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Protein Page:
FLT3 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
FLT3 a receptor tyrosine kinase of the PDGFR family that binds the FL cytokine. FLT3 -/- mice have an impaired developmental capacity of primitive hematopoietic progenitor cells of all lineages with the greatest impact on lymphopoietic precursors. Activating mutations found in one third of cases of acute myeloid leukemia (AML), as well as in acute lymphoblastic leukemia, acute promyelocytic leukemia and myelodysplastic syndrome. Inhibitors: Sutent and PKC412. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral; Protein kinase, TK; EC 2.7.10.1; Kinase, protein; Protein kinase, tyrosine (receptor); TK group; PDGFR family
Cellular Component: cell surface; integral to plasma membrane; endoplasmic reticulum lumen
Molecular Function: vascular endothelial growth factor receptor activity; hematopoietin/interferon-class (D200-domain) cytokine receptor activity; protein binding; protein homodimerization activity; phosphoinositide 3-kinase binding; transmembrane receptor protein tyrosine kinase activity; ATP binding
Biological Process: negative regulation of B cell differentiation; lymphocyte proliferation; pro-B cell differentiation; peptidyl-tyrosine phosphorylation; cytokine and chemokine mediated signaling pathway; protein amino acid autophosphorylation; positive regulation of phosphoinositide 3-kinase activity; positive regulation of phosphoinositide 3-kinase cascade; regulation of apoptosis; positive regulation of MAP kinase activity; negative regulation of cell proliferation; myeloid progenitor cell differentiation; positive regulation of tyrosine phosphorylation of STAT protein; positive regulation of MAPKKK cascade; B cell differentiation; positive regulation of cell proliferation; hemopoiesis; pro-T cell differentiation; transmembrane receptor protein tyrosine kinase signaling pathway; leukocyte homeostasis
Reference #:  P36888 (UniProtKB)
Alt. Names/Synonyms: CD135; CD135 antigen; fetal liver kinase 2; FL cytokine receptor; FLK2; FLT-3; FLT3; FLT3 receptor tyrosine kinase; Fms-like tyrosine kinase 3; fms-related tyrosine kinase 3; growth factor receptor tyrosine kinase type III; Stem cell tyrosine kinase 1; STK-1; STK1; Tyrosine-protein kinase receptor FLT3
Gene Symbols: FLT3
Molecular weight: 112,903 Da
Basal Isoelectric point: 5.48  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

FLT3

Protein Structure Not Found.


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Sites Implicated In
apoptosis, inhibited: Y842‑p
cell cycle regulation: Y768‑p, Y955‑p, Y969‑p
cell growth, altered: Y589‑p, Y591‑p, Y842‑p
enzymatic activity, induced: Y591‑p, Y599‑p
enzymatic activity, inhibited: Y589‑p
molecular association, regulation: Y572‑p, Y589‑p, Y599‑p, Y768‑p, Y793‑p, Y955‑p, Y969‑p
phosphorylation: Y589‑p, Y591‑p, Y597‑p, Y599‑p, Y726‑p, Y842‑p, Y955‑p
protein conformation: Y842‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 P2 ______MPALARDGG
0 1 R6 __MPALARDGGQLPL
0 1 S18 LPLLVVFSAMIFGTI
0 1 T24 FSAMIFGTITNQDLP
0 1 T26 AMIFGTITNQDLPVI
0 1 T163 FTVSIRNTLLyTLRR
0 1 Y166-p SIRNTLLyTLRRPYF
0 1 T343-p PSQSALVtIVEKGFI
0 1 Y416-p HKHQPGEyIFHAEND
2 0 Y572-p KYKKQFRyESQLQMV
6 1 Y589-p TGSSDNEyFyVDFRE
13 0 Y591-p SSDNEyFyVDFREyE
2 0 Y597-p FyVDFREyEyDLkWE
6 2 Y599-p VDFREyEyDLkWEFP
0 1 K602-ub REyEyDLkWEFPREN
0 2 K614-ub RENLEFGkVLGSGAF
0 1 K623-ub LGSGAFGkVMNATAy
0 44 Y630-p kVMNATAyGISkTGV
0 2 K634-ub ATAyGISkTGVSIQV
0 1 K644-ub VSIQVAVkMLKEKAD
0 1 K719-ub RTWTEIFkEHNFSFy
2 6 Y726-p kEHNFSFyPtFQSHP
0 3 T728-p HNFSFyPtFQSHPNS
0 1 S759-p ISGLHGNsFHSEDEI
2 0 Y768-p HSEDEIEyENQkRLE
0 1 K772-ub EIEyENQkRLEEEED
2 1 Y793-p EDLLCFAyQVAKGME
0 1 S840-p ARDIMSDsNyVVRGN
5 77 Y842-p DIMSDsNyVVRGNAR
0 1 Y865 ESLFEGIYTIKSDVW
1 0 Y889 FSLGVNPYPGIPVDA
1 0 Y919 FYATEEIYIIMQSCW
0 1 S924 EIYIIMQSCWAFDSR
0 1 K932-ub CWAFDSRkRPSFPNL
4 15 Y955-p ADAEEAMyQNVDGRV
0 1 T968-p RVSECPHtyQNRRPF
3 17 Y969-p VSECPHtyQNRRPFS
0 2 - gap
0 2 - gap
0 1 S993-p PQAQVEDs_______
3464 : Phospho-FLT3 (Tyr589/591) (30D4) Rabbit mAb
3461 : Phospho-FLT3 (Tyr591) Antibody
3464 : Phospho-FLT3 (Tyr589/591) (30D4) Rabbit mAb
3466 : Phospho-FLT3 (Tyr591) (54H1) Mouse mAb
3474 : Phospho-FLT3 (Tyr591) (33G6) Rabbit mAb
4577 : Phospho-FLT3 (Tyr842) (10A8) Rabbit mAb
3463 : Phospho-FLT3 (Tyr969) (C24D9) Rabbit mAb
  mouse

