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Protein Page:
TERF2IP (human)
p Phosphorylation
a Acetylation
m Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
u Ubiquitination
s Sumoylation
n Neddylation
gl O-GlcNAc
ga O-GalNAc
h Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage

Overview
TERF2IP Acts both as a regulator of telomere function and as a transcription regulator. Involved in the regulation of telomere length and protection as a component of the shelterin complex (telosome). In contrast to other components of the shelterin complex, it is dispensible for telomere capping and does not participate in the protection of telomeres against non-homologous end-joining (NHEJ)-mediated repair. Instead, it is required to negatively regulate telomere recombination and is essential for repressing homology-directed repair (HDR), which can affect telomere length. Does not bind DNA directly: recruited to telomeric double-stranded 5'-TTAGGG-3' repeats via its interaction with TERF2. Independently of its function in telomeres, also acts as a transcription regulator: recruited to extratelomeric 5'- TTAGGG-3' sites via its association with TERF2 or other factors, and regulates gene expression. When cytoplasmic, associates with the I-kappa-B-kinase (IKK) complex and acts as a regulator of the NF-kappa-B signaling by promoting IKK-mediated phosphorylation of RELA/p65, leading to activate expression of NF-kappa-B target genes. Associates with the I-kappa-B-kinase (IKK) core complex, composed of CHUK, IKBKB and IKBKG. Homodimer. Component of the shelterin complex (telosome) composed of TERF1, TERF2, TINF2, TERF2IP ACD and POT1. Interacts with TERF2; the interaction is direct. Does not interact with TERF1. Interacts with SLX4/BTBD12. Ubiquitous. Highly expressed. Belongs to the RAP1 family. Note: This description may include information from UniProtKB.
Protein type: DNA replication
Cellular Component: nucleoplasm; nuclear chromosome; chromosome, telomeric region; nuclear telomere cap complex; Mre11 complex; nuclear chromosome, telomeric region; cytoplasm; nucleus
Molecular Function: protein binding; telomeric DNA binding
Biological Process: negative regulation of telomere maintenance; positive regulation of I-kappaB kinase/NF-kappaB cascade; regulation of transcription, DNA-dependent; transcription, DNA-dependent; negative regulation of DNA recombination at telomere; telomere maintenance via telomerase; telomere maintenance; protection from non-homologous end joining at telomere; activation of NF-kappaB transcription factor
Reference #:  Q9NYB0 (UniProtKB)
Alt. Names/Synonyms: dopamine receptor interacting protein 5; DRIP5; hRap1; RAP1; TE2IP; telomeric repeat binding factor 2, interacting protein; Telomeric repeat-binding factor 2-interacting protein 1; TERF2IP; TRF2-interacting telomeric protein Rap1; TRF2-interacting telomeric RAP1 protein
Gene Symbols: TERF2IP
Molecular weight: 44,260 Da
Basal Isoelectric point: 4.64  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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TERF2IP

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
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Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 4 S36-p MSFYVRPsPAKRRLs
0 22 S43-p sPAKRRLstLILHGG
0 2 T44-p PAKRRLstLILHGGG
0 1 K114-u ADTGSEAkPGALAEG
0 13 S154-p YVKENARsPsSVTGN
0 1 S156-p KENARsPsSVTGNAL
0 8 S179-p LTQHSWQsLKDRYLK
0 1 K194-u HLRGQEHkYLLGDAP
1 68 S203-p LLGDAPVsPssQKLK
0 3 S205-p GDAPVsPssQKLKRK
0 15 S206-p DAPVsPssQKLKRKA
0 2 K240-u LPEEEYVkEEIQENE
0 1 K251-u QENEEAVkKMLVEAT
0 2 T286-p MCDDDPPtPEEDSET
0 2 K316-u PEVGAAIkIIRQLME
  mouse

 
S36 MSFYVRPSSAKRRLs
S43-p SSAKRRLstLILHGG
T44-p SAKRRLstLILHGGG
K111 TEQASDPKPGASTEG
S151-p YVKENARsPSSVTGN
S153 KENARsPSSVTGNAL
S176 LTQHSWQSLKDRYLK
K191 HLRGQEHKYLLGNAP
S200-p LLGNAPVsPssQKLK
S202-p GNAPVsPssQKLKRK
S203-p NAPVsPssQKLKRKA
K237 LPEEECVKGEIKENG
K249 ENGEADNKLFEEAAP
T282 MCDGDPPTPEEDSET
K310-u QEVGTAIkVIRQLME
  rat

 
S36 MSFYVRPSSAKRRLs
S43-p SSAKRRLsTLILHGG
T44 SAKRRLsTLILHGGG
K111 TEQASDPKPGASAEG
S151 YVKENARSPSSVTGN
S153 KENARSPSSVTGNAL
S176 LTQHSWQSLKDRYLK
K191 HLQGQEHKYLLGNAP
S200-p LLGNAPVsPSSQKLK
S202 GNAPVsPSSQKLKRK
S203 NAPVsPSSQKLKRKA
K237 LPEEECVKGETKENG
K249 ENGEADNKLFEEATP
T282 MCDGDPPTPEEDSET
K310 QEVGTAIKIIRQLME
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