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Protein Page:
FGFR1 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
FGFR1 a receptor tyrosine kinase of the highly-conserved fibroblast growth factor receptor (FGFR). Binds both acidic and basic fibroblast growth factors and is involved in limb induction. Point mutations cause Pfeffer syndrome (finger and toe malformations and other skeletal errors) and dominant Kallmann syndrome 2. Stem cell leukemia lymphoma syndrome (SCLL) may be caused by a t(8;13)(p12;q12) translocation that fuses a zinc finger gene, ZNF198, to FGFR1. Various myeloproliferative disorders have been linked to translocations that fuse FGFR1 to FOP, FIM, CEP1 or the atypical kinase, Bcr. Inhibitor: SU5402. 18 isoforms of the human protein produced by alternative splicing have been described. Note: This description may include information from UniProtKB.
Protein type: Protein kinase, tyrosine (receptor); Protein kinase, TK; EC 2.7.10.1; Kinase, protein; Membrane protein, integral; TK group; FGFR family
Cellular Component: integral to plasma membrane; cytoplasmic membrane-bound vesicle; extracellular region; plasma membrane; integral to membrane; nucleus; cytosol; receptor complex
Molecular Function: heparin binding; identical protein binding; protein binding; fibroblast growth factor binding; protein homodimerization activity; fibroblast growth factor receptor activity; protein-tyrosine kinase activity; ATP binding
Biological Process: paraxial mesoderm development; axon guidance; peptidyl-tyrosine phosphorylation; nerve growth factor receptor signaling pathway; protein amino acid autophosphorylation; cell maturation; neuron migration; negative regulation of transcription from RNA polymerase II promoter; middle ear morphogenesis; protein amino acid phosphorylation; positive regulation of MAP kinase activity; sensory perception of sound; positive regulation of MAPKKK cascade; ureteric bud development; induction of an organ; regulation of cell differentiation; positive regulation of mesenchymal cell proliferation; positive regulation of cell proliferation; midbrain development; chondrocyte differentiation; angiogenesis; skeletal development; embryonic limb morphogenesis; positive regulation of cardiac muscle cell proliferation; epidermal growth factor receptor signaling pathway; inner ear morphogenesis; cell migration; phosphoinositide-mediated signaling; chordate embryonic development; fibroblast growth factor receptor signaling pathway; transcription, DNA-dependent; in utero embryonic development; outer ear morphogenesis; MAPKKK cascade; positive regulation of cell cycle; positive regulation of phosphoinositide 3-kinase cascade; neuroblast division in the ventricular zone; mesenchymal cell differentiation; skeletal morphogenesis; insulin receptor signaling pathway; innate immune response; auditory receptor cell development; positive regulation of neuron differentiation; regulation of lateral mesodermal cell fate specification
Reference #:  P11362 (UniProtKB)
Alt. Names/Synonyms: Basic fibroblast growth factor receptor 1; bFGF-R-1; BFGFR; CD331; CEK; FGFBR; FGFR-1; FGFR1; fibroblast growth factor receptor 1; FLG; FLJ99988; FLT-2; FLT2; Fms-like tyrosine kinase 2; fms-related tyrosine kinase 2; HBGFR; heparin-binding growth factor receptor; KAL2; N-SAM; OGD; Proto-oncogene c-Fgr; soluble FGFR1 variant 1; soluble FGFR1 variant 2
Gene Symbols: FGFR1
Molecular weight: 91,868 Da
Basal Isoelectric point: 5.82  Predict pI for various phosphorylation states
CST Pathways:  Angiogenesis  |  ESC Pluripotency and Differentiation  |  Tyrosine Kinases & Substrates
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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FGFR1

Protein Structure Not Found.

Substrate Sequence Logo
Sequence Logo

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Sites Implicated In
apoptosis, inhibited: S779‑p
cell cycle regulation: Y463‑p, Y730‑p
cell differentiation, altered: Y653‑p, Y654‑p
cell differentiation, induced: S779‑p
cell growth, altered: Y463‑p, Y653‑p, Y654‑p
cell growth, inhibited: S777‑p
cell motility, altered: Y653‑p, Y654‑p
cell motility, inhibited: S777‑p
cytoskeletal reorganization: Y154‑p
transcription, altered: Y463‑p, Y730‑p
enzymatic activity, induced: Y653‑p, Y654‑p
intracellular localization: S777‑p
molecular association, regulation: Y463‑p, Y677‑p, Y766‑p
phosphorylation: Y653‑p, Y654‑p
protein degradation: Y154‑p
receptor desensitization, altered: Y154‑p
receptor internalization, altered: Y154‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

