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Protein Page:
acinus (human)
p Phosphorylation
a Acetylation
m Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
u Ubiquitination
s Sumoylation
n Neddylation
gl O-GlcNAc
ga O-GalNAc
h Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage

Overview
acinus an ubiquitous RNA-binding protein. Component of a splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junction on mRNAs. The EJC is a dynamic structure consisting of a few core proteins and several more peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. The EJC is composed of ACIN1, CASC3, DDX48, MAGOH, PNN, RBM8A, RNPS1, SAP18 and THOC4. Forms heterodimers with RNPS1. Found in a heterotrimeric complex with ACIN1, RNPS1 and SAP18. Interacts with API5. Phosphorylation by SRPK2 redistributes it from the nuclear speckles to the nucleoplasm, and up-regulates its stimulatory effect on cyclin A1. Activated by proteolytic cleavage. Induces apoptotic chromatin condensation after activation by CASP3. Regulates cyclin A1, but not cyclin A2, expression in leukemia cells. Four alternatively spliced human isoforms have been described. Note: This description may include information from UniProtKB.
Protein type: RNA splicing; Apoptosis; Spliceosome
Cellular Component: cytoplasm; plasma membrane; nucleolus; nuclear speck; cytosol; nucleus
Molecular Function: protein binding; enzyme binding; nucleic acid binding; ATPase activity; nucleotide binding
Biological Process: positive regulation of monocyte differentiation; ATP catabolic process; negative regulation of nuclear mRNA splicing, via spliceosome; positive regulation of apoptosis; apoptosis; RNA splicing; erythrocyte differentiation; mRNA processing; apoptotic chromosome condensation; cell structure disassembly during apoptosis
Reference #:  Q9UKV3 (UniProtKB)
Alt. Names/Synonyms: ACIN1; ACINU; ACINUS; ACN; apoptotic chromatin condensation inducer 1; Apoptotic chromatin condensation inducer in the nucleus; DKFZp667N107; fSAP152; functional spliceosome-associated protein 152; KIAA0670
Gene Symbols: ACIN1
Molecular weight: 151,862 Da
Basal Isoelectric point: 6.08  Predict pI for various phosphorylation states
