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Protein Page:
FAK (human)
p Phosphorylation
a Acetylation
m Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
u Ubiquitination
s Sumoylation
n Neddylation
g O-GlcNAc
h Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage

Overview
FAK a tyrosine kinase of the FAK family required for cell migration and contact-dependent survival signaling. Activated by tyrosine-phosphorylation in response to either integrin clustering induced by cell adhesion or antibody cross-linking, or via G-protein coupled receptor (GPCR) occupancy by ligands such as bombesin or lysophosphatidic acid, or via LDL receptor occupancy. Downstream of integrins and Src, upstream of Ras/MAPK. Localizes to focal adhesions that form between cells growing in the presence of extracellular matrix constituents. Interacts with CAS family members and with GIT1, SORBS1 and BCAR3. Interacts with Shb. Required for full Ras transformation of fibroblasts. Increased expression in breast and other cancers, related to chromosome 8q amplification. Overexpression and activation associated with increased migration, invasion and progression of ovarian cancer, and with progression in hepatocellular carcinoma, thyroid cancer, and acute myelogenous leukemia. siRNA increases chemosensitivity of pancreatic adenocarcinoma xenografts. Inhibitor: ISI15421 (antisense). Four splice-variant isoforms have been observed. Note: This description may include information from UniProtKB.
Protein type: EC 2.7.10.2; Protein kinase, tyrosine (non-receptor); Protein kinase, TK; Kinase, protein; EC 2.7.1.112; TK group; Fak family
Cellular Component: cytoskeleton; focal adhesion; lamellipodium; apical plasma membrane; cytoplasm; microtubule organizing center; cell cortex; cytosol; nucleus
Molecular Function: JUN kinase binding; signal transducer activity; protein binding; non-membrane spanning protein tyrosine kinase activity; SH2 domain binding; protein kinase binding; ATP binding; protein kinase activity
Biological Process: heart morphogenesis; axon guidance; extracellular matrix organization and biogenesis; establishment of nucleus localization; peptidyl-tyrosine phosphorylation; apoptosis; protein amino acid autophosphorylation; neuron migration; cell motility involved in cell locomotion; negative regulation of synaptogenesis; regulation of cell shape; regulation of cell adhesion mediated by integrin; positive regulation of cell proliferation; ephrin receptor signaling pathway; negative regulation of axonogenesis; angiogenesis; vasculogenesis; placenta development; cell structure disassembly during apoptosis; integrin-mediated signaling pathway; platelet activation; regulation of Rho GTPase activity; central nervous system neuron axonogenesis; regulation of osteoblast differentiation; signal complex assembly; positive regulation of phosphoinositide 3-kinase activity; microtubule cytoskeleton organization and biogenesis; negative regulation of organ growth; regulation of cell proliferation; positive regulation of phosphoinositide 3-kinase cascade; positive regulation of protein kinase B signaling cascade; embryonic development; establishment of cell polarity; positive regulation of protein kinase activity; regulation of focal adhesion formation; endothelial cell migration; positive regulation of protein amino acid phosphorylation; negative regulation of cell-cell adhesion; blood coagulation; regulation of cytoskeleton organization and biogenesis; positive regulation of cell migration; negative regulation of apoptosis
Reference #:  Q05397 (UniProtKB)
Alt. Names/Synonyms: FADK; FADK 1; FAK; FAK-related non-kinase polypeptide; FAK1; Focal adhesion kinase 1; FRNK; pp125FAK; Protein-tyrosine kinase 2; PTK2; PTK2 protein tyrosine kinase 2
Gene Symbols: PTK2
Molecular weight: 119,233 Da
Basal Isoelectric point: 6.19  Predict pI for various phosphorylation states
CST Pathways:  Angiogenesis  |  ErbB/HER Signaling  |  GPCRs Signaling to MAPK/Erk  |  MAPK/Erk in Growth and Differentiation  |  PI3K/Akt Signaling  |  Regulation of Actin Dynamics  |  Tyrosine Kinases
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

FAK
Protein Structure Not Found.

