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Protein Page:
SMRT (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
SMRT Transcriptional corepressor of NR4A2/NURR1 and acts through histone deacetylases (HDACs) to keep promoters of NR4A2/NURR1 target genes in a repressed deacetylated state. Mediates the transcriptional repression activity of some nuclear receptors by promoting chromatin condensation, thus preventing access of the basal transcription. Isoform 1 and isoform 5 have different affinities for different nuclear receptors. Interacts with BCL6, HDAC7 and C1D. Interacts with NR4A2; this interaction increases in the absence of PITX3. Forms a large corepressor complex that contains SIN3A/B and histone deacetylases HDAC1 and HDAC2. This complex associates with the thyroid (TR) and the retinoid acid receptors (RAR) in the absence of ligand, and may stabilize their interaction with TFIIB. Interacts directly with RARA in the absence of ligand; the interaction represses RARA activity. Interacts (isoform SRMT) with HDAC10. Interacts with MINT. Component of the N-Cor repressor complex, at least composed of NCOR1, NCOR2, HDAC3, TBL1X, TBL1R, CORO2A and GPS2. Interacts with CBFA2T3 and ATXN1L. Interacts with RARB; the interaction is weak and does not repress RARB transactivational activity. Regulated during cell cycle progression. Ubiquitous. High levels of expression are detected in lung, spleen and brain. Belongs to the N-CoR nuclear receptor corepressors family. 5 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Transcription, coactivator/corepressor; Nuclear receptor co-regulator
Cellular Component: nucleoplasm; nuclear body; nuclear matrix; membrane; transcriptional repressor complex; nucleolus; nucleus
Molecular Function: protein binding; DNA binding; histone deacetylase binding; protein N-terminus binding; chromatin binding; Notch binding; transcription corepressor activity
Biological Process: transcription initiation from RNA polymerase II promoter; Notch signaling pathway; transcription, DNA-dependent; transforming growth factor beta receptor signaling pathway; gene expression; cellular lipid metabolic process; negative regulation of transcription from RNA polymerase II promoter
Reference #:  Q9Y618 (UniProtKB)
Alt. Names/Synonyms: CTG repeat protein 26; CTG26; FLJ25011; N-CoR2; NCOR2; nuclear receptor co-repressor 2; Nuclear receptor corepressor 2; silencing mediator for retinoid and thyroid hormone receptors; Silencing mediator of retinoic acid and thyroid hormone receptor; SMAP270; SMRT; SMRTE; SMRTE-tau; T3 receptor-associating factor; Thyroid-, retinoic-acid-receptor-associated corepressor; TNRC14; TRAC; TRAC-1; TRAC1
Gene Symbols: NCOR2
Molecular weight: 274,804 Da
Basal Isoelectric point: 7.21  Predict pI for various phosphorylation states