CST Pathways:  Death Receptor Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

acinus

Protein Structure Not Found.


STRING  |  Scansite  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  Source  |  InnateDB  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene


Sites Implicated In
transcription, induced: S1180‑p
intracellular localization: S1180‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

► Hide Isoforms
 
1 1 K5-u ___MWRRkHPrTSGG
0 1 R8-m2 MWRRkHPrTSGGTrG
0 1 R14-m2 PrTSGGTrGVLSGNR
0 2 R29 GVEYGSGRGHLGTFE
0 2 R29-m2 GVEYGSGrGHLGTFE
0 1 S54 EAVGTDPSTSRKMAE
0 1 T55 AVGTDPSTSRKMAEL
0 1 S56 VGTDPSTSRKMAELE
0 1 D68-ca ELEEVTLdGKPLQAL
0 1 S92 EQRGLAKSGQKsALV
0 1 S96-p LAKSGQKsALVKRLk
0 1 K103-u sALVKRLkGALMLEN
0 1 S115-p LENLQKHstPHAAFQ
0 2 T116-p ENLQKHstPHAAFQP
0 5 S125-p HAAFQPNsQIGEEMs
0 20 S132-p sQIGEEMsQNsFIKQ
0 5 S135-p GEEMsQNsFIKQYLE
0 1 K143-u FIKQYLEkQQELLRQ
0 3 S166-p AAELEEAsAEsEDEM
0 4 S169-p LEEAsAEsEDEMIHP
0 3 S208-p HSPRKSSsIsEEKGD
0 3 S210-p PRKSSsIsEEKGDsD
0 36 S216-p IsEEKGDsDDEKPRK
0 4 S228-p PRKGERRssRVRQAR
0 1 S229-p RKGERRssRVRQARA
0 41 S240-p QARAAKLsEGsQPAE
0 38 S243-p AAKLsEGsQPAEEEE
0 27 T254-p EEEEDQEtPsRNLRV
0 3 S256-p EEDQEtPsRNLRVRA
0 8 T269-p RADRNLKtEEEEEEE
0 6 S295-p GDDEGQKsREAPILk
0 1 I300 QKsREAPILkEFKEE
0 1 K302-u sREAPILkEFKEEGE
0 1 T326-p MMDERPKtRsQEQEV
0 9 S328-p DERPKtRsQEQEVLE
0 4 K359-a LARQQQEkEMKTtsP
0 1 T364-p QEkEMKTtsPLEEEE
0 13 S365-p EkEMKTtsPLEEEER
0 3 S376-p EEEREIKssQGLKEK
0 7 S377-p EEREIKssQGLKEKs
0 1 G379 REIKssQGLKEKsKs
0 22 S384-p sQGLKEKsKsPsPPR
0 23 S386-p GLKEKsKsPsPPRLt
0 35 S388-p KEKsKsPsPPRLtED
0 6 T393-p sPsPPRLtEDRKKAs
0 7 S400-p tEDRKKAsLVALPEQ
0 9 T408-p LVALPEQtAsEEEtP
0 39 S410-p ALPEQtAsEEEtPPP
0 38 T414-p QtAsEEEtPPPLLtK
0 1 T420-p EtPPPLLtKEAssPP
0 5 S424-p PLLtKEAssPPPHPQ
0 7 S425-p LLtKEAssPPPHPQL
0 5 P428 KEAssPPPHPQLHsE
0 4 S434-p PPHPQLHsEEEIEPM
0 21 S453-p PAVLIQLsPPNTDAD
0 2 T461-p PPNTDADtRELLVSQ
0 2 S467 DtRELLVSQHTVQLV
0 1 T470 ELLVSQHTVQLVGGL
0 8 G476 HTVQLVGGLsPLssP
0 46 S478-p VQLVGGLsPLssPsD
0 6 S481-p VGGLsPLssPsDTKA
0 3 S482-p GGLsPLssPsDTKAE
0 3 P483 GLsPLssPsDTKAEs
0 3 S484-p LsPLssPsDTKAEsP
0 3 T486 PLssPsDTKAEsPAE
0 34 S490-p PsDTKAEsPAEKVPE
0 2 P496 EsPAEKVPEEsVLPL
