Javascript is not enabled on this browser. This site will not work properly without Javascript.
PhosphoSitePlus Homepage Cell Signaling Technology
PhosphoSitePlus
HomeAbout PhosphoSiteUsing PhosphoSiteCuration ProcessContact
NIH-logos NIGMS Logo NIAAA Logo NCI Logo NIH Logo
Protein Page:
Cbl-c (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
Cbl-c Regulator of EGFR mediated signal transduction. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Ubiquitin ligase; EC 6.3.2.-; Ubiquitin conjugating system; Ligase
Cellular Component: nucleus
Molecular Function: signal transducer activity; zinc ion binding; phosphotyrosine binding; ubiquitin-protein ligase activity; calcium ion binding; SH3 domain binding; epidermal growth factor receptor binding; ligase activity
Biological Process: negative regulation of epidermal growth factor receptor activity; negative regulation of epidermal growth factor receptor signaling pathway; negative regulation of MAP kinase activity; cell surface receptor linked signal transduction; protein ubiquitination during ubiquitin-dependent protein catabolic process
Reference #:  Q9ULV8 (UniProtKB)
Alt. Names/Synonyms: Cas-Br-M (murine) ecotropic retroviral transforming sequence c; Cas-Br-M (murine) ectropic retroviral transforming sequence c; CBL-3; CBL-SL; CBL3; CBLC; RING finger protein 57; RNF57; SH3-binding protein CBL-3; SH3-binding protein CBL-C; Signal transduction protein CBL-C
Gene Symbols: CBLC
Molecular weight: 52,456 Da
Basal Isoelectric point: 7.83  Predict pI for various phosphorylation states
CST Pathways:  B Cell Receptor Signaling
Select Structure to View Below

Cbl-c

Protein Structure Not Found.


STRING  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Scansite  |  Pfam  |  RCSB PDB  |  Phospho.ELM  |  NetworKIN  |  Source  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene


Sites Implicated In
enzymatic activity, induced: Y341‑p
molecular association, regulation: Y341‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 3 S40-p VDPRLSVsPPsLRDL
0 1 S43-p RLSVsPPsLRDLLPR
0 1 Y144-p ALFPGGKyCGHMYQL
0 1 T223-p RLFQPWPtLLKNWQL
0 1 Y309-p QKDGFYLyPDGkTHN
0 1 K313-ub FYLyPDGkTHNPDLT
2 0 Y341-p SEEQLQLyWAMDSTF
0 9 Y402-p GWEAVSIyQFHGQAT
0 1 S461-p VRLLKGNsPPAALGP
  mouse

 
G40 RDPRMVTGPPSLRDL
S43 RMVTGPPSLRDLLPR
Y143 ALFPAGKYCGHLYQL
T222 RLFQPWPTLLRNWQL
F308 QKDGIFLFPDGKKHN
K312 IFLFPDGKKHNPDLT
Y340 SEEQLLLYQAMNSTF
C401 GREAVSICQAQERPT
S484 SVLWEVTSRPRAREE
Home  |  Curator Login With enhanced literature mining using Linguamatics I2E I2E Logo Produced by 3rd Millennium  |  Design by Digizyme
©2003-2013 Cell Signaling Technology, Inc.