CST Pathways:  Notch Signaling  |  Protein Acetylation
Select Structure to View Below

SMRT

Protein Structure Not Found.


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Sites Implicated In
signaling pathway regulation: S2437‑p
transcription, induced: S2418‑p, S2437‑p
intracellular localization: S2418‑p, S2437‑p
molecular association, regulation: S2522‑p
protein degradation: S2418‑p, S2437‑p
ubiquitination: S2437‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

► Hide Isoforms
 
0 1 R18 TWRATEPRYPPHSLS
0 1 T35 VQIARTHTDVGLLEY
0 1 S51-p HHSRDYAsHLsPGSI
0 6 S54-p RDYAsHLsPGSIIQP
0 42 S67-p QPQRRRPsLLSEFQP
0 1 S79-p FQPGNERsQELHLRP
0 30 S149-p TGKLEPVsPPsPPHt
0 29 S152-p LEPVsPPsPPHtDPE
0 7 T156-p sPPsPPHtDPELELV
0 12 S215-p PEPEKPVsPPPIEsK
0 2 S221-p VsPPPIEsKHRSLVQ
0 1 S373-p ARSEHEVsEIIDGLS
0 1 K387 SEQENLEKQMRQLAV
0 1 K449 EKFMQHPKNFGLIAS
0 2 S493-p SYRRRGKsQQQQQQQ
0 3 T550-p EDLLKEKtDDtsGED
0 11 T553-p LKEKtDDtsGEDNDE
0 12 S554-p KEKtDDtsGEDNDEK
1 0 K672 ILQQHKLKMEKERNA
0 1 S745 GPATVNNSsDTEsIP
0 2 S746-p PATVNNSsDTEsIPs
0 1 T748 TVNNSsDTEsIPsPH
0 4 S750-p NNSsDTEsIPsPHtE
0 6 S753-p sDTEsIPsPHtEAAK
0 1 T756-p EsIPsPHtEAAKDTG
0 1 T803-p PTPASEAtGAPtPPP
0 1 T807-p SEAtGAPtPPPAPPs
0 1 S814-p tPPPAPPsPsAPPPV
0 1 S816-p PPAPPsPsAPPPVVP
0 1 S864 KAEEPVKSECTEEAE
0 1 K878-ac EEGPAKGkDAEAAEA
0 1 S908-p GRATTAKsSGAPQDS
0 19 S939-p GDKNRLLsPRPsLLt
0 8 S943-p RLLsPRPsLLtPTGD
0 11 T946-p sPRPsLLtPTGDPRA
0 2 A955 TGDPRANAsPQkPLD
0 22 S956-p GDPRANAsPQkPLDL
0 4 K959-ac RANAsPQkPLDLKQL
0 1 T979-p AIPPIQVtKVHEPPR
0 3 S1018-p APQQPGSsPRGKsRs
0 2 S1023-p GSsPRGKsRsPAPPA
0 4 S1025-p sPRGKsRsPAPPADK
0 1 T1157 KAPVGPVTMGLPLPM
0 7 S1181-p GVKQEQLsPRGQAGP
0 1 S1191 GQAGPPESLGVPTAQ
0 1 T1196 PESLGVPTAQEASVL
0 2 T1206-p EASVLRGtALGsVPG
0 1 S1210-p LRGtALGsVPGGsIT
0 1 S1215-p LGsVPGGsITkGIPS
0 1 K1218-ac VPGGsITkGIPSTRV
0 12 S1227-p IPSTRVPsDSAITYR
0 1 T1241-p RGSITHGtPADVLYk
0 1 K1248-ac tPADVLYkGTITRII
0 5 S1259-p TRIIGEDsPsRLDRG
0 2 S1261-p IIGEDsPsRLDRGRE
0 21 Y1278-p LPKGHVIyEGKKGHV
0 1 S1306-p KEDGRSSsGPPHEtA
0 1 T1312-p SsGPPHEtAAPKRTY
0 21 S1331-p GRVGRAIssAsIEGL
0 1 S1332-p RVGRAIssAsIEGLM
0 2 S1334-p GRAIssAsIEGLMGR
0 1 S1349-p AIPPERHsPHHLKEQ
0 1 Y1378-p YVEAQEDyLRREAKL
0 45 T1391-p KLLKREGtPPPPPPs
0 1 S1398-p tPPPPPPsRDLTEAY
0 8 T1444-p PREELRHtPELPLAP
0 1 S1458-p PRPLKEGsItQGtPL
0 1 T1460-p PLKEGsItQGtPLKY
0 2 T1463-p EGsItQGtPLKYDTG
0 1 Y1467 tQGtPLKYDTGAsTT
0 1 S1472-p LKYDTGAsTTGSKKH
0 1 T1474 YDTGAsTTGSKKHDV
0 1 S1476 TGAsTTGSKKHDVRs
0 2 S1483-p SKKHDVRsLIGsPGR
0 8 S1487-p DVRsLIGsPGRTFPP
0 1 Y1512-p RALERACyEESLKSR
0 1 T1522-p SLKSRPGtASSsGGS
0 1 S1526-p RPGtASSsGGSIARG
0 3 S1547-p ELGKPRQsPLTYEDH
0 1 T1569-gl LPRGSPVttrEPtPR
0 3 T1570-gl PRGSPVttrEPtPRL
0 1 R1571-m1 RGSPVttrEPtPRLQ
0 3 T1574-p PVttrEPtPRLQEGs