0 3 S499-p AEKVPEEsVLPLVQK
0 1 D511-ca VQKSTLAdysAQKDL
0 5 Y512-p QKSTLAdysAQKDLE
0 1 S513-p KSTLAdysAQKDLEP
0 1 S522-p QKDLEPEsDRSAQPL
0 1 K532-s SAQPLPLkIEELALA
0 7 S551-p EECLKQPsLEQKEGR
0 31 S561-p QKEGRRAsHtLLPSH
0 1 T563-p EGRRAsHtLLPSHRL
0 2 S595-p SSRSRSRsPDSsGSR
0 1 S599-p RSRsPDSsGSRSHSP
0 2 S641 TSESRSRSRSRsRSA
0 2 S645-p RSRSRSRsRSASSNS
0 1 S652 sRSASSNSRksLsPG
0 1 K654-m2 SASSNSRksLsPGVs
0 18 S655-p ASSNSRksLsPGVsR
0 24 S657-p SNSRksLsPGVsRDS
0 2 S661-p ksLsPGVsRDSStSY
0 1 T666-p GVsRDSStSYTETKD
0 1 S676-p TETKDPSsGQEVAtP
0 16 T682-p SsGQEVAtPPVPQLQ
0 3 S698-p CEPKERTsTSSsSVQ
0 1 S702-p ERTsTSSsSVQARRL
0 101 S710-p SVQARRLsQPEsAEk
0 9 S714-p RRLsQPEsAEkHVtQ
0 1 K717-a sQPEsAEkHVtQRLQ
0 2 T720-p EsAEkHVtQRLQPER
0 24 S729-p RLQPERGsPKKCEAE
0 8 T744-p EAEPPAAtQPQTSET
0 1 S814-p EDEEKKEssLPKsFK
0 1 S815-p DEEKKEssLPKsFKR
0 3 S819-p KEssLPKsFKRkIsV
0 1 K823-u LPKsFKRkIsVVsAt
0 27 S825-p KsFKRkIsVVsAtkG
0 1 S828-p KRkIsVVsAtkGVPA
0 3 T830-p kIsVVsAtkGVPAGN
0 1 K831-u IsVVsAtkGVPAGNs
0 26 S838-p kGVPAGNsDtEGGQP
0 7 T840-p VPAGNsDtEGGQPGR
0 1 K861-u STATTQKkPsISITT
0 4 S863-p ATTQKkPsISITTES
0 11 S895-p VDLHADDsRIsEDEt
0 12 S898-p HADDsRIsEDEtERN
0 3 T902-p sRIsEDEtERNGDDG
0 3 T976-p KKVTLGDtLtRRsIs
0 1 T978-p VTLGDtLtRRsIsQQ
0 9 S981-p GDtLtRRsIsQQKsG
0 3 S983-p tLtRRsIsQQKsGVs
0 11 S987-p RsIsQQKsGVsItID
0 3 S990-p sQQKsGVsItIDDPV
0 2 T992-p QKsGVsItIDDPVRT
0 68 S1004-p VRTAQVPsPPRGKIS
0 9 K1029-u PFTLGQLkELLGRTG
0 1 T1058 HCFVTYSTVEEAVAT
0 82 S1161-p ERRERTRsEREWDRD
0 3 S1176-p KVREGPRsRsRsRDR
0 3 S1178-p REGPRsRsRsRDRRR
3 2 S1180-p GPRsRsRsRDRRRKE
0 1 K1209-u AQEEPPAkLLDDLFR
0 69 Y1225-p TKAAPCIyWLPLTDs
0 2 S1232-p yWLPLTDsQIVQKEA
0 2 S1284-p REKRREHsRERDRER
0 1 S1325-p RRDTKRHsRsRsRst
0 2 S1327-p DTKRHsRsRsRstPV
0 5 S1329-p KRHsRsRsRstPVRD
1 5 S1331-p HsRsRsRstPVRDRG
0 4 T1332-p sRsRsRstPVRDRGG
  acinus iso5  
K5 ___MWRRKHPRTSGG
R8 MWRRKHPRTSGGTRG
R14 PRTSGGTRGVLSGNR
R29 GVEYGSGRGHLGTFE
R29 GVEYGSGRGHLGTFE
S54 EAVGTDPSTSRKMAE
T55 AVGTDPSTSRKMAEL
S56 VGTDPSTSRKMAELE
D68 ELEEVTLDGKPLQAL
S92 EQRGLAKSGQKSALV
S96 LAKSGQKSALVKRLK
K103 SALVKRLKGALMLEN
S115 LENLQKHSTPHAAFQ
T116 ENLQKHSTPHAAFQP
S125 HAAFQPNSQIGEEMS
S132 SQIGEEMSQNSFIKQ
S135 GEEMSQNSFIKQYLE
K143 FIKQYLEKQQELLRQ
S166 AAELEEASAESEDEM
