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Protein Page:
talin 2 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
talin 2 As a major component of focal adhesion plaques that links integrin to the actin cytoskeleton, may play an important role in cell adhesion. Recruits PIP5K1C to focal adhesion plaques and strongly activates its kinase activity. Note: This description may include information from UniProtKB.
Protein type: Motility/polarity/chemotaxis; Cytoskeletal protein
Cellular Component: ruffle; focal adhesion; cytoplasm; plasma membrane; synapse; fascia adherens; intercellular junction; actin cytoskeleton
Molecular Function: protein binding; structural constituent of cytoskeleton; actin binding; structural molecule activity; insulin receptor binding
Biological Process: intercellular junction assembly; cytoskeletal anchoring; cell adhesion
Reference #:  Q9Y4G6 (UniProtKB)
Alt. Names/Synonyms: DKFZp451B1011; DKFZp686I0976; DKFZp686K0979; KIAA0320; talin 2; Talin-2; TLN2
Gene Symbols: TLN2
Molecular weight: 271,613 Da
Basal Isoelectric point: 5.4  Predict pI for various phosphorylation states
Select Structure to View Below

talin 2

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 48 Y28-p FEPSTAVyDACRVIR
0 11 Y49-p QTGQASDyGLFLSDE
0 5 T69-p IWLEAGRtLDyYMLR
0 21 Y72-p EAGRtLDyYMLRNGD
0 1 T144 EEKKEEGTGtLKKDR
0 3 T146-p KKEEGTGtLKKDRTL
0 1 T192 QGVDENETLLLRRKF
0 1 S307-p KYVKLARsLRtyGVs
0 1 T310-p KLARsLRtyGVsFFL
0 1 Y311-p LARsLRtyGVsFFLV
0 1 S314-p sLRtyGVsFFLVKEK
0 1 T336-p VPRLLGItKDsVMRV
0 1 K337 PRLLGItKDsVMRVD
0 2 S339-p LLGItKDsVMRVDEK
0 6 S428-p TMLEESVsPKKSTIL
0 1 S449 TGKAEHGSVALPAVM
0 2 S460-p PAVMRSGsSGPETFN
0 1 T465 SGsSGPETFNVGSMP
0 3 S473-p FNVGSMPsPQQQVMV
0 1 S521-p DDLSELDsLPPLGQD
0 1 S585 CAITTISSNLTEMSK
0 1 T588 TTISSNLTEMSKGVK
0 2 S623-p RTLAGAVsDLLKAVQ
0 1 T632-p LLKAVQPtsGEPRQt
0 1 S633-p LKAVQPtsGEPRQtV
0 1 T639-p tsGEPRQtVLTAAGS
0 1 S673-p RFQDVLMsLAKAVAN
0 1 K690 AMLVLKAKNVAQVAE
0 1 S1000-p QNFLQPGsKMVssAK
0 1 S1004-p QPGsKMVssAKAAVP
0 1 S1005-p PGsKMVssAKAAVPT
0 1 S1023-p QAAAMQLsQCAKNLA
0 1 S1032 CAKNLATSLAELRTA
0 4 Y1118-p AAQGNEHyTGVAARE
0 1 S1277-p AAASGKFsDDFDEFL
0 1 T1296-p EMAGQAQtKEDQIQV
0 1 S1314 LKNISMASSKLLLAA
0 1 S1325 LLAAKSLSVDPGAPN
0 1 S1505 TIVAKHTSALCNACR
0 4 K1543-ub NSTANLVkTIKALDG
0 462 Y1665-p PGQRECDysIDGINR
0 10 S1666-p GQRECDysIDGINRC
0 1 T1793-p GNPKAQHtHDAITEA
0 1 K1838-ac AIAEAMSkLDEGtPP
0 43 T1843-p MSkLDEGtPPEPKGT
0 3 Y1854-p PKGTFVDyQtTVVKY
0 1 T1856-p GTFVDyQtTVVKYSK
0 1 S2052 LAQAAQSSAATITQL
0 1 S2069 VVKLGAASLGSDDPE
0 1 T2077-p LGSDDPEtQVVLINA
0 2 S2128-p VMVTNVTsLLKTVKA
0 1 S2214-p NLSRKAVsDMLtACK
0 1 T2218-p KAVsDMLtACKQASF
0 1 T2282-p KRVAGAVtELIQAAE
0 1 S2427-p ASEEKLIsSAKQVAA
0 1 K2477-ac NLVRAAQkAAFGkAD
0 1 K2477-m1 NLVRAAQkAAFGkAD
0 1 K2482-m1 AQkAAFGkADDDDVV
0 3 Y2530-p AQIRQQQyKFLPTEL
0 1 K2531 QIRQQQyKFLPTELR
  mouse