0 1 S1581-p tPRLQEGsLSSSKAS
0 1 T1596-p QDRKLTStPREIAKs
0 21 S1603-p tPREIAKsPHStVPE
0 2 T1607-p IAKsPHStVPEHHPH
0 9 S1617-p EHHPHPIsPYEHLLR
0 1 Y1619 HPHPIsPYEHLLRGV
0 1 S1627-p EHLLRGVsGVDLYRS
0 12 R1633 VsGVDLYRSHIPLAF
0 1 R1647 FDPTSIPRGIPLDAA
0 2 R1661-m2 AAAYYLPrHLAPNPT
0 1 Y1669-p HLAPNPTyPHLYPPY
0 8 R1719-m1 AQRADMLrGLSPRES
0 1 R1737-m1 LNYAAGPrGIIDLSQ
1 1 T1755 LPVLVPPTPGTPATA
0 1 S1782-p PFSSRHSssPLsPGG
0 5 S1783-p FSSRHSssPLsPGGP
0 11 S1786-p RHSssPLsPGGPtHL
0 1 T1791-p PLsPGGPtHLtkPTT
0 1 T1794-p PGGPtHLtkPTTTSS
0 1 K1795-ac GGPtHLtkPTTTSSs
0 1 S1802-p kPTTTSSsERERDRD
0 1 S1821-p RDREREKsILtSTtT
0 1 T1824-p EREKsILtSTtTVEH
0 1 T1827-p KsILtSTtTVEHAPI
0 1 S1863 SSRPASHSHAHQHsP
0 4 S1869-p HSHAHQHsPIsPRTQ
0 5 S1872-p AHQHsPIsPRTQDAL
0 1 T1875 HsPIsPRTQDALQQR
0 1 T1896 TGMKGIITAVEPstP
0 1 A1897 GMKGIITAVEPstPt
0 2 S1901-p IITAVEPstPtVLRS
0 5 T1902-p ITAVEPstPtVLRST
0 1 T1904-p AVEPstPtVLRSTST
0 1 R1907 PstPtVLRSTSTSSP
0 1 T1963-p PERPRADtGHAFLAk
0 2 K1970-ac tGHAFLAkPPARsGL
0 1 S1975-p LAkPPARsGLEPAss
0 2 S1981-p RsGLEPAssPSKGsE
0 4 S1982-p sGLEPAssPSKGsEP
0 1 S1987-p AssPSKGsEPRPLVP
0 1 P1991 SKGsEPRPLVPPVsG
0 1 S1997-p RPLVPPVsGHATIAR
0 1 S1997 RPLVPPVSGHATIAR
0 8 S2016-p NLAPHHAsPDPPAPP
0 1 K2033-ac ASDPHREkTQSkPFS
0 11 K2037-ac HREkTQSkPFSIQEL
0 3 S2048-p IQELELRsLGyHGSS
0 2 Y2051-p LELRsLGyHGSSYsP
0 1 G2053 LRsLGyHGSSYsPEG
0 2 Y2056 LGyHGSSYsPEGVEP
0 10 S2057-p GyHGSSYsPEGVEPV
0 16 S2065-p PEGVEPVsPVssPsL
0 8 S2068-p VEPVsPVssPsLtHD
0 9 S2069-p EPVsPVssPsLtHDK
0 3 S2071-p VsPVssPsLtHDKGL
0 6 T2073-p PVssPsLtHDKGLPK
0 2 S2088-p HLEELDKsHLEGELR
0 1 S2123-p PLPESQPsSsPLLQT
0 1 S2125-p PESQPsSsPLLQTAP
0 1 T2142 KGHQRVVTLAQHISE
0 5 Y2172-p APLPAPLysFPGASC
0 4 S2173-p PLPAPLysFPGASCP
0 1 S2189-p LDLRRPPsDLYLPPP
0 1 S2214-p HSEGGKRsPEPNKTS
0 17 S2234-p EDGIEPVsPPEGMtE
0 1 T2240-p VsPPEGMtEPGHSRs
0 1 S2247-p tEPGHSRsAVyPLLY
0 2 Y2250-p GHSRsAVyPLLYRDG
0 32 S2269-p PSRMGSKsPGNtsQP
0 2 T2273-p GSKsPGNtsQPPAFF
0 2 S2274-p SKsPGNtsQPPAFFS
0 1 S2281 sQPPAFFSKLTESNS
0 1 T2304 EINKKLNTHNRNEPE
0 2 S2404-p RSDHTLTsPGGGGKA
1 0 S2418-p AKVSGRPsSRKAKsP
0 2 S2424-p PsSRKAKsPAPGLAs
0 1 S2431-p sPAPGLAsGDRPPsV
1 0 S2437-p AsGDRPPsVSSVHSE
0 2 S2463-p RVWEDRPssAGstPF
1 4 S2464-p VWEDRPssAGstPFP
0 1 S2467-p DRPssAGstPFPYNP
0 2 T2468-p RPssAGstPFPYNPL
1 3 S2522-p CSQYETLsDsE____
0 3 S2524-p QYETLsDsE______
  SMRT iso3  
R18 TWRATEPRYPPHSLS
T35 VQIARTHTDVGLLEY
S51 HHSRDYASHLSPGSI
S54 RDYASHLSPGSIIQP
S67 QPQRRRPSLLSEFQP
S79 FQPGNERSQELHLRP
S149 TGKLEPVSPPSPPHT
S152 LEPVSPPSPPHTDPE
T156 SPPSPPHTDPELELV
S215 PEPEKPVSPPPIESK
S221 VSPPPIESKHRSLVQ
S373 ARSEHEVSEIIDGLS
K387 SEQENLEKQMRQLAV
K449 EKFMQHPKNFGLIAS
S493 SYRRRGKSQQQQQQQ
T550 EDLLKEKTDDTSGED
T553 LKEKTDDTSGEDNDE
S554 KEKTDDTSGEDNDEK
K672 ILQQHKLKMEKERNA
S745 GPATVNNSSDTESIP
S746 PATVNNSSDTESIPS
T748 TVNNSSDTESIPSPH
