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Smc4 (human)

Overview Smc4 Central component of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases. Forms an heterodimer with SMC2. Component of the condensin complex, which contains the SMC2 and SMC4 heterodimer, and three non SMC subunits that probably regulate the complex: BRRN1/CAPH, CNAP1/CAPD2 and CAPG. Widely expressed. Higher expression in testis, colon, thymus. Belongs to the SMC family. SMC4 subfamily. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB. Protein type: Cell cycle regulation Cellular Component: cytoplasm; condensin complex; nucleolus; nucleus Molecular Function: protein heterodimerization activity; ATP binding Biological Process: mitotic sister chromatid segregation; cell division; mitotic chromosome condensation; sister chromatid cohesion; DNA repair; DNA recombination Reference #:  Q9NTJ3 (UniProtKB) Alt. Names/Synonyms: CAPC; Chromosome-associated polypeptide C; hCAP-C; SMC protein 4; SMC-4; SMC4; SMC4 structural maintenance of chromosomes 4-like 1; SMC4L1; structural maintenance of chromosomes 4; Structural maintenance of chromosomes protein 4; XCAP-C homolog Gene Symbols: SMC4 Molecular weight: 147,182 Da Basal Isoelectric point: 6.37  Predict pI for various phosphorylation states Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below Smc4 3L51 - B=595-752 (mouse)

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	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	18		S22-p	EEGPPPPsPDGAssD
0	9		S27-p	PPsPDGAssDAEPEP
0	15		S28-p	PsPDGAssDAEPEPP
0	1		S36-p	DAEPEPPsGRtEsPA
0	10		T39-p	PEPPsGRtEsPAtAA
0	19		S41-p	PPsGRtEsPAtAAEt
0	7		T44-p	GRtEsPAtAAEtAsE
0	2		T48-p	sPAtAAEtAsEELDN
0	1		S50-p	AtAAEtAsEELDNRS
0	1		T85-p	GAPRLMItHIVNQNF
0	1		K93-u	HIVNQNFkSYAGEkI
0	1		K99-u	FkSYAGEkILGPFHk
0	1		K106-u	kILGPFHkRFSCIIG
0	3		S143-p	KIRSKKLsVLIHNSD
0	55		Y175-p	IDKEGDDyEVIPNSN
0	11		Y197-p	CRDNTSVyHISGkkK
0	8		K202-u	SVyHISGkkKTFkDV
0	1		K203-u	VyHISGkkKTFkDVG
0	21		K207-u	SGkkKTFkDVGNLLR
0	1		K241-u	QIAMMKPkGQTEHDE
0	1		K341-u	IAEMETQkEkIHEDT
0	1		K343-u	EMETQkEkIHEDTkE
0	1		K349-a	EkIHEDTkEINEksN
0	1		K354-a	DTkEINEksNILSNE
0	1		S355-p	TkEINEksNILSNEM
0	2		K363-a	NILSNEMkAKNKDVK
0	1		K374	KDVKDTEKKLNKITk
0	1		K378	DTEKKLNKITkFIEE
0	1		K381-a	KKLNKITkFIEENKE
0	1		K389-u	FIEENKEkFTQLDLE
0	1		K413-u	HATSKAKkLEKQLQK
0	1		S489-p	EKELMGFsKSVNEAR
0	1		S588-p	QKVEEAKssLAMNRs
0	1		S589-p	KVEEAKssLAMNRsR
0	1		S595-p	ssLAMNRsRGkVLDA
0	1		K598-u	AMNRsRGkVLDAIIQ
0	1		K598-a	AMNRsRGkVLDAIIQ
0	2		K607-u	LDAIIQEkkSGRIPG
0	1		K607-a	LDAIIQEkkSGRIPG
0	1		K608-a	DAIIQEkkSGRIPGI
0	1		Y616-p	SGRIPGIyGRLGDLG
0	1		A675	FIGLDKMAVWAkKMt
0	1		K679-a	DKMAVWAkKMtEIQt
0	1		T682-p	AVWAkKMtEIQtPEN
0	1		T686-p	kKMtEIQtPENTPRL
0	12		Y709-p	EKIRQAFyFALRDTL
0	1		T739-p	DRRWRVVtLQGQIIE
0	1		S982-p	NTNAAEEsLPEIQKE
0	1		S1013-p	ALQKDALsIKLKLEQ
0	1		K1031-a	HIAEHNSkIKYWHkE
0	1		K1037-a	SkIKYWHkEISKISL
0	4		S1056-p	DNPIEEIsVLSPEDL
0	1		K1098-u	GAIAEYKkkEELYLQ
0	5		K1099-u	AIAEYKkkEELYLQR
0	5		K1112-u	QRVAELDkITYERDS
0	1		K1145-u	GFYIITNkLKENYQM
0	1		T1154	KENYQMLTLGGDAEL
0	1		S1166	AELELVDSLDPFSEG
0	3		K1187-u	PPKKSWKkIFNLSGG
0	1		Y1266-p	SDRLIGIykTYNITk
0	3		K1267-u	DRLIGIykTYNITkS
0	7		K1273-u	ykTYNITkSVAVNPk
0	1		K1280-u	kSVAVNPkEIASkGL
0	5		K1285-u	NPkEIASkGLC____

