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Protein Page:
CHD-7 (human)
p Phosphorylation
a Acetylation
m Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
u Ubiquitination
s Sumoylation
n Neddylation
gl O-GlcNAc
ga O-GalNAc
h Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage

Overview
CHD-7 Probable transcription regulator. May interact with CTCF. Interacts with CHD8. Widely expressed in fetal and adult tissues. Belongs to the SNF2/RAD54 helicase family. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: EC 3.6.4.12; Helicase; DNA binding protein; EC 3.6.1.-
Cellular Component: nucleus
Molecular Function: identical protein binding; protein binding; DNA binding; chromatin binding; helicase activity; ATP binding
Biological Process: heart morphogenesis; limb development; central nervous system development; blood circulation; positive regulation of multicellular organism growth; palate development; embryonic hindlimb morphogenesis; female genitalia development; adult walking behavior; regulation of growth hormone secretion; sensory perception of sound; regulation of transcription, DNA-dependent; skeletal development; T cell differentiation; adult heart development; inner ear morphogenesis; transcription, DNA-dependent; in utero embryonic development; semicircular canal morphogenesis; cranial nerve development; chromatin modification; genitalia development; retina development in camera-type eye; artery morphogenesis; cognition; nose development
Reference #:  Q9P2D1 (UniProtKB)
Alt. Names/Synonyms: ATP-dependent helicase CHD7; CHD-7; CHD7; chromodomain helicase DNA binding protein 7; chromodomain helicase DNA binding protein 7 isoform CRA_e; Chromodomain-helicase-DNA-binding protein 7; FLJ20357; FLJ20361; IS3; KAL5; KIAA1416
Gene Symbols: CHD7
Molecular weight: 335,927 Da
Basal Isoelectric point: 5.95  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

CHD-7
Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


  MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


        human

 
0 2 Y75-p HFDHYNQyEQQKMHL
0 1 S199-p YMARGDFsMQQHGQP
0 1 R209-m1 QHGQPQQrMSQFSQG
0 1 T298 NFSSRSQTVPSPTIN
0 1 S307 PSPTINNSGQYSRYP
0 1 S557-p KVPVHQHsPsEPFLE
0 1 S559-p PVHQHsPsEPFLEKP
0 1 S612-p HIVAEDPsKGFGKDD
0 2 S637-p NRNSLDGsQEEKKKK
0 1 T689-p EKKAKTAtPKPKSSK
0 1 S708-p KKPDSEAsALKKKVN
0 2 S722 NKGKTEGSENsDLDK
0 3 S725-p KTEGSENsDLDKTPP
0 2 T730 ENsDLDKTPPPSPPP
0 2 S734 LDKTPPPSPPPEEDE
0 1 S808 VVEKIMSSRSVKKQK
0 1 K934-u AKIEEFEkLMSREPE
0 1 K1111 IDEAHRLKNRNCKLL
0 1 K1116 RLKNRNCKLLEGLKM
1 0 K1196-s RLKEDVEkNLAPKEE
0 1 T1204-p NLAPKEEtIIEVELT
0 1 Y1217-p LTNIQKKyyRAILEK
0 1 Y1218-p TNIQKKyyRAILEKN
0 1 R1308-m1 KLKAGGHrVLIFSQM
0 1 R1317-m1 LIFSQMVrCLDILED
0 1 T1449-p MSGRENAtNGVQQLs
0 1 S1456-p tNGVQQLsKKEIEDL
0 1 S1502 THTITIESEGKGSTF
0 11 T1555-p RNNLVIDtPRVRKQT
0 1 S1566-p RKQTRLYsAVKEDEL
0 5 S1577-p EDELMEFsDLEsDsE
0 4 S1581-p MEFsDLEsDsEEKPC
0 1 S1583-p FsDLEsDsEEKPCAK
0 1 K1694 APVPRGRKGKKVKAQ
0 1 K1696 VPRGRKGKKVKAQST
0 1 K1697 PRGRKGKKVKAQSTQ
0 4 S1874-p EIDEFANsPSEDKEE
0 1 K2005 RAFARLDKKSDESLE
0 1 S2110 GAAKHGVSRTDYHIL
0 3 T2153-p LAVGFVQtPPVISSA
0 1 S2231-p GADTGSKsIsEKGsE
0 1 S2233-p DTGSKsIsEKGsEED
0 1 K2235 GSKsIsEKGsEEDEE
0 1 S2237-p KsIsEKGsEEDEEEK
0 2 S2251-p KLEDDDKsEEssQPE
0 1 S2254-p DDDKsEEssQPEAGA
0 1 S2255-p DDKsEEssQPEAGAV
0 4 S2272-p GKNFDEEsNAsMstA
0 6 S2275-p FDEEsNAsMstARDE
0 2 S2277-p EEsNAsMstARDETR
0 2 T2278-p EsNAsMstARDETRD
0 7 T2283 MstARDETRDGFYME
0 1 T2350-p QGLIPGYtPTTVDsP
0 2 S2356-p YtPTTVDsPLQKRSF
0 1 S2395-p KEDALNLsVPRQRRR
1 1 S2471-p KFILPNVstPVSDAF
1 7 T2472-p FILPNVstPVSDAFK
0 1 T2532-p LFMSHKRtsLsAEDA
0 3 S2533-p FMSHKRtsLsAEDAE
0 1 S2535-p SHKRtsLsAEDAEVt
0 4 T2542-p sAEDAEVtKAFEEDI
0 27 T2551-p AFEEDIEtPPTRNIP
0 13 S2559-p PPTRNIPsPGQLDPD
0 1 Y2601-p WLKLHPTyTVDMPSy
0 1 Y2608-p yTVDMPSyVPKNADV
0 1 S2619-p NADVLFSsFQKPKQK
0 1 T2640-p PNKLDINtLTGEERV
0 8 S2956-p DGETLEGsDAEEsLD
0 3 S2961-p EGsDAEEsLDKTAES
0 1 S2983-p AQGEELDsLDGGDEI
  mouse

