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Protein Page:
Smc4 (human)
p Phosphorylation
a Acetylation
m Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
u Ubiquitination
s Sumoylation
n Neddylation
gl O-GlcNAc
ga O-GalNAc
h Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage

Overview
Smc4 Central component of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases. Forms an heterodimer with SMC2. Component of the condensin complex, which contains the SMC2 and SMC4 heterodimer, and three non SMC subunits that probably regulate the complex: BRRN1/CAPH, CNAP1/CAPD2 and CAPG. Widely expressed. Higher expression in testis, colon, thymus. Belongs to the SMC family. SMC4 subfamily. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Cell cycle regulation
Cellular Component: nucleoplasm; condensin complex; nucleus; cytosol
Molecular Function: protein binding; protein heterodimerization activity; ATP binding
Biological Process: mitotic sister chromatid segregation; meiotic chromosome condensation; mitotic chromosome condensation; mitotic cell cycle; DNA repair; kinetochore organization and biogenesis; meiotic chromosome segregation; DNA recombination
Reference #:  Q9NTJ3 (UniProtKB)
Alt. Names/Synonyms: CAPC; Chromosome-associated polypeptide C; hCAP-C; SMC protein 4; SMC-4; SMC4; SMC4 structural maintenance of chromosomes 4-like 1; SMC4L1; structural maintenance of chromosomes 4; Structural maintenance of chromosomes protein 4; XCAP-C homolog
Gene Symbols: SMC4
Molecular weight: 147,182 Da
Basal Isoelectric point: 6.37  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

Smc4

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 20 S22-p EEGPPPPsPDGAssD
0 11 S27-p PPsPDGAssDAEPEP
0 18 S28-p PsPDGAssDAEPEPP
0 1 S36-p DAEPEPPsGRtEsPA
0 12 T39-p PEPPsGRtEsPAtAA
0 21 S41-p PPsGRtEsPAtAAEt
0 7 T44-p GRtEsPAtAAEtAsE
0 2 T48-p sPAtAAEtAsEELDN
0 2 S50-p AtAAEtAsEELDNRS
0 4 S143-p KIRSKKLsVLIHNSD
0 55 Y175-p IDKEGDDyEVIPNSN
0 11 Y197-p CRDNTSVyHISGkKK
0 8 K202-u SVyHISGkKKTFkDV
0 21 K207-u SGkKKTFkDVGNLLR
0 1 S355-p TKEINEKsNILSNEM
0 2 K363-a NILSNEMkAKNKDVK
0 1 K381-a KKLNKITkFIEENKE
0 1 K389-u FIEENKEkFTQLDLE
0 1 K413-u HATSKAKkLEKQLQK
0 1 S588-p QKVEEAKssLAMNRs
0 1 S589-p KVEEAKssLAMNRsR
0 1 S595-p ssLAMNRsRGKVLDA
0 2 K607-u LDAIIQEkKSGRIPG
0 1 Y616-p SGRIPGIyGRLGDLG
0 1 A675 FIGLDKMAVWAkKMT
0 1 K679-a DKMAVWAkKMTEIQT
0 12 Y709-p EKIRQAFyFALRDTL
0 2 S982-p NTNAAEEsLPEIQKE
0 1 K1037-a SKIKYWHkEISKISL
0 5 S1056-p DNPIEEIsVLsPEDL
0 1 S1059-p IEEIsVLsPEDLEAI
0 5 K1099-u AIAEYKKkEELYLQR
0 5 K1112-u QRVAELDkITYERDS
0 3 K1187-u PPKKSWKkIFNLSGG
0 3 K1267-u DRLIGIYkTYNITkS
0 7 K1273-u YkTYNITkSVAVNPk
0 1 K1280-u kSVAVNPkEIASkGL
0 5 K1285-u NPkEIASkGLC____
  mouse

 
S21-p QEEGPPPsQDGAHsD
H26 PPsQDGAHsDEEMEQ
S27-p PsQDGAHsDEEMEQP
A35 DEEMEQPAGEAESAA
A38 MEQPAGEAESAAPAK
S40 QPAGEAESAAPAKPP
A42 AGEAESAAPAKPPGE
P46 ESAAPAKPPGEELDN
G48 AAPAKPPGEELDNRS
S141 KIRSKKLSVLIHNSD
Y173 IDKEGDDYEVLPNSN
Y195 YRDSTSVYHISGKKK
K200 SVYHISGKKKTFKDV
K205 SGKKKTFKDVGNLLR
S353 TKEITEKSNVLSNEM
K361 NVLSNEMKAKNSAVK
K379 KKLNKVTKFIEQNKE
K387 FIEQNKEKFTQLDLE
K411 HATSKAKKLEKQLQK
S586 QKVEEAKSSLAMNRS
S587 KVEEAKSSLAMNRSR
S593 SSLAMNRSRGKVLDA
K605 LDAIIQEKKSGRIPG
Y614 SGRIPGIYGRLGDLG
T673-p FIGLDKMtVWAKKMS
K677 DKMtVWAKKMSKIQT
Y707 EEIRQAFYFALRDTL
S980 NTKTAETSLPEIQKE
K1035 SKIKYWQKEISKIKL
A1054 DNPVETVAVLSQEEL
S1057 VETVAVLSQEELEAI
K1097 AIAEYKKKEDLYLQR
K1110 QRVAELDKITSERDN
K1185-u PPKKSWKkIFNLSGG
K1265 DRLIGIYKTYNSTKS
K1271 YKTYNSTKSVAVNPK
K1278 KSVAVNPKQIASKGL
K1283 NPKQIASKGLC____
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