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RBM8A
Component of a splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junction on mRNAs. The EJC is a dynamic structure consisting of a few core proteins and several more peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. Core components of the EJC, that remains bound to spliced mRNAs throughout all stages of mRNA metabolism, functions to mark the position of the exon-exon junction in the mature mRNA and thereby influences downstream processes of gene expression including mRNA splicing, nuclear mRNA export, subcellular mRNA localization, translation efficiency and nonsense-mediated mRNA decay (NMD). The heterodimer MAGOH-RBM8A interacts with PYM that function to enhance the translation of EJC-bearing spliced mRNAs by recruiting them to the ribosomal 48S preinitiation complex. Remains associated with mRNAs in the cytoplasm until the mRNAs engage the translation machinery. Its removal from cytoplasmic mRNAs requires translation initiation from EJC-bearing spliced mRNAs. Associates preferentially with mRNAs produced by splicing. Does not interact with pre-mRNAs, introns, or mRNAs produced from intronless cDNAs. Associates with both nuclear mRNAs and newly exported cytoplasmic mRNAs. Complex with MAGOH is a component of the nonsense mediated decay (NMD) pathway. Belongs to the RBM8A family. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
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| Protein type: RNA splicing; Translation; RNA binding protein |
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Cellular Component: nucleoplasm; cytoplasm; nucleolus; nuclear speck; cytosol; nucleus
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Molecular Function: mRNA binding; protein binding; RNA binding; nucleotide binding
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Biological Process: transcription from RNA polymerase II promoter; regulation of translation; nuclear mRNA splicing, via spliceosome; mRNA export from nucleus; RNA metabolic process; RNA splicing; mRNA catabolic process, nonsense-mediated decay; gene expression; mRNA 3'-end processing; termination of RNA polymerase II transcription; mRNA metabolic process
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Reference #:
Q9Y5S9 (UniProtKB)
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| Alt. Names/Synonyms: Binder of OVCA1-1; BOV-1; BOV-1A; BOV-1B; BOV-1C; MDS014; RBM8; RBM8A; RBM8B; ribonucleoprotein RBM8; Ribonucleoprotein RBM8A; RNA binding motif protein 8A; RNA binding motif protein 8B; RNA-binding motif protein 8A; RNA-binding protein 8A; RNA-binding protein Y14; Y14; ZNRP; ZRNP1 |
| Gene Symbols: RBM8A |
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Molecular weight: 19,889 Da
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Basal Isoelectric point: 5.5
Predict pI for various phosphorylation states
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