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Protein Page:
Fyn (human)

Overview
Fyn a tyrosine kinase of the Src family. Implicated in the control of cell growth. Plays a role in the regulation of intracellular calcium levels. Required in brain development and mature brain function with important roles in the regulation of axon growth, axon guidance, and neurite extension. Blocks axon outgrowth and attraction induced by NTN1 by phosphorylating its receptor DDC. Associates with the p85 subunit of phosphatidylinositol 3-kinase and interacts with the fyn-binding protein. Three alternatively spliced isoforms have been described. Isoform 2 shows a greater ability to mobilize cytoplasmic calcium than isoform 1. Induced expression aids in cellular transformation and xenograft metastasis. In squamous cell carcinoma, Fyn transduces signals from EGFR and Src and is required for cell migration and invasiveness. Activity linked to migration in a murine melanoma model. Appears to block late stage development of neuroblastoma. Mouse knockout deficient in kindling response, a model for human epilepsy. Note: This description may include information from UniProtKB.
Protein type: Protein kinase, TK; Protein kinase, tyrosine (non-receptor); EC 2.7.10.2; Kinase, protein; TK group; Src family
Cellular Component: mitochondrion; postsynaptic density; plasma membrane; cytosol; nucleus; endosome; lipid raft
Molecular Function: tubulin binding; CD8 receptor binding; protein binding; peptide hormone receptor binding; ephrin receptor binding; metal ion binding; protein-tyrosine kinase activity; non-membrane spanning protein tyrosine kinase activity; T cell receptor binding; phosphoinositide 3-kinase binding; glycoprotein binding; CD4 receptor binding; ATP binding
Biological Process: axon guidance; viral reproduction; nerve growth factor receptor signaling pathway; protein amino acid autophosphorylation; neuron migration; T cell receptor signaling pathway; protein amino acid phosphorylation; regulation of cell shape; calcium ion transport; forebrain development; feeding behavior; epidermal growth factor receptor signaling pathway; response to drug; platelet activation; fibroblast growth factor receptor signaling pathway; phosphoinositide-mediated signaling; dendrite morphogenesis; activated T cell proliferation; learning; regulation of defense response to virus by virus; detection of mechanical stimulus involved in sensory perception of pain; response to ethanol; T cell costimulation; innate immune response; blood coagulation; negative regulation of protein catabolic process; leukocyte migration
Reference #:  P06241 (UniProtKB)
Alt. Names/Synonyms: c-syn protooncogene; FYN; FYN oncogene related to SRC, FGR, YES; MGC45350; OKT3-induced calcium influx regulator; p59-Fyn; protein-tyrosine kinase fyn; Proto-oncogene c-Fyn; Proto-oncogene Syn; proto-oncogene tyrosine-protein kinase fyn; SLK; src-like kinase; src/yes-related novel; SYN; tyrosine kinase p59fyn(T); Tyrosine-protein kinase Fyn
Gene Symbols: FYN
Molecular weight: 60,762 Da
Basal Isoelectric point: 6.23  Predict pI for various phosphorylation states
CST Pathways:  Adherens Junction Dynamics  |  GPCR Signaling to MAPKs  |  Growth And Differentiation Control by MAPKs  |  Insulin Receptor Signaling  |  Tyrosine Kinases & Substrates
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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Fyn

Protein Structure Not Found.

Substrate Sequence Logo
Sequence Logo

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Sites Implicated In
cell growth, altered: Y531‑p
cell motility, altered: S21‑p
enzymatic activity, induced: S21‑p
enzymatic activity, inhibited: Y531‑p
intracellular localization: S21‑p, Y531‑p
molecular association, regulation: Y420‑p
phosphorylation: S21‑p, Y531‑p

Modification Sites and Domains  

Modification Sites in Parent Protein, Orthologs, and Isoforms  
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

