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Protein Page:
RBM8A (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
RBM8A Component of a splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junction on mRNAs. The EJC is a dynamic structure consisting of a few core proteins and several more peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. Core components of the EJC, that remains bound to spliced mRNAs throughout all stages of mRNA metabolism, functions to mark the position of the exon-exon junction in the mature mRNA and thereby influences downstream processes of gene expression including mRNA splicing, nuclear mRNA export, subcellular mRNA localization, translation efficiency and nonsense-mediated mRNA decay (NMD). The heterodimer MAGOH-RBM8A interacts with PYM that function to enhance the translation of EJC-bearing spliced mRNAs by recruiting them to the ribosomal 48S preinitiation complex. Remains associated with mRNAs in the cytoplasm until the mRNAs engage the translation machinery. Its removal from cytoplasmic mRNAs requires translation initiation from EJC-bearing spliced mRNAs. Associates preferentially with mRNAs produced by splicing. Does not interact with pre-mRNAs, introns, or mRNAs produced from intronless cDNAs. Associates with both nuclear mRNAs and newly exported cytoplasmic mRNAs. Complex with MAGOH is a component of the nonsense mediated decay (NMD) pathway. Belongs to the RBM8A family. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Translation; Spliceosome; RNA binding protein; RNA splicing
Cellular Component: nucleoplasm; cytoplasm; nucleolus; nuclear speck; nucleus; cytosol
Molecular Function: mRNA binding; protein binding; RNA binding; nucleotide binding
Biological Process: nuclear mRNA splicing, via spliceosome; regulation of translation; transcription from RNA polymerase II promoter; mRNA export from nucleus; RNA metabolic process; RNA splicing; mRNA catabolic process, nonsense-mediated decay; gene expression; mRNA 3'-end processing; termination of RNA polymerase II transcription; regulation of alternative nuclear mRNA splicing, via spliceosome; mRNA metabolic process
Reference #:  Q9Y5S9 (UniProtKB)
Alt. Names/Synonyms: Binder of OVCA1-1; BOV-1; BOV-1A; BOV-1B; BOV-1C; MDS014; RBM8; RBM8A; RBM8B; ribonucleoprotein RBM8; Ribonucleoprotein RBM8A; RNA binding motif protein 8A; RNA binding motif protein 8B; RNA-binding motif protein 8A; RNA-binding protein 8A; RNA-binding protein Y14; Y14; ZNRP; ZRNP1
Gene Symbols: RBM8A
Molecular weight: 19,889 Da
Basal Isoelectric point: 5.5  Predict pI for various phosphorylation states
Select Structure to View Below

RBM8A

Protein Structure Not Found.


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Sites Implicated In
RNA splicing, altered: S166‑p, S168‑p
molecular association, regulation: S166‑p, S168‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

► Hide Isoforms
 
0 6 S24-p MDEDGDEsIHkLKEK
0 1 K27-ac DGDEsIHkLKEKAKK
0 27 S42-p RKGRGFGsEEGsRAR
0 6 S46-p GFGsEEGsRARMRED
0 210 Y54-p RARMREDyDsVEQDG
0 84 S56-p RMREDyDsVEQDGDE
0 1 Y121-p KGYTLVEyETykEAQ
0 1 Y124-p TLVEyETykEAQAAM
0 2 K125-ub LVEyETykEAQAAME
1 7 S166-p RRGGRRRsRsPDRRR
2 7 S168-p GGRRRsRsPDRRRR_
0 1 - gap
  RBM8A iso2  
S24 MDEDGDESIHKLKEK
K27 DGDESIHKLKEKAKK
S42-p RKGRGFGsEGsRARM
S45-p RGFGsEGsRARMRED
Y53 RARMREDYDsVEQDG
S55-p RMREDYDsVEQDGDE
Y120 KGYTLVEYETYKEAQ
Y123 TLVEYETYKEAQAAM
K124 LVEYETYKEAQAAME
S165 RRGGRRRSRSPDRRR
S167 GGRRRSRSPDRRRR_
- gap
  RBM8A iso3  
S24 MDEDGDESIHKLKEK
K27 DGDESIHKLKEKAKK
S42 RKGRGFGSGECGENG
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
S54-p ENGVEWPsRAGATGF
  mouse

► Hide Isoforms
 
S24-p MDEDGDEsIHKLKEK
K27 DGDEsIHKLKEKAKK
S42-p RKGRGFGsKEGSRAR
S46 GFGsKEGSRARMRED
Y54-p RARMREDyDsVEQDG
S56-p RMREDyDsVEQDGDE
Y121 KGYTLVEYETYkEAQ
Y124 TLVEYETYkEAQAAM
K125-ub LVEYETYkEAQAAME
S166-p RRGGRRRsRsPDRRR
S168-p GGRRRsRsPDRRRR_
- gap
  RBM8A iso2  
S24 MDEDGDESIHKLKEK
K27 DGDESIHKLKEKAKK
S42-p RKGRGFGsEGSRARM
S45 RGFGsEGSRARMRED
Y53 RARMREDYDSVEQDG
S55 RMREDYDSVEQDGDE
Y120 KGYTLVEYETYKEAQ
Y123 TLVEYETYKEAQAAM
K124 LVEYETYKEAQAAME
S165 RRGGRRRSRSPDRRR
S167 GGRRRSRSPDRRRR_
- under review  
  rat

 
S24 MDEDGDESIHKLKEK
K27 DGDESIHKLKEKAKK
S42-p RKGRGFGsEEGSRAR
S46 GFGsEEGSRARMRED
Y54 RARMREDYDsVEQDG
S56-p RMREDYDsVEQDGDE
Y121 KGYTLVEYETYKEAQ
Y124 TLVEYETYKEAQAAM
K125 LVEYETYKEAQAAME
S166-p RRGGRRRsRsPDRRR
S168-p GGRRRsRsPDRRRR_
- under review  
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