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Protein Page:
HDAC6 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
HDAC6 Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Plays a central role in microtubule-dependent cell motility via deacetylation of tubulin. Interacts with CBFA2T3, HDAC11 and SIRT2. Interacts with F-actin. Interacts with BBIP10. Under proteasome impairment conditions, interacts with UBD via its histone deacetylase 1 and UBP-type zinc-finger regions. Interacts with CYLD. Interacts with ZMYND15. Belongs to the histone deacetylase family. HD type 2 subfamily. Note: This description may include information from UniProtKB.
Protein type: EC 3.5.1.98; Ubiquitin conjugating system; Deacetylase
Cellular Component: microtubule; histone deacetylase complex; leading edge; dendrite; perikaryon; caveola; inclusion body; cytosol; dynein complex; microtubule associated complex; axon; perinuclear region of cytoplasm; cytoplasmic microtubule; cytoplasm; nucleus
Molecular Function: zinc ion binding; histone deacetylase binding; microtubule binding; beta-tubulin binding; beta-catenin binding; Hsp90 protein binding; actin binding; protein binding; NAD-dependent histone deacetylase activity (H3-K9 specific); enzyme binding; tubulin deacetylase activity; NAD-dependent histone deacetylase activity (H3-K14 specific); NAD-dependent histone deacetylase activity (H4-K16 specific); polyubiquitin binding; histone deacetylase activity; tau protein binding; alpha-tubulin binding
Biological Process: negative regulation of proteolysis; response to misfolded protein; protein polyubiquitination; ubiquitin-dependent protein catabolic process via the multivesicular body pathway; transcription, DNA-dependent; positive regulation of signal transduction; macroautophagy; negative regulation of microtubule depolymerization; response to toxin; misfolded or incompletely synthesized protein catabolic process; histone deacetylation; response to organic substance; intracellular protein transport; protein complex disassembly; lysosome localization; protein amino acid deacetylation; negative regulation of oxidoreductase activity; regulation of receptor activity; negative regulation of transcription, DNA-dependent; negative regulation of protein complex disassembly
Reference #:  Q9UBN7 (UniProtKB)
Alt. Names/Synonyms: FLJ16239; HD6; HDAC6; Histone deacetylase 6; JM21; KIAA0901
Gene Symbols: HDAC6
Molecular weight: 131,419 Da
Basal Isoelectric point: 5.14  Predict pI for various phosphorylation states
CST Pathways:  Crosstalk between PTMs  |  G1/S Checkpoint  |  NF-kB Signaling  |  Protein Acetylation  |  Wnt/├č-Catenin Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

HDAC6

Protein Structure Not Found.


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Sites Implicated In
cell motility, induced: S1035‑p
enzymatic activity, induced: S1035‑p
enzymatic activity, inhibited: Y570‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 2 S16-p TTTRQRRsRQNPQsP
1 33 S22-p RsRQNPQsPPQDSsV
0 2 S28-p QsPPQDSsVtSKRNI
0 1 T30-p PPQDSsVtSKRNIkk
0 1 R33 DSsVtSKRNIkkGAV
0 1 K36-ac VtSKRNIkkGAVPRS
0 1 K37-ac tSKRNIkkGAVPRSI
0 1 S43 kkGAVPRSIPNLAEV
0 4 I44 kGAVPRSIPNLAEVK
0 1 G60 KGKMKKLGQAMEEDL
0 1 G108 WDDSFPEGPERLHAI
0 1 K116-ub PERLHAIkEQLIQEG
1 0 S458-p EEDNVEEsEEEGPWE
1 1 Y570-p SSNFDSIyICPSTFA
0 1 S846-p VEDREGPssSkLVTk
0 2 S847-p EDREGPssSkLVTkk
0 2 K849-ac REGPssSkLVTkkAP
0 2 K853-ac ssSkLVTkkAPQPAK
0 2 K854-ac sSkLVTkkAPQPAKP
0 1 K860 kkAPQPAKPRLAERM
0 1 T868-p PRLAERMtTREKKVL
0 1 T923-p GGATLAQtIsEAAIG
0 1 S925-p ATLAQtIsEAAIGGA
0 1 T966 GAILDQTTSEDAVGG
0 1 S967 AILDQTTSEDAVGGA
0 1 T993-p GGATLAQtTsEAAME
0 1 S995-p ATLAQtTsEAAMEGA
0 1 T1003-p EAAMEGAtLDQTTSE
0 1 T1016-p SEEAPGGtELIQtPL
0 2 T1021-p GGtELIQtPLASStD
0 1 T1027-p QtPLASStDHQtPPt
1 2 T1031-p ASStDHQtPPtsPVQ
0 1 T1034-p tDHQtPPtsPVQGtt
1 2 S1035-p DHQtPPtsPVQGttP
0 1 T1040-p PtsPVQGttPQISPS
0 1 T1041-p tsPVQGttPQISPSt
0 1 T1048-p tPQISPStLIGSLRt
0 1 T1055-p tLIGSLRtLELGSEs
0 2 S1062-p tLELGSEsQGASESQ
0 1 D1088-ca AGGQDMAdSMLMQGS
0 1 D1100 QGSRGLTDQAIFYAV
0 3 P1214 FGEDMPHPH______
  mouse