	mouse
S21-p	QEEGPPPsQDGAHsD
H26	PPsQDGAHsDEEMEQ
S27-p	PsQDGAHsDEEMEQP
A35	DEEMEQPAGEAESAA
A38	MEQPAGEAESAAPAK
S40	QPAGEAESAAPAKPP
A42	AGEAESAAPAKPPGE
P46	ESAAPAKPPGEELDN
G48	AAPAKPPGEELDNRS
T83	GAPRLMITHIVNQNF
K91	HIVNQNFKSYAGEKV
K97	FKSYAGEKVLGPFHK
K104	KVLGPFHKRFSCIIG
S141	KIRSKKLSVLIHNSD
Y173	IDKEGDDYEVLPNSN
Y195	YRDSTSVYHISGKKK
K200	SVYHISGKKKTFKDV
K201	VYHISGKKKTFKDVG
K205	SGKKKTFKDVGNLLR
K239	QIAMMKPKGQTEHDE
K339	IAEITTQKEKIHEDT
K341	EITTQKEKIHEDTKE
K347	EKIHEDTKEITEKSN
K352	DTKEITEKSNVLSNE
S353	TKEITEKSNVLSNEM
K361	NVLSNEMKAKNSAVK
K372-a	SAVKDVEkKLNkVTK
K376-a	DVEkKLNkVTKFIEQ
K379	kKLNkVTKFIEQNKE
K387	FIEQNKEKFTQLDLE
K411	HATSKAKKLEKQLQK
N487	EKELMGFNKSVNEAR
S586	QKVEEAKSSLAMNRS
S587	KVEEAKSSLAMNRSR
S593	SSLAMNRSRGKVLDA
K596	AMNRSRGKVLDAIIQ
K596	AMNRSRGKVLDAIIQ
K605	LDAIIQEKKSGRIPG
K605	LDAIIQEKKSGRIPG
K606	DAIIQEKKSGRIPGI
Y614	SGRIPGIYGRLGDLG
T673-p	FIGLDKMtVWAKKMS
K677	DKMtVWAKKMSKIQT
S680	tVWAKKMSKIQTPEN
T684	KKMSKIQTPENTPRL
Y707	EEIRQAFYFALRDTL
T737	DRRWRVVTLQGQIIE
S980	NTKTAETSLPEIQKE
S1011	ALQKDALSIKLKLEQ
K1029	HISEHNSKIKYWQKE
K1035	SKIKYWQKEISKIKL
A1054	DNPVETVAVLSQEEL
K1096	GAIAEYKKKEDLYLQ
K1097	AIAEYKKKEDLYLQR
K1110	QRVAELDKITSERDN
K1143	GFYVITNKLKENYQM
T1152-p	KENYQMLtLGGDAEL
S1164-p	AELELVDsLDPFSEG
K1185-u	PPKKSWKkIFNLSGG
Y1264	SDRLIGIYKTYNSTK
K1265	DRLIGIYKTYNSTKS
K1271	YKTYNSTKSVAVNPK
K1278	KSVAVNPKQIASKGL
K1283	NPKQIASKGLC____

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