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IRS2 (human)

Overview IRS2 May mediate the control of various cellular processes by insulin. Interacts with PHIP. Note: This description may include information from UniProtKB. Protein type: Adaptor/scaffold; Motility/polarity/chemotaxis Cellular Component: plasma membrane; cytosol Molecular Function: signal transducer activity; protein binding; phospholipid binding; phosphoinositide 3-kinase binding; protein kinase binding; insulin receptor binding Biological Process: negative regulation of kinase activity; phosphoinositide-mediated signaling; regulation of lipid metabolic process; nerve growth factor receptor signaling pathway; positive regulation of glycogen biosynthetic process; positive regulation of insulin secretion; glucose metabolic process; lipid homeostasis; signal transduction; positive regulation of fatty acid beta-oxidation; positive regulation of glucose import; cell proliferation; mammary gland development; cellular response to insulin stimulus; positive regulation of cell proliferation; positive regulation of mesenchymal cell proliferation; positive regulation of B cell proliferation; response to glucose stimulus; insulin receptor signaling pathway; brain development; negative regulation of B cell apoptosis; positive regulation of cell migration Reference #:  Q9Y4H2 (UniProtKB) Alt. Names/Synonyms: Insulin receptor substrate 2; IRS-2; IRS2 Gene Symbols: IRS2 Molecular weight: 137,334 Da Basal Isoelectric point: 8.9  Predict pI for various phosphorylation states CST Pathways:  Insulin Receptor Signaling  |  MAPK/Erk in Growth and Differentiation Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below IRS2 3BU3 - B=620-634 (mouse) 3BU5 - B=620-634 (mouse) 3BU6 - B=620-634 (mouse)

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	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
1	2		S66	EATAGGGSAPQPPRL
0	15		Y75-p	PQPPRLEyyESEKKW
0	4		Y76-p	QPPRLEyyESEKKWR
0	1		K295-u	LEAMKALkELFEFRP
0	5		S304-p	LFEFRPRsKsQsSGs
1	34		S306-p	EFRPRsKsQsSGssA
1	3		S308-p	RPRsKsQsSGssAtH
0	2		S311-p	sKsQsSGssAtHPIS
0	1		S312-p	KsQsSGssAtHPISV