Substrate Sequence Logo
Sequence Logo

STRING  |  Scansite  |  KinBase  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho3D  |  DISEASE  |  Source  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene


Sites Implicated In
apoptosis, altered: Y397‑p, Y861‑p
apoptosis, inhibited: Y397‑p, Y925‑p
carcinogenesis, induced: Y397‑p
cell adhesion, altered: Y397‑p, Y407‑p, Y576‑p, Y577‑p, S732‑p, Y861‑p, S910‑p, Y925‑p
cell differentiation, altered: Y397‑p, Y576‑p, Y577‑p, Y925‑p
cell growth, altered: Y194‑p, Y397‑p, Y861‑p, S910‑p
cell motility, altered: Y194‑p, Y397‑p, Y407‑p, S732‑p, Y925‑p
cytoskeletal reorganization: Y397‑p, Y407‑p, Y576‑p, Y577‑p, S843‑p, Y861‑p, S910‑p, Y925‑p
endocytosis, altered: Y397‑p
transcription, altered: Y397‑p, Y576‑p, Y577‑p, Y925‑p
activation: Y576‑p, Y861‑p
enzymatic activity, induced: Y194‑p, Y397‑p, Y407‑p, Y576‑p
intracellular localization: Y397‑p, Y576‑p, Y861‑p, Y925‑p
molecular association, regulation: Y397‑p, Y861‑p, Y925‑p
phosphorylation: Y194‑p, Y397‑p, Y576‑p, Y577‑p, Y861‑p, Y925‑p
protein conformation: Y194‑p
protein degradation: Y397‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


  MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


        human

► Hide Isoforms 		 
1 1 Y5-p ___MAAAyLDPNLNH
0 3 T13-p LDPNLNHtPNsSTKT
0 1 S16-p NLNHtPNsSTKTHLG
0 3 S29-p LGTGMERsPGAMERV
0 1 S45 KVFHYFESNSEPTTW
0 1 S54 SEPTTWASIIRHGDA
0 1 Y83 KVKHVACYGFRLSHL
0 1 Y148-p KPTLNFFyQQVKSDy
1 0 K152 NFFyQQVKSDyMLEI
0 2 Y155-p yQQVKSDyMLEIADQ
0 1 S192 GNALEKKSNyEVLEK
1 1 Y194-p ALEKKSNyEVLEKDV
0 1 K313 NSEDKDRKGMLQLKI
3 3 Y347-p MADLIDGyCRLVNGT
0 19 T386-p SEKQGMRtHAVsVsE
0 1 A388 KQGMRtHAVsVsEtD
0 33 S390-p GMRtHAVsVsEtDDy
0 41 S392-p RtHAVsVsEtDDyAE
1 27 T394-p HAVsVsEtDDyAEII
228 487 Y397-p sVsEtDDyAEIIDEE
0 18 T406-p EIIDEEDtytMPSTR
26 144 Y407-p IIDEEDtytMPSTRD
0 3 T408-p IDEEDtytMPSTRDY
0 22 Y441-p GDVHQGIyMsPENPA
0 1 S443-p VHQGIyMsPENPALA
0 1 T460-p IKTCKNCtsDsVREk
0 1 S461-p KTCKNCtsDsVREkF
0 1 S463-p CKNCtsDsVREkFLQ
0 1 K467-a tsDsVREkFLQEALT
0 1 T503-p WIIMELCtLGELRSF
0 1 S517-p FLQVRKYsLDLASLI
0 7 S568-p KLGDFGLsRyMEDst
0 500 Y570-p GDFGLsRyMEDstyy
0 101 S574-p LsRyMEDstyyKAsK
0 676 T575-p sRyMEDstyyKAsKG
65 2577 Y576-p RyMEDstyyKAsKGK
61 1786 Y577-p yMEDstyyKAsKGKL
0 48 S580-p DstyyKAsKGKLPIK
0 1 S677-p TELKAQLsTILEEEK