► Hide Isoforms
 
Y28-p FEPSTAVyDACRVIR
Y49 QTGQASDYGLFLSDE
T69 IWLEAGRTLDyYMLR
Y72-p EAGRTLDyYMLRNGD
T144-p EEKKEEGtGtLKKDR
T146-p KKEEGtGtLKKDRTL
T192-p QGVDENEtLLLRRKF
S307 KYVKLARSLRTYGVS
T310 KLARSLRTYGVSFFL
Y311 LARSLRTYGVSFFLV
S314 SLRTYGVSFFLVKEK
T336 VPRLLGITkDSVMRV
K337-ub PRLLGITkDSVMRVD
S339 LLGITkDSVMRVDEK
S428-p TMLEESVsPKKRSTI
S450-p TGKAEHGsVALPAVM
S461-p PAVMRSGsSGPEtFN
T466-p SGsSGPEtFNVGSMP
S474-p FNVGSMPsPQQQVMV
S522 DDLSELDSLPPLGQD
S586-p CAITTISsNLtEMSK
T589-p TTISsNLtEMSKGVK
S624-p RTLAGAVsDLLKAVQ
T633 LLKAVQPTSGEPRQT
S634 LKAVQPTSGEPRQTV
T640 TSGEPRQTVLTAAGS
S674 RFQDVLMSLAKAVAN
K691-ub AMLVLKAkNVAQVAE
S1001 QNFLQPGSKMVSSAK
S1005 QPGSKMVSSAKAAVP
S1006 PGSKMVSSAKAAVPT
S1024 QAAAMQLSQCAKNLA
S1033-p CAKNLATsLAELRTA
Y1119-p AAQGNEHyTGVAARE
S1278 AAASGKFSDDFDEFL
T1297 EMAGQAQTKEDQMQV
S1315 LKNISMASSKLLLAA
S1326 LLAAKSLSVDPGAPN
S1506-p TIVAKHTsALCNACR
K1544-ub NSTANLVkTIKALDG
Y1666-p PGQRECDysIDGINR
S1667-p GQRECDysIDGINRC
T1794 GNPKAVHTAPEPKGT
- gap
- gap
Y1805 PKGTFVDYQTTVVKY
T1807 GTFVDYQTTVVKYSK
S1963-p LAQAAQSsAATITQL
S1980-p VVKLGAAsLGSNDPE
T1988 LGSNDPETQVVLINA
S2039-p VMVTNVTsLLKTVKA
S2125 NLSRKAVSDMLIACK
I2129 KAVSDMLIACKQASF
T2193 KRVAGAVTELIQAAE
S2338-p ASEEKLIsSAKQVAA
K2388 under review
K2388 under review
K2393 under review
Y2441 under review
K2442 under review
  talin 2 iso2  
Y28 FEPSTAVYDACRVIR
Y49 QTGQASDYGLFLSDE
T69 IWLEAGRTLDYYMLR
Y72 EAGRTLDYYMLRNGD
T144 EEKKEEGTGTLKKDR
T146 KKEEGTGTLKKDRTL
T192 QGVDENETLLLRRKF
S307 KYVKLARSLRTYGVS
T310 KLARSLRTYGVSFFL
Y311 LARSLRTYGVSFFLV
S314 SLRTYGVSFFLVKEK
T336 VPRLLGITKDSVMRV
K337 PRLLGITKDSVMRVD
S339 LLGITKDSVMRVDEK
S428 TMLEESVSPKKSTIL
S449 TGKAEHGSVALPAVM
S460 PAVMRSGSSGPETFN
T465 SGSSGPETFNVGSMP
S473 FNVGSMPSPQQQVMV
S521 DDLSELDSLPPLGQD
S585 CAITTISSNLTEMSK
T588 TTISSNLTEMSKGVK
S623 RTLAGAVSDLLKAVQ
T632 LLKAVQPTSGEPRQT
S633 LKAVQPTSGEPRQTV
T639 TSGEPRQTVLTAAGS
S673 RFQDVLMSLAKAVAN
K690 AMLVLKAKNVAQVAE
S1000 QNFLQPGSKMVSSAK
S1004 QPGSKMVSSAKAAVP
S1005 PGSKMVSSAKAAVPT
S1023 QAAAMQLSQCAKNLA
S1032 CAKNLATSLAELRTA
Y1118 AAQGNEHYTGVAARE
S1277 AAASGKFSDDFDEFL
T1296 EMAGQAQTKEDQMQV
S1314 LKNISMASSKLLLAA
S1325 LLAAKSLSVDPGAPN
S1505 TIVAKHTSALCNACR
K1543 NSTANLVKTIKALDG
Y1665 PGQRECDYSIDGINR
S1666 GQRECDYSIDGINRC
T1793 GNPKAQHTHDAITEA
K1838 AIAEAMSKLDEGtPP
T1843-p MSKLDEGtPPEPKGT
Y1854 PKGTFVDYQTTVVKY
T1856 GTFVDYQTTVVKYSK
S2052 LAQAAQSSAATITQL
S2069 VVKLGAASLGSNDPE
T2077 LGSNDPETQVVLINA
S2128 VMVTNVTSLLKTVKA
S2214 NLSRKAVSDMLIACK
I2218 KAVSDMLIACKQASF
T2282 KRVAGAVTELIQAAE
S2427 ASEEKLISSAKQVAA
K2477 NLVRAAQKAAFGKAD
K2477 NLVRAAQKAAFGKAD
K2482 AQKAAFGKADDDDVV
Y2530 AQIRQQQYkFLPTEL
K2531-m1 QIRQQQYkFLPTELR
  rat

