Javascript is not enabled on this browser. This site will not work properly without Javascript.
PhosphoSitePlus Homepage Cell Signaling Technology
PhosphoSitePlus
HomeAbout PhosphoSiteUsing PhosphoSiteCuration ProcessContact
NIH-logos NIGMS Logo NIAAA Logo NCI Logo NIH Logo
Protein Page:
GSK3A (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
GSK3A a proline-directed protein kinase of the GSK family. Implicated in the control of several regulatory proteins including glycogen synthase, Myb, and c-Jun. GSK3 and GSK3 have similar functions. GSK3 phophorylates tau, the principal component of neurofibrillary tangles in Alzheimer disease and is required for maximal production of amyloid plaque peptides by secretase. A GSK3 promoter SNP effects progression of bipolar disorder. The GSK3 inhibitor, lithium, is used to treat bipolar disorder and is seen to block plaque formation. GSK3 generally opposes the action of insulin, and GSK3 hyperactivity is thought to contribute to insulin resistant (type II) diabetes. GSK3 also negatively regulates cardiac hypertrophy. A tumor suppressor role is indicated by the oncogenic potential of stabilized -catenin mutants that lack GSK3 phosphorylation sites. Inhibitor: AR-A014418 Note: This description may include information from UniProtKB.
Protein type: EC 2.7.11.1; Protein kinase, CMGC; Kinase, protein; EC 2.7.11.26; Protein kinase, Ser/Thr (non-receptor); CMGC group; GSK family; GSK subfamily
Chromosomal Location of Human Ortholog: 19q13.2
Cellular Component: beta-catenin destruction complex; cytosol
Molecular Function: protein serine/threonine kinase activity; protein binding; tau-protein kinase activity; ATP binding
Biological Process: epidermal growth factor receptor signaling pathway; glycogen metabolic process; proteasomal ubiquitin-dependent protein catabolic process; nervous system development; negative regulation of TOR signaling pathway; phosphoinositide-mediated signaling; Wnt receptor signaling pathway; fibroblast growth factor receptor signaling pathway; nerve growth factor receptor signaling pathway; unfolded protein response; negative regulation of insulin receptor signaling pathway; protein amino acid phosphorylation; negative regulation of transferase activity; negative regulation of glucose import; unfolded protein response, activation of signaling protein activity; cellular protein metabolic process; cellular response to insulin stimulus; positive regulation of cAMP biosynthetic process; positive regulation of protein catabolic process; regulation of systemic arterial blood pressure; insulin receptor signaling pathway; innate immune response; positive regulation of heart contraction; negative regulation of glycogen biosynthetic process
Reference #:  P49840 (UniProtKB)
Alt. Names/Synonyms: DKFZp686D0638; glycogen synthase kinase 3 alpha; Glycogen synthase kinase-3 alpha; GSK-3 alpha; GSK3A
Gene Symbols: GSK3A
Molecular weight: 50,981 Da
Basal Isoelectric point: 8.95  Predict pI for various phosphorylation states
CST Pathways:  Adherens Junction Dynamics  |  Alzheimer's Disease  |  B Cell Receptor Signaling  |  ErbB/HER Signaling  |  ESC Pluripotency and Differentiation  |  Growth And Differentiation Control by MAPKs  |  Inhibition of Apoptosis  |  Insulin Receptor Signaling  |  mTOR Signaling  |  PI3K/Akt Signaling  |  Translation: eIF4E and p70S6K  |  Wnt/├č-Catenin Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

GSK3A

Protein Structure Not Found.

