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Protein Page:
EVL (human)

Overview
EVL Ena/VASP proteins are actin-associated proteins involved in a range of processes dependent on cytoskeleton remodeling and cell polarity such as axon guidance and lamellipodial and filopodial dynamics in migrating cells. EVL enhances actin nucleation and polymerization. Required to transform actin polymerization into active movement for the propulsive force of Listeria monocytogenes. Belongs to the Ena/VASP family. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Motility/polarity/chemotaxis; Cytoskeletal protein
Cellular Component: focal adhesion; cytoskeleton; membrane; lamellipodium; cytoplasm; cytosol
Molecular Function: protein binding; actin binding; SH3 domain binding; profilin binding
Biological Process: axon guidance; nervous system development; organ morphogenesis; cell surface receptor linked signal transduction; actin polymerization and/or depolymerization; positive regulation of stress fiber formation; actin filament organization; protein homotetramerization
Reference #:  Q9UI08 (UniProtKB)
Alt. Names/Synonyms: Ena/vasodilator-stimulated phosphoprotein-like; Ena/VASP-like protein; Enah/Vasp-like; EVL; RNB6
Gene Symbols: EVL
Molecular weight: 44,620 Da
Basal Isoelectric point: 8.91  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

EVL

Protein Structure Not Found.


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Modification Sites and Domains  

Modification Sites in Parent Protein, Orthologs, and Isoforms  
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 83 Y16-p ARASVMVyDDTsKKW
0 1 S20-p VMVyDDTsKKWVPIK
0 10 Y39-p GFSRINIyHNTASNT
0 1 S152-p HQQQRQEsLERRTsA
1 3 S158-p EsLERRTsATGPILP
0 1 S171-p LPPGHPSsAASAPVS
0 2 S242-p VQRPEDAsGGSsPSG
0 2 S245 PEDAsGGSsPSGTSK
0 7 S246-p EDAsGGSsPSGTSKS
0 1 S248 AsGGSsPSGTSKSDA
0 5 S259-p KSDANRAsSGGGGGG
0 1 S260 SDANRAsSGGGGGGL
0 2 S283-p AKRRKAAsQSDKPAE
0 1 S296-p AEKKEDEsQMEDPst
0 1 S302-p EsQMEDPstsPsPGT
0 1 T303-p sQMEDPstsPsPGTR
0 29 S304-p QMEDPstsPsPGTRA
0 5 S306-p EDPstsPsPGTRAAs
0 1 T309 stsPsPGTRAAsQPP
0 1 S313-p sPGTRAAsQPPNSSE
0 21 S329-p GRKPWERsNsVEKPV
0 82 S331-p KPWERsNsVEKPVss
0 6 S337-p NsVEKPVssILsRtP
0 7 S338-p sVEKPVssILsRtPs
0 18 S341-p KPVssILsRtPsVAK
0 17 T343-p VssILsRtPsVAKsP
0 68 S345-p sILsRtPsVAKsPEA
0 81 S349-p RtPsVAKsPEAKsPL
0 28 S354-p AKsPEAKsPLQsQPH
0 4 S358-p EAKsPLQsQPHsRMK
0 1 S362-p PLQsQPHsRMKPAGs
0 18 S369-p sRMKPAGsVNDMALD
  mouse

 
Y16-p ARASVMVyDDTSKKW
S20 VMVyDDTSKKWVPIK
Y39-p GFSRINIyHNTASST
S150 EQQHRQESLERRISA
S156 ESLERRISATGPILP
S169 LPPGHPSSAASTTLS
S240-p VQRPEDAsGGssPsG
S243-p PEDAsGGssPsGTSK
S244-p EDAsGGssPsGTSKS
S246-p AsGGssPsGTSKSDA
S257-p KSDANRAssGGGGGG
S258-p SDANRAssGGGGGGL
S281-p AKRRKAAsQTDKPAD
S294 ADRKEDESQTEDPsT
S300-p ESQTEDPsTsPsPGt
T301 SQTEDPsTsPsPGtR
S302-p QTEDPsTsPsPGtRA
S304-p EDPsTsPsPGtRATS
T307-p sTsPsPGtRATSQPP
S311 sPGtRATSQPPNSSE
S327-p GRKPWERsNsVEKPV
S329-p KPWERsNsVEKPVSS
S335 NsVEKPVSSLLsRtP
S336 sVEKPVSSLLsRtPs
S339-p KPVSSLLsRtPsVAK
T341-p VSSLLsRtPsVAKsP
S343-p SLLsRtPsVAKsPEA
S347-p RtPsVAKsPEAKsPL
S352-p AKsPEAKsPLQSQPH
S356 EAKsPLQSQPHSRVK
S360 PLQSQPHSRVKPAGs
S367-p SRVKPAGsVNDVGLD
  rat

 
Y16 ARASVMVYDDTSKKW
S20 VMVYDDTSKKWVPIK
Y39 GFSRINIYHNTASNT
S150 EQQHRQESLERRISA
S156 ESLERRISATGPILP
S169 LPPGHPSSAASATFS
S240 VQRPEDASGGSSPSG
S243 PEDASGGSSPSGTSK
S244 EDASGGSSPSGTSKS
S246 ASGGSSPSGTSKSDA
S257 KSDANRASSGGGGGG
S258 SDANRASSGGGGGGL
S281 AKRRKAASQTDKPAD
N294 ADRKEDENQTEDPST
S300 ENQTEDPSTsPSPGS
T301 NQTEDPSTsPSPGSR
S302-p QTEDPSTsPSPGSRA
S304 EDPSTsPSPGSRATS
S307 STsPSPGSRATSQPP
S311 SPGSRATSQPPNSSE
S327 GRKPWERSNsVEKPV
S329-p KPWERSNsVEKPVSS
S335 NsVEKPVSSLLSRVK
S336 sVEKPVSSLLSRVKP
S339 KPVSSLLSRVKPAGS
- gap
- gap
- gap
- gap
- gap
- gap
S346 SRVKPAGSVNDVGLD
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