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Protein Page:
CHD-7 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
CHD-7 Probable transcription regulator. May interact with CTCF. Interacts with CHD8. Widely expressed in fetal and adult tissues. Belongs to the SNF2/RAD54 helicase family. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Nucleolus; EC 3.6.4.12; EC 3.6.1.-; Helicase; DNA binding protein
Cellular Component: nucleolus; nucleus
Molecular Function: protein binding; DNA binding; chromatin binding; helicase activity; ATP binding
Biological Process: heart morphogenesis; limb development; central nervous system development; blood circulation; positive regulation of multicellular organism growth; palate development; female genitalia development; embryonic hindlimb morphogenesis; adult walking behavior; regulation of growth hormone secretion; sensory perception of sound; regulation of transcription, DNA-dependent; skeletal development; T cell differentiation; adult heart development; inner ear morphogenesis; transcription, DNA-dependent; in utero embryonic development; cranial nerve development; semicircular canal morphogenesis; chromatin modification; genitalia development; retina development in camera-type eye; artery morphogenesis; cognition; nose development; rRNA processing
Reference #:  Q9P2D1 (UniProtKB)
Alt. Names/Synonyms: ATP-dependent helicase CHD7; CHD-7; CHD7; chromodomain helicase DNA binding protein 7; chromodomain helicase DNA binding protein 7 isoform CRA_e; Chromodomain-helicase-DNA-binding protein 7; FLJ20357; FLJ20361; IS3; KAL5; KIAA1416
Gene Symbols: CHD7
Molecular weight: 335,927 Da
Basal Isoelectric point: 5.95  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

CHD-7

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 2 Y75-p HFDHYNQyEQQKMHL
0 1 R148-m1 SSSMWGPrAVQVPDQ
0 1 S199-p YMARGDFsMQQHGQP
0 1 R209-m1 QHGQPQQrMSQFSQG
0 1 R286 PPQQGAVRPQTLNFS
0 1 T298 NFSSRSQTVPSPTIN
0 1 S307 PSPTINNSGQYSRYP
0 1 Y313 NSGQYSRYPYSNLNQ
0 1 Y315 GQYSRYPYSNLNQGL
0 1 S316 QYSRYPYSNLNQGLV
0 1 N325 LNQGLVNNTGMNQNL
0 1 N337 QNLGLTNNTPMNQSV
0 1 T338 NLGLTNNTPMNQSVP
0 1 S343 NNTPMNQSVPRYPNA
0 1 S557-p KVPVHQHsPsEPFLE
0 1 S559-p PVHQHsPsEPFLEKP
0 1 S612-p HIVAEDPsKGFGKDD
0 2 S633 NQELNRNSLDGsQEE
0 2 S637-p NRNSLDGsQEEKKKK
0 1 T689-p EKKAKTAtPKPKSSK
0 1 S708-p KKPDSEAsALKKKVN
0 2 S722-p NKGKTEGsENsDLDK
0 3 S725-p KTEGsENsDLDKTPP
0 3 T730 ENsDLDKTPPPsPPP
0 4 S734-p LDKTPPPsPPPEEDE
0 1 S807 PVVEKIMSSRSVKKQ
0 1 S808 VVEKIMSSRSVKKQK
0 1 K934-ub AKIEEFEkLMSREPE
0 1 K1111 IDEAHRLKNRNCKLL
0 1 K1116 RLKNRNCKLLEGLKM
1 0 K1196-sm RLKEDVEkNLAPKEE
0 1 T1204-p NLAPKEEtIIEVELT
0 1 Y1217-p LTNIQKKyyRAILEK
0 1 Y1218-p TNIQKKyyRAILEKN