0	1		T314-p	QsSGssAtHPISVPG
0	1		S334-p	HLVNLPPsQTGLVRR
0	18		S346-p	VRRSRTDsLAAtPPA
2	24		T350-p	RTDsLAAtPPAAKCS
0	1		S358-p	PPAAKCSsCRVRtAs
0	21		T363-p	CSsCRVRtAsEGDGG
0	46		S365-p	sCRVRtAsEGDGGAA
0	10		S384-p	AAGARPVsVAGsPLs
1	36		S388-p	RPVsVAGsPLsPGPV
2	83		S391-p	sVAGsPLsPGPVRAP
0	3		S400-p	GPVRAPLsRSHtLSG
1	6		T404-p	APLsRSHtLSGGCGG
0	1		R412-m1	LSGGCGGrGSKVALL
0	1		S428	AGGALQHSRsMsMPV
0	1		S430-p	GALQHSRsMsMPVAH
0	1		S432-p	LQHSRsMsMPVAHSP
1	0		S487	RPSSGSASASGSPSD
1	0		S491	GSASASGSPSDPGFM
0	2		S505-p	MSLDEYGssPGDLRA
0	2		S506-p	SLDEYGssPGDLRAF
0	3		S515-p	GDLRAFCsHRsNtPE
0	12		S518-p	RAFCsHRsNtPEsIA
1	14		T520-p	FCsHRsNtPEsIAEt
0	13		S523-p	HRsNtPEsIAEtPPA
0	34		T527-p	tPEsIAEtPPARDGG
0	5		Y540-p	GGGGGEFyGyMtMDR
0	38		Y542-p	GGGEFyGyMtMDRPL
0	3		T544-p	GEFyGyMtMDRPLsH
0	1		S550-p	MtMDRPLsHCGRSYR
1	22		S560-p	GRSYRRVsGDAAQDL
0	5		T575-p	DRGLRKRtysLttPA
0	4		Y576-p	RGLRKRtysLttPAR
1	20		S577-p	GLRKRtysLttPARQ
0	3		T579-p	RKRtysLttPARQRP
0	3		T580-p	KRtysLttPARQRPV
0	1		S591-p	QRPVPQPsSAsLDEy
0	10		S594-p	VPQPsSAsLDEytLM
0	147		Y598-p	sSAsLDEytLMRAtF
0	1		T599-p	SAsLDEytLMRAtFs
0	1		T604-p	EytLMRAtFsGsAGR
0	1		S606-p	tLMRAtFsGsAGRLC
0	6		S608-p	MRAtFsGsAGRLCPS
0	4		S620-p	CPSCPASsPKVAYHP
1	2		Y628-p	PKVAYHPyPEDyGDI
1	42		Y632-p	YHPyPEDyGDIEIGS
0	2		S645-p	GSHRSSSsNLGADDG
0	522		Y653-p	NLGADDGyMPMtPGA
1	3		T657-p	DDGyMPMtPGAALAG
0	1		G664	tPGAALAGSGSGSCR
0	1		S669	LAGSGSGSCRsDDyM
0	20		S672-p	SGSGSCRsDDyMPMs
0	356		Y675-p	GSCRsDDyMPMsPAS
1	8		S679-p	sDDyMPMsPASVSAP
0	1		A681	DyMPMsPASVSAPKQ
0	1		-	gap
0	1		T713-p	GPAGPAPtSAAGRTF
0	1		S714	PAGPAPtSAAGRTFP
1	2		S730-p	SGGGYKAssPAEssP
1	5		S731-p	GGGYKAssPAEssPE
1	9		S735-p	KAssPAEssPEDsGy
1	32		S736-p	AssPAEssPEDsGyM
0	10		S740-p	AEssPEDsGyMRMWC
0	392		Y742-p	ssPEDsGyMRMWCGS
0	26		Y766-p	KLLPNGDyLNVsPsD
1	4		S770-p	NGDyLNVsPsDAVtt
0	6		S772-p	DyLNVsPsDAVttGt
0	1		T776-p	VsPsDAVttGtPPDF
0	2		T777-p	sPsDAVttGtPPDFF
0	9		T779-p	sDAVttGtPPDFFSA
0	3		Y803-p	RGVPGCCyssLPRSY
0	1		S804-p	GVPGCCyssLPRSYK
0	3		S805-p	VPGCCyssLPRSYKA
0	8		Y814-p	PRSYKAPytCGGDsD
0	1		T815-p	RSYKAPytCGGDsDQ
0	1		G817	YKAPytCGGDsDQyV
0	4		S820-p	PytCGGDsDQyVLMS
