Javascript is not enabled on this browser. This site will not work properly without Javascript.
PhosphoSitePlus Homepage Cell Signaling Technology
PhosphoSitePlus
HomeAbout PhosphoSiteUsing PhosphoSiteCuration ProcessContact
NIH-logos NIGMS Logo NIAAA Logo NCI Logo NIH Logo
Protein Page:
Smc4 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
Smc4 Central component of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases. Forms an heterodimer with SMC2. Component of the condensin complex, which contains the SMC2 and SMC4 heterodimer, and three non SMC subunits that probably regulate the complex: BRRN1/CAPH, CNAP1/CAPD2 and CAPG. Widely expressed. Higher expression in testis, colon, thymus. Belongs to the SMC family. SMC4 subfamily. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Cell cycle regulation
Cellular Component: nucleoplasm; cytoplasm; nucleolus; condensin complex; cytosol; nucleus
Molecular Function: protein binding; protein heterodimerization activity; ATP binding
Biological Process: mitotic sister chromatid segregation; meiotic chromosome condensation; mitotic chromosome condensation; mitotic cell cycle; meiotic chromosome segregation; kinetochore organization and biogenesis
Reference #:  Q9NTJ3 (UniProtKB)
Alt. Names/Synonyms: CAPC; Chromosome-associated polypeptide C; hCAP-C; SMC protein 4; SMC-4; SMC4; SMC4 structural maintenance of chromosomes 4-like 1; SMC4L1; structural maintenance of chromosomes 4; Structural maintenance of chromosomes protein 4; XCAP-C homolog
Gene Symbols: SMC4
Molecular weight: 147,182 Da
Basal Isoelectric point: 6.37  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

Smc4

Protein Structure Not Found.


STRING  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Scansite  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  Source  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene


Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 25 S22-p EEGPPPPsPDGAssD
0 13 S27-p PPsPDGAssDAEPEP
0 21 S28-p PsPDGAssDAEPEPP
0 1 S36-p DAEPEPPsGRtEsPA
0 14 T39-p PEPPsGRtEsPAtAA
0 24 S41-p PPsGRtEsPAtAAEt
0 8 T44-p GRtEsPAtAAEtAsE
0 2 T48-p sPAtAAEtAsEELDN
0 4 S50-p AtAAEtAsEELDNRS
0 1 T85-p GAPRLMItHIVNQNF
0 1 K93-ub HIVNQNFkSYAGEkI
0 1 K99-ub FkSYAGEkILGPFHk
0 1 K106-ub kILGPFHkRFsCIIG
0 3 S109-p GPFHkRFsCIIGPNG
0 5 S143-p KIRSKKLsVLIHNsD
0 1 S149-p LsVLIHNsDEHKDIQ
0 54 Y175-p IDKEGDDyEVIPNSN
0 1 T188-p SNFYVSRtACRDNTS
0 12 Y197-p CRDNTSVyHIsGkkK
0 1 S200-p NTSVyHIsGkkKTFk
0 8 K202-ub SVyHIsGkkKTFkDV
0 1 K203-ub VyHIsGkkKTFkDVG
0 21 K207-ub sGkkKTFkDVGNLLR
0 1 K207-sc sGkkKTFkDVGNLLR
0 1 K241-ub QIAMMKPkGQTEHDE
0 1 K341-ub IAEMETQkEkIHEDT
0 1 K343-ub EMETQkEkIHEDTkE
0 1 K349-ac EkIHEDTkEINEksN
0 1 K354-ac DTkEINEksNILSNE
0 2 S355-p TkEINEksNILSNEM
0 2 K363-ac NILSNEMkAKNKDVK
0 1 K374 KDVKDTEKKLNKITk
0 1 K378 DTEKKLNKITkFIEE
0 1 K381-ac KKLNKITkFIEENKE
0 1 K389-ub FIEENKEkFTQLDLE
0 1 K413-ub HATSKAKkLEKQLQK
0 1 S489-p EKELMGFsKSVNEAR
0 1 S531-p KEALIAAsEtLKERK
0 1 T533-p ALIAAsEtLKERKAA
0 1 K573-ac TQEETNFksLVHDLF
0 1 S574-p QEETNFksLVHDLFQ
0 1 S588-p QKVEEAKssLAMNRs
0 1 S589-p KVEEAKssLAMNRsR
0 1 S595-p ssLAMNRsRGkVLDA
0 1 K598-ub AMNRsRGkVLDAIIQ
0 1 K598-ac AMNRsRGkVLDAIIQ
0 2 K607-ub LDAIIQEkkSGRIPG
0 2 K607-ac LDAIIQEkkSGRIPG
0 1 K608-ac DAIIQEkkSGRIPGI
0 1 Y616-p SGRIPGIyGRLGDLG
0 1 A675 FIGLDKMAVWAkKMt
0 1 K679-ac DKMAVWAkKMtEIQt
0 1 T682-p AVWAkKMtEIQtPEN
0 1 T686-p kKMtEIQtPENTPRL
0 11 Y709-p EKIRQAFyFALRDTL
0 1 T739-p DRRWRVVtLQGQIIE
0 5 S982-p NTNAAEEsLPEIQKE
0 1 K1009-ac ENEHALQkDALsIKL
0 1 S1013-p ALQkDALsIKLKLEQ
0 1 S1030-p GHIAEHNskIKYWHk
0 1 K1031-ac HIAEHNskIKYWHkE
0 1 K1037-ac skIKYWHkEISKISL
0 6 S1056-p DNPIEEIsVLsPEDL
0 2 S1059-p IEEIsVLsPEDLEAI
0 1 K1098-ub GAIAEYKkkEELYLQ
0 5 K1099-ub AIAEYKkkEELYLQR
0 5 K1112-ub QRVAELDkITYERDS
0 1 K1145-ub GFYIITNkLKENYQM
0 1 T1154 KENYQMLTLGGDAEL
0 1 S1166 AELELVDSLDPFSEG
0 3 K1187-ub PPKKSWKkIFNLSGG
0 1 Y1266-p SDRLIGIykTYNITk
0 3 K1267-ub DRLIGIykTYNITkS
0 7 K1273-ub ykTYNITkSVAVNPk
0 1 K1280-ub kSVAVNPkEIASkGL
0 5 K1285-ub NPkEIASkGLC____
  mouse

