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GSK3B (human)

Overview GSK3B a proline-directed protein kinase of the GSK family. Phosphorylates and inactivates glycogen synthase. Participates in the Wnt signaling pathway. Involved in energy metabolism, neuronal cell development, and body pattern formation Note: This description may include information from UniProtKB. Protein type: Protein kinase, Ser/Thr (non-receptor); Kinase, protein; Protein kinase, CMGC; EC 2.7.11.26; EC 2.7.11.1; CMGC group; GSK family; GSK subfamily Cellular Component: centrosome; dendritic spine; cytosol; beta-catenin destruction complex; ribonucleoprotein complex; lipid raft; growth cone; cell soma; cytoplasm; nucleolus; plasma membrane; dendritic shaft; nucleus Molecular Function: identical protein binding; p53 binding; beta-catenin binding; protein kinase binding; integrin binding; NF-kappaB binding; ionotropic glutamate receptor binding; protein serine/threonine kinase activity; protein binding; ubiquitin protein ligase binding; tau-protein kinase activity; kinase activity; tau protein binding; ATP binding Biological Process: fat cell differentiation; glycogen metabolic process; negative regulation of MAP kinase activity; axon guidance; re-entry into mitotic cell cycle; genetic imprinting; nerve growth factor receptor signaling pathway; positive regulation of protein binding; response to lithium ion; Wnt receptor signaling pathway through beta-catenin; protein amino acid phosphorylation; positive regulation of protein export from nucleus; protein export from nucleus; negative regulation of protein binding; positive regulation of cell-matrix adhesion; ER overload response; myoblast fusion; negative regulation of glycogen biosynthetic process; epidermal growth factor receptor signaling pathway; response to drug; regulation of microtubule-based process; cell migration; fibroblast growth factor receptor signaling pathway; phosphoinositide-mediated signaling; hippocampus development; negative regulation of dendrite morphogenesis; negative regulation of NFAT protein import into nucleus; positive regulation of peptidyl-serine phosphorylation; peptidyl-serine phosphorylation; organ morphogenesis; positive regulation of protein complex assembly; establishment of cell polarity; positive regulation of protein catabolic process; epithelial to mesenchymal transition; positive regulation of transcription from RNA polymerase II promoter; positive regulation of Rac GTPase activity; negative regulation of transcription, DNA-dependent; negative regulation of protein complex assembly; regulation of neuronal synaptic plasticity; negative regulation of apoptosis Reference #:  P49841 (UniProtKB) Alt. Names/Synonyms: glycogen synthase kinase 3 beta; Glycogen synthase kinase-3 beta; GSK-3 beta; GSK3B; GSK3beta isoform Gene Symbols: GSK3B Molecular weight: 46,744 Da Basal Isoelectric point: 8.98  Predict pI for various phosphorylation states CST Pathways:  Adherens Junction Dynamics  |  Alzheimer's Disease  |  B Cell Receptor Signaling  |  Cell Cycle: G1/S Checkpoint  |  ErbB/HER Signaling  |  ESC Pluripotency and Differentiation  |  Hedgehog Signaling  |  Inhibition of Apoptosis  |  Insulin Receptor Signaling  |  MAPK/Erk in Growth and Differentiation  |  mTOR Signaling  |  NF-kB Signaling  |  PI3K/Akt Signaling  |  Regulation of Microtubule Dynamics  |  Translation: eIF2  |  Translation: eIF4E and p70S6K  |  Wnt/ß-Catenin Signaling Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below GSK3B 1GNG - A/B=27-393 (human) 1H8F - A/B=35-386 (human) 1I09 - A/B=1-420 (human) 1J1B - A/B=1-420 (human) 1J1C - A/B=1-420 (human) 1O9U - A=35-384 (human) 1PYX - A/B=1-420 (human) 1Q3D - A/B=2-420 (human) 1Q3W - A/B=2-420 (human) 1Q41 - A/B=2-420 (human) 1Q4L - A/B=2-420 (human) 1Q5K - A/B=7-420 (human) 1R0E - A/B=35-420 (human) 1UV5 - A=35-384 (human) 2JDO - C=3-12 (human) 2JDR - C=3-12 (human) 2JLD - A/B=1-420 (human) 2O5K - A=29-393 (human) 2OW3 - A/B=35-386 (human) 2UW9 - C=3-12 (human) 2X39 - C=3-12 (human) 2XH5 - C=3-12 (human) 3CQU - C=3-12 (human) 3CQW - C=3-12 (human) 3DU8 - A/B=1-420 (human) 3E87 - D/C=3-12 (human) 3E88 - D/C=3-12 (human) 3E8D - D/C=3-12 (human) 3F7Z - A/B=35-383 (human) 3F88 - A/B=35-383 (human) 3GB2 - A=34-383 (human) 3I4B - A/B=7-420 (human) 3L1S - A/B=7-420 (human) 3M1S - A/B=1-420 (human) 3PUP - A/B=1-420 (human) 3Q3B - A/B=2-420 (human) 3SAY - A/B=1-420 (human) 3SD0 - A/B=35-384 (human) 3ZDI - A=35-384 (human) 3ZRK - A/B=23-393 (human) 3ZRL - A/B=23-393 (human) 3ZRM - A/B=23-393 (human) 4ACC - A/B=1-420 (human) 4ACD - A/B=1-420 (human) 4ACG - A/B=1-420 (human) 4ACH - A/B=1-420 (human) 4AFJ - A/B=27-393 (human) 4B7T - A=35-384 (human) 4DIT - A=27-393 (human) 4EKK - D/C=3-12 (human) 4J1R - A/D/C/B=1-420 (human) 4J71 - A/B=1-420 (human) Substrate Sequence Logo

