Home

acinus (human)

Overview acinus an ubiquitous nuclear protein that Induces apoptotic chromatin condensation after activation by CASP3. Three alternatively spliced isoforms have been described. Protein type: Apoptosis Cellular Component: cytoplasm; nucleolus; cytosol; nucleus Molecular Function: enzyme binding; nucleic acid binding; ATPase activity; nucleotide binding Biological Process: positive regulation of monocyte differentiation; apoptosis; erythrocyte differentiation; apoptotic chromosome condensation Reference #:  Q9UKV3 (UniProtKB) Alt. Names/Synonyms: ACIN1; ACINU; ACINUS; ACN; apoptotic chromatin condensation inducer 1; Apoptotic chromatin condensation inducer in the nucleus; DKFZp667N107; fSAP152; functional spliceosome-associated protein 152; KIAA0670 Gene Symbols: ACIN1 Molecular weight: 151,888 Da Basal Isoelectric point: 6.08  Predict pI for various phosphorylation states

acinus (human)

GeneCards  |  Entrez-Gene  |  OMIM  |  IPI  |  Pfam  |  Scansite  |  Source  |  UniProtKB  |  NetworKIN  |  InnateDB  |  Ensembl Gene

	Sites Implicated In
regulates transcription: S1180‑p altered intracellular location: S1180‑p

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

LTP	HTP			human
1	0		K5-u	MWRRkHPRTSGG
0	1		S96-p	LAKSGQKsALVKRLK
0	5		S132-p	SQIGEEMsQNSFIKQ
0	1		S166-p	AAELEEAsAEsEDEM
0	1		S169-p	LEEAsAEsEDEMIHP
0	1		S206-p	SRHSPRKsSsIsEEK
0	1		S208-p	HSPRKsSsIsEEKGD
0	2		S210-p	PRKsSsIsEEKGDsD
0	14		S216-p	IsEEKGDsDDEKPRK
0	1		S228-p	PRKGERRssRVRQAR
0	1		S229-p	RKGERRssRVRQARA
0	12		S240-p	QARAAKLsEGsQPAE
0	10		S243-p	AAKLsEGsQPAEEEE
0	6		T254-p	EEEEDQEtPsRNLRV
0	1		S256-p	EEDQEtPsRNLRVRA
0	3		T269-p	RADRNLKtEEEEEEE
0	3		S295-p	GDDEGQKsREAPILK
0	3		S328-p	DERPKTRsQEQEVLE
0	1		K359-a	LARQQQEkEMKTtsP
0	1		T364-p	QEkEMKTtsPLEEEE
0	6		S365-p	EkEMKTtsPLEEEER
0	1		S376-p	EEEREIKsSQGLKEK
1	9		S384-p	SQGLKEKsKsPsPPR
0	11		S386-p	GLKEKsKsPsPPRLt
1	13		S388-p	KEKsKsPsPPRLtED
0	1		T393-p	sPsPPRLtEDRKKAs
0	1		S400-p	tEDRKKAsLVALPEQ
0	4		T408-p	LVALPEQtAsEEEtP
0	10		S410-p	ALPEQtAsEEEtPPP
0	8		T414-p	QtAsEEEtPPPLLtK
0	1		T420-p	EtPPPLLtKEAssPP
0	3		S424-p	PLLtKEAssPPPHPQ
0	4		S425-p	LLtKEAssPPPHPQL
0	3		S434-p	PPHPQLHsEEEIEPM
0	4		S453-p	PPVLIQLsPPNTDAD
0	2		G476	HTVQLVGgLsPLsSP
0	8		S478-p	VQLVGgLsPLsSPSD
0	1		S481	VGgLsPLsSPSDtKA
0	1		T486	PLsSPSDtKAEsPAE
0	8		S490-p	PSDtKAEsPAEKVPE
0	1		S499-p	AEKVPEEsVLPLVQK
0	1		Y512-p	QKSTLADysAQKDLE
0	1		S513-p	KSTLADysAQKDLEP
0	4		S561-p	QKEGRRAsHTLLPSH
0	1		K654-m2	SASSNSRksLsPGVs
0	3		S655-p	ASSNSRksLsPGVsR
0	9		S657-p	SNSRksLsPGVsRDs
0	1		S661-p	ksLsPGVsRDsStSy
0	1		S664-p	sPGVsRDsStSyTEt
0	1		T666-p	GVsRDsStSyTEtKD
0	1		Y668-p	sRDsStSyTEtKDPS
0	1		T671-p	sStSyTEtKDPSsGQ
0	2		S676-p	TEtKDPSsGQEVAtP
0	5		T682-p	SsGQEVAtPPVPQLQ
0	1		S702-p	ERTSTSSsSVQARRL
0	> 25		S710-p	SVQARRLsQPEsAEk
0	1		S714-p	RRLsQPEsAEkHVtQ
0	1		K717-a	sQPEsAEkHVtQRLQ
0	2		T720-p	EsAEkHVtQRLQPER
0	4		S729-p	RLQPERGsPKKCEAE
0	5		T744-p	EAEPPAAtQPQTSET
0	1		S814-p	EDEEKKEssLPKSFK
0	1		S815-p	DEEKKEssLPKSFKR
0	4		S825-p	KSFKRKIsVVSAtKG
0	2		T830-p	KIsVVSAtKGVPAGN
0	9		S838-p	KGVPAGNsDtEGGQP
0	2		T840-p	VPAGNsDtEGGQPGR
0	4		S895-p	VDLHADDsRIsEDEt
0	4		S898-p	HADDsRIsEDEtERN
0	1		T902	sRIsEDEtERNGDDG
0	1		T976-p	KKVTLGDtLtRRsIs
0	1		T978-p	VTLGDtLtRRsIsQQ
0	3		S981-p	GDtLtRRsIsQQKsG
0	2		S983-p	tLtRRsIsQQKsGVs
0	1		S987-p	RsIsQQKsGVsITID
0	1		S990-p	sQQKsGVsITIDDPV
0	17		S1004-p	VRTAQVPsPPRGKIS
0	1		S1104	GLLVDRPsETKTEEQ
0	3		S1176-p	KVREGPRsRsRsRDR
0	2		S1178-p	REGPRsRsRsRDRRR
3	1		S1180-p	GPRsRsRsRDRRRKE
0	1		S1284-p	REKRREHsRERDRER
0	1		S1325-p	RRDTKRHsRsRsRst
0	1		S1327-p	DTKRHsRsRsRstPV
0	1		S1329	KRHsRsRsRstPVRD
1	1		S1331-p	HsRsRsRstPVRDRG
0	1		T1332	sRsRsRstPVRDRGG

