Regulator of EGFR mediated signal transduction. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: EC 6.3.2.-; Ligase; Ubiquitin ligase; Ubiquitin conjugating system
Chromosomal Location of Human Ortholog: 19q13.2
Cellular Component: nucleus
Molecular Function: signal transducer activity; phosphotyrosine binding; zinc ion binding; ubiquitin-protein ligase activity; calcium ion binding; SH3 domain binding; epidermal growth factor receptor binding; ligase activity
Biological Process: negative regulation of epidermal growth factor receptor activity; negative regulation of epidermal growth factor receptor signaling pathway; negative regulation of MAP kinase activity; cell surface receptor linked signal transduction; protein ubiquitination during ubiquitin-dependent protein catabolic process
SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.