSDCAIDN
S686 KKDKRNSSDCAIDNP
C688 DKRNSSDCAIDNPKP
A701 KPHKVPKAKQPGIGD
P704 KVPKAKQPGIGDQNS
I706 PKAKQPGIGDQNSDS
S711 PGIGDQNSDSDEMLA
S713 IGDQNSDSDEMLAIL
S730 ASQMCHSSSSDTDIN
S731 SQMCHSSSSDTDINE
S732 QMCHSSSSDTDINEL
T734 CHSSSSDTDINELPI
N759 NGKRKRKNSTSGSDF
S760 GKRKRKNSTSGSDFD
T761 KRKRKNSTSGSDFDT
S762 RKRKNSTSGSDFDTK
S764 RKNSTSGSDFDTKKG
T768 TSGSDFDTKKGKSAE
N786 ISKKKRQNYSESSNY
S788 KKKRQNYSESSNYDS
S790 KRQNYSESSNYDSEL
S791 RQNYSESSNYDSELE
S795 SESSNYDSELEREIK
F822 SDKEEHDFSEDEKQS
S823 DKEEHDFSEDEKQSK
A844 GHERRRSAQEGSSGD
S848 RRSAQEGSSGDDTGD
S849 RSAQEGSSGDDTGDA
S863 AEGGPGGSSSPRQGS
S865 GGPGGSSSPRQGSVE
P866 GPGGSSSPRQGSVEK
- gap
R875 QGSVEKGRSVVEFGD
S876 GSVEKGRSVVEFGDM
S901 SAGSEKPSGKEENVH
S909 GKEENVHSPEDKRVT
- gap
S935 RTGRKVKSDVTDRFR
R940 VKSDVTDRFRKKEQS
R940 VKSDVTDRFRKKEQS
K944 VTDRFRKKEQSSESS
S947 RFRKKEQSSESSEGE
S950 KKEQSSESSEGEKKQ
S951 KEQSSESSEGEKKQG
S985 KREREYESSSDGTEK
S986 REREYESSSDGTEKL
S987 EREYESSSDGTEKLP
T990 YESSSDGTEKLPEGE
S1035 CEKKEELSDSVDRLP
S1037 KKEELSDSVDRLPVK
P1042 SDSVDRLPVKGESCD
S1047 RLPVKGESCDSSEDK
S1050 VKGESCDSSEDKKTR
S1051 KGESCDSSEDKKTRN
S1061 KKTRNRVSLREKKQF
S1069 LREKKQFSLPAKSSG
S1082 SGKRPECSSSDTERS
S1083 GKRPECSSSDTERSV
S1113 DLRERRSSNSKRSTK
N1114 LRERRSSNSKRSTKE
S1115 RERRSSNSKRSTKEV
S1126 TKEVKSGSSSSDAEG
S1127 KEVKSGSSSSDAEGS
S1134 SSSDAEGSSEDAKKQ
T1213 NLVLPSHTGFCQssG
S1218-p SHTGFCQssGDEAFS
S1219-p HTGFCQssGDEAFSK
S1225 ssGDEAFSKSVPATV
S1227 GDEAFSKSVPATVDD
T1231 FSKSVPATVDDDDDD
S1259 EEIKANLSSDEDGSS
S1260 EIKANLSSDEDGSSD
S1265 LSSDEDGSSDDEPEE
S1266 SSDEDGSSDDEPEEG
S1282 KKRIGKQSEETPGDD
T1285 IGKQSEETPGDDGEL
S1304 LSSNQVNSESDSDSE
S1306 SNQVNSESDSDSEES
S1308 QVNSESDSDSEESKK
S1328 RLLRHKLSLSDGESG
S1330 LRHKLSLSDGESGEE
S1334 LSLSDGESGEEKKTK
K1339 GESGEEKKTKPKEHK
T1340 ESGEEKKTKPKEHKE
K1341 SGEEKKTKPKEHKET
K1343 EEKKTKPKEHKETKG
K1411 KKKRRRIKVQEDSSS
S1416 RIKVQEDSSSDNKAR
S1417 IKVQEDSSSDNKARM
S1418 KVQEDSSSDNKARMI
A1422 DSSSDNKARMIHSEE
M1424 SSDNKARMIHSEEER
T1470 LKDDKLRTETQNALK
T1472 DDKLRTETQNALKEE
S1506 VIEIEDASPTKCPIT
T1508 EIEDASPTKCPITTK
S1633 DAEKLEVSELATVKR
S1751 IKENLLGSIKEFRNR
K1753 ENLLGSIKEFRNRFI
K1824 RMTAIQCKLYQYYLD
Y1828 IQCKLYQYYLDHLTG
K1875 LQLDYISKENKGYFD
S1885 KGYFDEDSMDEFIAS
S1892 SMDEFIASDSDETSM
T1897 IASDSDETSMSLSSD
S1900 DSDETSMSLSSDEKK
S1902 DETSMSLSSDEKKKT
S1903 ETSMSLSSDEKKKTK
K1907 SLSSDEKKKTKGKKG
K1910 SDEKKKTKGKKGRKD
K1912 EKKKTKGKKGRKDSS
K1913 KKKTKGKKGRKDSSS
K1916 TKGKKGRKDSSSSGS
S1925 SSSSGSGSDNDVEVI
S1957 TGNNPSVSLKLDESK
K1959 NNPSVSLKLDESKTT
K1964 SLKLDESKTTSTSNP
T1966 KLDESKTTSTSNPSS
S1967 LDESKTTSTSNPSSP
T1968 DESKTTSTSNPSSPA
S1969 ESKTTSTSNPSSPAP
S1972 TTSTSNPSSPAPDWY
S1973 TSTSNPSSPAPDWYK
Y1979 SSPAPDWYKDFVTDA
S1994 DAEVLEHSGKMVLLF
K2053 LIYKGEGKWLRNIDY
S2066 DYYRLDGSTNAQSRK
T2067 YYRLDGSTNAQSRKK
N2068 YRLDGSTNAQSRKKW
S2071 DGSTNAQSRKKWAEE
S2197 DLLDDPNSEKKKKRD
K2210 RDTPMLPKDTILAEL
K2259 WAEYEAEKKGLTMRF
T2270 TMRFNIPTGTNLPPV
T2272 RFNIPTGTNLPPVTF
T2278 GTNLPPVTFTSQTPY
T2280 NLPPVTFTSQTPYIP
S2294 PFNLGALSAMSNQQL
S2297 LGALSAMSNQQLEDL
T2316 REKVVEATNSVTSVR
S2332 QPLEDIISTVWKENM
S2356 LALSRQASQELDVKR
R2451 MQPPPLQRAPPPMRS
R2451 MQPPPLQRAPPPMRS
R2457 QRAPPPMRSKNPGPS
R2457 QRAPPPMRSKNPGPS
S2464 RSKNPGPSPGKSM__
K2467 NPGPSPGKSM_____
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