	mouse
K5	MWGRkRPNSSGE
S96	LAKSGQKsALVKRLK
S132-p	SQIGEEMsQNSFIKQ
S166-p	AAELEEAsAEsEDEM
S169-p	LEEAsAEsEDEMTHP
S206	STHSPRKsSsFsEEK
S208-p	HSPRKsSsFsEEKGE
S210-p	PRKsSsFsEEKGEsD
S216-p	FsEEKGEsDDEKPRK
S228	PRKGERRssRVRQAK
S229	RKGERRssRVRQAKS
P239	RQAKSKLpEYsQTAE
S242	KSKLpEYsQTAEEEE
T253-p	EEEEDQEtPsRNLRV
S255	EEDQEtPsRNLRVRA
I268	RADRNLKiEEEEEEE
S295-p	EVDEAQKsREAEAPT
S332	EKPLNIRsQEKGELE
K363	LARQQQEkETQIvsL
V368	QEkETQIvsLPQEEN
S369	EkETQIvsLPQEENE
S379	QEENEVKsSQSLEEK
S387-p	SQSLEEKsQsPsPPP
S389-p	SLEEKsQsPsPPPLp
S391-p	EEKsQsPsPPPLpED
P396	sPsPPPLpEDLEKAp
P403	pEDLEKApVVLQPEQ
I411	VVLQPEQiVsEEEtP
S413-p	LQPEQiVsEEEtPPP
T417-p	QiVsEEEtPPPLLtK
T423-p	EtPPPLLtKEAssPP
S427-p	PLLtKEAssPPTHIQ
S428-p	LLtKEAssPPTHIQL
-	gap
S454-p	PPVLIQLsPPNTDAG
S477-p	HPAQLLRsLsPLsGT
S479-p	AQLLRsLsPLsGTTD
S482-p	LRsLsPLsGTTDtKA
T487-p	PLsGTTDtKAEsPAG
S491-p	TTDtKAEsPAGRVSD
S500	AGRVSDEsVLPLAQK
C513	QKSSLPEcsTQKGVE
S514	KSSLPEcsTQKGVES
S561	QKEGRRAsHALFPEH
K654	SASSSSRksLsPGVs
S655-p	ASSSSRksLsPGVsR
S657-p	SSSRksLsPGVsRDs
S661-p	ksLsPGVsRDsNtSy
S664	sPGVsRDsNtSyTEt
T666	GVsRDsNtSyTEtKD
Y668	sRDsNtSyTEtKDPS
T671	sNtSyTEtKDPScGQ
C676	TEtKDPScGQEAAaP
A682	ScGQEAAaPSGPQLQ
A702	EKAPTFSaSVRGRHL
S710-p	SVRGRHLsHPEpEQq
P714	RHLsHPEpEQqHViQ
Q717	sHPEpEQqHViQRLQ
I720	EpEQqHViQRLQPEQ
S729-p	RLQPEQGsPKKCEAE
T744	EAEPPAAtQPQTSET
S814	EEEEKKEssMPKSFK
S815	EEEKKEssMPKSFKR
S825-p	KSFKRKIsVVSAtKG
T830	KIsVVSAtKGVQAGN
S838-p	KGVQAGNsDtEGGQP
T840-p	VQAGNsDtEGGQPGR
S895-p	VDLHADDsQIsEDEt
S898-p	HADDsQIsEDEtERN
T902-p	sQIsEDEtERNGDDG
T975	KKVTLGDtLtRRsIs
T977	VTLGDtLtRRsIsQQ
S980-p	GDtLtRRsIsQQKsG
S982	tLtRRsIsQQKsGVs
S986-p	RsIsQQKsGVsITID
S989-p	sQQKsGVsITIDDPV
S1003-p	VRTAQVPsPPRGKIS
S1103-p	GLLVDRPsETKAEEQ
S1175	KVREGPRsRsRsRDR
S1177	REGPRsRsRsRDRRR
S1179	GPRsRsRsRDRRRKE
S1283-p	REKRREHsRERERDR
S1322	RRDTKRHsRsRsRst
S1324	DTKRHsRsRsRstPV
S1326-p	KRHsRsRsRstPVRD
S1328-p	HsRsRsRstPVRDRG
T1329-p	sRsRsRstPVRDRGG

