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Fyn
a tyrosine kinase of the Src family. Implicated in the control of cell growth. Plays a role in the regulation of intracellular calcium levels. Required in brain development and mature brain function with important roles in the regulation of axon growth, axon guidance, and neurite extension. Blocks axon outgrowth and attraction induced by NTN1 by phosphorylating its receptor DDC. Associates with the p85 subunit of phosphatidylinositol 3-kinase and interacts with the fyn-binding protein. Three alternatively spliced isoforms have been described. Isoform 2 shows a greater ability to mobilize cytoplasmic calcium than isoform 1. Induced expression aids in cellular transformation and xenograft metastasis. In squamous cell carcinoma, Fyn transduces signals from EGFR and Src and is required for cell migration and invasiveness. Activity linked to migration in a murine melanoma model. Appears to block late stage development of neuroblastoma. Mouse knockout deficient in kindling response, a model for human epilepsy. Note: This description may include information from UniProtKB.
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| Protein type: Protein kinase, TK; Protein kinase, tyrosine (non-receptor); EC 2.7.10.2; Kinase, protein; TK group; Src family |
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Cellular Component: mitochondrion; plasma membrane; cytosol; endosome
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Molecular Function: tubulin binding; identical protein binding; CD8 receptor binding; ephrin receptor binding; metal ion binding; non-membrane spanning protein tyrosine kinase activity; protein binding; peptide hormone receptor binding; protein-tyrosine kinase activity; T cell receptor binding; phosphoinositide 3-kinase binding; glycoprotein binding; CD4 receptor binding; ATP binding
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Biological Process: axon guidance; peptidyl-tyrosine phosphorylation; viral reproduction; protein amino acid autophosphorylation; neuron migration; protein kinase cascade; protein amino acid phosphorylation; T cell receptor signaling pathway; regulation of cell shape; calcium ion transport; forebrain development; feeding behavior; response to drug; platelet activation; dendrite morphogenesis; activated T cell proliferation; learning; regulation of defense response to virus by virus; detection of mechanical stimulus involved in sensory perception of pain; response to ethanol; virus-host interaction; T cell costimulation; negative regulation of protein catabolic process; blood coagulation; leukocyte migration
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Reference #:
P06241 (UniProtKB)
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| Alt. Names/Synonyms: c-syn protooncogene; FYN; FYN oncogene related to SRC, FGR, YES; MGC45350; OKT3-induced calcium influx regulator; p59-Fyn; protein-tyrosine kinase fyn; Proto-oncogene c-Fyn; Proto-oncogene Syn; proto-oncogene tyrosine-protein kinase fyn; SLK; src-like kinase; src/yes-related novel; SYN; tyrosine kinase p59fyn(T); Tyrosine-protein kinase Fyn |
| Gene Symbols: FYN |
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Molecular weight: 60,762 Da
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Basal Isoelectric point: 6.23
Predict pI for various phosphorylation states
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CST Pathways:
Adherens Junction Dynamics
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GPCRs Signaling to MAPK/Erk
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Insulin Receptor Signaling
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MAPK/Erk in Growth and Differentiation
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Tyrosine Kinases
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Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®
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