1 1 T1227-p AILEKNFtFLSKGGG
0 1 R1308-m1 KLKAGGHrVLIFSQM
0 1 R1317-m1 LIFSQMVrCLDILED
0 1 T1449-p MSGRENAtNGVQQLs
0 1 S1456-p tNGVQQLsKKEIEDL
0 1 S1502 THTITIESEGKGSTF
0 12 T1555-p RNNLVIDtPRVRKQT
0 1 S1566-p RKQTRLYsAVKEDEL
0 8 S1577-p EDELMEFsDLEsDsE
0 7 S1581-p MEFsDLEsDsEEKPC
0 1 S1583-p FsDLEsDsEEKPCAK
0 1 K1694 APVPRGRKGKKVKAQ
0 1 K1696 VPRGRKGKKVKAQST
0 1 K1697 PRGRKGKKVKAQSTQ
0 6 S1874-p EIDEFANsPSEDKEE
0 1 S1882 PSEDKEESMEIHATG
0 1 K2005 RAFARLDKKSDESLE
0 1 S2110 GAAKHGVSRTDYHIL
0 4 T2153-p LAVGFVQtPPVISSA
0 1 S2231-p GADTGSKsIsEKGsE
0 1 S2233-p DTGSKsIsEKGsEED
0 1 K2235 GSKsIsEKGsEEDEE
0 1 S2237-p KsIsEKGsEEDEEEK
0 2 S2251-p KLEDDDKsEEssQPE
0 1 S2254-p DDDKsEEssQPEAGA
0 1 S2255-p DDKsEEssQPEAGAV
0 6 S2272-p GKNFDEEsNAsMstA
0 6 S2275-p FDEEsNAsMstARDE
0 2 S2277-p EEsNAsMstARDETR
0 2 T2278-p EsNAsMstARDETRD
0 7 T2283 MstARDETRDGFYME
0 1 Y2349-p FQGLIPGytPtTVDs
0 2 T2350-p QGLIPGytPtTVDsP
0 1 T2352-p LIPGytPtTVDsPLQ
0 3 S2356-p ytPtTVDsPLQKRSF
0 1 S2395-p KEDALNLsVPRQRRR
1 1 S2471-p KFILPNVstPVSDAF
1 7 T2472-p FILPNVstPVSDAFK
0 1 T2492-p LQAGLSRtPTRHLLN
0 1 T2532-p LFMSHKRtsLsAEDA
0 4 S2533-p FMSHKRtsLsAEDAE
0 1 S2535-p SHKRtsLsAEDAEVt
0 4 T2542-p sAEDAEVtKAFEEDI
0 30 T2551-p AFEEDIEtPPtRNIP
0 1 T2554-p EDIEtPPtRNIPsPG
0 18 S2559-p PPtRNIPsPGQLDPD
0 1 Y2601-p WLKLHPTyTVDMPSy
0 1 Y2608-p yTVDMPSyVPKNADV
0 1 S2619-p NADVLFSsFQKPKQK
0 1 T2640-p PNKLDINtLTGEERV
0 10 S2956-p DGETLEGsDAEEsLD
0 4 S2961-p EGsDAEEsLDKTAES
0 1 S2983-p AQGEELDsLDGGDEI
  mouse

 
Y75 HFDHYSQYEQKMHLM
R147 GGSMWGPRAVQVPDQ
S193 YLARGDFSMQQHGQP
R203 QHGQPQQRMGQFSQG
R280-m2 PPQQGAVrPQTLNFS
T292-p NFSSRNQtVPSPTVN
S301-p PSPTVNNsGQYSRyP
Y307-p NsGQYSRyPysNLNQ
Y309-p GQYSRyPysNLNQGL
S310-p QYSRyPysNLNQGLV
S319-p LNQGLVNsTGMNQNL
S331-p QNLGLTNstPMNQsV
T332-p NLGLTNstPMNQsVP
S337-p NstPMNQsVPRYPNA
S550 KVPVHQHSPSEPFLE
S552 PVHQHSPSEPFLEKP
S605 HIAAGDSSKGFGKDD
S626-p NQELRRNsLDVSQEE
S630 RRNsLDVSQEEKKKK
T679 EKKAKTVTPKPKSSK
S698 KKPDSEASALKKKVN
S712-p NKGKTEGsENsDLDK
S715-p KTEGsENsDLDKtPP
T720-p ENsDLDKtPPPsPAP
S724-p LDKtPPPsPAPEEDE
S797-p PVVEKIMssRLVKKQ
S798-p VVEKIMssRLVKKQK
K924 TKIEEFEKLMSREPE
K1101-ac IDEAHRLkNRNCkLL
K1106-ac RLkNRNCkLLEGLKM
K1186 RLKEDVEKNLAPKEE
T1194 NLAPKEETIIEVELT
Y1207 LTNIQKKYYRAILEK
Y1208 TNIQKKYYRAILEKN
T1217 AILEKNFTFLSKGGG
R1298 KLKAGGHRVLIFSQM
R1307 LIFSQMVRCLDILED
T1439 MSGRENATNGVQQLS
S1446 TNGVQQLSKKEIEDL
S1492-p THTITIEsEGKGSTF
T1545 RNNLVIDTPRVRKQT
S1556 RKQTRLYSAVKEDEL
S1567-p EDELMEFsDLEsDSE
S1571-p MEFsDLEsDSEEKPC
S1573 FsDLEsDSEEKPCAK
K1684-ub APVPRGRkGkkVKAQ
K1686-ub VPRGRkGkkVKAQST
K1687-ub PRGRkGkkVKAQSTQ
S1864 EIDEFANSPAEDKEE
S1872-p PAEDKEEsMEVHSSG
K1995-ac RAFARLDkKSDESLG
S2100-p GAAKHGVsRTDYHIL
T2143 LAMGFGQTPPVISSA
S2220 SADPGSKSVSEkGSE