1 1 S695-p EERMRMEsRRQAtVs
1 2 T700-p MEsRRQAtVsWDsGG
0 2 S702-p sRRQAtVsWDsGGSD
0 5 S705-p QAtVsWDsGGSDEAP
0 5 S708 VsWDsGGSDEAPPKP
0 1 Y720-p PKPSRPGyPsPRSsE
7 7 S722-p PSRPGyPsPRSsEGF
1 1 S726-p GyPsPRSsEGFYPsP
5 1 S732-p SsEGFYPsPQHMVQT
0 1 Y742-p HMVQTNHyQVSGYPG
0 2 S759-p GITAMAGsIyPGQAS
0 3 Y761-p TAMAGsIyPGQASLL
0 1 S766 sIyPGQASLLDQTDS
0 1 V793 PNVEDSTVLDLRGIG
0 1 T805-p GIGQVLPtHLMEERL
2 12 S840-p LKPDVRLsRGsIDRE
7 12 S843-p DVRLsRGsIDREDGs
0 4 S850-p sIDREDGsLQGPIGN
0 2 I855 DGsLQGPIGNQHIyQ
56 291 Y861-p PIGNQHIyQPVGKPD
0 2 S887-p GAPGHLGsLASLSSP
0 1 S890 GHLGsLASLSSPADS
0 1 S893 GsLASLSSPADSyNE
0 1 S897 SLSSPADSyNEGVKL
0 4 Y898-p LSSPADSyNEGVKLQ
16 21 S910-p KLQPQEIsPPPtANL
0 3 T914-p QEIsPPPtANLDRsN
0 1 S920-p PtANLDRsNDKVyEN
67 442 Y925-p DRsNDKVyENVtGLV
0 2 T929-p DKVyENVtGLVKAVI
0 1 T967-p ALRTLLAtVDEtIPL
0 1 T971-p LLAtVDEtIPLLPAS
0 1 K1000-u DLGELINkMKLAQQy
0 1 Y1007-p kMKLAQQyVMTSLQQ
0 1 K1017-a TSLQQEYkKQMLTAA
3283 : Phospho-FAK (Tyr397) Antibody
8556 : Phospho-FAK (Tyr397) (D20B1) Rabbit mAb
3281 : Phospho-FAK (Tyr576/577) Antibody
3281 : Phospho-FAK (Tyr576/577) Antibody
3284 : Phospho-FAK (Tyr925) Antibody
  FAK iso2  
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
S11 YWVVGKKSNYEVLEK
Y13 VVGKKSNYEVLEKDV
K132 NSEDKDRKGMLQLKI
Y166 MADLIDGYCRLVNGT
T205 SEKQGMRTHAVSVSE
A207 KQGMRTHAVSVSETD
S209 GMRTHAVSVSETDDY
S211 RTHAVSVSETDDYAE
T213 HAVSVSETDDYAEII
Y216 SVSETDDYAEIIDEE
T225 EIIDEEDTYTMPSTR
Y226 IIDEEDTYTMPSTRD
T227 IDEEDTYTMPSTRDY
Y260 GDVHQGIYMSPENPA
S262 VHQGIYMSPENPALA
T279 IKTCKNCTSDSVREK
S280 KTCKNCTSDSVREKF
S282 CKNCTSDSVREKFLQ
K286 TSDSVREKFLQEACH
T351 WIIMELCTLGELRSF
S365 FLQVRKYSLDLASLI
S416 KLGDFGLSRYMEDST
Y418 GDFGLSRYMEDSTYY
S422 LSRYMEDSTYYKASK
T423 SRYMEDSTYYKASKG
Y424 RYMEDSTYYKASKGK
Y425 YMEDSTYYKASKGKL
S428 DSTYYKASKGKLPIK
S525 TELKAQLSTILEEEK
S543 EERMRMESRRQATVS
T548 MESRRQATVSWDSGG
S550 SRRQATVSWDSGGSD
S553 QATVSWDSGGSDEAP
S556 VSWDSGGSDEAPPKP
Y568 PKPSRPGYPSPRSSE
S570 PSRPGYPSPRSSEGF
S574 GYPSPRSSEGFYPSP
S580 SSEGFYPSPQHMVQT
Y590 HMVQTNHYQVSGYPG
S607 GITAMAGSIYPGQAS
Y609 TAMAGSIYPGQASLL
S614 SIYPGQASLLDQTDS
V641 PNVEDSTVLDLRGIG
T653 GIGQVLPTHLMEERL
- gap
- gap
- gap
I682 EKEERFLIGNQHIyQ
Y688-p LIGNQHIyQPVGKPD
S714 GAPGHLGSLASLSSP
S717 GHLGSLASLSSPADS
S720 GSLASLSSPADSYNE
S724 SLSSPADSYNEGVKL
Y725 LSSPADSYNEGVKLQ
S737 KLQPQEISPPPTANL