S750 NNSSDTESIPSPHTE
S753 SDTESIPSPHTEAAK
T756 ESIPSPHTEAAKDTG
T803 PTPASEATGAPTPPP
T807 SEATGAPTPPPAPPS
S814 TPPPAPPSPSAPPPV
S816 PPAPPSPSAPPPVVP
S864 KAEEPVKSECTEEAE
K878 EEGPAKGKDAEAAEA
S908 GRATTAKSSGAPQDS
S939 GDKNRLLSPRPSLLT
S943 RLLSPRPSLLTPTGD
T946 SPRPSLLTPTGDPRA
A955 TGDPRANASPQKPLD
S956 GDPRANASPQKPLDL
K959 RANASPQKPLDLKQL
T979 AIPPIQVTKVHEPPR
S1018 APQQPGSSPRGKsRS
S1023-p GSSPRGKsRSPAPPA
S1025 SPRGKsRSPAPPADK
T1149 KAPVGPVTMGLPLPM
S1173 GVKQEQLSPRGQAGP
S1183 GQAGPPESLGVPTAQ
T1188 PESLGVPTAQEASVL
T1198 EASVLRGTALGSVPG
S1202 LRGTALGSVPGGSIT
S1207 LGSVPGGSITKGIPS
K1210 VPGGSITKGIPSTRV
S1219 IPSTRVPSDSAITYR
T1233 RGSITHGTPADVLYK
K1240 TPADVLYKGTITRII
S1251 TRIIGEDSPSRLDRG
S1253 IIGEDSPSRLDRGRE
Y1270 LPKGHVIYEGKKGHV
S1298 KEDGRSSSGPPHETA
T1304 SSGPPHETAAPKRTY
S1323 GRVGRAISSASIEGL
S1324 RVGRAISSASIEGLM
S1326 GRAISSASIEGLMGR
S1341 AIPPERHSPHHLKEQ
Y1370 YVEAQEDYLRREAKL
T1383 KLLKREGTPPPPPPS
S1390 TPPPPPPSRDLTEAY
T1436 PREELRHTPELPLAP
S1450 PRPLKEGSITQGTPL
T1452 PLKEGSITQGTPLKY
T1455 EGSITQGTPLKYDTG
Y1459 TQGTPLKYDTGASTT
S1464 LKYDTGASTTGSKKH
T1466 YDTGASTTGSKKHDV
S1468 TGASTTGSKKHDVRS
S1475 SKKHDVRSLIGSPGR
S1479 DVRSLIGSPGRTFPP
Y1504 RALERACYEESLKSR
T1514 SLKSRPGTASSSGGS
S1518 RPGTASSSGGSIARG
S1539 ELGKPRQSPLTYEDH
T1561 LPRGSPVTTREPTPR
T1562 PRGSPVTTREPTPRL
R1563 RGSPVTTREPTPRLQ
T1566 PVTTREPTPRLQEGS
S1573 TPRLQEGSLSSSKAS
T1588 QDRKLTSTPREIAKS
S1595 TPREIAKSPHSTVPE
T1599 IAKSPHSTVPEHHPH
S1609 EHHPHPISPYEHLLR
Y1611 HPHPISPYEHLLRGV
S1619 EHLLRGVSGVDLYRS
R1625 VSGVDLYRSHIPLAF
R1639 FDPTSIPRGIPLDAA
R1653 AAAYYLPRHLAPNPT
Y1661 HLAPNPTYPHLYPPY
R1711 AQRADMLRGLSPRES
R1729 LNYAAGPRGIIDLSQ
T1747 LPVLVPPTPGTPATA
S1774 PFSSRHSSSPLSPGG
S1775 FSSRHSSSPLSPGGP
S1778 RHSSSPLSPGGPTHL
T1783 PLSPGGPTHLTKPTT
T1786 PGGPTHLTKPTTTSS
K1787 GGPTHLTKPTTTSSS
S1794 KPTTTSSSERERDRD
S1813 RDREREKSILTSTTT
T1816 EREKSILTSTTTVEH
T1819 KSILTSTTTVEHAPI
S1855 SSRPASHSHAHQHSP
S1861 HSHAHQHSPISPRTQ
S1864 AHQHSPISPRTQDAL
T1867 HSPISPRTQDALQQR
T1888 TGMKGIITAVEPSTP
A1889 GMKGIITAVEPSTPT
S1893 IITAVEPSTPTVLRS
T1894 ITAVEPSTPTVLRST
T1896 AVEPSTPTVLRSTST
R1899 PSTPTVLRSTSTSSP
T1955 PERPRADTGHAFLAK
K1962 TGHAFLAKPPARSGL
S1967 LAKPPARSGLEPASS
S1973 RSGLEPASSPSKGSE
S1974 SGLEPASSPSKGSEP
S1979 ASSPSKGSEPRPLVP
P1983 SKGSEPRPLVPPVSG
S1989 RPLVPPVSGHATIAR
S1989 RPLVPPVSGHATIAR
S2008 NLAPHHASPDPPAPP
K2025 ASDPHREKTQSKPFS
K2029 HREKTQSKPFSIQEL
S2040 IQELELRSLGYHGSS
Y2043 LELRSLGYHGSSYSP
G2045 LRSLGYHGSSYSPEG
Y2048 LGYHGSSYSPEGVEP
S2049 GYHGSSYSPEGVEPV
S2057 PEGVEPVSPVSSPSL
S2060 VEPVSPVSSPSLTHD
S2061 EPVSPVSSPSLTHDK
S2063 VSPVSSPSLTHDKGL
T2065 PVSSPSLTHDKGLPK
S2080 HLEELDKSHLEGELR
S2115 PLPESQPSSSPLLQT
S2117 PESQPSSSPLLQTAP
T2134 KGHQRVVTLAQHISE
Y2164 APLPAPLYSFPGASC
S2165 PLPAPLYSFPGASCP
S2181 LDLRRPPSDLYLPPP
S2206 HSEGGKRSPEPNKTS
S2226 EDGIEPVSPPEGMTE
T2232 VSPPEGMTEPGHSRS
S2239 TEPGHSRSAVYPLLY
