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Protein Page:
IRS2 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
IRS2 May mediate the control of various cellular processes by insulin. Interacts with PHIP. Note: This description may include information from UniProtKB.
Protein type: Motility/polarity/chemotaxis; Adaptor/scaffold
Cellular Component: plasma membrane; cytosol
Molecular Function: protein domain specific binding; protein binding; signal transducer activity; phosphoinositide 3-kinase binding; protein kinase binding; protein phosphatase binding; insulin receptor binding
Biological Process: negative regulation of kinase activity; regulation of lipid metabolic process; nerve growth factor receptor signaling pathway; positive regulation of glycogen biosynthetic process; lipid homeostasis; signal transduction; positive regulation of glucose import; mammary gland development; positive regulation of cell proliferation; positive regulation of mesenchymal cell proliferation; positive regulation of B cell proliferation; response to glucose stimulus; epidermal growth factor receptor signaling pathway; phosphoinositide-mediated signaling; fibroblast growth factor receptor signaling pathway; positive regulation of insulin secretion; glucose metabolic process; positive regulation of fatty acid beta-oxidation; cell proliferation; cellular response to insulin stimulus; insulin receptor signaling pathway; innate immune response; brain development; negative regulation of B cell apoptosis; positive regulation of cell migration
Reference #:  Q9Y4H2 (UniProtKB)
Alt. Names/Synonyms: Insulin receptor substrate 2; IRS-2; IRS2
Gene Symbols: IRS2
Molecular weight: 137,334 Da
Basal Isoelectric point: 8.9  Predict pI for various phosphorylation states
CST Pathways:  Growth And Differentiation Control by MAPKs  |  Insulin Receptor Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

IRS2

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
1 2 S66 EATAGGGSAPQPPRL