	rat
K5	MWRRkRPNSSGG
-	under review
S132	SQIGEEMsQNSFIKQ
S166	AAELEEAsAEsEDEM
S169	LEEAsAEsEDEMTHP
S206	STHSPRKsSsFsEEK
S208	HSPRKsSsFsEEKGE
S210	PRKsSsFsEEKGEsD
S216-p	FsEEKGEsDDEKPRK
S228	PRKGERRssRVRQAR
S229	RKGERRssRVRQARA
P239	RQARAKLpEYsQAAE
S242	RAKLpEYsQAAEEEE
T253	EEEEDQEtPsRNLRV
S255	EEDQEtPsRNLRVRA
V268	RADRNLKvEEEEEEE
S293	EVDEGQKsREAEAPI
S330	EKPPIIRsQEKDELE
K361	LARQQQEkETQIvsL
V366	QEkETQIvsLPQEEN
S367	EkETQIvsLPQEENE
S377	QEENEVKsSQGLEEK
S385	SQGLEEKsQsPsLPP
S387	GLEEKsQsPsLPPLp
S389	EEKsQsPsLPPLpED
P394	sPsLPPLpEDLEKAp
P401	pEDLEKApVVLQPEQ
I409	VVLQPEQiVsEEEtP
S411	LQPEQiVsEEEtPPP
T415	QiVsEEEtPPPLLtK
T421	EtPPPLLtKEAssPP
S425	PLLtKEAssPPTHMQ
S426	LLtKEAssPPTHMQL
D435	PTHMQLQdEEEVEPA
S454	PPVLIQLsPPGTDAG
G477	HTVQLLRgLsPLsST
S479-p	VQLLRgLsPLsSTAD
S482	LRgLsPLsSTADtKA
T487	PLsSTADtKAEsPAE
S491	TADtKAEsPAERVSE
S500	AERVSEEsVLPLAQR
H513	QRSILPEhsAQKGAE
S514	RSILPEhsAQKGAES
S562	QEEGRRAsHTLFPDH
K655	SASSGSRksLsPGVs
S656	ASSGSRksLsPGVsR
S658	SGSRksLsPGVsRDg
S662	ksLsPGVsRDgNtTy
G665	sPGVsRDgNtTyTEt
T667	GVsRDgNtTyTEtKD
Y669	sRDgNtTyTEtKDPS
T672	gNtTyTEtKDPScGQ
C677	TEtKDPScGQEAAaP
A683	ScGQEAAaPSVPQLQ
A703	EKAPTCSaSVRGRHM
S711	SVRGRHMsQPEpEQk
P715	RHMsQPEpEQkHViQ
K718	sQPEpEQkHViQRLQ
I721	EpEQkHViQRLQPEQ
S730	RLQPEQEsPKKCEAE
T745	EAEPPAAtQPQTSEP
S815	EEEERKEssMPKSFK
S816	EEERKEssMPKSFKR
S826	KSFKRKIsVVSAtKG
T831	KIsVVSAtKGVQAGN
S839	KGVQAGNsDtEGGQP
T841	VQAGNsDtEGGQPGR
S896	VDLHADDsRIsEDEt
S899	HADDsRIsEDEtERN
T903	sRIsEDEtERNGDDG
T976	KKVTLGDtLtRRsIs
T978	VTLGDtLtRRsIsQQ
S981	GDtLtRRsIsQQKsG
S983	tLtRRsIsQQKsGVs
S987	RsIsQQKsGVsITID
S990	sQQKsGVsITIDDPV
S1004	VRTAQVPsPPRGKIS
S1104	GLLVDRPsEAKTEEQ
S1176	KVREGPRsRsRsRDR
S1178	REGPRsRsRsRDRRR
S1180-p	GPRsRsRsRDRRRKE
S1284	REKRREHsRERERDR
S1323	RRDTKRHsRsRsRst
S1325	DTKRHsRsRsRstPV
S1327	KRHsRsRsRstPVRD
S1329-p	HsRsRsRstPVRDRG
T1330	sRsRsRstPVRDRGG

Home  |  Curator Login	Developed by Cell Signaling Technology, with grant support from:
Produced by 3rd Millennium  |  Design by Digizyme
©2003-2010 Cell Signaling Technology, Inc.