T741 QEISPPPTANLDRSN
S747 PTANLDRSNDKVYEN
Y752 DRSNDKVYENVTGLV
T756 DKVYENVTGLVKAVI
T794 ALRTLLATVDETIPL
T798 LLATVDETIPLLPAS
K827 DLGELINKMKLAQQY
Y834 KMKLAQQYVMTSLQQ
K844 TSLQQEYKKQMLTAA
3283 : Phospho-FAK (Tyr397) Antibody
8556 : Phospho-FAK (Tyr397) (D20B1) Rabbit mAb
  FAK iso5  
Y5 ___MAAAYLDPNLNH
T13 LDPNLNHTPNSSTKT
S16 NLNHTPNSSTKTHLG
S29 LGTGMERSPGAMERV
S45 KVFHYFESNSEPTTW
S54 SEPTTWASIIRHGDA
Y83 KVKHVACYGFRLSHL
Y148 KPTLNFFYQQVKSDY
K152 NFFYQQVKSDYMLEI
Y155 YQQVKSDYMLEIADQ
S192 GNALEKKSNYEVLEK
Y194 ALEKKSNYEVLEKDV
K313 NSEDKDRKGMLQLKI
Y347 MADLIDGYCRLVNGT
T386 SEKQGMRTHAVSVSE
A388 KQGMRTHAVSVSETD
S390 GMRTHAVSVSETDDY
S392 RTHAVSVSETDDYAE
T394 HAVSVSETDDYAEII
Y397 SVSETDDYAEIIDEE
T406 EIIDEEDTYTMPSTR
Y407 IIDEEDTYTMPSTRD
T408 IDEEDTYTMPSTRDY
Y441 GDVHQGIYMSPENPA
S443 VHQGIYMSPENPALA
T460 IKTCKNCTSDSVREK
S461 KTCKNCTSDSVREKF
S463 CKNCTSDSVREKFLQ
K467 TSDSVREKFLQEALT
T503 WIIMELCTLGELRSF
S517 FLQVRKYSLDLASLI
S568 KLGDFGLSRYMEDST
Y570 GDFGLSRYMEDSTYY
S574 LSRYMEDSTYYKASK
T575 SRYMEDSTYYKASKG
Y576 RYMEDSTYYKASKGK
Y577 YMEDSTYYKASKGKL
S580 DSTYYKASKGKLPIK
S677 TELKAQLSTILEEEK
S695 EERMRMESRRQATVS
T700 MESRRQATVSWDSGG
S702 SRRQATVSWDSGGSD
S705 QATVSWDSGGSDEAP
S708 VSWDSGGSDEAPPKP
Y720 PKPSRPGYPSPRSSE
S722 PSRPGYPSPRSSEGF
S726 GYPSPRSSEGFYPSP
S732 SSEGFYPSPQHMVQT
Y742 HMVQTNHYQVSGYPG
S759 GITAMAGSIYPGQAS
Y761 TAMAGSIYPGQASLL
S766 SIYPGQASLLDQTDS
V793 PNVEDSTVLDLRGIG
T805 GIGQVLPTHLMEERL
S840 LKPDVRLSRGSIDRE
S843 DVRLSRGSIDREDGS
S850 SIDREDGSLQGPIGN
I855 DGSLQGPIGNQHIyQ
Y861-p PIGNQHIyQPVGKPG
S897 GAPGHLGSLASLSSP
S900 GHLGSLASLSSPADS
S903 GSLASLSSPADSYNE
S907 SLSSPADSYNEGVKP
Y908 LSSPADSYNEGVKPW
S923 RLQPQEISPPPTANL
T927 QEISPPPTANLDRSN
S933 PTANLDRSNDKVYEN
Y938 DRSNDKVYENVTGLV
T942 DKVYENVTGLVKAVI
T980 ALRTLLATVDETIPL
T984 LLATVDETIPLLPAS
K1013 DLGELINKMKLAQQY
Y1020 KMKLAQQYVMTSLQQ
K1030 TSLQQEYKKQMLTAA
  mouse

► Hide Isoforms 		 
Y5 ___MAAAYLDPNLNH
T13 LDPNLNHTPSSSTKT
S16 NLNHTPSSSTKTHLG
S29 LGTGMERSPGAMERV
S45-p KVFHYFEsSSEPTTW
S54-p SEPTTWAsIIRHGDA
Y83-p KVKHVACyGFRLSHL
Y148 KPTLNFFYQQVKSDY
K152 NFFYQQVKSDYMQEI
Y155 YQQVKSDYMQEIADQ
S192-p GNALEKKsNyEVLEK
Y194-p ALEKKsNyEVLEKDV
K313-a NSEDKDRkGMLQLKI
Y347-p MADLIDGyCRLVNGA
T386 SEKQGMRTHAVSVSH
A388 KQGMRTHAVSVSHCQ
S390 GMRTHAVSVSHCQHK
S392 RTHAVSVSHCQHKVK
T425 DEISGDETDDyAEII
Y428-p SGDETDDyAEIIDEE
T437 EIIDEEDTyTMPSKS