 
S21-p QEEGPPPsQDGAHsD
H26 PPsQDGAHsDEEMEQ
S27-p PsQDGAHsDEEMEQP
A35 DEEMEQPAGEAESAA
A38 MEQPAGEAESAAPAK
S40 QPAGEAESAAPAKPP
A42 AGEAESAAPAKPPGE
P46 ESAAPAKPPGEELDN
G48 AAPAKPPGEELDNRS
T83 GAPRLMITHIVNQNF
K91 HIVNQNFKSYAGEKV
K97 FKSYAGEKVLGPFHK
K104 KVLGPFHKRFSCIIG
S107 GPFHKRFSCIIGPNG
S141 KIRSKKLSVLIHNSD
S147 LSVLIHNSDEHKDIQ
Y173 IDKEGDDYEVLPNSN
T186 SNFYVSRTAYRDSTS
Y195 YRDSTSVYHISGKKK
S198 STSVYHISGKKKTFK
K200 SVYHISGKKKTFKDV
K201 VYHISGKKKTFKDVG
K205 SGKKKTFKDVGNLLR
K205 SGKKKTFKDVGNLLR
K239 QIAMMKPKGQTEHDE
K339 IAEITTQKEKIHEDT
K341 EITTQKEKIHEDTKE
K347 EKIHEDTKEITEKSN
K352 DTKEITEKSNVLSNE
S353 TKEITEKSNVLSNEM
K361 NVLSNEMKAKNSAVK
K372-ac SAVKDVEkKLNkVTK
K376-ac DVEkKLNkVTKFIEQ
K379 kKLNkVTKFIEQNKE
K387 FIEQNKEKFTQLDLE
K411 HATSKAKKLEKQLQK
N487 EKELMGFNKSVNEAR
S529 KEALITASETLKERK
T531 ALITASETLKERKAA
K571 TQEEINLKSLVHDLF
S572 QEEINLKSLVHDLFQ
S586 QKVEEAKSSLAMNRS
S587 KVEEAKSSLAMNRSR
S593 SSLAMNRSRGKVLDA
K596 AMNRSRGKVLDAIIQ
K596 AMNRSRGKVLDAIIQ
K605 LDAIIQEKKSGRIPG
K605 LDAIIQEKKSGRIPG
K606 DAIIQEKKSGRIPGI
Y614 SGRIPGIYGRLGDLG
T673-p FIGLDKMtVWAKKMS
K677 DKMtVWAKKMSKIQT
S680 tVWAKKMSKIQTPEN
T684 KKMSKIQTPENTPRL
Y707 EEIRQAFYFALRDTL
T737 DRRWRVVTLQGQIIE
S980 NTKTAETSLPEIQKE
K1007 ENEHALQKDALSIKL
S1011 ALQKDALSIKLKLEQ
S1028 GHISEHNSKIKYWQK
K1029 HISEHNSKIKYWQKE
K1035 SKIKYWQKEISKIKL
A1054 DNPVETVAVLSQEEL
S1057 VETVAVLSQEELEAI
K1096 GAIAEYKKKEDLYLQ
K1097 AIAEYKKKEDLYLQR
K1110 QRVAELDKITSERDN
K1143 GFYVITNKLKENYQM
T1152-p KENYQMLtLGGDAEL
S1164-p AELELVDsLDPFSEG
K1185-ub PPKKSWKkIFNLSGG
Y1264 SDRLIGIYKTYNSTK
K1265 DRLIGIYKTYNSTKS
K1271 YKTYNSTKSVAVNPK
K1278 KSVAVNPKQIASKGL
K1283 NPKQIASKGLC____
Home  |  Curator Login With enhanced literature mining using Linguamatics I2E I2E Logo Produced by 3rd Millennium  |  Design by Digizyme
©2003-2013 Cell Signaling Technology, Inc.