S169 LEEASAESEDEMIHP
S208 HSPRKSSSISEEKGD
S210 PRKSSSISEEKGDSD
S216 ISEEKGDSDDEKPRK
S228 PRKGERRSSRVRQAR
S229 RKGERRSSRVRQARA
S240 QARAAKLSEGSQPAE
S243 AAKLSEGSQPAEEEE
T254 EEEEDQETPSRNLRV
S256 EEDQETPSRNLRVRA
T269 RADRNLKTEEEEEEE
S295 GDDEGQKSREAPILK
I300 QKSREAPILKEFKEE
K302 SREAPILKEFKEEGE
T326 MMDERPKTRSQEQEV
S328 DERPKTRSQEQEVLE
K359 LARQQQEKEMKTTSP
T364 QEKEMKTTSPLEEEE
S365 EKEMKTTSPLEEEER
S376 EEEREIKSSQGLKEK
S377 EEREIKSSQGLKEKS
G379 REIKSSQGLKEKSKS
S384 SQGLKEKSKSPSPPR
S386 GLKEKSKSPSPPRLT
S388 KEKSKSPSPPRLTED
T393 SPSPPRLTEDRKKAS
S400 TEDRKKASLVALPEQ
T408 LVALPEQTASEEETP
S410 ALPEQTASEEETPPP
T414 QTASEEETPPPLLTK
T420 ETPPPLLTKEASSPP
S424 PLLTKEASSPPPHPQ
S425 LLTKEASSPPPHPQL
P428 KEASSPPPHPQLHSE
S434 PPHPQLHSEEEIEPM
S453 PAVLIQLSPPNTDAD
T461 PPNTDADTRELLVSQ
S467 DTRELLVSQHTVQLV
T470 ELLVSQHTVQLVGGL
G476 HTVQLVGGLSPLSSP
S478 VQLVGGLSPLSSPSD
S481 VGGLSPLSSPSDTKA
S482 GGLSPLSSPSDTKAE
P483 GLSPLSSPSDTKAES
S484 LSPLSSPSDTKAESP
T486 PLSSPSDTKAESPAE
S490 PSDTKAESPAEKVPE
P496 ESPAEKVPEESVLPL
S499 AEKVPEESVLPLVQK
D511 VQKSTLADYSAQKDL
Y512 QKSTLADYSAQKDLE
S513 KSTLADYSAQKDLEP
S522 QKDLEPESDRSAQPL
K532 SAQPLPLKIEELALA
S551 EECLKQPSLEQKEGR
S561 QKEGRRASHTLLPSH
T563 EGRRASHTLLPSHRL
S595 SSRSRSRSPDSSGSR
S599 RSRSPDSSGSRSHSP
S641 TSESRSRSRSRSRSA
S645 RSRSRSRSRSASSNS
S652 SRSASSNSRKSLSPG
K654 SASSNSRKSLSPGVS
S655 ASSNSRKSLSPGVSR
S657 SNSRKSLSPGVSRDS
S661 KSLSPGVSRDSSTSY
T666 GVSRDSSTSYTETKD
S676 TETKDPSSGQEVATP
T682 SSGQEVATPPVPQLQ
S698 CEPKERTSTSSSSVQ
S702 ERTSTSSSSVQARRL
S710 SVQARRLSQPESAEK
S714 RRLSQPESAEKHVTQ
K717 SQPESAEKHVTQRLQ
T720 ESAEKHVTQRLQPER
S729 RLQPERGSPKKCEAE
T744 EAEPPAATQPQTSET
S814 EDEEKKESSLPKSFK
S815 DEEKKESSLPKSFKR
S819 KESSLPKSFKRKIsV
K823 LPKSFKRKIsVVSTK
S825-p KSFKRKIsVVSTKGV
S828 KRKIsVVSTKGVPAG
T829 RKIsVVSTKGVPAGN
K830 KIsVVSTKGVPAGNS
S837 KGVPAGNSDTEGGQP
T839 VPAGNSDTEGGQPGR
K860 STATTQKKPSISITT
S862 ATTQKKPSISITTES
S882 VDLHADDSRISEDET
S885 HADDSRISEDETERN
T889 SRISEDETERNGDDG
T963 KKVTLGDTLTRRSIS
T965 VTLGDTLTRRSISQQ
S968 GDTLTRRSISQQKSG
S970 TLTRRSISQQKSGVS
S974 RSISQQKSGVSITID
S977 SQQKSGVSITIDDPV
T979 QKSGVSITIDDPVRT
S991 VRTAQVPSPPRGKIS
K1016 PFTLGQLKELLGRTG
T1045 HCFVTYSTVEEAVAT
S1148 ERRERTRSEREWDRD
S1163 KVREGPRSRSRSRDR
S1165 REGPRSRSRSRDRRR