► Hide Isoforms
 
1 2 T12-p QCKDKEAtKLTEERD
1 29 S21-p LTEERDGsLNQssGy
0 4 S25-p RDGsLNQssGyRyGT
0 3 S26-p DGsLNQssGyRyGTD
2 10 Y28-p sLNQssGyRyGTDPT
1 0 Y30-p NQssGyRyGTDPTPQ
1 0 Y39-p TDPTPQHyPSFGVTS
0 10 Y91-p VTLFVALyDYEARTE
0 4 Y150 SIQAEEWYFGKLGRK
0 283 Y185-p SETTKGAysLSIRDW
0 8 S186-p ETTKGAysLSIRDWD
0 1803 Y213-p RKLDNGGyyITTRAQ
1 685 Y214-p KLDNGGyyITTRAQF
0 2 S257-p MPRLTDLsVKTKDVW
0 4 S270 VWEIPRESLQLIKRL
0 4 Y339-p VVSEEPIyIVTEYMN
0 1 S393 YIHRDLRSANILVGN
18 3101 Y420-p RLIEDNEytARQGAK
0 17 T421-p LIEDNEytARQGAKF
0 526 Y440-p TAPEAALyGRFTIKS
16 1045 Y531-p FTATEPQyQPGENL_
2101 : Phospho-Src Family (Tyr416) Antibody
6943 : Phospho-Src Family (Tyr416) (D49G4) Rabbit mAb
  Fyn iso2  
T12 QCKDKEATKLTEERD
S21 LTEERDGSLNQSSGY
S25 RDGSLNQSSGYRYGT
S26 DGSLNQSSGYRYGTD
Y28 SLNQSSGYRYGTDPT
Y30 NQSSGYRYGTDPTPQ
Y39 TDPTPQHYPSFGVTS
Y91 VTLFVALYDYEARTE
Y150 SIQAEEWYFGKLGRK
Y185 SETTKGAYSLSIRDW
S186 ETTKGAYSLSIRDWD
Y213 RKLDNGGYYITTRAQ
Y214 KLDNGGYYITTRAQF
A257 TPQTSGLAKDAWEVA
S267-p AWEVARRsLCLEKKL
Y336 VVSEEPIYIVTEYMN
S390 YIHRDLRSANILVGN
Y417-p RLIEDNEyTARQGAK
T418 LIEDNEyTARQGAKF
Y437 TAPEAALYGRFTIKS
Y528-p FTATEPQyQPGENL_
  Fyn iso3  
T12 QCKDKEATKLTEERD
S21 LTEERDGSLNQSSGY
S25 RDGSLNQSSGYRYGT
S26 DGSLNQSSGYRYGTD
Y28 SLNQSSGYRYGTDPT
Y30 NQSSGYRYGTDPTPQ
Y39 TDPTPQHYPSFGVTS
Y91 VTLFVALYDYEARTE
Y150 SIQAEEWYFGKLGRK
Y185 SETTKGAYSLSIRDW
S186 ETTKGAYSLSIRDWD
Y213 RKLDNGGYYITTRAQ
Y214 KLDNGGYYITTRAQF
- gap
- gap
Y284 VVSEEPIYIVTEYMN
S338 YIHRDLRSANILVGN
Y365 RLIEDNEYTARQGAK
T366 LIEDNEYTARQGAKF
Y385 TAPEAALYGRFTIKS
Y476 FTATEPQYQPGENL_
  mouse

 
A12 QCKDKEAAKLTEERD
S21-p LTEERDGsLNQssGy
S25-p RDGsLNQssGyRYGT
S26-p DGsLNQssGyRYGTD
Y28-p sLNQssGyRYGTDPT
Y30 NQssGyRYGTDPTPQ
Y39 TDPTPQHYPSFGVTS
Y91-p VTLFVALyDYEARTE
Y150 SIQAEEWYFGKLGRK
Y185-p SETTKGAysLSIRDW
S186-p ETTKGAysLSIRDWD
Y213-p RKLDNGGyyITTRAQ
Y214-p KLDNGGyyITTRAQF
S257-p MPRLTDLsVKTKDVW
S270 VWEIPRESLQLIKRL
Y339-p VVSEEPIyIVTEYMS
S393-p YIHRDLRsANILVGN
Y420-p RLIEDNEytARQGAK
T421-p LIEDNEytARQGAKF
Y440-p TAPEAALyGRFTIKS
Y531-p FTATEPQyQPGENL_
2101 : Phospho-Src Family (Tyr416) Antibody
6943 : Phospho-Src Family (Tyr416) (D49G4) Rabbit mAb
  rat

 
A12 QCKDKEAAKLTEERD
S21-p LTEERDGsLNQSSGY
S25 RDGsLNQSSGYRYGT
S26 DGsLNQSSGYRYGTD
Y28 sLNQSSGYRYGTDPT
Y30 NQSSGYRYGTDPTPQ
Y39 TDPTPQHYPSFGVTS
Y91 VTLFVALYDYEARTE
Y150-p SIQAEEWyFGKLGRK
Y185-p SETTKGAySLSIRDW
S186 ETTKGAySLSIRDWD
Y213-p RKLDNGGyyITTRAQ
Y214-p KLDNGGyyITTRAQF
S257 MPRLTDLSVKTKDVW
S270 VWEIPRESLQLIKRL
Y339 VVSEEPIYIVTEYMN
S393 YIHRDLRSANILVGN
Y420-p RLIEDNEyTARQGAK
T421 LIEDNEyTARQGAKF
Y440-p TAPEAALyGRFTIKS
Y531-p FTATEPQyQPGENL_
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