Y438-p IIDEEDTyTMPSKSY
T439 IDEEDTyTMPSKSYG
Y479 GDVHQGVYLSPENPA
S481 VHQGVYLSPENPALA
T498 IKTCKNCTSDSVREK
S499 KTCKNCTSDSVREKF
S501 CKNCTSDSVREKFLQ
K505 TSDSVREKFLQEALT
T541 WIIMELCTLGELRSF
S555 FLQVRKYSLDLASLI
S606-p KLGDFGLsRyMEDst
Y608-p GDFGLsRyMEDstyy
S612-p LsRyMEDstyyKAsK
T613-p sRyMEDstyyKAsKG
Y614-p RyMEDstyyKAsKGK
Y615-p yMEDstyyKAsKGKL
S618-p DstyyKAsKGKLPIK
S715 TELKAQLSTILEEEK
S733 EERMRMESRRQATVS
T738 MESRRQATVSWDsGG
S740 SRRQATVSWDsGGsD
S743-p QATVSWDsGGsDEAP
S746-p VSWDsGGsDEAPPKP
Y758-p PKPSRPGyPsPRSSE
S760-p PSRPGyPsPRSSEGF
S764 GyPsPRSSEGFYPsP
S770-p SSEGFYPsPQHMVQT
Y780 HMVQTNHYQVSGYPG
S797-p GIPAMAGsIyQGQAS
Y799-p PAMAGsIyQGQASLL
S804 sIyQGQASLLDQTEL
A831 PSVEDSAALDLRGMG
P843 GMGQVLPPHLMEERL
S878-p LKPDVRLsRGsIDRE
S881-p DVRLsRGsIDREDGS
S888 sIDREDGSFQGPtGN
T893-p DGSFQGPtGNQHIyQ
Y899-p PtGNQHIyQPVGKPD
N925 GAPGHLSNLSSISSP
S928 GHLSNLSSISSPADS
S931 SNLSSISSPADSYNE
S935 SISSPADSYNEGVKL
Y936 ISSPADSYNEGVKLQ
S948-p KLQPQEIsPPPtANL
T952-p QEIsPPPtANLDRSN
S958 PtANLDRSNDKVyEN
Y963-p DRSNDKVyENVTGLV
T967 DKVyENVTGLVKAVI
T1005 ALRTLLATVDETIPA
T1009 LLATVDETIPALPAS
K1038 DLGELISKMKLAQQY
Y1045 KMKLAQQYVMTSLQQ
K1055 TSLQQEYKKQMLTAA
3283 : Phospho-FAK (Tyr397) Antibody
8556 : Phospho-FAK (Tyr397) (D20B1) Rabbit mAb
3281 : Phospho-FAK (Tyr576/577) Antibody
3281 : Phospho-FAK (Tyr576/577) Antibody
3284 : Phospho-FAK (Tyr925) Antibody
  FAK iso3  
Y5 ___MAAAYLDPNLNH
T13 LDPNLNHTPSSSTKT
S16 NLNHTPSSSTKTHLG
S29 LGTGMERSPGAMERV
S45 KVFHYFESSSEPTTW
S54 SEPTTWASIIRHGDA
Y83 KVKHVACYGFRLSHL
Y148 KPTLNFFYQQVKSDY
K152 NFFYQQVKSDYMQEI
Y155 YQQVKSDYMQEIADQ
S192 GNALEKKSNYEVLEK
Y194 ALEKKSNYEVLEKDV
K313 NSEDKDRKGMLQLKI
Y347 MADLIDGYCRLVNGA
T386-p SEKQGMRtHAVsVsE
A388 KQGMRtHAVsVsEtD
S390-p GMRtHAVsVsEtDDy
S392-p RtHAVsVsEtDDyAE
T394-p HAVsVsEtDDyAEII
Y397-p sVsEtDDyAEIIDEE
T406-p EIIDEEDtytMPSTR
Y407-p IIDEEDtytMPSTRD
T408-p IDEEDtytMPSTRDY
Y441 GDVHQGVYLSPENPA
S443 VHQGVYLSPENPALA
T460 IKTCKNCTSDSVREK
S461 KTCKNCTSDSVREKF
S463 CKNCTSDSVREKFLQ
K467 TSDSVREKFLQEALT
T503 WIIMELCTLGELRSF
S517 FLQVRKYSLDLASLI
S568-p KLGDFGLsRyMEDst
Y570-p GDFGLsRyMEDstyy
S574-p LsRyMEDstyyKASK
T575-p sRyMEDstyyKASKG
Y576-p RyMEDstyyKASKGK
Y577-p yMEDstyyKASKGKL
S580 DstyyKASKGKLPIK
S677 TELKAQLSTILEEEK
S695 EERMRMESRRQATVS
T700 MESRRQATVSWDsGG
S702 SRRQATVSWDsGGsD
S705-p QATVSWDsGGsDEAP
