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talin 2 (human)

Overview talin 2 As a major component of focal adhesion plaques that links integrin to the actin cytoskeleton, may play an important role in cell adhesion. Recruits PIP5K1C to focal adhesion plaques and strongly activates its kinase activity. Note: This description may include information from UniProtKB. Protein type: Motility/polarity/chemotaxis; Cytoskeletal protein Cellular Component: ruffle; focal adhesion; cytoplasm; plasma membrane; synapse; intercellular junction; fascia adherens; actin cytoskeleton Molecular Function: protein binding; structural constituent of cytoskeleton; structural molecule activity; actin binding; insulin receptor binding Biological Process: intercellular junction assembly; cytoskeletal anchoring; cell adhesion Reference #:  Q9Y4G6 (UniProtKB) Alt. Names/Synonyms: DKFZp451B1011; DKFZp686I0976; DKFZp686K0979; ILWEQ; KIAA0320; talin 2; Talin-2; TLN2 Gene Symbols: TLN2 Molecular weight: 271,613 Da Basal Isoelectric point: 5.4  Predict pI for various phosphorylation states

Select Structure to View Below talin 2

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	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	48		Y28-p	FEPSTAVyDACRVIR
0	13		Y49-p	QTGQASDyGLFLSDE
0	5		T69-p	IWLEAGRtLDyYMLR
0	22		Y72-p	EAGRtLDyYMLRNGD
0	1		T144	EEKKEEGTGtLKKDR
0	3		T146-p	KKEEGTGtLKKDRTL
0	1		T192	QGVDENETLLLRRKF
0	4		Y201-p	LLRRKFFySDQNVDS
0	1		S307-p	KYVKLARsLRtYGVs
0	1		T310-p	KLARsLRtYGVsFFL
0	1		S314-p	sLRtYGVsFFLVKEK
0	1		T336-p	VPRLLGItKDsVMRV
0	1		K337	PRLLGItKDsVMRVD
0	2		S339-p	LLGItKDsVMRVDEK
0	5		S428-p	TMLEESVsPKKSTIL
0	1		S449	TGKAEHGSVALPAVM
0	2		S473-p	FNVGSMPsPQQQVMV
0	1		S585	CAITTISSNLTEMSK
0	1		T588	TTISSNLTEMSKGVK
0	2		S623-p	RTLAGAVsDLLKAVQ
0	1		T632-p	LLKAVQPtsGEPRQt
0	1		S633-p	LKAVQPtsGEPRQtV
0	1		T639-p	tsGEPRQtVLTAAGS
0	1		S673-p	RFQDVLMsLAKAVAN
0	1		K690	AMLVLKAKNVAQVAE
0	1		S1032	CAKNLATSLAELRTA
0	3		Y1118-p	AAQGNEHyTGVAARE
0	1		S1505	TIVAKHTSALCNACR
0	4		K1543-u	NSTANLVkTIKALDG
0	481		Y1665-p	PGQRECDysIDGINR
0	12		S1666-p	GQRECDysIDGINRC
0	1		T1793-p	GNPKAQHtHDAITEA
0	1		K1838-a	AIAEAMSkLDEGtPP
0	37		T1843-p	MSkLDEGtPPEPKGT
0	3		Y1854-p	PKGTFVDyQtTVVKY
0	1		T1856-p	GTFVDyQtTVVKYSK
0	1		S2052	LAQAAQSSAATITQL
0	1		S2069	VVKLGAASLGSDDPE
0	1		T2077-p	LGSDDPEtQVVLINA
0	1		S2128-p	VMVTNVTsLLKTVKA
0	1		T2282-p	KRVAGAVtELIQAAE
0	1		K2477-a	NLVRAAQkAAFGkAD
0	1		K2477-m1	NLVRAAQkAAFGkAD
0	1		K2482-m1	AQkAAFGkADDDDVV
0	1		K2531	QIRQQQYKFLPTELR