STRING  |  Scansite  |  KinBase  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  RCSB PDB 1GNG 1H8F 1I09 1J1B 1J1C 1O9U 1PYX 1Q3D 1Q3W 1Q41 1Q4L 1Q5K 1R0E 1UV5 2JDO 2JDR 2JLD 2O5K 2OW3 2UW9 2X39 2XH5 3CQU 3CQW 3DU8 3E87 3E88 3E8D 3F7Z 3F88 3GB2 3I4B 3L1S 3M1S 3PUP 3Q3B 3SAY 3SD0 3ZDI 3ZRK 3ZRL 3ZRM 4ACC 4ACD 4ACG 4ACH 4AFJ 4B7T 4DIT 4EKK 4J1R 4J71  |  ENZYME  |  Phospho3D  |  DISEASE 605004 606784  |  Source  |  UCSD-Nature  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene

	Sites Implicated In
apoptosis, altered: S9‑p, Y216‑p apoptosis, induced: Y216‑p apoptosis, inhibited: S9‑p cell adhesion, altered: S9‑p cell differentiation, induced: S9‑p cell growth, altered: S9‑p, Y216‑p cell motility, altered: S9‑p cytoskeletal reorganization: S9‑p transcription, altered: S9‑p, Y216‑p enzymatic activity, induced: Y216‑p enzymatic activity, inhibited: S9‑p inhibition: S9‑p intracellular localization: S9‑p, Y216‑p molecular association, regulation: Y216‑p phosphorylation: S9‑p protein conformation: Y216‑p protein degradation: S9‑p protein stabilization: Y216‑p

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human ► Hide Isoforms
0	19		T7-p	_MSGRPRttsFAEsC
0	19		T8-p	MSGRPRttsFAEsCK
336	221		S9-p	SGRPRttsFAEsCKP
0	4		S13-p	RttsFAEsCKPVQQP
3	9		S21-p	CKPVQQPsAFGsMKV
0	70		S25-p	QQPsAFGsMKVSRDK
0	1		S35-p	VSRDKDGsKVTTVVA
1	1		T43-p	KVTTVVAtPGQGPDR
0	9		Y71-p	NGSFGVVyQAKLCDS
1	0		-	under review
0	7		K205-u	LCDFGSAkQLVRGEP
0	1207		S215-p	VRGEPNVsyICsRyy
57	4239		Y216-p	RGEPNVsyICsRyyR
1	1108		S219-p	PNVsyICsRyyRAPE
0	111		Y221-p	VsyICsRyyRAPELI
0	7		Y222-p	syICsRyyRAPELIF
0	3		K292-u	NPNYTEFkFPQIKAH
1	0		K292-s	NPNYTEFkFPQIKAH
1	6		S389-p	ARIQAAAstPtNATA
0	19		T390-p	RIQAAAstPtNATAA
0	2		T392-p	QAAAstPtNATAASD
0	1		T395	AstPtNATAASDANt
0	1		T402-p	TAASDANtGDRGQTN
0	1		S417-p	NAASASAsNST____

