a proline-directed protein kinase of the GSK family. Phosphorylates and inactivates glycogen synthase. Participates in the Wnt signaling pathway. Involved in energy metabolism, neuronal cell development, and body pattern formation Note: This description may include information from UniProtKB.
Protein type: Kinase, protein; EC 220.127.116.11; Protein kinase, Ser/Thr (non-receptor); Protein kinase, CMGC; EC 18.104.22.168; CMGC group; GSK family; GSK subfamily
Molecular Function: p53 binding; beta-catenin binding; protein kinase binding; integrin binding; NF-kappaB binding; protein serine/threonine kinase activity; ionotropic glutamate receptor binding; protein binding; ubiquitin protein ligase binding; tau-protein kinase activity; kinase activity; tau protein binding; ATP binding
Biological Process: fat cell differentiation; glycogen metabolic process; circadian rhythm; negative regulation of MAP kinase activity; axon guidance; genetic imprinting; re-entry into mitotic cell cycle; positive regulation of protein binding; nerve growth factor receptor signaling pathway; response to lithium ion; Wnt receptor signaling pathway through beta-catenin; protein amino acid phosphorylation; positive regulation of protein export from nucleus; protein export from nucleus; negative regulation of protein binding; positive regulation of cell-matrix adhesion; ER overload response; myoblast fusion; negative regulation of glycogen biosynthetic process; response to drug; epidermal growth factor receptor signaling pathway; regulation of microtubule-based process; cell migration; fibroblast growth factor receptor signaling pathway; phosphoinositide-mediated signaling; hippocampus development; negative regulation of dendrite morphogenesis; negative regulation of NFAT protein import into nucleus; positive regulation of peptidyl-serine phosphorylation; organ morphogenesis; peptidyl-serine phosphorylation; positive regulation of protein complex assembly; establishment of cell polarity; positive regulation of protein catabolic process; innate immune response; epithelial to mesenchymal transition; positive regulation of transcription from RNA polymerase II promoter; positive regulation of Rac GTPase activity; negative regulation of protein complex assembly; negative regulation of apoptosis; regulation of neuronal synaptic plasticity
SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.