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Cbl-c (human)

Overview Cbl-c Regulator of EGFR mediated signal transduction. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB. Protein type: Ubiquitin conjugating system; Ligase; Ubiquitin ligase; EC 6.3.2.- Cellular Component: nucleus Molecular Function: signal transducer activity; phosphotyrosine binding; zinc ion binding; ubiquitin-protein ligase activity; calcium ion binding; SH3 domain binding; epidermal growth factor receptor binding Biological Process: negative regulation of epidermal growth factor receptor activity; negative regulation of epidermal growth factor receptor signaling pathway; negative regulation of MAP kinase activity; cell surface receptor linked signal transduction; protein ubiquitination during ubiquitin-dependent protein catabolic process Reference #:  Q9ULV8 (UniProtKB) Alt. Names/Synonyms: Cas-Br-M (murine) ecotropic retroviral transforming sequence c; Cas-Br-M (murine) ectropic retroviral transforming sequence c; CBL-3; CBL-SL; CBL3; CBLC; RING finger protein 57; RNF57; SH3-binding protein CBL-3; SH3-binding protein CBL-C; Signal transduction protein CBL-C Gene Symbols: CBLC Molecular weight: 52,456 Da Basal Isoelectric point: 7.83  Predict pI for various phosphorylation states CST Pathways:  B Cell Receptor Signaling

Select Structure to View Below Cbl-c 3OP0 - A/B=9-323 (human) 3VRN - A=1-323 (human) 3VRO - B=412-424 (human) 3VRP - B=1062-1074 (human) 3VRQ - A/B=1-323 (human) 3VRR - C=1062-1074 (human)

STRING  |  Scansite  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  RCSB PDB 3OP0 3VRN 3VRO 3VRP 3VRQ 3VRR  |  DISEASE  |  Source  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene

	Sites Implicated In
enzymatic activity, induced: Y341‑p molecular association, regulation: Y341‑p

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	4		S40-p	VDPRLSVsPPsLRDL
0	1		S43-p	RLSVsPPsLRDLLPR
0	1		Y144-p	ALFPGGKyCGHMYQL
0	1		T223-p	RLFQPWPtLLKNWQL
0	1		K313-u	FYLYPDGkTHNPDLT
1	0		Y341-p	SEEQLQLyWAMDSTF
0	7		Y402-p	GWEAVSIyQFHGQAT

	mouse
G40	RDPRMVTGPPSLRDL
S43	RMVTGPPSLRDLLPR
Y143	ALFPAGKYCGHLYQL
T222	RLFQPWPTLLRNWQL
K312	IFLFPDGKKHNPDLT
Y340	SEEQLLLYQAMNSTF
C401	GREAVSICQAQERPT

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