S1167 GPRSRSRSRDRRRKE
K1196 AQEEPPAKLLDDLFR
Y1212 TKAAPCIYWLPLTDS
S1219 YWLPLTDSQIVQKEA
S1271 REKRREHSRERDRER
S1312 RRDTKRHSRSRSRST
S1314 DTKRHSRSRSRSTPV
S1316 KRHSRSRSRSTPVRD
S1318 HSRSRSRSTPVRDRG
T1319 SRSRSRSTPVRDRGG
  mouse

► Hide Isoforms
 
K5 ___MWGRKRPNSSGE
N8 MWGRKRPNSSGETRG
R14 PNSSGETRGILSGNR
R29-m1 GVDYGSGrGQSGPFE
R29 GVDYGSGRGQSGPFE
S54-p EAVGTDPstsRKMAE
T55-p AVGTDPstsRKMAEL
S56-p VGTDPstsRKMAELE
D68 ELEEVTLDGKPLQAL
S92-p EQRGLAKsGQKSALV
S96 LAKsGQKSALVKRLK
K103 SALVKRLKGALMLEN
S115 LENLQKHSTPHAAFQ
T116 ENLQKHSTPHAAFQP
S125 HAAFQPNSQIGEEMs
S132-p SQIGEEMsQNSFIKQ
S135 GEEMsQNSFIKQYLE
K143 FIKQYLEKQQELLRQ
S166-p AAELEEAsAEsEDEM
S169-p LEEAsAEsEDEMTHP
S208-p HSPRKSSsFsEEKGE
S210-p PRKSSsFsEEKGEsD
S216-p FsEEKGEsDDEKPRK
S228 PRKGERRSSRVRQAK
S229 RKGERRSSRVRQAKS
- gap
S242 KSKLPEYSQTAEEEE
T253 EEEEDQETPSRNLRV
S255 EEDQETPSRNLRVRA
- gap
S295-p EVDEAQKsREAEAPt
T302-p sREAEAPtLKQFEDE
K304 EAEAPtLKQFEDEEG
- gap
S332 EKPLNIRSQEKGELE
K363 LARQQQEKETQIVSL
- gap
S369 EKETQIVSLPQEENE
S379 QEENEVKSSQsLEEK
S380 EENEVKSSQsLEEKs
S382-p NEVKSSQsLEEKsQs
S387-p SQsLEEKsQsPsPPP
S389-p sLEEKsQsPsPPPLP
S391-p EEKsQsPsPPPLPED
- gap
- gap
- gap
S413-p LQPEQIVsEEEtPPP
T417-p QIVsEEEtPPPLLtK
T423-p EtPPPLLtKEAssPP
S427-p PLLtKEAssPPtHIQ
S428-p LLtKEAssPPtHIQL
T431-p KEAssPPtHIQLQEE
- gap
S454-p PPVLIQLsPPNTDAG
A462 PPNTDAGAREPLAsP
S468-p GAREPLAsPHPAQLL
P471 EPLAsPHPAQLLRsL
S477-p HPAQLLRsLsPLsGt
S479-p AQLLRsLsPLsGttD
S482-p LRsLsPLsGttDtKA
G483 RsLsPLsGttDtKAE
T484-p sLsPLsGttDtKAEs
T485-p LsPLsGttDtKAEsP
T487-p PLsGttDtKAEsPAG
S491-p ttDtKAEsPAGRVsD
S497-p EsPAGRVsDEsVLPL
S500-p AGRVsDEsVLPLAQK
E512 AQKSSLPECSTQKGV
C513 QKSSLPECSTQKGVE
S514 KSSLPECSTQKGVES
R523 QKGVESEREKSAPLP
T532 KSAPLPLTVEEFAPA
S551 EEPMKKQSLEQKEGR
S561-p QKEGRRAsHALFPEH
- gap
S595 SSPSRSPSPDSVASR
V599 RSPSPDSVASRPQSS
S641-p TSESRSRsRSRsRSA
S645-p RSRsRSRsRSASSSs
S652-p sRSASSSsRKsLsPG
K654 SASSSsRKsLsPGVS
S655-p ASSSsRKsLsPGVSR
S657-p SSsRKsLsPGVSRDS
S661 KsLsPGVSRDSNTSY
T666 GVSRDSNTSYTETKD
C676 TETKDPSCGQEAAAP
A682 SCGQEAAAPSGPQLQ
P698 LEPKEKAPTFSASVR
A702 EKAPTFSASVRGRHL
S710-p SVRGRHLsHPEPEQQ
P714 RHLsHPEPEQQHVIQ
Q717 sHPEPEQQHVIQRLQ
I720 EPEQQHVIQRLQPEQ
S729-p RLQPEQGsPKKCEAE
T744 EAEPPAATQPQTSET
S814 EEEEKKESSMPKSFK