Y2242 GHSRSAVYPLLYRDG
S2261 PSRMGSKSPGNTSQP
T2265 GSKSPGNTSQPPAFF
S2266 SKSPGNTSQPPAFFS
S2273 SQPPAFFSKLTESNS
T2296 EINKKLNTHNRNEPE
S2396 RSDHTLTSPGGGGKA
S2410 AKVSGRPSSRKAKSP
S2416 PSSRKAKSPAPGLAS
S2423 SPAPGLASGDRPPSV
S2429 ASGDRPPSVSSVHSE
S2455 RVWEDRPSSAGSTPF
S2456 VWEDRPSSAGSTPFP
S2459 DRPSSAGSTPFPYNP
T2460 RPSSAGSTPFPYNPL
S2514 CSQYETLSDSE____
S2516 QYETLSDSE______
  mouse

► Hide Isoforms
 
R18-m2 TWRAAEPrYPPHGIS
T35-p VQIARSHtDVGLLEY
S51 HHPRDYTSHLSPGSI
S54 RDYTSHLSPGSIIQP
S67-p QPQRRRPsLLSEFQP
S79 FQPGSERSQELHLRP
S149-p AGKLEPVsPPsPPHA
S152-p LEPVsPPsPPHADPE
A156 sPPsPPHADPELELA
S215-p PEPEKPVsPPPIEsK
S221-p VsPPPIEsKHRSLVQ
S373 ARSEHEVSEIIDGLS
K387-ub SEQENLEkQMRQLAV
K449-ac EKFMQHPkNFGLIAS
S493-p SYRRRGKsQQQQQQQ
T546-p EELSKEKtDDtsGED
T549-p SKEKtDDtsGEDNDE
S550-p KEKtDDtsGEDNDEK
K668-sm ILQQHKLkMEKERNA
S742-p GPAAVNNssDtEsVP
S743-p PAAVNNssDtEsVPs
T745-p AVNNssDtEsVPsPR
S747-p NNssDtEsVPsPRSE
S750-p sDtEsVPsPRSEATK
S753 EsVPsPRSEATKDTG
S797 PSPVPDASGPPSPEP
S801 PDASGPPSPEPSPSP
S805 GPPSPEPSPSPAAPP
S807 PSPEPSPSPAAPPAT
S863-p EPPESVKsDHKEETE
K878 EEPEDKAKGTEAIET
S907 AAVTKGSSSGATQDS
S938-p GDKGRLLsPRPsLLT
S942-p RLLsPRPsLLTPAGD
T945 sPRPsLLTPAGDPRA
T954-p AGDPRAStsPQKPLD
S955-p GDPRAStsPQKPLDL
K958 RAStsPQKPLDLKQL
T977 AAIPPIVTKVHEPPR
S1016-p VSQQSGGsPRGKSRs
S1021 GGsPRGKSRsPVPPA
S1023-p sPRGKSRsPVPPAEK
T1155-p KAPMGPLtMGLPLAV
- gap
- gap
- gap
T1169 VDPKKLGTALGSATS
S1173 KLGTALGSATSGSIT
S1178 LGSATSGSITKGLPS
K1181 ATSGSITKGLPSTRA
- gap
T1202 RGSITHGTPADVLYK
K1209 TPADVLYKGTISRIV
S1220-p SRIVGEDsPsRLDRA
S1222-p IVGEDsPsRLDRARE
Y1239 LPKGHVIYEGKKGHV
S1267 KEDGRSSSGPPHETA
T1273 SSGPPHETAAPKRTY
T1292 GRVGRTVTSASIEGL
S1293 RVGRTVTSASIEGLM
S1295 GRTVTSASIEGLMGR
S1309-p RAIPEQHsPHLKEQH
Y1337 YVEAQEDYLRREAKL
T1350-p KLLKREGtPPPPPPP
- gap
T1406-p PREELRRtPELPLAP
S1420 PRPLKEGSITQGTPL
T1422 PLKEGSITQGTPLKy
T1425 EGSITQGTPLKyDSG
Y1429-p TQGTPLKyDSGAPSt
P1434 LKyDSGAPStGtKKH
T1436-p yDSGAPStGtKKHDV
T1438-p SGAPStGtKKHDVRs
S1445-p tKKHDVRsIIGsPGR
S1449-p DVRsIIGsPGRPFPA
Y1474 RALERACYEESLKSR
T1484 SLKSRSGTSSGAGGS
- gap
S1509-p ELGKPRQsPLTYEDH
T1531 LPRGSPVTtREPTPR
T1532-gl PRGSPVTtREPTPRL
R1533 RGSPVTtREPTPRLQ
T1536 PVTtREPTPRLQEGS
S1543 TPRLQEGSLLSSKAS
T1558 QDRKLTSTPREIAKs
S1565-p TPREIAKsPHSTVPE
T1569 IAKsPHSTVPEHHPH
S1579-p EHHPHPIsPyEHLLR
Y1581-p HPHPIsPyEHLLRGV
T1589 EHLLRGVTGVDLYrG
R1595-m1 VTGVDLYrGHIPLAF
R1609-m1 FDPTSIPrGIPLEAA
R1624-m2 AAAYYLPrHLAPSPT
Y1632 HLAPSPTYPHLYPPY
R1682-m1 AQRADMLrGLSPRES
R1700 LNYAAGPRGIIDLSQ
T1718-p LPVLVPPtPGTPATA
S1745-p PFSSRHSssPLsPGG
S1746-p FSSRHSssPLsPGGP
S1749-p RHSssPLsPGGPTHL
T1754 PLsPGGPTHLAKPTA
A1757 PGGPTHLAKPTATSS
K1758 GGPTHLAKPTATSSS
S1765 KPTATSSSERERERE
S1778 RERERDKSILTSTTT
T1781 ERDKSILTSTTTVEH
T1784 KSILTSTTTVEHAPI
T1812-p SSRPASHtHQHsPIs
S1816-p ASHtHQHsPIsPRtQ
S1819-p tHQHsPIsPRtQDAL
