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TACC3 (human)

Overview TACC3 Plays a role in the microtubule-dependent coupling of the nucleus and the centrosome. Involved in the processes that regulate centrosome-mediated interkinetic nuclear migration (INM) of neural progenitors. May be involved in the control of cell growth and differentiation. May contribute to cancer. Interacts with microtubules. Interacts with CCDC100/CEP120. The coiled coil C-terminus region interacts with AH receptor nuclear translocator protein (ARNT) and ARNT2. Interacts with GCN5L2 and PCAF. Up-regulated in various cancer cell lines. Belongs to the TACC family. Note: This description may include information from UniProtKB. Protein type: Cell cycle regulation Cellular Component: centrosome; cytoplasm Molecular Function: protein domain specific binding Biological Process: regulation of microtubule-based process; cytoplasmic sequestering of transcription factor; astral microtubule organization and biogenesis; neurogenesis; regulation of cell cycle; response to stress; hemopoiesis; cerebral cortex development; interkinetic nuclear migration Reference #:  Q9Y6A5 (UniProtKB) Alt. Names/Synonyms: ERIC-1; ERIC1; MGC117382; MGC133242; TACC3; Transforming acidic coiled-coil-containing protein 3; transforming, acidic coiled-coil containing protein 3 Gene Symbols: TACC3 Molecular weight: 90,360 Da Basal Isoelectric point: 4.97  Predict pI for various phosphorylation states Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below TACC3

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	Sites Implicated In
intracellular localization: S558‑p

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	8		S25-p	ENCDFLFsPPEVTGR
0	12		S39-p	RSSVLRVsQKENVPP
0	3		T56-p	LAKAMKVtFQtPLRD
0	37		T59-p	AMKVtFQtPLRDPQt
0	1		T66-p	tPLRDPQtHRILsPs
0	8		S71-p	PQtHRILsPsMASKL
0	1		S73-p	tHRILsPsMASKLEA
0	2		S170-p	SSENQMVsPGKVsGs
0	2		S175-p	MVsPGKVsGsPEQAV
0	2		S177-p	sPGKVsGsPEQAVEE
0	1		T216-p	ESQHKAEtPHGAEEE
0	1		T228-p	EEECKAEtPHGAEEE
0	1		T249-p	CAPAAVAtsPPGAIP
0	9		S250-p	APAAVAtsPPGAIPK
0	3		T315-p	LVAGRAMtLsPQEEV
0	10		S317-p	AGRAMtLsPQEEVAA
0	1		S402-p	PMPASRGsYHLDWDK
0	1		K423-a	IPFGGDTkSGCSEAQ
0	12		S434-p	SEAQPPEsPETRLGQ
0	1		T481-p	VVQLAAEtPTAESKE
0	1		T496-p	RALNSAStSLPTSCP
0	1		T534-p	DPAEVLGtGAEVDyL
0	6		Y540-p	GtGAEVDyLEQFGTS
0	1		K550-u	QFGTSSFkESALRKQ
6	27		S558-p	ESALRKQsLyLkFDP
0	23		Y560-p	ALRKQsLyLkFDPLL
0	2		K562-u	RKQsLyLkFDPLLRD
0	1		T590-p	SMHGANEtPsGRPRE
0	1		S592-p	HGANEtPsGRPREAK
0	16		K649-u	KDLDAVVkATQEENR
0	1		C662	NRELRSRCEELHGKN
0	2		K674-u	GKNLELGkIMDRFEE
0	4		Y684-p	DRFEEVVyQAMEEVQ
0	1		K720	TDLNSMEKSFSDLFK
0	1		S723	NSMEKSFSDLFKRFE
0	1		K731	DLFKRFEKQKEVIEG
0	1		Y739-p	QKEVIEGyRKNEESL
0	1		K741	EVIEGyRKNEESLKK
0	1		S799	EALALQASLRKEQMR
0	1		K819-u	KTVEQKTkENEELTR
0	2		K834-u	ICDDLISkMEKI___

	mouse
L25	QCRDFQFLPPELTGR
S39	RSSVLCLSQKENVPP
T56	QAKATNVTFQtPPRD
T59-p	ATNVTFQtPPRDPQT
T66	tPPRDPQTHRILsPN
S71-p	PQTHRILsPNMTNKR
N73	THRILsPNMTNKREA
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
T323	DPSEVLGTGAEVDYL
Y329	GTGAEVDYLEQFGTS
K339	QFGTSSFKESAWRKQ
S347-p	ESAWRKQsLYVKFDP
Y349	AWRKQsLYVKFDPLL
K351	RKQsLYVKFDPLLKD
S380	TQDTEEESGSGKPTE
S382	DTEEESGSGKPTEAE
N439	KDLDAVVNVMQQENL
Y452-p	NLELKSKyEDLNTKY
K464	TKYLEMGKSVDEFEK
Y474	DEFEKIAYKSLEEAE
K513-a	ADLNSMEkSFsDLFK
S516-p	NSMEkSFsDLFKRFE
K524-a	DLFKRFEkRKEVIEG
Y532	RKEVIEGYQkNEESL
K534-a	EVIEGYQkNEESLKK
S592-p	EVLALQAsLRKAQMQ
K612	MTLEQKTKEIDELTR
K627	ICDDLISKMEKI___

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