0	693		Y823-p	CGGDsDQyVLMSsPV
0	9		S828-p	DQyVLMSsPVGRILE
0	1		T891-p	RGRAVRPtRLsLEGL
0	2		S894-p	AVRPtRLsLEGLPSL
0	1		S903-p	EGLPSLPsMHEYPLP
1	14		S915-p	PLPPEPKsPGEYINI
0	1		S950	ASSSSLLSASSPASS
0	1		S952	SSSLLSASSPASSLG
0	1		S960	SPASSLGSGTPGTSS
0	1		S969	TPGTSSDSRQRsPLS
0	4		S973-p	SSDSRQRsPLSDyMN
1	1		S976	SRQRsPLSDyMNLDF
0	22		Y978-p	QRsPLSDyMNLDFSS
1	1		S985	yMNLDFSSPKSPKPG
1	1		S1007	GSLDGLLSPEASSPY
1	14		S1100-p	PEAARVAsPTsGVKR
0	1		S1103-p	ARVAsPTsGVKRLsL
0	1		S1109-p	TsGVKRLsLMEQVSG
0	1		K1134-m2	PDPHRGAkVIRADPQ
0	28		S1148-p	QGGRRRHssEtFSsT
1	59		S1149-p	GGRRRHssEtFSsTt
0	10		T1151-p	RRRHssEtFSsTttV
0	2		S1154-p	HssEtFSsTttVtPV
0	3		T1156-p	sEtFSsTttVtPVsP
0	8		T1157-p	EtFSsTttVtPVsPs
0	1		T1159-p	FSsTttVtPVsPsFA
1	84		S1162-p	TttVtPVsPsFAHNP
0	20		S1164-p	tVtPVsPsFAHNPkR
0	1		K1170-m1	PsFAHNPkRHNsAsV
0	2		S1174-p	HNPkRHNsAsVENVS
1	17		S1176-p	PkRHNsAsVENVSLR
0	1		T1202-p	GGGDEPPtsPRQLQP
1	9		S1203-p	GGDEPPtsPRQLQPA
0	1		Y1253-p	GFQNGLNyIAIDVRE
1	1		S1283	PQPGDKSSWGRTRSL
0	2		Y1320-p	ALPPANTyASIDFLS

	mouse
S66-p	EASAAGGsPPQPPRL
Y75	PQPPRLEYyESEKKW
Y76-p	QPPRLEYyESEKKWR
K292	LEAMKALKELFEFRP
S301	LFEFRPRSKsQsSGS
S303-p	EFRPRSKsQsSGSSA
S305-p	RPRSKsQsSGSSATH
S308	SKsQsSGSSATHPIS
S309	KsQsSGSSATHPISV
T311	QsSGSSATHPISVPG
S331	HLVNLPPSQTGLVRR
S343-p	VRRSRTDsLAAtPPA
T347-p	RTDsLAAtPPAAKCT
S355	PPAAKCTSCRVRtAs
T360-p	CTSCRVRtAsEGDGG
S362-p	SCRVRtAsEGDGGAA
S381-p	TAGGRPMsVAGsPLs
S385-p	RPMsVAGsPLsPGPV
S388-p	sVAGsPLsPGPVRAP
S397	GPVRAPLSRSHtLSA
T401-p	APLSRSHtLSAGCGG
R409	LSAGCGGRPSKVTLA
S425-g	AGGALQHsRSMSMPV
S427	GALQHsRSMSMPVAH
S429	LQHsRSMSMPVAHSP
S484-p	RPSSGSAsASGsPSD
S488-p	GSAsASGsPSDPGFM
S502	MSLDEYGSSPGDLRA
S503	SLDEYGSSPGDLRAF
S512-p	GDLRAFSsHRsNtPE
S515-p	RAFSsHRsNtPESIA
T517-p	FSsHRsNtPESIAEt
S520	HRsNtPESIAEtPPA
T524-p	tPESIAEtPPARDGS
Y536	DGSGGELYGyMSMDR
Y538-p	SGGELYGyMSMDRPL
S540	GELYGyMSMDRPLSH
S546	MSMDRPLSHCGRPYR
S556-p	GRPYRRVsGDGAQDL
T571	DRGLRKRTYsLttPA
Y572	RGLRKRTYsLttPAR
S573-p	GLRKRTYsLttPARQ
T575-p	RKRTYsLttPARQRQ
T576-p	KRTYsLttPARQRQV
S587	QRQVPQPSSAsLDEy
S590-p	VPQPSSAsLDEyTLM
Y594-p	SSAsLDEyTLMRATF
T595	SAsLDEyTLMRATFS
T600	EyTLMRATFSGSSGR