T1822-gl HsPIsPRtQDALQQR
T1843-gl TSMKGVVtsVEPGtP
S1844-gl SMKGVVtsVEPGtPT
G1848 VVtsVEPGtPTVLrW
T1849-p VtsVEPGtPTVLrWA
T1851 sVEPGtPTVLrWARS
R1854-m1 PGtPTVLrWARSTST
A1913 PERPRVDAGHAFLTK
K1920 AGHAFLTKPPAREPA
- gap
S1928 PPAREPASSPSKSSE
S1929 PAREPASSPSKSSEP
S1934 ASSPSKSSEPRsLAP
S1938-gl SKSSEPRsLAPPSsS
S1944 RsLAPPSSSHTAIAR
S1944-gl RsLAPPSsSHTAIAR
S1963-p NLAPHHAsPDPPAPT
K1979 ASDLHREKTQSkPFS
K1983-ac HREKTQSkPFSIQEL
S1994 IQELELRSLGYHsGA
Y1997 LELRSLGYHsGAGys
S1999-p LRSLGYHsGAGysPD
Y2003-p GYHsGAGysPDGVEP
S2004-p YHsGAGysPDGVEPI
S2012-p PDGVEPIsPVssPsL
S2015-p VEPIsPVssPsLtHD
S2016-p EPIsPVssPsLtHDK
S2018-p IsPVssPsLtHDKGL
T2020-p PVssPsLtHDKGLSK
S2035-p PLEELEKsHLEGELR
S2070 PLPESQPSSSPLLQT
S2072 PESQPSSSPLLQTAP
T2089-gl KGHQRVVtLAQHISE
Y2119 GPLPAPLYSFPGASC
S2120 PLPAPLYSFPGASCP
S2136 LDLRRPPSDLYLPPP
S2161-p HSEGGKRsPEPSKTS
S2181-p EDAIEPVsPPEGMTE
T2187 VsPPEGMTEPGHARS
S2194 TEPGHARSTAYPLLY
Y2197 GHARSTAYPLLYRDG
S2215-p EPRMGSKsPGNTSQP
T2219 GSKsPGNTSQPPAFF
S2220 SKsPGNTSQPPAFFs
S2227-p SQPPAFFsKLTESNS
T2250-p EINKKLNtHNRNEPE
S2351-p RSDHALTsPGGGGKA
S2365 AKVSGRPSSRKAKsP
S2371-p PSSRKAKsPAPGLAS
S2378 sPAPGLASGDRPPSV
S2384 ASGDRPPSVSSVHSE
S2410-p RVWEDRPssAGsTPF
S2411-p VWEDRPssAGsTPFP
S2414-p DRPssAGsTPFPYNP
T2415 RPssAGsTPFPYNPL
S2469-p CSQYETLsDsE____
S2471-p QYETLsDsE______
  SMRT iso4  
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
S40 PEPEKPVSPPPIESK
S46 VSPPPIESKHRSLVQ
S198 ARSEHEVSEIIDGLS
K212 SEQENLEKQMRQLAV
K274 EKFMQHPKNFGLIAS
S318 SYRRRGKSQQQQQQQ
T371 EELSKEKTDDTSGED
T374 SKEKTDDTSGEDNDE
S375 KEKTDDTSGEDNDEK
K493 ILQQHKLKMEKERNA
S567 GPAAVNNSSDTESVP
S568 PAAVNNSSDTESVPS
T570 AVNNSSDTESVPSPR
S572 NNSSDTESVPSPRSE
S575 SDTESVPSPRSEATK
S578 ESVPSPRSEATKDTG
S622 PSPVPDASGPPSPEP
S626 PDASGPPSPEPSPSP
S630 GPPSPEPSPSPAAPP
S632 PSPEPSPSPAAPPAT
S688 EPPESVKSDHKEETE
K703 EEPEDKAKGTEAIET
S732 AAVTKGSSSGATQDS
S763 GDKGRLLSPRPSLLT
S767 RLLSPRPSLLTPAGD
T770 SPRPSLLTPAGDPRA
T779 AGDPRASTSPQKPLD
S780 GDPRASTSPQKPLDL
K783 RASTSPQKPLDLKQL
T802 AAIPPIVTKVHEPPR
S841 VSQQSGGSPRGKSRS
S846 GGSPRGKSRSPVPPA
S848 SPRGKSRSPVPPAEK
T980 KAPMGPLTMGLPLAV
S1004-p GVKQEQLsPRGQAGP
S1014-p GQAGPPEsLGVPtAQ
T1019-p PEsLGVPtAQETSVL
T1029 ETSVLRGTALGSATS
S1033 LRGTALGSATSGSIT
S1038 LGSATSGSITKGLPS
K1041 ATSGSITKGLPSTRA
- gap
T1062 RGSITHGTPADVLYK
K1069 TPADVLYKGTISRIV
S1080 SRIVGEDSPSRLDRA
S1082 IVGEDSPSRLDRARE
Y1099 LPKGHVIYEGKKGHV
S1127 KEDGRSSSGPPHETA
T1133 SSGPPHETAAPKRTY
T1152 GRVGRTVTSASIEGL
S1153 RVGRTVTSASIEGLM
S1155 GRTVTSASIEGLMGR
S1169 RAIPEQHSPHLKEQH
Y1197 YVEAQEDYLRREAKL
T1210 KLLKREGTPPPPPPP
- gap
T1266 PREELRRTPELPLAP
S1280 PRPLKEGSITQGTPL
T1282 PLKEGSITQGTPLKY
T1285 EGSITQGTPLKYDSG
Y1289 TQGTPLKYDSGAPST
P1294 LKYDSGAPSTGTKKH
T1296 YDSGAPSTGTKKHDV
T1298 SGAPSTGTKKHDVRS
S1305 TKKHDVRSIIGSPGR
S1309 DVRSIIGSPGRPFPA
Y1334 RALERACYEESLKSR