 
Y30-p FEPSTAVyDACRVIR
Y51-p QTGQASDyGLFLSDE
T71 IWLEAGRTLDYYMLR
Y74 EAGRTLDYYMLRNGD
T146 EEKKEEGTGTLRKDR
T148 KKEEGTGTLRKDRTL
T194 QGVDENETLLLRRKF
S309 KYVKLARSLRTYGVS
T312 KLARSLRTYGVSFFL
Y313 LARSLRTYGVSFFLV
S316 SLRTYGVSFFLVKEK
T338 VPRLLGITKDSVMRV
K339 PRLLGITKDSVMRVD
S341 LLGITKDSVMRVDEK
S430 TMLEESVSPKKSTIL
S451 TGKAEHGSVALPAVM
S462 PAVMRSGSSGPETFN
T467 SGSSGPETFNVGSMP
S475 FNVGSMPSPQQQVMV
S523 DDLSELDSLPPLGQD
S587 CAITTISSNLTEMSK
T590 TTISSNLTEMSKGVK
S625 RTLAGAVSDLLKAVQ
T634 LLKAVQPTSGEPRQT
S635 LKAVQPTSGEPRQTV
T641 TSGEPRQTVLTAAGS
S675 RFQDVLMSLAKAVAN
K692 AMLVLKAKNVAQVAE
S1002 QNFLQPGSKMVSSAK
S1006 QPGSKMVSSAKAAVP
S1007 PGSKMVSSAKAAVPT
S1025 QAAAMQLSQCAKNLA
S1034 CAKNLATSLAELRTA
Y1120 AAQGNEHYTGVAARE
S1279 AAASGKFSDDFDEFL
T1298 EMAGQAQTKEDQMQV
S1316-p LKNISMAsSKLLLAA
S1327-p LLAAKSLsVDPGAPN
S1507 TIVAKHTSALCNACR
K1545 NSTANLVKTIKALDG
Y1667-p PGQRECDySIDGINR
S1668 GQRECDySIDGINRC
T1795 GNPKAQHTHDAITEA
K1840 AIAEAMSKLDEGtPP
T1845-p MSKLDEGtPPEPKGT
Y1856 PKGTFVDYQTTVVKY
T1858 GTFVDYQTTVVKYSK
S2054 LAQAAQSSAATITQL
S2071 VVKLGAASLGSNDPE
T2079 LGSNDPETQVVLINA
S2130 VMVTNVTSLLKTVKA
S2216 NLSRKAVSDMLIACK
I2220 KAVSDMLIACKQASF
T2284 KRVAGAVTELIQAAE
S2429 ASEEKLISSAKQVAA
K2479 NLVRAAQKAAFGKAD
K2479 NLVRAAQKAAFGKAD
K2484 AQKAAFGKADDDDVV
Y2532 AQIRQQQYKFLPTEL
K2533 QIRQQQYKFLPTELR
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