S815 EEEKKESSMPKSFKR
S819 KESSMPKSFKRKIsV
K823 MPKSFKRKIsVVSAT
S825-p KSFKRKIsVVSATKG
S828 KRKIsVVSATKGVQA
T830 KIsVVSATKGVQAGN
K831 IsVVSATKGVQAGNs
S838-p KGVQAGNsDtEGGQP
T840-p VQAGNsDtEGGQPGR
K861 STAATQKKPsISITT
S863-p AATQKKPsISITTES
S895-p VDLHADDsRIsEDEt
S898-p HADDsRIsEDEtERN
T902-p sRIsEDEtERNGDDG
T975 KKVTLGDTLTRRsIS
T977 VTLGDTLTRRsISQQ
S980-p GDTLTRRsISQQKsG
S982 TLTRRsISQQKsGVs
S986-p RsISQQKsGVsITID
S989-p SQQKsGVsITIDDPV
T991 QKsGVsITIDDPVRT
S1003-p VRTAQVPsPPRGKIS
K1028 PFTLGQLKELLGRTG
T1057-p HCFVTYStVEEAVAT
S1160-p ERRERTRsEREWDRD
S1175 KVREGPRSRSRSRDR
S1177 REGPRSRSRSRDRRR
S1179 GPRSRSRSRDRRRKE
K1208 AQEEPPAKLLDDLFR
Y1224 TKAAPCIYWLPLTES
S1231 YWLPLTESQIVQKEA
S1283-p REKRREHsRERERDR
S1322 RRDTKRHSRSRsRst
S1324 DTKRHSRSRsRstPV
S1326-p KRHSRSRsRstPVRD
S1328-p HSRSRsRstPVRDRG
T1329-p SRSRsRstPVRDRGG
  acinus iso5  
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S41 EEEEKKESSMPKSFK
S42 EEEKKESSMPKSFKR
S46 KESSMPKSFKRKIsV
K48 SSMPKSFKRKIsVVS
S52-p KSFKRKIsVVSTKGV
S55 KRKIsVVSTKGVQAG
T56 RKIsVVSTKGVQAGN
K57 KIsVVSTKGVQAGNS
S64 KGVQAGNSDTEGGQP
T66 VQAGNSDTEGGQPGR
K87 STAATQKKPSISITT
S89 AATQKKPSISITTES
S109 VDLHADDSRISEDET
S112 HADDSRISEDETERN
T116 SRISEDETERNGDDG
T189 KKVTLGDTLTRRSIS
T191 VTLGDTLTRRSISQQ
S194 GDTLTRRSISQQKSG
S196 TLTRRSISQQKSGVS
S200 RSISQQKSGVSITID
S203 SQQKSGVSITIDDPV
T205 QKSGVSITIDDPVRT
S217 VRTAQVPSPPRGKIS
K242 PFTLGQLKELLGRTG
T271 HCFVTYSTVEEAVAT
S374 ERRERTRSEREWDRD
S389 KVREGPRSRSRSRDR
S391 REGPRSRSRSRDRRR
S393 GPRSRSRSRDRRRKE
K422 AQEEPPAKLLDDLFR
Y438 TKAAPCIYWLPLTES
S445 YWLPLTESQIVQKEA
S497 REKRREHSRERERDR
S536 RRDTKRHSRSRSRST
S538 DTKRHSRSRSRSTPV
S540 KRHSRSRSRSTPVRD
S542 HSRSRSRSTPVRDRG
T543 SRSRSRSTPVRDRGG
  rat

 
K5 ___MWRRKRPNSSGG
N8 MWRRKRPNSSGGTRG
R14 PNSSGGTRGILSGNR
R29 GVDYGSGRGQFGTFE
R29 GVDYGSGRGQFGTFE
S54 EAVGTDPSTSRKMAE
T55 AVGTDPSTSRKMAEL
S56 VGTDPSTSRKMAELE
D68 ELEEVTLDGKPLQAL
S92 EQRGLAKSGQKSALV
S96 LAKSGQKSALVKRLK
K103 SALVKRLKGALMLEN
S115 LENLQKHSTPHAAFQ
T116 ENLQKHSTPHAAFQP
S125 HAAFQPNSQIGEEMS
S132 SQIGEEMSQNSFIKQ
S135 GEEMSQNSFIKQYLE
K143 FIKQYLEKQQELLRQ
S166 AAELEEASAEsEDEM
S169-p LEEASAEsEDEMTHP
S208 HSPRKSSSFSEEKGE
S210 PRKSSSFSEEKGEsD
S216-p FSEEKGEsDDEKPRK
S228 PRKGERRSSRVRQAR
S229 RKGERRSSRVRQARA
- gap