0 15 Y75-p PQPPRLEyyESEKKW
0 4 Y76-p QPPRLEyyESEKKWR
0 1 T117 KYLIALYTKDEYFAV
0 1 Y184-p AAGAEDSyGLVAPAT
0 1 K295-ub LEAMKALkELFEFRP
0 6 S304-p LFEFRPRsKsQsSGs
2 39 S306-p EFRPRsKsQsSGssA
1 3 S308-p RPRsKsQsSGssAtH
0 3 S311-p sKsQsSGssAtHPIS
0 2 S312-p KsQsSGssAtHPISV
0 2 T314-p QsSGssAtHPISVPG
0 1 S334-p HLVNLPPsQTGLVRR
0 1 S342-p QTGLVRRsRtDsLAA
0 1 T344-p GLVRRsRtDsLAAtP
1 20 S346-p VRRsRtDsLAAtPPA
2 30 T350-p RtDsLAAtPPAAKCS
0 1 S358-p PPAAKCSsCRVRtAs
0 23 T363-p CSsCRVRtAsEGDGG
0 51 S365-p sCRVRtAsEGDGGAA
0 13 S384-p AAGARPVsVAGsPLs
1 44 S388-p RPVsVAGsPLsPGPV
2 101 S391-p sVAGsPLsPGPVRAP
0 3 S400-p GPVRAPLsRSHtLsG
1 8 T404-p APLsRSHtLsGGCGG
0 1 S406-p LsRSHtLsGGCGGrG
0 2 R412-m1 LsGGCGGrGSKVALL
0 1 S428 AGGALQHSrsMsMPV
0 1 R429-m1 GGALQHSrsMsMPVA
0 1 S430-p GALQHSrsMsMPVAH
0 1 S432-p LQHSrsMsMPVAHSP
1 0 S487 RPSSGSASASGSPSD
1 0 S491 GSASASGSPSDPGFM
0 2 S505-p MSLDEYGssPGDLRA
0 2 S506-p SLDEYGssPGDLRAF
0 4 S515-p GDLRAFCsHRsNtPE
0 16 S518-p RAFCsHRsNtPEsIA
1 20 T520-p FCsHRsNtPEsIAEt
0 16 S523-p HRsNtPEsIAEtPPA
0 39 T527-p tPEsIAEtPPARDGG
0 6 Y540-p GGGGGEFyGyMtMDR
1 39 Y542-p GGGEFyGyMtMDRPL
0 3 T544-p GEFyGyMtMDRPLsH
0 3 S550-p MtMDRPLsHCGRSYR
1 34 S560-p GRSYRRVsGDAAQDL
0 5 T575-p DRGLRKRtysLttPA
0 4 Y576-p RGLRKRtysLttPAR
1 26 S577-p GLRKRtysLttPARQ
0 4 T579-p RKRtysLttPARQRP
0 5 T580-p KRtysLttPARQRPV
0 1 S591-p QRPVPQPsSAsLDEy
0 18 S594-p VPQPsSAsLDEytLM
0 155 Y598-p sSAsLDEytLMRAtF
0 3 T599-p SAsLDEytLMRAtFs
0 1 T604-p EytLMRAtFsGsAGR
0 2 S606-p tLMRAtFsGsAGRLC
0 8 S608-p MRAtFsGsAGRLCPs
0 1 S615-p sAGRLCPsCPAssPK
0 1 S619-p LCPsCPAssPKVAYH
0 6 S620-p CPsCPAssPKVAYHP
1 2 Y628-p PKVAYHPyPEDyGDI
2 45 Y632-p YHPyPEDyGDIEIGs
0 3 S639-p yGDIEIGsHRSSSsN
0 2 S645-p GsHRSSSsNLGADDG
1 529 Y653-p NLGADDGyMPMtPGA
2 3 T657-p DDGyMPMtPGAALAG
0 1 G664 tPGAALAGSGSGSCR
0 3 S669 LAGSGSGSCRsDDyM
0 21 S672-p SGSGSCRsDDyMPMs
2 351 Y675-p GSCRsDDyMPMsPAs
2 13 S679-p sDDyMPMsPAsVSAP
0 1 A681 DyMPMsPAsVSAPKQ
0 3 S682-p yMPMsPAsVSAPKQI
0 1 - gap