T1344 SLKSRSGTSSGAGGS
- gap
S1369 ELGKPRQSPLTYEDH
T1391 LPRGSPVTTREPTPR
T1392 PRGSPVTTREPTPRL
R1393 RGSPVTTREPTPRLQ
T1396 PVTTREPTPRLQEGS
S1403 TPRLQEGSLLSSKAS
T1418 QDRKLTSTPREIAKS
S1425 TPREIAKSPHSTVPE
T1429 IAKSPHSTVPEHHPH
S1439 EHHPHPISPYEHLLR
Y1441 HPHPISPYEHLLRGV
T1449 EHLLRGVTGVDLYRG
R1455 VTGVDLYRGHIPLAF
R1469 FDPTSIPRGIPLEAA
R1484 AAAYYLPRHLAPSPT
Y1492 HLAPSPTYPHLYPPY
R1542 AQRADMLRGLSPRES
R1560 LNYAAGPRGIIDLSQ
T1578 LPVLVPPTPGTPATA
S1605 PFSSRHSSSPLSPGG
S1606 FSSRHSSSPLSPGGP
S1609 RHSSSPLSPGGPTHL
T1614 PLSPGGPTHLAKPTA
A1617 PGGPTHLAKPTATSS
K1618 GGPTHLAKPTATSSS
S1625 KPTATSSSERERERE
S1638 RERERDKSILTSTTT
T1641 ERDKSILTSTTTVEH
T1644 KSILTSTTTVEHAPI
T1672 SSRPASHTHQHSPIS
S1676 ASHTHQHSPISPRTQ
S1679 THQHSPISPRTQDAL
T1682 HSPISPRTQDALQQR
T1703 TSMKGVVTSVEPGTP
S1704 SMKGVVTSVEPGTPT
G1708 VVTSVEPGTPTVLRW
T1709 VTSVEPGTPTVLRWA
T1711 SVEPGTPTVLRWARS
R1714 PGTPTVLRWARSTST
A1773 PERPRVDAGHAFLTK
K1780 AGHAFLTKPPAREPA
- gap
S1788 PPAREPASSPSKSSE
S1789 PAREPASSPSKSSEP
S1794 ASSPSKSSEPRSLAP
S1798 SKSSEPRSLAPPSSS
S1804 RSLAPPSSSHTAIAR
S1804 RSLAPPSSSHTAIAR
S1823 NLAPHHASPDPPAPT
K1839 ASDLHREKTQSKPFS
K1843 HREKTQSKPFSIQEL
S1854 IQELELRSLGYHSGA
Y1857 LELRSLGYHSGAGYS
S1859 LRSLGYHSGAGYSPD
Y1863 GYHSGAGYSPDGVEP
S1864 YHSGAGYSPDGVEPI
S1872 PDGVEPISPVSSPSL
S1875 VEPISPVSSPSLTHD
S1876 EPISPVSSPSLTHDK
S1878 ISPVSSPSLTHDKGL
T1880 PVSSPSLTHDKGLSK
S1895 PLEELEKSHLEGELR
S1930 PLPESQPSSSPLLQT
S1932 PESQPSSSPLLQTAP
T1949 KGHQRVVTLAQHISE
Y1979 GPLPAPLYSFPGASC
S1980 PLPAPLYSFPGASCP
S1996 LDLRRPPSDLYLPPP
S2021 HSEGGKRSPEPSKTS
S2041 EDAIEPVSPPEGMTE
T2047 VSPPEGMTEPGHARS
S2054 TEPGHARSTAYPLLY
Y2057 GHARSTAYPLLYRDG
S2075-p EPRMGSKsPGNTsQP
T2079 GSKsPGNTsQPPAFF
S2080-p SKsPGNTsQPPAFFS
S2087 sQPPAFFSKLTESNS
T2110 EINKKLNTHNRNEPE
S2211 RSDHALTSPGGGGKA
S2225 AKVSGRPSSRKAKSP
S2231 PSSRKAKSPAPGLAS
S2238 SPAPGLASGDRPPSV
S2244 ASGDRPPSVSSVHSE
S2270 RVWEDRPSSAGSTPF
S2271 VWEDRPSSAGSTPFP
S2274 DRPSSAGSTPFPYNP
T2275 RPSSAGSTPFPYNPL
S2329 CSQYETLSDSE____
S2331 QYETLSDSE______
  rat

 
R18 TWRAAEPRYPPHGIS
T35 VQIARPHTDVGLLEY
S51 HHPRDYTSHLSPGSI
S54 RDYTSHLSPGSIIQP
S67-p QPQRRRPsLLSEFQP
S79 FQPGSERSQELHLRP
S149-p AGKLEPVsPPsPPHA
S152-p LEPVsPPsPPHADPE
A156 sPPsPPHADPELELT
S215 PEPEKPVSPPPIESK
S221 VSPPPIESKHRSLVQ
S373 ARSEHEVSEIIDGLS
K387 SEQENLEKQMRQLAV
K449 EKFMQHPKNFGLIAS
S493 SYRRRGKSQQQQQQQ
T546 EELSKEKTDDTsGED
T549 SKEKTDDTsGEDNDE
S550-p KEKTDDTsGEDNDEK
K668 ILQQHKLKMEKERNA
S742 GPAAVNNSSDTESVP
S743 PAAVNNSSDTESVPS
T745 AVNNSSDTESVPSPR
S747 NNSSDTESVPSPRTE
S750 SDTESVPSPRTEATK
T753 ESVPSPRTEATKDAG
S797 PCPAPDASGPPSPVA
S801 PDASGPPSPVASPPP
S805 GPPSPVASPPPAAPP
P807 PSPVASPPPAAPPAA
S864 EPPESVKSDHKEETE
K879 EEPEDKAKGPEAIET
S908 AAVTKGSSSGATQDS
S939 GDKGRLLSPRPSLLT
S943 RLLSPRPSLLTPAGD
T946 SPRPSLLTPAGDPRA
T955 AGDPRASTsPQKPLD
S956-p GDPRASTsPQKPLDL
K959 RASTsPQKPLDLKQL