S602	TLMRATFSGSSGRLC
S604	MRATFSGSSGRLCPS
S616-p	CPSFPASsPKVAYNP
Y624-p	PKVAYNPyPEDyGDI
Y628-p	YNPyPEDyGDIEIGS
S641	GSHKSSSSNLGADDG
Y649-p	NLGADDGyMPMtPGA
T653-p	DDGyMPMtPGAALRs
S660-p	tPGAALRsGGPNsCK
S665-p	LRsGGPNsCKsDDyM
S668-p	GGPNsCKsDDyMPMs
Y671-p	NsCKsDDyMPMsPtS
S675-p	sDDyMPMsPtSVSAP
T677-p	DyMPMsPtSVSAPKQ
-	gap
P705	GAAVPAPPSGVGRTF
S706	AAVPAPPSGVGRTFP
S722-p	NGGGYKAssPAEssP
S723-p	GGGYKAssPAEssPE
S727-p	KAssPAEssPEDsGy
S728-p	AssPAEssPEDsGyM
S732-p	AEssPEDsGyMRMWC
Y734-p	ssPEDsGyMRMWCGS
Y758	KLLPNGDYLNMsPSE
S762-p	NGDYLNMsPSEAGTA
S764	DYLNMsPSEAGTAGt
T768	MsPSEAGTAGtPPDF
A769	sPSEAGTAGtPPDFS
T771-p	SEAGTAGtPPDFSAA
Y794	KGIPGHCYSSLPRSY
S795	GIPGHCYSSLPRSYK
S796	IPGHCYSSLPRSYKA
C805	PRSYKAPCSCsGDND
S806	RSYKAPCSCsGDNDQ
S808-p	YKAPCSCsGDNDQyV
N811	PCSCsGDNDQyVLMS
Y814-p	CsGDNDQyVLMSSPV
S819	DQyVLMSSPVGRILE
T883	RCRAVRPTRLSLEGL
S886	AVRPTRLSLEGLQTL
S895	EGLQTLPSMQEYPLP
S907-p	PLPTEPKsPGEYINI
S942	ASSSSLLSASSPASS
S944	SSSLLSASSPASSLG
S952	SPASSLGSGTPGTSS
S961	TPGTSSDSRQRsPLs
S965-p	SSDSRQRsPLsDyMN
S968-p	SRQRsPLsDyMNLDF
Y970-p	QRsPLsDyMNLDFSs
S977-p	yMNLDFSsPKSPKPS
S999-p	GSMDGLLsPEASSPY
S1089-p	PEGARVAsPTSGLKR
S1092	ARVAsPTSGLKRLSL
S1098	TSGLKRLSLMDQVSG
K1123	PDPHRGAKVIRADPQ
S1137-p	QGGRRRHssEtFSsT
S1138-p	GGRRRHssEtFSsTt
T1140-p	RRRHssEtFSsTttV
S1143-p	HssEtFSsTttVTPV
T1145-p	sEtFSsTttVTPVsP
T1146-p	EtFSsTttVTPVsPs
T1148	FSsTttVTPVsPsFA
S1151-p	TttVTPVsPsFAHNS
S1153-p	tVTPVsPsFAHNSKR
K1159	PsFAHNSKRHNSAsV
S1163	HNSKRHNSAsVENVS
S1165-p	SKRHNSAsVENVSLR
T1189	GGGDEPPTsPGQAQP
S1190-p	GGDEPPTsPGQAQPL
Y1242	GFQNGLNYIAIDVRG
S1266-p	PQPGDKNsWSRTRSL
Y1303-p	ALPSASTyASIDFLS

	rat
S67	EAAAAGGSPPQPPRL
Y76	PQPPRLEYYESEKKW
Y77	QPPRLEYYESEKKWK
K293	LEAMKALKELFEFRP
S302	LFEFRPRSKSQSSGS
S304	EFRPRSKSQSSGSSA
S306	RPRSKSQSSGSSATH
S309	SKSQSSGSSATHPIS
S310	KSQSSGSSATHPISV
T312	QSSGSSATHPISVPG
S332	HLVNLPPSQTGLVRR
S344-p	VRRSRTDsLAAtPPA
T348-p	RTDsLAAtPPAAKCT
S356	PPAAKCTSCRVRTAS
T361	CTSCRVRTASEGDGG
S363	SCRVRTASEGDGGAA
S382	TAGGRPMSVAGSPLS
S386	RPMSVAGSPLSPGPV
S389	SVAGSPLSPGPVRAP
S398	GPVRAPLSRSHTLSA
T402	APLSRSHTLSAGCGG
R410	LSAGCGGRPSKVALA
S426	AGGALQHSRSMSMPV
S428	GALQHSRSMSMPVAH
S430	LQHSRSMSMPVAHSP