 
S15-p SSTRQRKsRHNPQsP
S21-p KsRHNPQsPLQESsA
S27-p QsPLQESsATLKrGG
T29 PLQESsATLKrGGKK
R32-m1 ESsATLKrGGKKCAV
K35 ATLKrGGKKCAVPHs
K36 TLKrGGKKCAVPHss
S42-p KKCAVPHssPNLAEV
S43-p KCAVPHssPNLAEVK
S59-p KGKMKKLsQPAEEDL
S107-p WDDSFPEsPERLHAI
R115 PERLHAIREQLILEG
E457 EEAVLEEEEEEGGWE
Y569 GANFDSIYICPSTFA
S845 MEDKEECSSSRLVIK
S846 EDKEECSSSRLVIKK
R848 KEECSSSRLVIKKLP
K852 SSSRLVIKKLPPTAs
K853 SSRLVIKKLPPTAsP
S859-p KKLPPTAsPVSAKEM
T867 PVSAKEMTTPKGKVP
- gap
- gap
S909-p AVLAQGQssEQAAKG
S910-p VLAQGQssEQAAKGT
W936 GGATTDLWASAAAPE
S938 ATTDLWASAAAPENF
F945 SAAAPENFPNQTTSV
T958 SVEALGETEPtPPAS
T961-p ALGETEPtPPASHTN
T967 PtPPASHTNKQTTGA
T971 ASHTNKQTTGASPLQ
A974 TNKQTTGASPLQGVT
S975 NKQTTGASPLQGVTA
V980 GASPLQGVTAQQSLQ
T981 ASPLQGVTAQQSLQL
- gap
T993 LQLGVLSTLELSREA
A1000 TLELSREAEEAHDSE
- gap
T1034-p QGFGDFNtQDVFYAV
S1148-p FGEDMPHsH______
  rat

 
S15 SSTRQRKSRHNPQsP
S21-p KSRHNPQsPLQDSSA
S27 QsPLQDSSATLKRGG
T29 PLQDSSATLKRGGKK
R32 DSSATLKRGGKKGAV
K35 ATLKRGGKKGAVPHS
K36 TLKRGGKKGAVPHSS
S42 KKGAVPHSSPNLAEV
S43 KGAVPHSSPNLAEVK
S59 KGKMKKLSQPAEEDL
N107 WDDSFPENPERLHAI
K115 PERLHAIKEQLILEG
E457 EGDMLEDEEEEGHWE
Y569 GANFESIYICPSTFA
S845 MEDKEERSSSRLVIK
S846 EDKEERSSSRLVIKK
R848 KEERSSSRLVIKKLP
K852 SSSRLVIKKLPQSAS
K853 SSRLVIKKLPQSASP
S859 KKLPQSASPVSAKGM
T867 PVSAKGMTTPKGKVL
- gap
- gap
S909 ALLAQGQSSEQAAKG
S910 LLAQGQSSEQAAKGT
C936 GGATTDQCASVAATE
S938 ATTDQCASVAATENS
S945 SVAATENSANQTTSG
T959 GEEASGETESFGTSP
T964 GETESFGTSPSSNAS
A970 GTSPSSNASKQTTGA
T974 SSNASKQTTGASPLH
A977 ASKQTTGASPLHGAA
S978 SKQTTGASPLHGAAA
A983 GASPLHGAAAQQSPE
A984 ASPLHGAAAQQSPEL
- gap
T996 PELGLSSTLELSSEA
A1003 TLELSSEAQEVQESE
- gap
T1037 QGFGDFNTQDVFYAV
L1151 FGEGMPHLQ______
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