S708-p VSWDsGGsDEAPPKP
Y720-p PKPSRPGyPsPRSSE
S722-p PSRPGyPsPRSSEGF
S726 GyPsPRSSEGFYPsP
S732-p SSEGFYPsPQHMVQT
Y742 HMVQTNHYQVSGYPG
S759 GIPAMAGSIYQGQAS
Y761 PAMAGSIYQGQASLL
S766 SIYQGQASLLDQTEL
A793 PSVEDSAALDLRGMG
P805 GMGQVLPPHLMEERL
S840-p LKPDVRLsRGsIDRE
S843-p DVRLsRGsIDREDGS
S850 sIDREDGSFQGPTGN
T855 DGSFQGPTGNQHIyQ
Y861-p PTGNQHIyQPVGKPD
N887 GAPGHLSNLSSISSP
S890 GHLSNLSSISSPADS
S893 SNLSSISSPADSYNE
S897 SISSPADSYNEGVKL
Y898 ISSPADSYNEGVKLQ
S910-p KLQPQEIsPPPTANL
T914 QEIsPPPTANLDRSN
S920 PTANLDRSNDKVyEN
Y925-p DRSNDKVyENVTGLV
T929 DKVyENVTGLVKAVI
T967 ALRTLLATVDETIPA
T971 LLATVDETIPALPAS
K1000 DLGELISKMKLAQQY
Y1007 KMKLAQQYVMTSLQQ
K1017 TSLQQEYKKQMLTAA
3283 : Phospho-FAK (Tyr397) Antibody
8556 : Phospho-FAK (Tyr397) (D20B1) Rabbit mAb
3281 : Phospho-FAK (Tyr576/577) Antibody
3281 : Phospho-FAK (Tyr576/577) Antibody
3284 : Phospho-FAK (Tyr925) Antibody
  FAK iso4  
Y5 ___MAAAYLDPNLNH
T13 LDPNLNHTPSSSTKT
S16 NLNHTPSSSTKTHLG
S29 LGTGMERSPGAMERV
S45 KVFHYFESSSEPTTW
S54 SEPTTWASIIRHGDA
Y83 KVKHVACYGFRLSHL
Y148 KPTLNFFYQQVKSDY
K152 NFFYQQVKSDYMQEI
Y155 YQQVKSDYMQEIADQ
S192 GNALEKKSNYEVLEK
Y194 ALEKKSNYEVLEKDV
K313 NSEDKDRKGMLQLKI
Y347 MADLIDGYCRLVNGA
T386-p SEKQGMRtHAVsVsE
A388 KQGMRtHAVsVsEtD
S390-p GMRtHAVsVsEtDDy
S392-p RtHAVsVsEtDDyAE
T394-p HAVsVsEtDDyAEII
Y397-p sVsEtDDyAEIIDEE
T406-p EIIDEEDtytMPSTR
Y407-p IIDEEDtytMPSTRD
T408-p IDEEDtytMPSTRDY
Y441 GDVHQGVYLSPENPA
S443 VHQGVYLSPENPALA
T460 IKTCKNCTSDSVREK
S461 KTCKNCTSDSVREKF
S463 CKNCTSDSVREKFLQ
K467 TSDSVREKFLQEALT
T503 WIIMELCTLGELRSF
S517 FLQVRKYSLDLASLI
S568 KLGDFGLSRYMEDST
Y570 GDFGLSRYMEDSTYY
S574 LSRYMEDSTYYKASK
T575 SRYMEDSTYYKASKG
Y576 RYMEDSTYYKASKGK
Y577 YMEDSTYYKASKGKL
S580 DSTYYKASKGKLPIK
S677 TELKAQLSTILEEEK
S695 EERMRMESRRQATVS
T700 MESRRQATVSWDSGG
S702 SRRQATVSWDSGGSD
S705 QATVSWDSGGSDEAP
S708 VSWDSGGSDEAPPKP
Y720 PKPSRPGYPSPRSSE
S722 PSRPGYPSPRSSEGF
S726 GYPSPRSSEGFYPSP
S732 SSEGFYPSPQHMVQT
Y742 HMVQTNHYQVSGYPG
S759 GIPAMAGSIYQGQAS
Y761 PAMAGSIYQGQASLL
S766 SIYQGQASLLDQTEL
A793 PSVEDSAALDLRGMG
P805 GMGQVLPPHLMEERL
S840 LKPDVRLSRGSIDRE
S843 DVRLSRGSIDREDGS
S850 SIDREDGSFQGPTGN
T855 DGSFQGPTGNQHIYQ
Y861 PTGNQHIYQPVGKPD
N887 GAPGHLSNLSSISSP
S890 GHLSNLSSISSPADS
S893 SNLSSISSPADSYNE
S897 SISSPADSYNEGVKP
Y898 ISSPADSYNEGVKPW
S913-p RLQPQEIsPPPtANL
T917-p QEIsPPPtANLDRSN
S923 PtANLDRSNDKVYEN