	mouse
Y28-p	FEPSTAVyDACRVIR
Y49	QTGQASDYGLFLSDE
T69	IWLEAGRTLDyYMLR
Y72-p	EAGRTLDyYMLRNGD
T144-p	EEKKEEGtGtLKKDR
T146-p	KKEEGtGtLKKDRTL
T192-p	QGVDENEtLLLRRKF
Y201	LLRRKFFYSDQNVDS
S307	KYVKLARSLRTYGVS
T310	KLARSLRTYGVSFFL
S314	SLRTYGVSFFLVKEK
T336	VPRLLGITkDSVMRV
K337-u	PRLLGITkDSVMRVD
S339	LLGITkDSVMRVDEK
S428-p	TMLEESVsPKKSTIL
S449-p	TGKAEHGsVALPAVM
S473-p	FNVGSMPsPQQQVMV
S585-p	CAITTISsNLtEMSK
T588-p	TTISsNLtEMSKGVK
S623-p	RTLAGAVsDLLKAVQ
T632	LLKAVQPTSGEPRQT
S633	LKAVQPTSGEPRQTV
T639	TSGEPRQTVLTAAGS
S673	RFQDVLMSLAKAVAN
K690-u	AMLVLKAkNVAQVAE
S1032-p	CAKNLATsLAELRTA
Y1118-p	AAQGNEHyTGVAARE
S1505-p	TIVAKHTsALCNACR
K1543-u	NSTANLVkTIKALDG
Y1665-p	PGQRECDysIDGINR
S1666-p	GQRECDysIDGINRC
T1793	GNPKAQHTHDAITEA
K1838	AIAEAMSKLDEGtPP
T1843-p	MSKLDEGtPPEPKGT
Y1854	PKGTFVDYQTTVVKY
T1856	GTFVDYQTTVVKYSK
S2052-p	LAQAAQSsAATITQL
S2069-p	VVKLGAAsLGSNDPE
T2077	LGSNDPETQVVLINA
S2128	VMVTNVTSLLKTVKA
T2282	KRVAGAVTELIQAAE
K2477	NLVRAAQKAAFGKAD
K2477	NLVRAAQKAAFGKAD
K2482	AQKAAFGKADDDDVV
K2531-m1	QIRQQQYkFLPTELR

	rat
Y30-p	FEPSTAVyDACRVIR
Y51-p	QTGQASDyGLFLSDE
T71	IWLEAGRTLDYYMLR
Y74	EAGRTLDYYMLRNGD
T146	EEKKEEGTGTLRKDR
T148	KKEEGTGTLRKDRTL
T194	QGVDENETLLLRRKF
Y203	LLRRKFFYSDQNVDS
S309	KYVKLARSLRTYGVS
T312	KLARSLRTYGVSFFL
S316	SLRTYGVSFFLVKEK
T338	VPRLLGITKDSVMRV
K339	PRLLGITKDSVMRVD
S341	LLGITKDSVMRVDEK
S430	TMLEESVSPKKSTIL
S451	TGKAEHGSVALPAVM
S475	FNVGSMPSPQQQVMV
S587	CAITTISSNLTEMSK
T590	TTISSNLTEMSKGVK
S625	RTLAGAVSDLLKAVQ
T634	LLKAVQPTSGEPRQT
S635	LKAVQPTSGEPRQTV
T641	TSGEPRQTVLTAAGS
S675	RFQDVLMSLAKAVAN
K692	AMLVLKAKNVAQVAE
S1034	CAKNLATSLAELRTA
Y1120	AAQGNEHYTGVAARE
S1507	TIVAKHTSALCNACR
K1545	NSTANLVKTIKALDG
Y1667-p	PGQRECDySIDGINR
S1668	GQRECDySIDGINRC
T1795	GNPKAQHTHDAITEA
K1840	AIAEAMSKLDEGtPP
T1845-p	MSKLDEGtPPEPKGT
Y1856	PKGTFVDYQTTVVKY
T1858	GTFVDYQTTVVKYSK
S2054	LAQAAQSSAATITQL
S2071	VVKLGAASLGSNDPE
T2079	LGSNDPETQVVLINA
S2130	VMVTNVTSLLKTVKA
T2284	KRVAGAVTELIQAAE
K2479	NLVRAAQKAAFGKAD
K2479	NLVRAAQKAAFGKAD
K2484	AQKAAFGKADDDDVV
K2533	QIRQQQYKFLPTELR

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