Home

HDAC6 (human)

Overview HDAC6 Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Plays a central role in microtubule-dependent cell motility via deacetylation of tubulin. Interacts with CBFA2T3, HDAC11 and SIRT2. Interacts with F-actin. Interacts with BBIP10. Under proteasome impairment conditions, interacts with UBD via its histone deacetylase 1 and UBP-type zinc-finger regions. Interacts with CYLD. Interacts with ZMYND15. Belongs to the histone deacetylase family. HD type 2 subfamily. Note: This description may include information from UniProtKB. Protein type: Deacetylase; EC 3.5.1.98; Ubiquitin conjugating system Cellular Component: microtubule; leading edge; histone deacetylase complex; caveola; inclusion body; cytosol; dynein complex; microtubule associated complex; cytoplasmic microtubule; perinuclear region of cytoplasm; cytoplasm; nucleolus; nucleus Molecular Function: zinc ion binding; histone deacetylase binding; microtubule binding; beta-catenin binding; beta-tubulin binding; Hsp90 protein binding; actin binding; protein binding; NAD-dependent histone deacetylase activity (H3-K9 specific); enzyme binding; tubulin deacetylase activity; NAD-dependent histone deacetylase activity (H3-K14 specific); NAD-dependent histone deacetylase activity (H4-K16 specific); polyubiquitin binding; histone deacetylase activity; tau protein binding; alpha-tubulin binding Biological Process: negative regulation of proteolysis; response to misfolded protein; protein polyubiquitination; transcription, DNA-dependent; positive regulation of signal transduction; ubiquitin-dependent protein catabolic process via the multivesicular body pathway; negative regulation of microtubule depolymerization; positive regulation of apoptosis; macroautophagy; response to toxin; misfolded or incompletely synthesized protein catabolic process; histone deacetylation; response to organic substance; intracellular protein transport; protein complex disassembly; lysosome localization; protein amino acid deacetylation; negative regulation of oxidoreductase activity; regulation of receptor activity; negative regulation of transcription, DNA-dependent; negative regulation of protein complex disassembly Reference #:  Q9UBN7 (UniProtKB) Alt. Names/Synonyms: FLJ16239; HD6; HDAC6; Histone deacetylase 6; JM21; KIAA0901 Gene Symbols: HDAC6 Molecular weight: 131,419 Da Basal Isoelectric point: 5.14  Predict pI for various phosphorylation states CST Pathways:  Cell Cycle: G1/S Checkpoint  |  NF-kB Signaling  |  Protein Acetylation  |  Wnt/ß-Catenin Signaling Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below HDAC6 3C5K - A=1109-1215 (human) 3GV4 - A=1109-1215 (human) 3PHD - A/D/C/B=1109-1215 (human)

STRING  |  Scansite  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  RCSB PDB 3C5K 3GV4 3PHD  |  ENZYME  |  Phospho3D  |  DISEASE  |  Source  |  UCSD-Nature  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene

	Sites Implicated In
enzymatic activity, inhibited: Y570‑p

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	1		S16	TTTRQRRSRQNPQsP
1	29		S22-p	RSRQNPQsPPQDSSV
0	1		S28	QsPPQDSSVtSKRNI
0	1		T30-p	PPQDSSVtSKRNIkk
0	1		K36-a	VtSKRNIkkGAVPRS
0	1		K37-a	tSKRNIkkGAVPRSI
0	1		S43	kkGAVPRSIPNLAEV
0	3		I44	kGAVPRSIPNLAEVK
0	1		G60	KGKMKKLGQAMEEDL
0	1		G108	WDDSFPEGPERLHAI
0	1		K116-u	PERLHAIkEQLIQEG
1	0		S458-p	EEDNVEEsEEEGPWE
1	1		Y570-p	SSNFDSIyICPSTFA
0	1		S846-p	VEDREGPssSkLVTk
0	2		S847-p	EDREGPssSkLVTkk
0	2		K849-a	REGPssSkLVTkkAP
0	2		K853-a	ssSkLVTkkAPQPAK
0	2		K854-a	sSkLVTkkAPQPAKP
0	1		K860	kkAPQPAKPRLAERM
0	1		T868-p	PRLAERMtTREKKVL
0	1		T1021	GGTELIQTPLASSTD
0	2		S1062-p	TLELGSEsQGASESQ
0	1		D1088-ca	AGGQDMAdSMLMQGS
0	1		D1100	QGSRGLTDQAIFYAV
0	3		P1214	FGEDMPHPH______

	mouse
S15-p	SSTRQRKsRHNPQsP
S21-p	KsRHNPQsPLQESsA
S27-p	QsPLQESsATLKRGG
T29	PLQESsATLKRGGKK
K35	ATLKRGGKKCAVPHs
K36	TLKRGGKKCAVPHss
S42-p	KKCAVPHssPNLAEV
S43-p	KCAVPHssPNLAEVK
S59-p	KGKMKKLsQPAEEDL
S107-p	WDDSFPEsPERLHAI
R115	PERLHAIREQLILEG
E457	EEAVLEEEEEEGGWE
Y569	GANFDSIYICPSTFA
S845	MEDKEECSSSRLVIK
S846	EDKEECSSSRLVIKK
R848	KEECSSSRLVIKKLP
K852	SSSRLVIKKLPPTAs
K853	SSRLVIKKLPPTAsP
S859-p	KKLPPTAsPVSAKEM
T867	PVSAKEMTTPKGKVP
T961-p	ALGETEPtPPASHTN
A1000	TLELSREAEEAHDSE
S1022	AGGQDMNSLMLTQGF
T1034-p	QGFGDFNtQDVFYAV
S1148-p	FGEDMPHsH______

	rat
S15	SSTRQRKSRHNPQsP
S21-p	KSRHNPQsPLQDSSA
S27	QsPLQDSSATLKRGG
T29	PLQDSSATLKRGGKK
K35	ATLKRGGKKGAVPHS
K36	TLKRGGKKGAVPHSS
S42	KKGAVPHSSPNLAEV
S43	KGAVPHSSPNLAEVK
S59	KGKMKKLSQPAEEDL
N107	WDDSFPENPERLHAI
K115	PERLHAIKEQLILEG
E457	EGDMLEDEEEEGHWE
Y569	GANFESIYICPSTFA
S845	MEDKEERSSSRLVIK
S846	EDKEERSSSRLVIKK
R848	KEERSSSRLVIKKLP
K852	SSSRLVIKKLPQSAS
K853	SSRLVIKKLPQSASP
S859	KKLPQSASPVSAKGM
T867	PVSAKGMTTPKGKVL
T964	GETESFGTSPSSNAS
A1003	TLELSSEAQEVQESE
S1025	AGGQDMNSLMLTQGF
T1037	QGFGDFNTQDVFYAV
L1151	FGEGMPHLQ______

Home  |  Curator Login With enhanced literature mining using Linguamatics I2E Produced by 3rd Millennium  |  Design by Digizyme ©2003-2013 Cell Signaling Technology, Inc.