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Protein Page:
SRC-3 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
SRC-3 a histone acetyltransferase and nuclear receptor coactivator. Plays a central role in creating a multisubunit coactivator complex, which probably acts via remodeling of chromatin. Involved in the coactivation of different nuclear receptors, such as for steroids (GR and ER), retinoids (RARs and RXRs), thyroid hormone (TRs), vitamin D3 (VDR) and prostanoids (PPARs). Involved in the coactivation of the NF-kappa-B pathway via its interaction with the NFKB1 subunit. Activity is enhanced by various hormones and TNF. Acetylation by CREBBP may suppress coactivation of target genes by disrupting its association with nuclear receptors. Frequently amplified or overexpressed in breast and ovarian cancers. Five alternatively spliced isoforms have been described. Note: This description may include information from UniProtKB.
Protein type: EC 2.3.1.48; Nuclear receptor co-regulator; Acetyltransferase; Transcription, coactivator/corepressor; Motility/polarity/chemotaxis
Cellular Component: cytoplasm; nucleolus; nucleus
Molecular Function: ligand-dependent nuclear receptor binding; protein dimerization activity; protein binding; signal transducer activity; histone acetyltransferase activity; ligand-dependent nuclear receptor transcription coactivator activity; androgen receptor binding; transcription coactivator activity; protein N-terminus binding; thyroid hormone receptor binding; chromatin binding; nuclear hormone receptor binding
Biological Process: developmental growth; transcription, DNA-dependent; positive regulation of transcription, DNA-dependent; multicellular organism growth; androgen receptor signaling pathway; vagina development; positive regulation of transcription from RNA polymerase II promoter; histone acetylation; positive regulation of keratinocyte differentiation
Reference #:  Q9Y6Q9 (UniProtKB)
Alt. Names/Synonyms: ACTR; AIB-1; AIB1; Amplified in breast cancer 1 protein; BHLHE42; CAGH16; CBP-interacting protein; Class E basic helix-loop-helix protein 42; CTG26; KAT13B; MGC141848; NCoA-3; NCOA3; Nuclear receptor coactivator 3; pCIP; RAC-3; RAC3; Receptor-associated coactivator 3; SRC-3; SRC3; Steroid receptor coactivator protein 3; Thyroid hormone receptor activator molecule 1; TNRC14; TNRC16; TRAM-1; TRAM1
Gene Symbols: NCOA3
Molecular weight: 155,293 Da
Basal Isoelectric point: 7.16  Predict pI for various phosphorylation states
CST Pathways:  Crosstalk between PTMs  |  Protein Acetylation
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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SRC-3