Substrate Sequence Logo
Sequence Logo

STRING  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Scansite  |  KinBase  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  Source  |  UCSD-Nature  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene


Sites Implicated In
apoptosis, altered: Y279‑p
enzymatic activity, induced: Y279‑p
enzymatic activity, inhibited: S21‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 5 S2-p ______MsGGGPsGG
0 3 S7-p _MsGGGPsGGGPGGs
0 2 S14-p sGGGPGGsGRARtss
1 75 T19-p GGsGRARtssFAEPG
0 49 S20-p GsGRARtssFAEPGG
130 287 S21-p sGRARtssFAEPGGG
0 7 S39-p GGGGPGGsAsGPGGt
0 5 S41-p GGPGGsAsGPGGtGG
0 4 T46-p sAsGPGGtGGGKAsV
0 1 S52-p GtGGGKAsVGAMGGG
0 2 S63-p MGGGVGAsSSGGGPG
0 2 S72-p SGGGPGGsGGGGsGG
0 2 S77-p GGsGGGGsGGPGAGT
0 1 T84 sGGPGAGTSFPPPGV
0 1 S85 GGPGAGTSFPPPGVK
0 2 S97-p GVKLGRDsGKVTTVV
0 1 K123-ac EVAYTDIkVIGNGSF
0 24 Y134-p NGSFGVVyQARLAET
0 3 Y197-p YLNLVLEyVPETVYR
0 1 Y220-p KLTIPILyVKVYMYQ
0 7 K268-ub LCDFGSAkQLVRGEP
1 1258 S278-p VRGEPNVsyICsRyy
17 4231 Y279-p RGEPNVsyICsRyyR
0 1118 S282-p PNVsyICsRyyRAPE
0 110 Y284-p VsyICsRyyRAPELI
0 7 Y285-p syICsRyyRAPELIF
0 3 K355-ub NPNYTEFkFPQIKAH
0 1 R371 WTKVFKSRTPPEAIA
0 1 T480-p TDATPTLtNSS____
5090 : Phospho-GSK-3alpha (Ser21) (27E5) Mouse mAb
8452 : Phospho-GSK-3-alpha (Ser21) (D1G2) Rabbit mAb
8566 : Phospho-GSK-3-alpha/beta (Ser21/9) (D17D2) Rabbit mAb
9316 : Phospho-GSK-3alpha (Ser21) (36E9) Rabbit mAb
9327 : Phospho-GSK-3alpha/beta (Ser21/9) (37F11) Rabbit mAb (GSK-3alpha Preferred)
9331 : Phospho-GSK-3alpha/beta (Ser21/9) Antibody
9337 : Phospho-GSK-3alpha (Ser21) (46H12) Mouse mAb
  mouse

 
S2-p ______MsGGGPsGG
S7-p _MsGGGPsGGGPGGs
S14-p sGGGPGGsGRARtss
T19-p GGsGRARtssFAEPG
S20-p GsGRARtssFAEPGG
S21-p sGRARtssFAEPGGG
S39-p GGGGPGGsAsGPGGT
S41-p GGPGGsAsGPGGTGG
T46 sAsGPGGTGGGKASV
S52 GTGGGKASVGAMGGG
S63 MGGGVGASSSGGGPS
S72-p SGGGPSGsGGGGsGG
S77-p SGsGGGGsGGPGAGt
T84-p sGGPGAGtsFPPPGV
S85-p GGPGAGtsFPPPGVK
S97 GVKLGRDSGKVTTVV
K123 EVAYTDIKVIGNGSF
Y134 NGSFGVVYQARLAET
Y197 YLNLVLEYVPETVYR
Y220 KLITPIIYIKVYMYQ
K268-ub LCDFGSAkQLVRGEP
S278-p VRGEPNVsyICsRYY
Y279-p RGEPNVsyICsRYYR
S282-p PNVsyICsRYYRAPE
Y284 VsyICsRYYRAPELI
Y285 syICsRYYRAPELIF
K355-ub NPNYTEFkFPQIKAH
K372-ub TKVFKSSkTPPEAIA
A487 DATTATLASSS____
8452 : Phospho-GSK-3-alpha (Ser21) (D1G2) Rabbit mAb
8566 : Phospho-GSK-3-alpha/beta (Ser21/9) (D17D2) Rabbit mAb
9316 : Phospho-GSK-3alpha (Ser21) (36E9) Rabbit mAb
9327 : Phospho-GSK-3alpha/beta (Ser21/9) (37F11) Rabbit mAb (GSK-3alpha Preferred)
9331 : Phospho-GSK-3alpha/beta (Ser21/9) Antibody
9337 : Phospho-GSK-3alpha (Ser21) (46H12) Mouse mAb
  rat

