a receptor tyrosine kinase of the PDGFR family that binds the FL cytokine. FLT3 -/- mice have an impaired developmental capacity of primitive hematopoietic progenitor cells of all lineages with the greatest impact on lymphopoietic precursors. Activating mutations found in one third of cases of acute myeloid leukemia (AML), as well as in acute lymphoblastic leukemia, acute promyelocytic leukemia and myelodysplastic syndrome. Inhibitors: Sutent and PKC412. Note: This description may include information from UniProtKB.
Protein type: Kinase, protein; EC 188.8.131.52; Membrane protein, integral; Protein kinase, tyrosine (receptor); Protein kinase, TK; TK group; PDGFR family
Cellular Component: cell surface; endoplasmic reticulum lumen; integral to plasma membrane
Molecular Function: vascular endothelial growth factor receptor activity; hematopoietin/interferon-class (D200-domain) cytokine receptor activity; protein binding; protein homodimerization activity; phosphoinositide 3-kinase binding; transmembrane receptor protein tyrosine kinase activity; ATP binding
Biological Process: negative regulation of B cell differentiation; lymphocyte proliferation; pro-B cell differentiation; peptidyl-tyrosine phosphorylation; cytokine and chemokine mediated signaling pathway; protein amino acid autophosphorylation; positive regulation of phosphoinositide 3-kinase activity; positive regulation of phosphoinositide 3-kinase cascade; regulation of apoptosis; positive regulation of MAP kinase activity; negative regulation of cell proliferation; myeloid progenitor cell differentiation; positive regulation of MAPKKK cascade; positive regulation of tyrosine phosphorylation of STAT protein; B cell differentiation; positive regulation of cell proliferation; hemopoiesis; pro-T cell differentiation; transmembrane receptor protein tyrosine kinase signaling pathway; leukocyte homeostasis
SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.