0 2 T713-p GPAGPAPtsAAGRTF
0 2 S714-p PAGPAPtsAAGRTFP
1 3 S730-p SGGGYKAssPAEssP
2 8 S731-p GGGYKAssPAEssPE
1 13 S735-p KAssPAEssPEDsGy
1 36 S736-p AssPAEssPEDsGyM
0 10 S740-p AEssPEDsGyMRMWC
1 402 Y742-p ssPEDsGyMRMWCGS
0 1 S752-p MWCGSKLsMEHADGK
1 28 Y766-p KLLPNGDyLNVsPsD
1 6 S770-p NGDyLNVsPsDAVtt
0 8 S772-p DyLNVsPsDAVttGt
0 1 T776-p VsPsDAVttGtPPDF
0 2 T777-p sPsDAVttGtPPDFF
0 12 T779-p sDAVttGtPPDFFSA
0 4 Y803-p RGVPGCCyssLPRSY
0 2 S804-p GVPGCCyssLPRSYK
0 5 S805-p VPGCCyssLPRSYKA
0 9 Y814-p PRSYKAPytCGGDsD
0 1 T815-p RSYKAPytCGGDsDQ
0 1 G817 YKAPytCGGDsDQyV
0 6 S820-p PytCGGDsDQyVLMs
1 702 Y823-p CGGDsDQyVLMssPV
0 1 S827-p sDQyVLMssPVGRIL
0 11 S828-p DQyVLMssPVGRILE
0 1 T891-p RGRAVRPtRLsLEGL
0 2 S894-p AVRPtRLsLEGLPSL
0 1 S903-p EGLPSLPsMHEYPLP
1 21 S915-p PLPPEPKsPGEyINI
2 1 Y919-p EPKsPGEyINIDFGE
1 0 S932 GEPGARLSPPAPPLL
0 1 S950 ASSSSLLSASSPASS
0 1 S952 SSSLLSASSPASSLG
0 1 S960 SPASSLGSGTPGTSS
0 1 S969 TPGTSSDSRQRsPLs
0 8 S973-p SSDSRQRsPLsDyMN
1 3 S976-p SRQRsPLsDyMNLDF
0 24 Y978-p QRsPLsDyMNLDFSS
1 1 S985 yMNLDFSSPKSPKPG
1 1 S1007 GSLDGLLSPEASSPY
0 1 T1082-p MAFGVAAtPPQPIAA
1 18 S1100-p PEAARVAsPTsGVKR
0 2 S1103-p ARVAsPTsGVKRLsL
0 2 S1109-p TsGVKRLsLMEQVSG
0 1 K1134-m2 PDPHRGAkVIRADPQ
1 30 S1148-p QGGRRRHssEtFSsT
2 64 S1149-p GGRRRHssEtFSsTt
0 11 T1151-p RRRHssEtFSsTttV
0 2 S1154-p HssEtFSsTttVtPV
0 3 T1156-p sEtFSsTttVtPVsP
0 8 T1157-p EtFSsTttVtPVsPs
0 1 T1159-p FSsTttVtPVsPsFA
1 105 S1162-p TttVtPVsPsFAHNP
0 27 S1164-p tVtPVsPsFAHNPkR
0 1 K1170-m1 PsFAHNPkRHNsAsV
0 5 S1174-p HNPkRHNsAsVENVS
1 25 S1176-p PkRHNsAsVENVSLR
0 1 S1185-p ENVSLRKssEGGVGV
0 1 S1186-p NVSLRKssEGGVGVG
0 2 T1202-p GGGDEPPtsPRQLQP
1 13 S1203-p GGDEPPtsPRQLQPA
0 1 Y1253-p GFQNGLNyIAIDVRE
1 2 S1283-p PQPGDKSsWGRTRSL
0 2 Y1320-p ALPPANTyASIDFLS
2385 : Phospho-IRS-1 (Ser1101) Antibody
  mouse

 
S66-p EASAAGGsPPQPPRL
Y75 PQPPRLEYyESEKKW
Y76-p QPPRLEYyESEKKWR
T117-p KYLIALYtKDEYFAV
Y181 AAGCDDNYGLVTPAT
K292 LEAMKALKELFEFRP
S301 LFEFRPRSKsQsSGS
S303-p EFRPRSKsQsSGSSA
