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FLT3 (human)

Overview FLT3 a receptor tyrosine kinase of the PDGFR family that binds the FL cytokine. FLT3 -/- mice have an impaired developmental capacity of primitive hematopoietic progenitor cells of all lineages with the greatest impact on lymphopoietic precursors. Activating mutations found in one third of cases of acute myeloid leukemia (AML), as well as in acute lymphoblastic leukemia, acute promyelocytic leukemia and myelodysplastic syndrome. Inhibitors: Sutent and PKC412. Note: This description may include information from UniProtKB. Protein type: Protein kinase, tyrosine (receptor); Protein kinase, TK; EC 2.7.10.1; Membrane protein, integral; Kinase, protein; TK group; PDGFR family Cellular Component: cell surface; integral to plasma membrane; endoplasmic reticulum lumen Molecular Function: hematopoietin/interferon-class (D200-domain) cytokine receptor activity; vascular endothelial growth factor receptor activity; protein binding; protein homodimerization activity; phosphoinositide 3-kinase binding; transmembrane receptor protein tyrosine kinase activity; ATP binding Biological Process: negative regulation of B cell differentiation; lymphocyte proliferation; pro-B cell differentiation; peptidyl-tyrosine phosphorylation; protein amino acid autophosphorylation; cytokine and chemokine mediated signaling pathway; positive regulation of phosphoinositide 3-kinase activity; regulation of apoptosis; positive regulation of phosphoinositide 3-kinase cascade; positive regulation of MAP kinase activity; negative regulation of cell proliferation; positive regulation of tyrosine phosphorylation of STAT protein; positive regulation of MAPKKK cascade; myeloid progenitor cell differentiation; B cell differentiation; positive regulation of cell proliferation; hemopoiesis; pro-T cell differentiation; transmembrane receptor protein tyrosine kinase signaling pathway; leukocyte homeostasis Reference #:  P36888 (UniProtKB) Alt. Names/Synonyms: CD135; CD135 antigen; fetal liver kinase 2; FL cytokine receptor; FLK2; FLT-3; FLT3; FLT3 receptor tyrosine kinase; Fms-like tyrosine kinase 3; fms-related tyrosine kinase 3; growth factor receptor tyrosine kinase type III; Stem cell tyrosine kinase 1; STK-1; STK1; Tyrosine-protein kinase receptor FLT3 Gene Symbols: FLT3 Molecular weight: 112,903 Da Basal Isoelectric point: 5.48  Predict pI for various phosphorylation states CST Pathways:  Tyrosine Kinases Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below FLT3 1RJB - A=564-958 (human) 3QS7 - H/F/G/E=27-436 (human) 3QS9 - H/F/G/E=27-540 (human)

STRING  |  Scansite  |  KinBase  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  RCSB PDB 1RJB 3QS7 3QS9  |  ENZYME  |  Phospho3D  |  DISEASE 136351 601626  |  Source  |  InnateDB  |  UCSD-Nature  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene

	Sites Implicated In
apoptosis, inhibited: Y842‑p cell cycle regulation: Y768‑p, Y955‑p, Y969‑p cell growth, altered: Y589‑p, Y591‑p, Y842‑p enzymatic activity, induced: Y591‑p, Y599‑p enzymatic activity, inhibited: Y589‑p molecular association, regulation: Y589‑p, Y599‑p, Y768‑p, Y955‑p, Y969‑p phosphorylation: Y589‑p, Y591‑p, Y597‑p, Y599‑p, Y726‑p, Y842‑p, Y955‑p protein conformation: Y842‑p

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	1		P2	______MPALARDGG
0	1		R6	__MPALARDGGQLPL
0	1		S18	LPLLVVFSAMIFGTI
0	1		T24	FSAMIFGTITNQDLP
0	1		T26	AMIFGTITNQDLPVI
0	1		T163	FTVSIRNTLLyTLRR
0	1		Y166-p	SIRNTLLyTLRRPYF
0	1		T343-p	PSQSALVtIVEKGFI
0	1		Y416-p	HKHQPGEyIFHAEND
1	0		Y572-p	KYKKQFRyESQLQMV
6	1		Y589-p	TGSSDNEyFyVDFRE
13	0		Y591-p	SSDNEyFyVDFREyE
2	0		Y597-p	FyVDFREyEyDLkWE
6	2		Y599-p	VDFREyEyDLkWEFP
0	1		K602-u	REyEyDLkWEFPREN
0	2		K614-u	RENLEFGkVLGSGAF
0	1		K623-u	LGSGAFGkVMNATAy
0	45		Y630-p	kVMNATAyGISkTGV
0	2		K634-u	ATAyGISkTGVSIQV
0	1		K644-u	VSIQVAVkMLKEKAD
0	1		K719-u	RTWTEIFkEHNFSFy
2	6		Y726-p	kEHNFSFyPtFQSHP
0	3		T728-p	HNFSFyPtFQSHPNS
0	1		S759-p	ISGLHGNsFHSEDEI
2	0		Y768-p	HSEDEIEyENQkRLE
0	1		K772-u	EIEyENQkRLEEEED
1	1		Y793-p	EDLLCFAyQVAKGME
0	1		S840-p	ARDIMSDsNyVVRGN
5	77		Y842-p	DIMSDsNyVVRGNAR
0	1		Y865-p	ESLFEGIyTIKSDVW
1	0		Y889	FSLGVNPYPGIPVDA
1	0		Y919	FYATEEIYIIMQSCW
0	1		S924	EIYIIMQSCWAFDSR
0	1		K932-u	CWAFDSRkRPSFPNL
4	15		Y955-p	ADAEEAMyQNVDGRV
0	1		T968-p	RVSECPHtyQNRRPF
3	17		Y969-p	VSECPHtyQNRRPFS
0	1		-	gap
0	1		-	gap
0	1		S993-p	PQAQVEDs_______