► Hide Isoforms
 
R2-m1 ______MrALAQrSD
R7-m1 _MrALAQrSDRRLLL
S19-p LLLLVVLsVMILEtV
T25-p LsVMILEtVtNQDLP
T27-p VMILEtVtNQDLPVI
T164-p FTVNVRDtQLYVLRR
Y167 NVRDtQLYVLRRPYF
T344 PSQSALVTILEKGFI
Y417 HKNKPGEYIFYAEND
Y573 KYKKQFRYESQLQMI
Y590-p TGPLDNEyFyVDFRD
Y592-p PLDNEyFyVDFRDYE
Y598 FyVDFRDYEyDLKWE
Y600-p VDFRDYEyDLKWEFP
K603 RDYEyDLKWEFPREN
K615 RENLEFGKVLGSGAF
R624 LGSGAFGRVMNATAy
Y631-p RVMNATAyGISKTGV
K635 ATAyGISKTGVSIQV
K645 VSIQVAVKMLKEKAD
K720 RTWTEIFKEHNFSSY
Y727 KEHNFSSYPTFQAHS
T729 HNFSSYPTFQAHSNS
S760 LSGFNGNSIHSEDEI
Y769 HSEDEIEYENQKRLA
K773 EIEYENQKRLAEEEE
Y796-p EDLLCFAyQVAKGME
S843 ARDILSDSSyVVRGN
Y845-p DILSDSSyVVRGNAR
Y868-p ESLFEGIyTIKSDVW
Y892-p FSLGVNPyPGIPVDA
Y922-p FYATEGIyFVMQsCW
S927-p GIyFVMQsCWAFDSR
K935 CWAFDSRKRPSFPNL
I958 AEAEEACIRTSIHLP
P970 HLPKQAAPQQRGGLR
Q971 LPKQAAPQQRGGLRA
- gap
- gap
H988 PQRQVKIHRERS___
3464 : Phospho-FLT3 (Tyr589/591) (30D4) Rabbit mAb
3461 : Phospho-FLT3 (Tyr591) Antibody
3464 : Phospho-FLT3 (Tyr589/591) (30D4) Rabbit mAb
3466 : Phospho-FLT3 (Tyr591) (54H1) Mouse mAb
4577 : Phospho-FLT3 (Tyr842) (10A8) Rabbit mAb
3463 : Phospho-FLT3 (Tyr969) (C24D9) Rabbit mAb
  FLT3 iso3  
R2 ______MRALAQRSD
R7 _MRALAQRSDRRLLL
S19 LLLLVVLSVMILETV
T25 LSVMILETVTNQDLP
T27 VMILETVTNQDLPVI
T164 FTVNVRDTQLYVLRR
Y167 NVRDTQLYVLRRPYF
T344 PSQSALVTILEKGFI
Y417 HKNKPGEYIFYAEND
Y573 KYKKQFRYESQLQMI
Y590-p TGPLDNEyFyVDFRD
Y592-p PLDNEyFyVDFRDYE
Y598 FyVDFRDYEyDLKWE
Y600-p VDFRDYEyDLKWEFP
K603 RDYEyDLKWEFPREN
K615 RENLEFGKVLGSGAF
R624 LGSGAFGRVMNATAY
Y631 RVMNATAYGISKTGV
K635 ATAYGISKTGVSIQV
K645 VSIQVAVKMLKEKAD
K720 RTWTEIFKEHNFSFy
Y727-p KEHNFSFyPtFQAHS
T729-p HNFSFyPtFQAHSNS
L760 LSGFNGNLIHSEDEI
Y769-p HSEDEIEyENQKRLA
K773 EIEyENQKRLAEEEE
Y796-p EDLLCFAyQVAKGME
S843 ARDILSDSSyVVRGN
Y845-p DILSDSSyVVRGNAR
Y868-p ESLFEGIyTIKSDVW
Y892 FSLGVNPYPGIPVDA
Y922 FYATEGIYFVMQSCW
S927 GIYFVMQSCWAFDSR
K935 CWAFDSRKRPSFPNL
Y958-p AEAEEAMyQNMGGNV
I971 NVPEHPSIYQNRRPL
Y972 VPEHPSIYQNRRPLS
S984-p PLSREAGsEPPsPQA
S988-p EAGsEPPsPQAQVKI
H996 PQAQVKIHGERS___
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