S305-p RPRSKsQsSGSSATH
S308 SKsQsSGSSATHPIS
S309 KsQsSGSSATHPISV
T311 QsSGSSATHPISVPG
S331 HLVNLPPSQTGLVRR
S339 QTGLVRRSRTDsLAA
T341 GLVRRSRTDsLAAtP
S343-p VRRSRTDsLAAtPPA
T347-p RTDsLAAtPPAAKCT
S355 PPAAKCTSCRVRtAs
T360-p CTSCRVRtAsEGDGG
S362-p SCRVRtAsEGDGGAA
S381-p TAGGRPMsVAGsPLs
S385-p RPMsVAGsPLsPGPV
S388-p sVAGsPLsPGPVRAP
S397 GPVRAPLSRSHtLSA
T401-p APLSRSHtLSAGCGG
S403 LSRSHtLSAGCGGRP
R409 LSAGCGGRPSKVTLA
S425-gl AGGALQHsRSMSMPV
R426 GGALQHsRSMSMPVA
S427 GALQHsRSMSMPVAH
S429 LQHsRSMSMPVAHSP
S484-p RPSSGSAsASGsPSD
S488-p GSAsASGsPSDPGFM
S502 MSLDEYGSSPGDLRA
S503 SLDEYGSSPGDLRAF
S512-p GDLRAFSsHRsNtPE
S515-p RAFSsHRsNtPEsIA
T517-p FSsHRsNtPEsIAEt
S520-p HRsNtPEsIAEtPPA
T524-p tPEsIAEtPPARDGS
Y536 DGSGGELYGyMSMDR
Y538-p SGGELYGyMSMDRPL
S540 GELYGyMSMDRPLSH
S546 MSMDRPLSHCGRPYR
S556-p GRPYRRVsGDGAQDL
T571 DRGLRKRTYsLttPA
Y572 RGLRKRTYsLttPAR
S573-p GLRKRTYsLttPARQ
T575-p RKRTYsLttPARQRQ
T576-p KRTYsLttPARQRQV
S587 QRQVPQPSSAsLDEy
S590-p VPQPSSAsLDEyTLM
Y594-p SSAsLDEyTLMRATF
T595 SAsLDEyTLMRATFS
T600 EyTLMRATFSGSSGR
S602 TLMRATFSGSSGRLC
S604 MRATFSGSSGRLCPS
S611 SSGRLCPSFPASsPK
S615 LCPSFPASsPKVAYN
S616-p CPSFPASsPKVAYNP
Y624-p PKVAYNPyPEDyGDI
Y628-p YNPyPEDyGDIEIGs
S635-p yGDIEIGsHKSSSSN
S641 GsHKSSSSNLGADDG
Y649-p NLGADDGyMPMtPGA
T653-p DDGyMPMtPGAALRs
S660-p tPGAALRsGGPNsCK
S665-p LRsGGPNsCKsDDyM
S668-p GGPNsCKsDDyMPMs
Y671-p NsCKsDDyMPMsPtS
S675-p sDDyMPMsPtSVSAP
T677-p DyMPMsPtSVSAPKQ
S678 yMPMsPtSVSAPKQI
- gap
P705 GAAVPAPPSGVGRTF
S706 AAVPAPPSGVGRTFP
S722-p NGGGYKAssPAEssP
S723-p GGGYKAssPAEssPE
S727-p KAssPAEssPEDsGy
S728-p AssPAEssPEDsGyM
S732-p AEssPEDsGyMRMWC
Y734-p ssPEDsGyMRMWCGS
S744 MWCGSKLSMENPDPK
Y758-p KLLPNGDyLNMsPSE
S762-p NGDyLNMsPSEAGTA
S764 DyLNMsPSEAGTAGt
T768 MsPSEAGTAGtPPDF
A769 sPSEAGTAGtPPDFS
T771-p SEAGTAGtPPDFSAA
Y794 KGIPGHCYSSLPRSY
S795 GIPGHCYSSLPRSYK
S796 IPGHCYSSLPRSYKA
C805 PRSYKAPCSCsGDND
S806 RSYKAPCSCsGDNDQ
S808-p YKAPCSCsGDNDQyV
N811 PCSCsGDNDQyVLMS
Y814-p CsGDNDQyVLMSSPV
S818 NDQyVLMSSPVGRIL
S819 DQyVLMSSPVGRILE