► Hide Isoforms
 
0 1 S76 DGVQLAESNRTRITG
0 1 S91-p EEVEVQDsVPADSGL
2 1 Y154-p NRMPVAPyWTSPEKM
0 1 K164-ac SPEKMEKkLHAVPAA
0 1 K172-ac LHAVPAAkTVKFKCP
0 1 S180 TVKFKCPSSGTPNPT
0 1 K198 LKNGKEFKPDHRIGG
1 1 Y210-p IGGYKVRyATWSIIM
1 1 Y280-p VEFMCKVySDPQPHI
1 1 Y307-p IGPDNLPyVQILKTA
0 1 S410-p TKKSDFHsQMAVHKL
0 7 T428-p IPLRRQVtVSADSSA
0 1 S439-p DSSASMNsGVLLVRP
0 2 S447-p GVLLVRPsRLsssGt
0 9 S450-p LVRPsRLsssGtPML
0 7 S451-p VRPsRLsssGtPMLA
0 4 S452-p RPsRLsssGtPMLAG
0 1 T454-p sRLsssGtPMLAGVS
6 8 Y463-p MLAGVSEyELPEDPR
0 1 K482-ub RDRLVLGkPLGEGCF
0 2 Y572-p SKGNLREyLQARRPP
4 63 Y583-p RRPPGLEyCyNPsHN
4 41 Y585-p PPGLEyCyNPsHNPE
0 2 S588-p LEyCyNPsHNPEEQL
1 13 Y605-p KDLVSCAyQVARGME
0 6 Y613-p QVARGMEyLASKKCI
0 1 K638-ub VTEDNVMkIADFGLA
10 319 Y653-p RDIHHIDyyKKTTNG
10 180 Y654-p DIHHIDyyKKTTNGR
2 0 Y677-p EALFDRIyTHQSDVW
1 0 Y701 FTLGGSPYPGVPVEE
5 2 Y730-p SNCTNELyMMMRDCW
0 2 K748-ub PSQRPTFkQLVEDLD
8 0 Y766-p ALTSNQEyLDLSMPL
2 1 Y776-p LSMPLDQysPsFPDT
3 0 S777-p SMPLDQysPsFPDTR
1 0 S779-p PLDQysPsFPDTRSS
1 1 S789-p DTRSSTCsSGEDSVF
0 1 S790 TRSSTCsSGEDSVFS
3471 : Phospho-FGF Receptor (Tyr653/654) Antibody
3476 : Phospho-FGF Receptor (Tyr653/654) (55H2) Mouse mAb
3471 : Phospho-FGF Receptor (Tyr653/654) Antibody
3476 : Phospho-FGF Receptor (Tyr653/654) (55H2) Mouse mAb
2544 : Phospho-FGF Receptor 1 (Tyr766) (1E5) Rabbit mAb
  FGFR1 iso21  
S109 DGVQLAESNRTRITG
S124 EEVEVQDSVPADSGL
Y185 KPNPVAPYWTSPEKM
K195 SPEKMEKKLHAVPAA
K203 LHAVPAAKTVKFKCP
S211 TVKFKCPSSGTPNPT
K229 LKNGKEFKPDHRIGG
Y241 IGGYKVRYATWSIIM
Y311 VEFMCKVYSDPQPHI
Y338 IGPDNLPYVQILKTA
S441 TKKSDFHSQMAVHKL
T459 IPLRRQVTVSADSSA
S470 DSSASMNSGVLLVRP
S478 GVLLVRPSRLSSSGT
S481 LVRPSRLSSSGTPML
S482 VRPSRLSSSGTPMLA
S483 RPSRLSSSGTPMLAG
T485 SRLSSSGTPMLAGVS
Y494 MLAGVSEYELPEDPR
K513 RDRLVLGKPLGEGCF
Y603 SKGNLREYLQARRPP
Y614 RRPPGLEYCYNPSHN
Y616 PPGLEYCYNPSHNPE
S619 LEYCYNPSHNPEEQL
Y636 KDLVSCAYQVARGME
Y644 QVARGMEYLASKKCI
K669 VTEDNVMKIADFGLA
Y684 RDIHHIDYYKKTTNG
Y685 DIHHIDYYKKTTNGR
Y708 EALFDRIYTHQSDVW
Y732 FTLGGSPYPGVPVEE
Y761 SNCTNELYMMMRDCW
K779 PSQRPTFKQLVEDLD
Y797 ALTSNQEYLDLSMPL
Y807 LSMPLDQYSPSFPDT
S808 SMPLDQYSPSFPDTR
S810 PLDQYSPSFPDTRSS
S820 DTRSSTCSSGEDSVF
S821 TRSSTCSSGEDSVFS
  mouse

