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Protein Page:
ZNF198 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
ZNF198 a probable transcriptional regulator of the krueppel C2H2-type zinc-finger protein family. The translocation between FGFR and ZNF198 (8;13)(p11;q12) is oncogenic, causing stem cell leukemia lymphoma syndrome (SCLL), a myeloproliferative disorder (MPD) that evolves to acute myeloid leukemia and/or lymphoma. The transforming activity of ZNF198-FGFR1 requires the proline-rich domains, but not the ZNF domains, of ZNF198. Note: This description may include information from UniProtKB.
Protein type: Transcription factor
Cellular Component: PML body; cytosol
Molecular Function: zinc ion binding; ubiquitin conjugating enzyme binding
Biological Process: regulation of transcription, DNA-dependent; transcription, DNA-dependent
Reference #:  Q9UBW7 (UniProtKB)
Alt. Names/Synonyms: FIM; fused in myeloproliferative disorder; Fused in myeloproliferative disorders protein; MYM; RAMP; rearranged in an atypical myeloproliferative disorder; Rearranged in atypical myeloproliferative disorder protein; SCLL; Zinc finger MYM-type protein 2; Zinc finger protein 198; zinc finger, MYM-type 2; ZMYM2; ZNF198
Gene Symbols: ZMYM2
Molecular weight: 154,911 Da
Basal Isoelectric point: 5.95  Predict pI for various phosphorylation states
Select Structure to View Below

ZNF198

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 S46-p ANPLVSRsNKFQNSS
0 1 K104-ac SKITPSSkELASQKG
0 1 S114-p ASQKGSVsETIVIDD
0 2 P144 NFIERRPPETKNRTN
0 1 S159-p DVDFSTSsFSRSKVN
0 2 S303-p QKQPGVDsLsPVASL
0 18 S305-p QPGVDsLsPVASLPK
0 2 S309 DsLsPVASLPKQIFQ
0 1 S362-p CSTTCLSsFSHKPAP
0 4 Y502-p CQSCVSEyKQVGSHP
0 4 Y557-p QCIGPNGyMEPYCSt
0 1 T564-p yMEPYCStACMNsHK
0 1 S569-p CStACMNsHKTKYAK
0 4 Y595-p KRNSLPQyQATMPDG
0 2 Y605-p TMPDGKLyNFCNsSC
0 1 S610-p KLyNFCNsSCVAKFQ
0 1 S624-p QALSMQSsPNGQFVA
0 1 Y671 SKTCSDDYKKLHCIV
0 4 Y680-p KLHCIVTyCEyCQEE
0 5 Y683-p CIVTyCEyCQEEKTL
0 1 Y712-p SEGCKLLyKQDFARR
0 8 Y729-p LRCVTCNyCSQLCKK
0 1 Y800-p QHCLLRFyCQQNEPN
0 1 Y819 KGPENLHYDQGCQTS
0 2 T831-p QTSRTKMtGsAPPPs
0 1 S833-p SRTKMtGsAPPPsPt
0 8 S838-p tGsAPPPsPtPNKEM
0 2 T840-p sAPPPsPtPNKEMKN
0 3 Y862-p LTMTKATyCKPHMQT
0 1 K938 PAAIEELKSKVSSDA
0 1 S958-p LTMTDMMsEDEGkTE
1 0 K963-sm MMsEDEGkTETTNIN
0 1 Y1033-p PPVFGEEyEEQPRPR
0 5 S1056-p KAVSGYQsHDDssDN
0 2 S1060-p GYQsHDDssDNSECS
0 2 S1061-p YQsHDDssDNSECSF
0 1 S1064 HDDssDNSECSFPFK
0 2 K1099 LLVLDELKSSkSVKL
0 1 K1102-ac LDELKSSkSVKLKED
0 1 T1114-p KEDLLSHtTAELNYG
0 1 T1218-p SPVALLNtLFyFNtK
0 1 Y1221-p ALLNtLFyFNtKYFG
0 1 T1224-p NtLFyFNtKYFGLKT
0 1 T1253-p HWKKNPLtMENKACL
0 23 K1280-ac EDKITTGkRKHEDDE
0 1 K1362 LVRVLLVKDIYDKDN
0 13 T1376-p NYELDEDtD______
  mouse