	GSK3B iso2
T7	_MSGRPRTTsFAESC
T8	MSGRPRTTsFAESCK
S9-p	SGRPRTTsFAESCKP
S13	RTTsFAESCKPVQQP
S21	CKPVQQPSAFGSMKV
S25	QQPSAFGSMKVSRDK
S35	VSRDKDGSKVTTVVA
T43	KVTTVVATPGQGPDR
Y71	NGSFGVVYQAKLCDS
-	under review
K205	LCDFGSAKQLVRGEP
S215	VRGEPNVSyICSRYY
Y216-p	RGEPNVSyICSRYYR
S219	PNVSyICSRYYRAPE
Y221	VSyICSRYYRAPELI
Y222	SyICSRYYRAPELIF
K292	NPNYTEFKFPQIKAH
K292	NPNYTEFKFPQIKAH
S402	ARIQAAASTPTNATA
T403	RIQAAASTPTNATAA
T405	QAAASTPTNATAASD
T408	ASTPTNATAASDANT
T415	TAASDANTGDRGQTN
S430	NAASASASNST____

	mouse
T7-p	_MSGRPRttsFAEsC
T8-p	MSGRPRttsFAEsCK
S9-p	SGRPRttsFAEsCKP
S13-p	RttsFAEsCKPVQQP
S21-p	CKPVQQPsAFGsMKV
S25-p	QQPsAFGsMKVSRDK
S35	VSRDKDGSKVTTVVA
T43	KVTTVVATPGQGPDR
Y71	NGSFGVVYQAKLCDS
-	under review
K205-u	LCDFGSAkQLVRGEP
S215-p	VRGEPNVsyICsRYY
Y216-p	RGEPNVsyICsRYYR
S219-p	PNVsyICsRYYRAPE
Y221	VsyICsRYYRAPELI
Y222	syICsRYYRAPELIF
K292-u	NPNYTEFkFPQIKAH
K292	NPNYTEFKFPQIKAH
S389-p	ARIQAAAsPPANAtA
P390	RIQAAAsPPANAtAA
A392	QAAAsPPANAtAASD
T395-p	AsPPANAtAASDTNA
A402	tAASDTNAGDRGQTN
S417	NAASASASNST____

	rat
T7	_MSGRPRTTsFAESC
T8	MSGRPRTTsFAESCK
S9-p	SGRPRTTsFAESCKP
S13	RTTsFAESCKPVQQP
S21	CKPVQQPSAFGSMKV
S25	QQPSAFGSMKVSRDK
S35	VSRDKDGSKVTTVVA
T43	KVTTVVATPGQGPDR
Y71-p	NGSFGVVyQAKLCDS
K205-a	LCDFGSAkQLVRGEP
K205	LCDFGSAKQLVRGEP
S215-p	VRGEPNVsyICsRyY
Y216-p	RGEPNVsyICsRyYR
S219-p	PNVsyICsRyYRAPE
Y221-p	VsyICsRyYRAPELI
Y222	syICsRyYRAPELIF
K292	NPNYTEFKFPQIKAH
K292	NPNYTEFKFPQIKAH
S389	ARIQAAASPPANATA
P390	RIQAAASPPANATAA
A392	QAAASPPANATAASD
T395	ASPPANATAASDTNA
A402	TAASDTNAGDRGQTN
S417	NAASASASNST____

	rabbit
-	gap
T2	______XTSFAESXK
S3	_____XTSFAESXKP
S7	_XTSFAESXKPVQQP
S15	XKPVQQPSAFGS___
S19	QQPSAFGS_______
-	gap
-	gap
-	gap
-	under review
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap

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