	mouse ► Hide Isoforms
R2-m1	______MrALAQrSD
R7-m1	_MrALAQrSDRRLLL
S19-p	LLLLVVLsVMILEtV
T25-p	LsVMILEtVtNQDLP
T27-p	VMILEtVtNQDLPVI
T164-p	FTVNVRDtQLYVLRR
Y167	NVRDtQLYVLRRPYF
T344	PSQSALVTILEKGFI
Y417	HKNKPGEYIFYAEND
Y573	KYKKQFRYESQLQMI
Y590-p	TGPLDNEyFyVDFRD
Y592-p	PLDNEyFyVDFRDYE
Y598	FyVDFRDYEyDLKWE
Y600-p	VDFRDYEyDLKWEFP
K603	RDYEyDLKWEFPREN
K615	RENLEFGKVLGSGAF
R624	LGSGAFGRVMNATAy
Y631-p	RVMNATAyGISKTGV
K635	ATAyGISKTGVSIQV
K645	VSIQVAVKMLKEKAD
K720	RTWTEIFKEHNFSSY
Y727	KEHNFSSYPTFQAHS
T729	HNFSSYPTFQAHSNS
S760	LSGFNGNSIHSEDEI
Y769	HSEDEIEYENQKRLA
K773	EIEYENQKRLAEEEE
Y796-p	EDLLCFAyQVAKGME
S843	ARDILSDSSyVVRGN
Y845-p	DILSDSSyVVRGNAR
Y868-p	ESLFEGIyTIKSDVW
Y892-p	FSLGVNPyPGIPVDA
Y922-p	FYATEGIyFVMQsCW
S927-p	GIyFVMQsCWAFDSR
K935	CWAFDSRKRPSFPNL
I958	AEAEEACIRTSIHLP
P970	HLPKQAAPQQRGGLR
Q971	LPKQAAPQQRGGLRA
-	gap
-	gap
H988	PQRQVKIHRERS___

	FLT3 iso3
R2	______MRALAQRSD
R7	_MRALAQRSDRRLLL
S19	LLLLVVLSVMILETV
T25	LSVMILETVTNQDLP
T27	VMILETVTNQDLPVI
T164	FTVNVRDTQLYVLRR
Y167	NVRDTQLYVLRRPYF
T344	PSQSALVTILEKGFI
Y417	HKNKPGEYIFYAEND
Y573	KYKKQFRYESQLQMI
Y590-p	TGPLDNEyFyVDFRD
Y592-p	PLDNEyFyVDFRDYE
Y598	FyVDFRDYEyDLKWE
Y600-p	VDFRDYEyDLKWEFP
K603	RDYEyDLKWEFPREN
K615	RENLEFGKVLGSGAF
R624	LGSGAFGRVMNATAY
Y631	RVMNATAYGISKTGV
K635	ATAYGISKTGVSIQV
K645	VSIQVAVKMLKEKAD
K720	RTWTEIFKEHNFSFy
Y727-p	KEHNFSFyPtFQAHS
T729-p	HNFSFyPtFQAHSNS
L760	LSGFNGNLIHSEDEI
Y769-p	HSEDEIEyENQKRLA
K773	EIEyENQKRLAEEEE
Y796-p	EDLLCFAyQVAKGME
S843	ARDILSDSSyVVRGN
Y845-p	DILSDSSyVVRGNAR
Y868-p	ESLFEGIyTIKSDVW
Y892	FSLGVNPYPGIPVDA
Y922	FYATEGIYFVMQSCW
S927	GIYFVMQSCWAFDSR
K935	CWAFDSRKRPSFPNL
Y958-p	AEAEEAMyQNMGGNV
I971	NVPEHPSIYQNRRPL
Y972	VPEHPSIYQNRRPLS
S984-p	PLSREAGsEPPsPQA
S988-p	EAGsEPPsPQAQVKI
H996	PQAQVKIHGERS___

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