 
S46 PNPLVSRSSKFQNSS
K104 PKILPSSKELAPQKG
S114 APQKGSVSETIVIDD
S144-p NFIERRPsETKNRTN
T159 DVDFSSSTFSRSKVN
S303-p QKQQGVDsLsPVAsL
S305-p QQGVDsLsPVAsLPK
S309-p DsLsPVAsLPKQIFQ
S361 CSTTCLSSFSHKPAP
Y501 CQSCVTEYKQVGSHP
Y556 QCIGPNGYMEPYCST
T563 YMEPYCSTACMNSHK
S568 CSTACMNSHKTKYAK
Y594-p KRNSLPQyQATMPDG
Y604 TMPDGKLYNFCNSSC
S609 KLYNFCNSSCVAKFQ
S623 QALSMQSSPNGQFVA
Y670-p SKTCSDDyKKLHCIV
Y679-p KLHCIVTyCEyCQEE
Y682-p CIVTyCEyCQEEKTL
Y711 SEGCKLLYKQDFARR
Y728-p LRCVTCNyCSQLCKK
Y799 QHCLLRFYCQQNEPN
Y818-p KGPENLHyDQGCQTS
T830 QTSRTKMTGSAPPPS
S832 SRTKMTGSAPPPSPT
S837 TGSAPPPSPTPNKEM
T839 SAPPPSPTPNKEMKN
Y861-p LTMTKATyCKPHMQT
K937-ub PATVEDLkSKVSSDP
T957 LTMTDMMTEEEGKAE
K962 MMTEEEGKAEASNIN
Y1032 PPVFGEEYEEQPRPR
S1055-p KAVSGYQsHDDssDN
S1059-p GYQsHDDssDNsECS
S1060-p YQsHDDssDNsECSF
S1063-p HDDssDNsECSFPFK
K1098-ub LLVLDELkSSKSVKL
K1101 LDELkSSKSVKLKED
T1113 KEDLLSHTTAELNYG
T1217 SPVALLNTLFYFNTK
Y1220 ALLNTLFYFNTKYFG
T1223 NTLFYFNTKYFGLKT
T1252 HWKKNPLTMENKACL
K1279-ac EDKIATGkRKHEDDE
K1361-ac LVRVLLVkDIYDKDN
T1375-p NYELDEDtD______
  rat

 
S182 PNPLVSRSSKFQNSS
K240 PKILPSSKELAPQKG
S250 APQKGSVSETIVIDD
S280 NFIERRPSETKNRTN
T295 DVDFSSSTFSRSKVN
S439 QKQQGVDSLsPVAsL
S441-p QQGVDSLsPVAsLPK
S445-p DSLsPVAsLPKQNFQ
S497 CSTTCLSSFSHKPAP
Y637 CQSCVSEYKQVGSHP
Y692 QCIGPNGYMEPYCST
T699 YMEPYCSTACMNSHK
S704 CSTACMNSHKTKYAK
Y730 KRNSLPQYQATMPDG
Y740 TMPDGKLYNFCNSSC
S745 KLYNFCNSSCVAKFQ
S759 QALSMQSSPNGQFVA
Y806 SRTCSDDYKKLHCIV
Y815 KLHCIVTYCEYCQEE
Y818 CIVTYCEYCQEEKTL
Y847 SEGCKLLYKQDFARR
Y864 LRCVTCNYCSQLCKK
- gap
- gap
T912 QTSRTKMTGSAPPPS
S914 SRTKMTGSAPPPSPT
S919 TGSAPPPSPTPNKEM
T921 SAPPPSPTPNKEMKN
Y943 LTMTKATYCKPHMQT
K1019 PASVEDLKSKVSSDP
T1039 LTMTDMMTEEEGKTE
K1044 MMTEEEGKTEASNIN
Y1114 PPVFGEEYEEQPRPR
S1137 KAVSGYQSHDDSSDN
S1141 GYQSHDDSSDNSECS
S1142 YQSHDDSSDNSECSF
S1145 HDDSSDNSECSFPFK
K1180 LLELDELKSSKSVKL
K1183 LDELKSSKSVKLKED
T1195 KEDLLSHTTAELNYG
T1299 SPVALLNTLFYFNTK
Y1302 ALLNTLFYFNTKYFG
T1305 NTLFYFNTKYFGLKT
T1334 HWKKNPLTMENKACL
K1361 EDKIATGKRKHEDDE
K1443 LVRVLLVKDIYDKDN
T1457 NYELDEDTD______
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