 
S2-p ______MsGGGPSGG
S7 _MsGGGPSGGGPGGS
S14 SGGGPGGSGRARtSs
T19-p GGSGRARtSsFAEPG
S20 GSGRARtSsFAEPGG
S21-p SGRARtSsFAEPGGG
S39 GGGGPGGSASGPGGT
S41 GGPGGSASGPGGTGG
T46 SASGPGGTGGGKASV
S52 GTGGGKASVGAMGGG
S63 MGGGVGASSSGGGPS
S72 SGGGPSGSGGGGSGG
S77 SGSGGGGSGGPGAGT
T84 SGGPGAGTSFPPPGV
S85 GGPGAGTSFPPPGVK
S97 GVKLGRDSGKVTTVV
K123 EVAYTDIKVIGNGSF
Y134-p NGSFGVVyQARLAET
Y197 YLNLVLEYVPETVYR
Y220 KLIIPIIYVKVYMYQ
K268 LCDFGSAKQLVRGEP
S278-p VRGEPNVsyICsRyY
Y279-p RGEPNVsyICsRyYR
S282-p PNVsyICsRyYRAPE
Y284-p VsyICsRyYRAPELI
Y285 syICsRyYRAPELIF
K355 NPNYTEFKFPQIKAH
R371 WTKVFKSRTPPEAIA
T480 PDATPTLTNSS____
8452 : Phospho-GSK-3-alpha (Ser21) (D1G2) Rabbit mAb
8566 : Phospho-GSK-3-alpha/beta (Ser21/9) (D17D2) Rabbit mAb
9316 : Phospho-GSK-3alpha (Ser21) (36E9) Rabbit mAb
9327 : Phospho-GSK-3alpha/beta (Ser21/9) (37F11) Rabbit mAb (GSK-3alpha Preferred)
9331 : Phospho-GSK-3alpha/beta (Ser21/9) Antibody
9337 : Phospho-GSK-3alpha (Ser21) (46H12) Mouse mAb
  cow

 
S2 ______MSGGAPSGG
S7 _MSGGAPSGGGPGGS
S14 SGGGPGGSGRARTSS
T19 GGSGRARTSSFAEPG
S20 GSGRARTSSFAEPGG
S21 SGRARTSSFAEPGGG
S39 GGGGPGGSASGPGGS
S41 GGPGGSASGPGGSGG
S46 SASGPGGSGGGKTSV
S52 GSGGGKTSVGAMGGG
S63 MGGGVGASSSGGGPG
S72 SGGGPGGSGGGGSGG
S77 GGSGGGGSGGPGAGT
T84 SGGPGAGTSFPPPGV
S85 GGPGAGTSFPPPGVK
S97 GVKLGRDSGKVTTVV
K123 EVAYTDIKVIGSGSF
Y134 SGSFGVVYQARLADT
Y197 YLNLVLEYVPETVYR
Y220 KLSIPIIYVKVYMYQ
K268 LCDFGSAKQLVRGEP
S278 VRGEPNVSYICSRYY
Y279 RGEPNVSYICSRYYR
S282 PNVSYICSRYYRAPE
Y284 VSYICSRYYRAPELI
Y285 SYICSRYYRAPELIF
K355 NPNYTEFKFPQIKAH
R371 WTKVFKSRTPPEAIA
P480 TDNTATLPPGLHLLQ
8452 : Phospho-GSK-3-alpha (Ser21) (D1G2) Rabbit mAb
8566 : Phospho-GSK-3-alpha/beta (Ser21/9) (D17D2) Rabbit mAb
Home  |  Curator Login With enhanced literature mining using Linguamatics I2E I2E Logo Produced by 3rd Millennium  |  Design by Digizyme
©2003-2013 Cell Signaling Technology, Inc.