Y928 DRSNDKVYENVTGLV
T932 DKVYENVTGLVKAVI
T970 ALRTLLATVDETIPA
T974 LLATVDETIPALPAS
K1003 DLGELISKMKLAQQY
Y1010 KMKLAQQYVMTSLQQ
K1020 TSLQQEYKKQMLTAA
3283 : Phospho-FAK (Tyr397) Antibody
8556 : Phospho-FAK (Tyr397) (D20B1) Rabbit mAb
  rat

 
Y5 ___MAAAYLDPNLNH
T13 LDPNLNHTPSSSTKT
S16 NLNHTPSSSTKTHLG
S29 LGTGTERSPGAMERV
S45 KVFHYFESSNEPTTW
S54 NEPTTWASIIRHGDA
Y83 KVKHVACYGFRLSHL
Y148 KPTLNFFYQQVkSDY
K152-s NFFYQQVkSDYMLEI
Y155 YQQVkSDYMLEIADQ
S192 GNALEKKSNYEVLEK
Y194 ALEKKSNYEVLEKDV
K313 NSEDKDRKGMLQLKI
Y347 MADLIDGYCRLVNGA
T386 NEKQGMRTHAVSVSE
A388 KQGMRTHAVSVSETD
S390 GMRTHAVSVSETDDy
S392 RTHAVSVSETDDyAE
T394 HAVSVSETDDyAEII
Y397-p SVSETDDyAEIIDEE
T406 EIIDEEDTyTMPSTR
Y407-p IIDEEDTyTMPSTRD
T408 IDEEDTyTMPSTRDY
Y441 GDVHQGVYLSPENPA
S443 VHQGVYLSPENPALA
T460 IKTCKNCTSDSVREK
S461 KTCKNCTSDSVREKF
S463 CKNCTSDSVREKFLQ
K467 TSDSVREKFLQEALT
T503 WIIMELCTLGELRSF
S517 FLQVRKYSLDLASLI
S568 KLGDFGLSRyMEDSt
Y570-p GDFGLSRyMEDStyy
S574 LSRyMEDStyyKASK
T575-p SRyMEDStyyKASKG
Y576-p RyMEDStyyKASKGK
Y577-p yMEDStyyKASKGKL
S580 DStyyKASKGKLPIK
S677 TELKAQLSTILEEEK
S695 EERMRMESRRQATVS
T700 MESRRQATVSWDSGG
S702 SRRQATVSWDSGGSD
S705 QATVSWDSGGSDEAP
S708 VSWDSGGSDEAPPKP
Y720 PKPSRPGYPsPRSSE
S722-p PSRPGYPsPRSSEGF
S726 GYPsPRSSEGFYPSP
S732 SSEGFYPSPQHMVQT
Y742 HMVQTNHYQISGYPG
S759 GIPAMAGSIYPGQAS
Y761 PAMAGSIYPGQASLL
S766 SIYPGQASLLDQTEL
A793 PSVEDSAALDLRGMG
P805 GMGQVLPPHLMEERL
S840 LKPDVRLSRGsIDRE
S843-p DVRLSRGsIDREDGS
S850 sIDREDGSFQGPTGN
T855 DGSFQGPTGNQHIyQ
Y861-p PTGNQHIyQPVGKPD
N887 GAPGHLSNLSSISSP
S890 GHLSNLSSISSPAES
S893 SNLSSISSPAESYNE
S897 SISSPAESYNEGVKP
Y898 ISSPAESYNEGVKPW
S913-p RLQPQEIsPPPTANL
T917 QEIsPPPTANLDRSN
S923 PTANLDRSNDKVyEN
Y928-p DRSNDKVyENVTGLV
T932 DKVyENVTGLVKAVI
T970 ALRTLLATVDETIPI
T974 LLATVDETIPILPAS
K1003 DLGELISKMKLAQQY
Y1010 KMKLAQQYVMTSLQQ
K1020 TSLQQEYKKQMLTAA
3283 : Phospho-FAK (Tyr397) Antibody
8556 : Phospho-FAK (Tyr397) (D20B1) Rabbit mAb
3281 : Phospho-FAK (Tyr576/577) Antibody
3281 : Phospho-FAK (Tyr576/577) Antibody
  chicken

► Hide Isoforms 		 
Y5 ___MAAAYLDPNLNH
T13-p LDPNLNHtPSSSAKT
S16 NLNHtPSSSAKTHLG
S29-p LGTGMERsPGAMERV
N45 KVFHYFENSSEPTTW
S54 SEPTTWASIIRHGDA
Y83 KVKNVACYGLRLSHL
Y148 KPTLNFFYQQVKNDy
K152 NFFYQQVKNDyMLEI
Y155-p YQQVKNDyMLEIADQ
S192 GNALEKKSNYEVLEK
Y194 ALEKKSNYEVLEKDV
K313 NSEDKDRKGMLQLKI
Y347 MADLIDGYCRLVNGA
S386-p NEKQGVRsHtVsVsE
