Probable transcription regulator. May interact with CTCF. Interacts with CHD8. Widely expressed in fetal and adult tissues. Belongs to the SNF2/RAD54 helicase family. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: EC 3.6.1.-; DNA binding protein; Helicase; EC 184.108.40.206
Cellular Component: nucleolus; nucleus
Molecular Function: protein binding; DNA binding; chromatin binding; helicase activity; ATP binding
Biological Process: limb development; adult heart development; heart morphogenesis; inner ear morphogenesis; central nervous system development; transcription, DNA-dependent; in utero embryonic development; blood circulation; semicircular canal morphogenesis; cranial nerve development; palate development; chromatin modification; positive regulation of multicellular organism growth; adult walking behavior; regulation of growth hormone secretion; female genitalia development; embryonic hindlimb morphogenesis; genitalia development; sensory perception of sound; regulation of transcription, DNA-dependent; retina development in camera-type eye; artery morphogenesis; cognition; nose development; skeletal development; rRNA processing; T cell differentiation
SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.