 
Y75 HFDHYSQYEQKMHLM
S193 YLARGDFSMQQHGQP
R203 QHGQPQQRMGQFSQG
T292-p NFSSRNQtVPSPTVN
S301-p PSPTVNNsGQYSRYP
S550 KVPVHQHSPSEPFLE
S552 PVHQHSPSEPFLEKP
S605 HIAAGDSSKGFGKDD
S630 RRNSLDVSQEEKKKK
T679 EKKAKTVTPKPKSSK
S698 KKPDSEASALKKKVN
S712-p NKGKTEGsENsDLDK
S715-p KTEGsENsDLDKtPP
T720-p ENsDLDKtPPPsPAP
S724-p LDKtPPPsPAPEEDE
S798-p VVEKIMSsRLVKKQK
K924 TKIEEFEKLMSREPE
K1101-a IDEAHRLkNRNCkLL
K1106-a RLkNRNCkLLEGLKM
K1186 RLKEDVEKNLAPKEE
T1194 NLAPKEETIIEVELT
Y1207 LTNIQKKYYRAILEK
Y1208 TNIQKKYYRAILEKN
R1298 KLKAGGHRVLIFSQM
R1307 LIFSQMVRCLDILED
T1439 MSGRENATNGVQQLS
S1446 TNGVQQLSKKEIEDL
S1492-p THTITIEsEGKGSTF
T1545 RNNLVIDTPRVRKQT
S1556 RKQTRLYSAVKEDEL
S1567-p EDELMEFsDLEsDSE
S1571-p MEFsDLEsDSEEKPC
S1573 FsDLEsDSEEKPCAK
K1684-u APVPRGRkGkkVKAQ
K1686-u VPRGRkGkkVKAQST
K1687-u PRGRkGkkVKAQSTQ
S1864 EIDEFANSPAEDKEE
K1995-a RAFARLDkKSDESLG
S2100-p GAAKHGVsRTDYHIL
T2143 LAMGFGQTPPVISSA
S2220 SADPGSKSVSEkGSE
S2222 DPGSKSVSEkGSEED
K2224-a GSKSVSEkGSEEDEE
S2226 KSVSEkGSEEDEEEK
S2240 KLEDDDKSEESSQPE
S2243 DDDKSEESSQPEAGA
S2244 DDKSEESSQPEAGAV
S2261-p GKTFDEEsNAsLStA
S2264-p FDEEsNAsLStARDE
S2266 EEsNAsLStARDEtR
T2267-p EsNAsLStARDEtRD
T2272-p LStARDEtRDGFYME
P2339 QGLVPGYPPSAVDSP
S2345 YPPSAVDSPLQKRSF
S2384 KDDALNLSVPRQRRR
S2460 KFILPNVSTPVSDAF
T2461 FILPNVSTPVSDAFK
T2521 LFMSHKRTPLSAEDA
P2522 FMSHKRTPLSAEDAE
S2524 SHKRTPLSAEDAEVT
T2531 SAEDAEVTKAFEEDI
T2540-p AFEEDIEtPPIRNIP
S2548-p PPIRNIPsPGQLDPD
Y2590 WLKLHPTYTVDMPSY
Y2597 YTVDMPSYVPKNTDV
S2608 NTDVLFSSFQKPKQK
T2629 PNKLDINTLTGEERV
S2945-p DGETLEGsDAEENLD
N2950 EGsDAEENLDKTVES
S2972 AQGEELDSLEGGDEI
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