S485	RPSSGSASASGSPSD
S489	GSASASGSPSDPGFM
S503	MSLDEYGSSPGDLRA
S504	SLDEYGSSPGDLRAF
S513	GDLRAFSSHRsNtPE
S516-p	RAFSSHRsNtPESIA
T518-p	FSSHRsNtPESIAEt
S521	HRsNtPESIAEtPPA
T525-p	tPESIAEtPPARDGS
Y537	DGSGGELYGYMSMDR
Y539	SGGELYGYMSMDRPL
S541	GELYGYMSMDRPLSH
S547	MSMDRPLSHCGRPYR
S557-p	GRPYRRVsGDGAQDL
T572	DRGLRKRTYsLTTPA
Y573	RGLRKRTYsLTTPAR
S574-p	GLRKRTYsLTTPARQ
T576	RKRTYsLTTPARQRQ
T577	KRTYsLTTPARQRQV
S588	QRQVPQPSSASLDEY
S591	VPQPSSASLDEYTLM
Y595	SSASLDEYTLMRATF
T596	SASLDEYTLMRATFS
T601	EYTLMRATFSGSSGR
S603	TLMRATFSGSSGRLC
S605	MRATFSGSSGRLCPS
S617	CPSLPASSPKVAYNP
Y625	PKVAYNPYPEDYGDI
Y629	YNPYPEDYGDIEIGS
S642	GSHKSSSSNLGADDG
Y650-p	NLGADDGyMPMTPGA
T654	DDGyMPMTPGAALRS
S661	TPGAALRSGGPNSCK
S666	LRSGGPNSCKSDDyM
S669	GGPNSCKSDDyMPMS
Y672-p	NSCKSDDyMPMSPTS
S676	SDDyMPMSPTSVSAP
T678	DyMPMSPTSVSAPKQ
S691-p	KQILQPRsAAALPPS
P706	GAAVPAPPsGAGRTF
S707-p	AAVPAPPsGAGRTFP
S723	NGGGYKASSPAESsP
S724	GGGYKASSPAESsPE
S728	KASSPAESsPEDSGy
S729-p	ASSPAESsPEDSGyM
S733	AESsPEDSGyMRMWC
Y735-p	SsPEDSGyMRMWCGS
Y759	KLLPNGDYLNMSPSE
S763	NGDYLNMSPSEAGTA
S765	DYLNMSPSEAGTAGT
T769	MSPSEAGTAGTPPDF
A770	SPSEAGTAGTPPDFF
T772	SEAGTAGTPPDFFSA
Y796	KGVPGHCYSSLPRSY
S797	GVPGHCYSSLPRSYK
S798	VPGHCYSSLPRSYKA
C807	PRSYKAPCTCGGGDN
T808	RSYKAPCTCGGGDND
S810	under review
N814	CTCGGGDNDQyVLMS
Y817-p	GGGDNDQyVLMSSPV
S822	DQyVLMSSPVGRILE
T886	RCRAVRPTRLSLEGL
S889	AVRPTRLSLEGLQTL
S898	EGLQTLPSMQEYPLP
S910	PLPTEPKSPGEYINI
S945-p	ASSSSLLsAsSPASS
S947-p	SSSLLsAsSPASSLG
S955-p	SPASSLGsGTPGTSS
S964-p	TPGTSSDsRQRSPLS
S968	SSDsRQRSPLSDYMN
S971	sRQRSPLSDYMNLDF
Y973	QRSPLSDYMNLDFSS
S980	YMNLDFSSPKSPKPS
S1002	GSIDGLLSPEASSPY
S1092-p	PEGARVTsPTSGLKR
S1095	ARVTsPTSGLKRLSL
S1101	TSGLKRLSLMDQVSG
K1126	PDPHRGAKVIRADPQ
S1140	QGGRRRHSSETFSST
S1141	GGRRRHSSETFSSTT
T1143	RRRHSSETFSSTTTV
S1146	HSSETFSSTTTVTPV
T1148	SETFSSTTTVTPVSP
T1149	ETFSSTTTVTPVSPS
T1151	FSSTTTVTPVSPSFA
S1154	TTTVTPVSPSFAHNS
S1156	TVTPVSPSFAHNSKR
K1162	PSFAHNSKRHNSASV
S1166	HNSKRHNSASVENVS
S1168	SKRHNSASVENVSLR
T1192	GGSDEPSTSPGQAQP
S1193	GSDEPSTSPGQAQPS
Y1245	GFQNGLNYIAIDVRG
S1272	PQPGDKNSWGRTRSL
Y1309	ALPSASTYASIDFLS

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