T883 RCRAVRPTRLSLEGL
S886 AVRPTRLSLEGLQTL
S895 EGLQTLPSMQEYPLP
S907-p PLPTEPKsPGEyINI
Y911-p EPKsPGEyINIDFGE
S924-p GEAGTRLsPPAPPLL
S942 ASSSSLLSASSPASS
S944 SSSLLSASSPASSLG
S952 SPASSLGSGTPGTSS
S961 TPGTSSDSRQRsPLs
S965-p SSDSRQRsPLsDyMN
S968-p SRQRsPLsDyMNLDF
Y970-p QRsPLsDyMNLDFSs
S977-p yMNLDFSsPKSPKPS
S999-p GSMDGLLsPEASSPY
T1071 MAFGVAATPPQPIVA
S1089-p PEGARVAsPTsGLKR
S1092-p ARVAsPTsGLKRLSL
S1098 TsGLKRLSLMDQVSG
K1123 PDPHRGAKVIRADPQ
S1137-p QGGRRRHssEtFSsT
S1138-p GGRRRHssEtFSsTt
T1140-p RRRHssEtFSsTttV
S1143-p HssEtFSsTttVTPV
T1145-p sEtFSsTttVTPVsP
T1146-p EtFSsTttVTPVsPs
T1148 FSsTttVTPVsPsFA
S1151-p TttVTPVsPsFAHNS
S1153-p tVTPVsPsFAHNSKR
K1159 PsFAHNSKRHNSAsV
S1163 HNSKRHNSAsVENVS
S1165-p SKRHNSAsVENVSLR
S1174 ENVSLRKSSEGSSTL
S1175 NVSLRKSSEGSSTLG
T1189 GGGDEPPTsPGQAQP
S1190-p GGDEPPTsPGQAQPL
Y1242 GFQNGLNYIAIDVRG
S1266-p PQPGDKNsWSRTRSL
Y1303-p ALPSASTyASIDFLS
2385 : Phospho-IRS-1 (Ser1101) Antibody
  rat

 
S67 EAAAAGGSPPQPPRL
Y76 PQPPRLEYYESEKKW
Y77 QPPRLEYYESEKKWK
T118 KYLIALYTKDEYFAV
Y182 AAGCDDNYGLVTPAT
K293 LEAMKALKELFEFRP
S302 LFEFRPRSKsQSSGS
S304-p EFRPRSKsQSSGSSA
S306 RPRSKsQSSGSSATH
S309 SKsQSSGSSATHPIS
S310 KsQSSGSSATHPISV
T312 QSSGSSATHPISVPG
S332 HLVNLPPSQTGLVRR
S340 QTGLVRRSRTDsLAA
T342 GLVRRSRTDsLAAtP
S344-p VRRSRTDsLAAtPPA
T348-p RTDsLAAtPPAAKCT
S356 PPAAKCTSCRVRTAS
T361 CTSCRVRTASEGDGG
S363 SCRVRTASEGDGGAA
S382 TAGGRPMSVAGSPLS
S386 RPMSVAGSPLSPGPV
S389 SVAGSPLSPGPVRAP
S398 GPVRAPLSRSHTLSA
T402 APLSRSHTLSAGCGG
S404 LSRSHTLSAGCGGRP
R410 LSAGCGGRPSKVALA
S426 AGGALQHSRSMSMPV
R427 GGALQHSRSMSMPVA
S428 GALQHSRSMSMPVAH
S430 LQHSRSMSMPVAHSP
S485 RPSSGSASASGSPSD
S489 GSASASGSPSDPGFM
S503 MSLDEYGSSPGDLRA
S504 SLDEYGSSPGDLRAF
S513 GDLRAFSSHRsNtPE
S516-p RAFSSHRsNtPESIA
T518-p FSSHRsNtPESIAEt
S521 HRsNtPESIAEtPPA
T525-p tPESIAEtPPARDGS
Y537 DGSGGELYGYMSMDR
Y539 SGGELYGYMSMDRPL
S541 GELYGYMSMDRPLSH
S547 MSMDRPLSHCGRPYR
S557-p GRPYRRVsGDGAQDL
T572 DRGLRKRTYsLTTPA
Y573 RGLRKRTYsLTTPAR
S574-p GLRKRTYsLTTPARQ
T576 RKRTYsLTTPARQRQ