S2222 DPGSKSVSEkGSEED
K2224-ac GSKSVSEkGSEEDEE
S2226 KSVSEkGSEEDEEEK
S2240 KLEDDDKSEESSQPE
S2243 DDDKSEESSQPEAGA
S2244 DDKSEESSQPEAGAV
S2261-p GKTFDEEsNAsLStA
S2264-p FDEEsNAsLStARDE
S2266 EEsNAsLStARDEtR
T2267-p EsNAsLStARDEtRD
T2272-p LStARDEtRDGFYME
Y2338 FQGLVPGYPPSAVDS
P2339 QGLVPGYPPSAVDSP
S2341 LVPGYPPSAVDSPLQ
S2345 YPPSAVDSPLQKRSF
S2384 KDDALNLSVPRQRRR
S2460 KFILPNVSTPVSDAF
T2461 FILPNVSTPVSDAFK
T2481 LQAGLSRTPTRHMLN
T2521 LFMSHKRTPLSAEDA
P2522 FMSHKRTPLSAEDAE
S2524 SHKRTPLSAEDAEVT
T2531 SAEDAEVTKAFEEDI
T2540-p AFEEDIEtPPIRNIP
I2543 EDIEtPPIRNIPsPG
S2548-p PPIRNIPsPGQLDPD
Y2590 WLKLHPTYTVDMPSY
Y2597 YTVDMPSYVPKNTDV
S2608 NTDVLFSSFQKPKQK
T2629 PNKLDINTLTGEERV
S2945-p DGETLEGsDAEENLD
N2950 EGsDAEENLDKTVES
S2972 AQGEELDSLEGGDEI
  rat

 
Y75 HFDHYNQYEQKMHLM
R148 GGSMWGPRAVQVPDQ
S194 YLARGDFSMQQPQQR
R201 SMQQPQQRMSQFSQG
R279 PPQQGAVRPQTLNFS
T291 NFSSRSQTVPSPTVN
S300 PSPTVNNSGQYSPYP
Y306 NSGQYSPYPYRNLNQ
Y308 GQYSPYPYRNLNQGL
R309 QYSPYPYRNLNQGLV
S318 LNQGLVNSTGMNQNL
S330 QNLGLTNSTPMNQSV
T331 NLGLTNSTPMNQSVP
S336 NSTPMNQSVPRYPNA
S549 KVPVRQHSPSEPFLE
S551 PVRQHSPSEPFLEKP
S604 HIAAGDPSKGFGKDD
S625 NQELSRNSLDASQEE
S629 SRNSLDASQEETKKR
T678 ERKAKTVTPKPKSSK
S697 KKPDSEASALKKKVN
S711 NKGKTEGSENSDLDK
S714 KTEGSENSDLDKTPP
T719 ENSDLDKTPPPSPGP
S723 LDKTPPPSPGPEEDE
S796 PVVEKIMSSRLVKKQ
S797 VVEKIMSSRLVKKQK
K923 AKIEEFEKLMSREPE
K1100 IDEAHRLKNRNCKLL
K1105 RLKNRNCKLLEGLKM
K1185 RLKEDVEKNLAPKEE
T1193 NLAPKEETIIEVELT
Y1206 LTNIQKKYYRAILEK
Y1207 TNIQKKYYRAILEKN
T1216 AILEKNFTFLSKGGG
R1297 KLKAGGHRVLIFSQM
R1306 LIFSQMVRCLDILED
T1438 MSGRENATNGVQQLS
S1445 TNGVQQLSKKEIEDL
S1491 THTITIESEGKGSTF
T1544 RNNLVIDTPRVRKQT
S1555 RKQTRLYSAVKEDEL
S1566 EDELMEFSDLESDSE
S1570 MEFSDLESDSEEKPC
S1572 FSDLESDSEEKPCIK
K1683 APVPRGRKGKKVKAQ
K1685 VPRGRKGKKVKAQSM
K1686 PRGRKGKKVKAQSMQ
S1863-p EIDEFANsPPEDKED
S1871 PPEDKEDSMEAQSTG
K1994 RAFARLDKKSDESLE
S2099 GAAKHGVSRTDYHIL
A2142 LAMGFGQAPPVIASA
S2219 SGDPGSKSVSEKGSE
S2221 DPGSKSVSEKGSEED
K2223 GSKSVSEKGSEEDEE
S2225 KSVSEKGSEEDEEEK
S2239 KLEDDDKSEESSQPE
S2242 DDDKSEESSQPEAGA
S2243 DDKSEESSQPEAGAV
S2260 GKTFDEESNASMSTA
S2263 FDEESNASMSTARDE
S2265 EESNASMSTARDETR
T2266 ESNASMSTARDETRD
T2271 MSTARDETRDGFYME
Y2337 FQGLVPGYPPSTVDS
P2338 QGLVPGYPPSTVDSP
S2340 LVPGYPPSTVDSPLQ
S2344 YPPSTVDSPLQKRSF
S2383 KDDALNLSVPRQRRR
S2459 KFILPNVSTPVSDAF
T2460 FILPNVSTPVSDAFK
T2480 LQAGLSRTPTRHVLN
T2520 LFMSHKRTPLSAEDA
P2521 FMSHKRTPLSAEDAE
S2523 SHKRTPLSAEDAEVT
T2530 SAEDAEVTKAFEEDI
T2539 AFEEDIETPPIRNIP
I2542 EDIETPPIRNIPSPG
S2547 PPIRNIPSPGQLDPD
Y2589 WLKLHPMYTVDMPSY
Y2596 YTVDMPSYVPKNADV
P2607 NADVLFSPFQKPKQK
T2628 PNKLDINTLTGEERV
S2944 DGETLEGSDAEENLD
N2949 EGSDAEENLDKTIES
S2971 AQGEELDSLEGGDEI
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