S242 RAKLPEYSQAAEEEE
T253 EEEEDQETPSRNLRV
S255 EEDQETPSRNLRVRA
- gap
S293 EVDEGQKSREAEAPI
- gap
K302 EAEAPILKQFEDEDG
- gap
S330 EKPPIIRSQEKDELE
K361 LARQQQEKETQIVSL
- gap
S367 EKETQIVSLPQEENE
S377 QEENEVKSSQGLEEK
S378 EENEVKSSQGLEEKS
- gap
S385 SQGLEEKSQsPSLPP
S387-p GLEEKSQsPSLPPLP
S389 EEKSQsPSLPPLPED
- gap
- gap
- gap
S411-p LQPEQIVsEEEtPPP
T415-p QIVsEEEtPPPLLTK
T421 EtPPPLLTKEAsSPP
S425-p PLLTKEAsSPPtHMQ
S426 LLTKEAsSPPtHMQL
T429-p KEAsSPPtHMQLQDE
- gap
S454-p PPVLIQLsPPGTDAG
T462 PPGTDAGTREPIVSP
S468 GTREPIVSPHtVQLL
T471-p EPIVSPHtVQLLRGL
- gap
S479-p VQLLRGLsPLsSTAD
S482-p LRGLsPLsSTADtKA
S483 RGLsPLsSTADtKAE
T484 GLsPLsSTADtKAEs
- gap
T487-p PLsSTADtKAEsPAE
S491-p TADtKAEsPAERVSE
S497 EsPAERVSEEsVLPL
S500-p AERVSEEsVLPLAQR
E512 AQRSILPEHSAQKGA
H513 QRSILPEHSAQKGAE
S514 RSILPEHSAQKGAES
R523 QKGAESEREKSAPLL
T533 SAPLLPLTREELAPA
S552 EESVKKQSLEQEEGR
S562 QEEGRRASHTLFPDH
T564 EGRRASHTLFPDHSL
S596-p SSRSRSRsPDSSASR
S600 RSRsPDSSASRSQSS
S642 TSESRSRSRSRSRSA
S646 RSRSRSRSRSASSGS
S653 SRSASSGSRKsLsPG
K655 SASSGSRKsLsPGVS
S656-p ASSGSRKsLsPGVSR
S658-p SGSRKsLsPGVSRDG
S662 KsLsPGVSRDGNTTY
T667 GVSRDGNTTYTETKD
C677 TETKDPSCGQEAAAP
A683 SCGQEAAAPSVPQLQ
P699 LEPKEKAPTCSASVR
A703 EKAPTCSASVRGRHM
S711-p SVRGRHMsQPEPEQK
P715 RHMsQPEPEQKHVIQ
K718 sQPEPEQKHVIQRLQ
I721 EPEQKHVIQRLQPEQ
S730-p RLQPEQEsPKKCEAE
T745 EAEPPAATQPQTSEP
S815 EEEERKESSMPKSFK
S816 EEERKESSMPKSFKR
S820 KESSMPKSFKRKISV
K824 MPKSFKRKISVVSAT
S826 KSFKRKISVVSATKG
S829 KRKISVVSATKGVQA
T831 KISVVSATKGVQAGN
K832 ISVVSATKGVQAGNs
S839-p KGVQAGNsDTEGGQP
T841 VQAGNsDTEGGQPGR
K862 STAATQKKPSISITT
S864 AATQKKPSISITTES
S896 VDLHADDSRIsEDET
S899-p HADDSRIsEDETERN
T903 SRIsEDETERNGDDG
T976 KKVTLGDTLTRRSIS
T978 VTLGDTLTRRSISQQ
S981 GDTLTRRSISQQKSG
S983 TLTRRSISQQKSGVS
S987 RSISQQKSGVSITID
S990 SQQKSGVSITIDDPV
T992 QKSGVSITIDDPVRT
S1004-p VRTAQVPsPPRGKIS
K1029 PFTLGQLKELLGRTG
T1058 HCFVTYSTVEEAVAT
S1161 ERRERTRSEREWDRD
S1176 KVREGPRSRSRsRDR
S1178 REGPRSRSRsRDRRR
S1180-p GPRSRSRsRDRRRKE
K1209 AQEEPPAKLLDDLFR
Y1225 TKAAPCIYWLPLTES
S1232 YWLPLTESQIVQKEA
S1284 REKRREHSRERERDR
S1323 RRDTKRHSRSRSRsT
S1325 DTKRHSRSRSRsTPV
S1327 KRHSRSRSRsTPVRD
S1329-p HSRSRSRsTPVRDRG
T1330 SRSRSRsTPVRDRGG
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