T388-p KQGVRsHtVsVsETD
S390-p GVRsHtVsVsETDDy
S392-p RsHtVsVsETDDyAE
T394 HtVsVsETDDyAEII
Y397-p sVsETDDyAEIIDEE
T406-p EIIDEEDtyTMPSTR
Y407-p IIDEEDtyTMPSTRD
T408 IDEEDtyTMPSTRDY
Y441 GDVHQGIYMSPENPA
S443 VHQGIYMSPENPAMA
T460 IKTCKNCTSDSVREK
S461 KTCKNCTSDSVREKF
S463 CKNCTSDSVREKFLQ
K467 TSDSVREKFLQEALT
T503 WIIMELCTLGELRSF
S517 FLQVRKFSLDLASLI
S568 KLGDFGLSRyMEDST
Y570-p GDFGLSRyMEDSTyy
S574 LSRyMEDSTyyKASK
T575 SRyMEDSTyyKASKG
Y576-p RyMEDSTyyKASKGK
Y577-p yMEDSTyyKASKGKL
S580 DSTyyKASKGKLPIK
S677 TELKAQLSTILEEEK
S695 EERMRMESRRQVtVS
T700-p MESRRQVtVSWDSGG
S702 SRRQVtVSWDSGGsD
S705 QVtVSWDSGGsDEAP
S708-p VSWDSGGsDEAPPKP
Y720 PKPSRPGYPsPRSsE
S722-p PSRPGYPsPRSsEGF
S726-p GYPsPRSsEGFYPsP
S732-p SsEGFYPsPQHMVQP
Y742 HMVQPNHYQVSGYSG
S759 GIPAMAGSIYPGQAs
Y761 PAMAGSIYPGQAsLL
S766-p SIYPGQAsLLDQTDS
T793-p PNMEDSGtLDVRGMG
T805 GMGQVLPTHLMEERL
S842-p MKPDVRLsRGsIERE
S845-p DVRLsRGsIEREDGG
G852 sIEREDGGLQGPAGN
A857 DGGLQGPAGNQHIyQ
Y863-p PAGNQHIyQPVGKPD
S888-p PGAPHLGsLAsLNsP
S891-p PHLGsLAsLNsPVDs
S894-p GsLAsLNsPVDsyNE
S898-p sLNsPVDsyNEGVKI
Y899-p LNsPVDsyNEGVKIK
S911-p KIKPQEIsPPPTANL
T915 QEIsPPPTANLDRSN
S921 PTANLDRSNDKVyEN
Y926-p DRSNDKVyENVTGLV
T930 DKVyENVTGLVKAVI
T968 ALRTLLATVDESLPV
S972 LLATVDESLPVLPAS
K1001 DLAELINKMKLAQQY
Y1008 KMKLAQQYVMTSLQQ
K1018 TSLQQEYKKQMLTAA
3283 : Phospho-FAK (Tyr397) Antibody
8556 : Phospho-FAK (Tyr397) (D20B1) Rabbit mAb
3281 : Phospho-FAK (Tyr576/577) Antibody
3281 : Phospho-FAK (Tyr576/577) Antibody
  FAK iso5  
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S3 _____MESRRQVTVS
T8 MESRRQVTVSWDSGG
S10 SRRQVTVSWDSGGSD
S13 QVTVSWDSGGSDEAP
S16 VSWDSGGSDEAPPKP
Y28 PKPSRPGYPsPRSSE
S30-p PSRPGYPsPRSSEGF
S34 GYPsPRSSEGFYPSP
S40 SSEGFYPSPQHMVQP
Y50 HMVQPNHYQVSGYSG
S67 GIPAMAGSIYPGQAS
Y69 PAMAGSIYPGQASLL
S74 SIYPGQASLLDQTDS
T101 PNMEDSGTLDVRGMG
T113 GMGQVLPTHLMEERL
S148-p LKPDVRLsRGsIERE
S151-p DVRLsRGsIEREDGG
G158 sIEREDGGLQGPAGN
A163 DGGLQGPAGNQHIYQ
Y169 PAGNQHIYQPVGKPD
S194 PGAPHLGSLASLNSP
S197 PHLGSLASLNSPVDS
S200 GSLASLNSPVDSYNE
S204 SLNSPVDSYNEGVKI
Y205 LNSPVDSYNEGVKIK
S217-p KIKPQEIsPPPTANL
T221 QEIsPPPTANLDRSN
S227 PTANLDRSNDKVYEN
Y232 DRSNDKVYENVTGLV
T236 DKVYENVTGLVKAVI
T274 ALRTLLATVDESLPV
S278 LLATVDESLPVLPAS
K307 DLAELINKMKLAQQY
Y314 KMKLAQQYVMTSLQQ
K324 TSLQQEYKKQMLTAA
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