T577 KRTYsLTTPARQRQV
S588 QRQVPQPSSASLDEY
S591 VPQPSSASLDEYTLM
Y595 SSASLDEYTLMRATF
T596 SASLDEYTLMRATFS
T601 EYTLMRATFSGSSGR
S603 TLMRATFSGSSGRLC
S605 MRATFSGSSGRLCPS
S612 SSGRLCPSLPASSPK
S616 LCPSLPASSPKVAYN
S617 CPSLPASSPKVAYNP
Y625 PKVAYNPYPEDYGDI
Y629 YNPYPEDYGDIEIGS
S636 YGDIEIGSHKSSSSN
S642 GSHKSSSSNLGADDG
Y650-p NLGADDGyMPMTPGA
T654 DDGyMPMTPGAALRS
S661 TPGAALRSGGPNsCK
S666-p LRSGGPNsCKsDDyM
S669-p GGPNsCKsDDyMPMs
Y672-p NsCKsDDyMPMsPTS
S676-p sDDyMPMsPTSVSAP
T678 DyMPMsPTSVSAPKQ
S679 yMPMsPTSVSAPKQI
S691-p KQILQPRsAAALPPS
P706 GAAVPAPPsGAGRTF
S707-p AAVPAPPsGAGRTFP
S723 NGGGYKASSPAESsP
S724 GGGYKASSPAESsPE
S728 KASSPAESsPEDSGy
S729-p ASSPAESsPEDSGyM
S733 AESsPEDSGyMRMWC
Y735-p SsPEDSGyMRMWCGS
S745 MWCGSKLSMENPDPK
Y759 KLLPNGDYLNMSPSE
S763 NGDYLNMSPSEAGTA
S765 DYLNMSPSEAGTAGT
T769 MSPSEAGTAGTPPDF
A770 SPSEAGTAGTPPDFF
T772 SEAGTAGTPPDFFSA
Y796 KGVPGHCYSSLPRSY
S797 GVPGHCYSSLPRSYK
S798 VPGHCYSSLPRSYKA
C807 PRSYKAPCTCGGGDN
T808 RSYKAPCTCGGGDND
G810 YKAPCTCGGGDNDQy
N814 CTCGGGDNDQyVLMS
Y817-p GGGDNDQyVLMSSPV
S821 NDQyVLMSSPVGRIL
S822 DQyVLMSSPVGRILE
T886 RCRAVRPTRLSLEGL
S889 AVRPTRLSLEGLQTL
S898 EGLQTLPSMQEYPLP
S910 PLPTEPKSPGEyINI
Y914-p EPKSPGEyINIDFGE
S927 GEGGTRLSPPAPPLL
S945-p ASSSSLLsAsSPASS
S947-p SSSLLsAsSPASSLG
S955-p SPASSLGsGTPGTSS
S964-p TPGTSSDsRQRSPLS
S968 SSDsRQRSPLSDYMN
S971 sRQRSPLSDYMNLDF
Y973 QRSPLSDYMNLDFSS
S980 YMNLDFSSPKSPKPS
S1002 GSIDGLLSPEASSPY
T1074 MAFGVAATPPQPIAA
S1092-p PEGARVTsPTSGLKR
S1095 ARVTsPTSGLKRLSL
S1101 TSGLKRLSLMDQVSG
K1126 PDPHRGAKVIRADPQ
S1140 QGGRRRHSSETFSST
S1141 GGRRRHSSETFSSTT
T1143 RRRHSSETFSSTTTV
S1146 HSSETFSSTTTVTPV
T1148 SETFSSTTTVTPVSP
T1149 ETFSSTTTVTPVSPS
T1151 FSSTTTVTPVSPSFA
S1154 TTTVTPVSPSFAHNS
S1156 TVTPVSPSFAHNSKR
K1162 PSFAHNSKRHNSAsV
S1166 HNSKRHNSAsVENVS
S1168-p SKRHNSAsVENVSLR
S1177 ENVSLRKSSEGNSIL
S1178 NVSLRKSSEGNSILG
T1192 GGSDEPSTSPGQAQP
S1193 GSDEPSTSPGQAQPS
Y1245 GFQNGLNYIAIDVRG
S1272 PQPGDKNSWGRTRSL
Y1309 ALPSASTYASIDFLS
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