 
S76-p DGVQLVEsNRTRITG
S91 EEVEVRDSIPADSGL
Y154 NRRPVAPYWTSPEKM
K164 SPEKMEKKLHAVPAA
K172 LHAVPAAKTVKFKCP
S180-p TVKFKCPsSGTPNPT
K198-ub LKNGKEFkPDHRIGG
Y210 IGGYKVRYATWSIIM
Y280 VEFMCKVYSDPQPHI
Y307 IGPDNLPYVQILKTA
S410 TKKSDFHSQMAVHKL
T428 IPLRRQVTVSADSSA
S439 DSSASMNSGVLLVRP
S447 GVLLVRPSRLSSSGT
S450 LVRPSRLSSSGTPML
S451 VRPSRLSSSGTPMLA
S452 RPSRLSSSGTPMLAG
T454 SRLSSSGTPMLAGVS
Y463 MLAGVSEYELPEDPR
K482 RDRLVLGKPLGEGCF
Y572 SKGNLREYLQARRPP
Y583-p RRPPGLEyCyNPSHN
Y585-p PPGLEyCyNPSHNPE
S588 LEyCyNPSHNPEEQL
Y605-p KDLVSCAyQVARGME
Y613-p QVARGMEyLASKKCI
K638 VTEDNVMKIADFGLA
Y653-p RDIHHIDyyKKTTNG
Y654-p DIHHIDyyKKTTNGR
Y677 EALFDRIYTHQSDVW
Y701 FTLGGSPYPGVPVEE
Y730 SNCTNELYMMMRDCW
K748 PSQRPTFKQLVEDLD
Y766-p ALTSNQEyLDLSIPL
Y776 LSIPLDQYSPSFPDT
S777 SIPLDQYSPSFPDTR
S779 PLDQYSPSFPDTRSS
S789-p DTRSSTCssGEDSVF
S790-p TRSSTCssGEDSVFS
3471 : Phospho-FGF Receptor (Tyr653/654) Antibody
3476 : Phospho-FGF Receptor (Tyr653/654) (55H2) Mouse mAb
3471 : Phospho-FGF Receptor (Tyr653/654) Antibody
3476 : Phospho-FGF Receptor (Tyr653/654) (55H2) Mouse mAb
  rat

► Hide Isoforms
 
- gap
- gap
Y63 KPNPVAPYWTSPEKM
K73 SPEKMEKKLHAVPAA
K81 LHAVPAAKTVKFKCP
S89 TVKFKCPSSGTPSPT
K107 LKNGKEFKPDHRIGG
Y119 IGGYKVRYATWSIIM
Y189 VEFMCKVYSDPQPHI
Y216 IGPDNLPYVQILKTA
S319 TKKSDFHSQMAVHKL
- gap
S346 DSSASMNSGVLLVRP
S354 GVLLVRPSRLSSSGT
S357 LVRPSRLSSSGTPML
S358 VRPSRLSSSGTPMLA
S359 RPSRLSSSGTPMLAG
T361 SRLSSSGTPMLAGVS
Y370 MLAGVSEYELPEDPR
K389 RDRLVLGKPLGEGCF
Y479 SKGNLREYLQARRPP
Y490 RRPPGLEYCYNPSHN
Y492 PPGLEYCYNPSHNPE
S495 LEYCYNPSHNPEEQL
Y512 KDLVSCAYQVARGME
Y520 QVARGMEYLASKKCI
K545 VTEDNVMKIADFGLA
Y560-p RDIHHIDyyKKTTNG
Y561-p DIHHIDyyKKTTNGR
Y584-p EALFDRIyTHQSDVW
Y608-p FTLGGSPyPGVPVEE
Y637-p SNCTNELyMMMRDCW
K655 PSQRPTFKQLVEDLD
Y673-p ALTSNQEyLDLSMPL
Y683-p LSMPLDQySPSFPDT
S684 SMPLDQySPSFPDTR
S686 PLDQySPSFPDTRSS
S696 DTRSSTCSSGEDSVF
S697 TRSSTCSSGEDSVFS
  FGFR1 iso2  
S76 DGVQLAESNRTRITG
S91 EEVEVRDSIPADSGL
Y154 NRRPVAPYWTSPEKM
K164 SPEKMEKKLHAVPAA
K172 LHAVPAAKTVKFKCP
S180 TVKFKCPSSGTPSPT
K198 LKNGKEFKPDHRIGG
Y210 IGGYKVRYATWSIIM
Y280 VEFMCKVYSDPQPHI
Y307 IGPDNLPYDQILKTA
S410 TKKSDFHSQMAVHKL
T428 IPLRRQVTVSADSSA
S439 DSSASMNSGVLLVRP
S447 GVLLVRPSRLSSSGT
S450 LVRPSRLSSSGTPML
S451 VRPSRLSSSGTPMLA
S452 RPSRLSSSGTPMLAG
T454 SRLSSSGTPMLAGVS
Y463 MLAGVSEYELPEDPR
K482 RDRLVLGKPLGEGCF
Y572 SKGNLREYLQARRPP
Y583 RRPPGLEYCYNPSHN
Y585 PPGLEYCYNPSHNPE
S588 LEYCYNPSHNPEEQL
Y605 KDLVSCAYQVARGME
Y613 QVARGMEYLASKKCI
K638 VTEDNVMKIADFGLA
Y653 RDIHHIDYYKKTTNG
Y654 DIHHIDYYKKTTNGR
Y677 EALFDRIYTHQSDVW
N701 FTLGGSPNPGVPVEE
Y730 SNCTNELYMMMRDCW
K748 PSQRPTFKQLVEDLD
Y766 ALTSNQEYLDLSMPL
D776 LSMPLDQDSPSFPDT
S777 SMPLDQDSPSFPDTR
S779 PLDQDSPSFPDTRSS
S789 DTRSSTCSSGEDSVF
S790 TRSSTCSSGEDSVFS
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