Protein Structure Not Found.


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Sites Implicated In
carcinogenesis, induced: S857‑p
cell growth, altered: S102‑p, Y1357‑p
cell motility, induced: S857‑p
transcription, altered: Y1357‑p
transcription, induced: S601‑p, S857‑p
transcription, inhibited: K619‑ac, K620‑ac
intracellular localization: S728‑p
molecular association, regulation: T24‑p, S505‑p, S543‑p, K619‑ac, K620‑ac, S857‑p, S860‑p, S867‑p, S1033‑p, S1042‑p, S1048‑p, T1059‑p, S1062‑p, T1064‑p, T1067‑p, T1114‑p, Y1357‑p
protein degradation: S101‑p, S102‑p
protein stabilization: S601‑p, S1033‑p, S1042‑p, S1048‑p, T1059‑p, S1062‑p, T1064‑p, T1067‑p, T1114‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
3 1 T24-p KRKLPCDtPGQGLtC
0 1 T30-p DtPGQGLtCSGEkRR
0 1 K35-ac GLtCSGEkRRREQES
0 1 K65-ub DIDNFNVkPDkCAIL
0 1 K68-ub NFNVkPDkCAILKET
2 0 S101-p DVQKADVssTGQGVI
2 0 S102-p VQKADVssTGQGVID
0 1 T184-p TVNGVSWtNETQRQK
0 20 S214-p ILEDINAsPEMRQRY
0 1 S244-p EEGEDLQsCMICVAr
0 1 R251-m1 sCMICVArRITTGER
0 1 N263 GERTFPSNPESFITR
0 1 S274-p FITRHDLsGKVVNID
0 1 T282-p GKVVNIDtNsLRssM
0 1 S284-p VVNIDtNsLRssMRP
0 1 S287-p IDtNsLRssMRPGFE
0 1 S288-p DtNsLRssMRPGFED
5 0 S505-p SPVAGVHsPMAsSGN
1 0 S509-p GVHsPMAsSGNTGNH
5 0 S543-p SLLSTLSsPGPKLDN
0 11 S551-p PGPKLDNsPNMNItQ
0 1 T557-p NsPNMNItQPSKVsN
0 1 S563-p ItQPSKVsNQDSKsP
0 5 S569-p VsNQDSKsPLGFyCD
0 1 Y574-p SKsPLGFyCDQNPVE
1 0 S601-p SDKESKEsSVEGAEN
1 0 K616-ac QRGPLESkGHkkLLQ
1 0 K619-ac PLESkGHkkLLQLLT
1 0 K620-ac LESkGHkkLLQLLTC
0 1 S636 SDDRGHSSLTNsPLD
0 4 S640-p GHSSLTNsPLDSSCK
0 1 S652 SCKESSVSVTSPSGV
0 1 S661 TSPSGVSSSTSGGVS
0 1 S668 SSTSGGVSSTSNMHG
0 2 K687-ac EKHRILHkLLQNGNs
0 3 S694-p kLLQNGNsPAEVAKI
0 2 S715-p KDTSSITsCGDGNVV
1 0 K723-sm CGDGNVVkQEQLsPK
1 7 S728-p VVkQEQLsPKKKENN
1 0 K786-sm QEKDPKIkTETSEEG
0 1 K840-m1 GTNSLGLkSSQSVQS
1 0 R849 SQSVQSIRPPYNRAV
1 0 R854 SIRPPYNRAVsLDsP
8 26 S857-p PPYNRAVsLDsPVSV
5 9 S860-p NRAVsLDsPVSVGss
0 1 S866-p DsPVSVGssPPVKNI
4 4 S867-p sPVSVGssPPVKNIS
0 1 S935 GRMEPMNSNSMGRPG
0 3 N936 RMEPMNSNSMGRPGG
0 1 R951-m2 DYNTSLPrPALGGSI
1 3 S1033-p NRPLLRNsLDDLVGP
1 0 S1042-p DDLVGPPsNLEGQsD
1 0 S1048-p PsNLEGQsDERALLD
1 0 T1059-p ALLDQLHtLLsNtDA
1 1 S1062-p DQLHtLLsNtDAtGL
1 0 T1064-p LHtLLsNtDAtGLEE
1 0 T1067-p LLsNtDAtGLEEIDR
0 1 K1091-m1 QGQALEPkQDAFQGQ
1 0 T1114-p KAGLYGQtYPAQGPP
1 12 R1171-m2 TNTPKQLrMQLQQrL
1 12 R1177-m2 LrMQLQQrLQGQQFL
0 3 R1188 QQFLNQSRQALELkM
1 11 R1188-m2 QQFLNQSrQALELkM
1 0 K1194-sm SrQALELkMENPTAG
0 1 R1242 SHHFRQQRVAMMMQQ
0 5 S1330-p PAFGRVSsPPNAMMS
1 1 Y1357-p HPQAASIyQSSEMKG
0 1 S1360 AASIyQSSEMKGWPS
2979 : Phospho-SRC-3 (Thr24) Antibody
  mouse

 
A25 KRKLPCDAPGQGLVY