T978 AAIPPIVTKVHEPPR
S1017 VSQQSGGSPRGKCRS
C1022 GGSPRGKCRSPVPPA
S1024 SPRGKCRSPVPPAEK
T1156 KAPMGPLTMGLPLAV
- gap
- gap
- gap
T1170 VDPKKLGTALGSTAS
S1174 KLGTALGSTASGSIT
S1179 LGSTASGSITKGLPS
K1182 TASGSITKGLPSTRT
- gap
T1203 RGSITHGTPADVLYK
K1210 TPADVLYKGTISRIV
S1221 SRIVGEDSPSRLDRA
S1223 IVGEDSPSRLDRARE
Y1240 LPKGHVIYEGKKGHV
S1268 KEDGRSSSGPPHETA
T1274 SSGPPHETAAPKRTY
T1293 GRVGRTITSASIEGL
S1294 RVGRTITSASIEGLM
S1296 GRTITSASIEGLMGR
S1310 RAIPEQHSPHLKEQH
Y1338 YVEAQEDYLRREAKL
T1351-p KLLKREGtPPPPPPP
- gap
T1407-p PREELRRtPELPLAP
S1421 PRPLKEGSITQGTPL
T1423 PLKEGSITQGTPLKY
T1426 EGSITQGTPLKYDSG
Y1430 TQGTPLKYDSGVPSS
P1435 LKYDSGVPSSGSKKH
S1437 YDSGVPSSGSKKHDV
S1439 SGVPSSGSKKHDVRS
S1446 SKKHDVRSIIGSPGR
S1450 DVRSIIGSPGRPFPA
Y1475 RALERACYEESLKSR
T1485 SLKSRSGTSSGAGGS
- gap
S1510 ELGKPRQSPLAYEDH
T1532 LPRGSPVTTREPTPR
T1533 PRGSPVTTREPTPRL
R1534 RGSPVTTREPTPRLQ
T1537 PVTTREPTPRLQEGS
S1544 TPRLQEGSLLSSKAS
T1559 QDRKLTSTPREIAKS
S1566 TPREIAKSPHSTVPE
T1570 IAKSPHSTVPEHHPH
S1580 EHHPHPISPYEHLLR
Y1582 HPHPISPYEHLLRGV
T1590 EHLLRGVTGVDLYrG
R1596-m1 VTGVDLYrGHIPLAF
R1610 FDPTSIPRGIPLEAA
R1625 AAAYYLPRHLAPSPT
Y1633 HLAPSPTYPHLYPPY
R1683 AQRADMLRGLSPRES
R1701 LNYAAGPRGIIDLSQ
T1719 LPVLVPPTPGTPATA
S1746 PFSSRHSSSPLSPGG
S1747 FSSRHSSSPLSPGGP
S1750 RHSSSPLSPGGPTHL
T1755 PLSPGGPTHLAKPTA
A1758 PGGPTHLAKPTATSS
K1759 GGPTHLAKPTATSSS
S1766 KPTATSSSERERERE
S1779 RERERDKSILTSTTT
T1782 ERDKSILTSTTTVEH
T1785 KSILTSTTTVEHAPI
T1813 SSRPASHTHQHSPIS
S1817 ASHTHQHSPISPRTQ
S1820 THQHSPISPRTQDAL
T1823 HSPISPRTQDALQQR
T1844 TSMKGVVTSVEPGTP
S1845 SMKGVVTSVEPGTPT
G1849 VVTSVEPGTPTVLRW
T1850 VTSVEPGTPTVLRWA
T1852 SVEPGTPTVLRWARS
R1855 PGTPTVLRWARSTST
A1914 PERPRVDAGHAFLTK
K1921 AGHAFLTKPPAREPA
- gap
S1929 PPAREPASSPSKSSE
S1930 PAREPASSPSKSSEP
S1935 ASSPSKSSEPRSLAP
S1939 SKSSEPRSLAPPSSS
S1945 RSLAPPSSSHTAIAR
S1945 RSLAPPSSSHTAIAR
S1964 SLAPHHASPDLPAPT
K1980 ASDLHREKTQSKPFS
K1984 HREKTQSKPFSIQEL
S1995-p IQELELRsLGyHSGA
Y1998-p LELRsLGyHSGAGyS
S2000 LRsLGyHSGAGySPD
Y2004-p GyHSGAGySPDGVEP
S2005 yHSGAGySPDGVEPI
S2013 PDGVEPISPVSsPsL
S2016 VEPISPVSsPsLTHD
S2017-p EPISPVSsPsLTHDK
S2019-p ISPVSsPsLTHDKGL
T2021 PVSsPsLTHDKGLSK
S2036 PLEELEKSHLEGELR
S2071 PLPESQPSSSPLLQT
S2073 PESQPSSSPLLQTAP
T2090 KGHQRVVTLAQHISE
Y2120 GPLPAPLYSFPGASC
S2121 PLPAPLYSFPGASCP
S2137 LDLRRPPSDLYLPPP
S2162 HSEGGKRSPEPSKTV
S2181-p EDAIEPVsPPEGMTE
T2187 VsPPEGMTEPGHARS
S2194 TEPGHARSTAYPLLY
Y2197 GHARSTAYPLLYRDG
S2215-p EPRMGSKsPGNTSQP
T2219 GSKsPGNTSQPPAFF
S2220 SKsPGNTSQPPAFFS
S2227 SQPPAFFSKLTESNS
T2250 EINKKLNTHNRNEPE
S2351 RSDHPLTSPGGGGKA
S2365 AKVSGRPSSRKAKSP
S2371 PSSRKAKSPAPGLAP
P2378 SPAPGLAPGDRPPSV
S2384 APGDRPPSVSSVHSE
S2410 RVWEDRPSSAGSTPF
S2411 VWEDRPSSAGSTPFP
S2414 DRPSSAGSTPFPYNP
T2415 RPSSAGSTPFPYNPL
S2469 CSQYETLSDSE____
S2471 QYETLSDSE______
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