V31 DAPGQGLVYSGEKWR
K36 GLVYSGEKWRREQES
K66 DIDNFNVKPDKCAIL
K69 NFNVKPDKCAILKET
S102 DVQKADVSSTGQGVI
S103 VQKADVSSTGQGVID
L185 QLMEFLGLMRTRDKK
S215-p ILEDVNAsPETRQRY
C245 EEGEDLQCCMICVAR
R252 CCMICVARRVTAPFP
S261-p VTAPFPSsPESFITR
S272 FITRHDLSGKVVNID
T280 GKVVNIDTNSLRSSM
S282 VVNIDTNSLRSSMRP
S285 IDTNSLRSSMRPGFE
S286 DTNSLRSSMRPGFED
S498-p SPAAGAHsPMGPSGN
P502 GAHsPMGPSGNTGSH
S536-p SLLSTLSsPGPKLDN
S544-p PGPKLDNsPNMNISQ
S550 NsPNMNISQPSKVSG
S556 ISQPSKVSGQDSKsP
S562-p VSGQDSKsPLGLyCE
Y567-p SKsPLGLyCEQNPVE
S594 VKKESKESSGEVSET
K609 PRGPLESKGHKKLLQ
K612 PLESKGHKKLLQLLT
K613 LESKGHKKLLQLLTC
S629-p SDDRGHSsLTNsPLD
S633-p GHSsLTNsPLDPNCK
S645-p NCKDSSVsVTSPSGV
S654-p TSPSGVSsSTSGTVs
S661-p sSTSGTVsSTSNVHG
K680 EKHRILHKLLQNGNS
S687 KLLQNGNSPAEVAKI
S708 KDTSSTASCGEGTTR
R715 SCGEGTTRQEQLsPK
S720-p TTRQEQLsPKKKENN
K778 QEKDPKIKTETNDEV
R830 GPSSLGLRSPQPVQS
R839-me PQPVQSVrPPYNrAV
R844-me SVrPPYNrAVsLDsP
S847-p PPYNrAVsLDsPVSV
S850-p NrAVsLDsPVSVGSG
S856 DsPVSVGSGPPVKNV
G857 sPVSVGSGPPVKNVS
S924-p SRMEPLAssPLGRTG
S925-p RMEPLAssPLGRTGA
R940 DYSATLPRPAMGGSV
S1040-p NRPLLRNsLDDLLGP
S1049 DDLLGPPSNAEGQSD
S1055 PSNAEGQSDERALLD
T1066 ALLDQLHTFLSNTDA
S1069 DQLHTFLSNTDATGL
T1071 LHTFLSNTDATGLEE
T1074 FLSNTDATGLEEIDR
K1098 QGQALESKQDVFQGQ
T1121 KAALYGQTYPAQGPP
R1178-m2 TNTPKQLrMQLQQrL
R1184-m2 LrMQLQQrLQGQQFL
R1195-m1 QQFLNQSrQALEMKM
R1195-m2 QQFLNQSrQALEMKM
K1201 SrQALEMKMENPAGT
R1241-m1 SHHLQQQrMAMMMSQ
S1304-p PAFGRGSsPPSAMMS
Y1331-p HPQPTPMyQPsDMKG
S1334-p PTPMyQPsDMKGWPS
  rat

 
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
S205 SPAAGVHSPMGSSGN
S209 GVHSPMGSSGNTGSH
S243 SLLSTLSSPGPKLDN
S251-p PGPKLDNsPNMNINQ
N257 NsPNMNINQPSKASS
S263 INQPSKASSQDSKSP
S269 ASSQDSKSPLGLYCE
Y274 SKSPLGLYCEQNPVE
N301 VTKENKENSGEASET
K316 PRGPLESKGHKKLLQ
K319 PLESKGHKKLLQLLT
K320 LESKGHKKLLQLLTC
S336 SDDRGHSSLTNSPLD
S340 GHSSLTNSPLDSNCK
S352 NCKDSSISVTSPSGV
S361 TSPSGVSSSTSGAVS
S368 SSTSGAVSSTSNMHG
K387 EKHRILHKLLQNGNS
S394 KLLQNGNSPAEVAKI
S415 KDTSSTASGGEGSVX
- gap
S427 SVXQEQLSPXKKENN
K485 QEKDPKIKTEEVSGD
R534 GPSSLGLRSPQPVQS
R543 PQPVQSVRPPYNRAL
R548 SVRPPYNRALSLDSP
S551 PPYNRALSLDSPVSV
S554 NRALSLDSPVSVGSV
S560 DSPVSVGSVPPVKNV
V561 SPVSVGSVPPVKNVS
S629 SRMEPLASSPLGRAG
S630 RMEPLASSPLGRAGG
R645 DYSAALPRPALGSSG
S722 NRPLLRNSLDELLGP
S731 DELLGPPSNPEGQSD
S737 PSNPEGQSDERALLD
T748 ALLDQLHTLLSNTDA
S751 DQLHTLLSNTDATGL
T753 LHTLLSNTDATGLEE
T756 LLSNTDATGLEEIDR
K780 QGQALESKQDVFQGQ
T803 KAALYGQTYPAQGPP
R860 TNTPKQLRMQLQQRL
R866 LRMQLQQRLQGQQFL
R877 QQFLNQSRQALEMKM
R877 QQFLNQSRQALEMKM
K883 SRQALEMKMESPTGA
R925 NHHLQQQRMAMMMSQ
S988 PAFGRGSSPPSAMMS
Y1015 HPQTAPMYQSSEMKG
S1018 TAPMYQSSEMKGWPS
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