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Protein Page:
SMARCAD1 (human)
p Phosphorylation
a Acetylation
m Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
u Ubiquitination
s Sumoylation
n Neddylation
gl O-GlcNAc
ga O-GalNAc
h Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage

Overview
SMARCAD1 an ubiquitous enzyme with ATP-dependent DNA helicase activity. Belongs to the SNF2/RAD54 helicase family. Two alternatively spliced human isoforms have been described. Note: This description may include information from UniProtKB.
Protein type: EC 3.6.1.-; Adaptor/scaffold; Helicase; EC 3.6.4.12
Cellular Component: heterochromatin; nuclear matrix; nuclear replication fork
Molecular Function: protein binding; nucleic acid binding; DNA binding; helicase activity; ATP binding
Biological Process: chromatin remodeling; regulation of DNA recombination; positive regulation of transcription, DNA-dependent; DNA double-strand break processing; ATP-dependent chromatin remodeling; nucleotide metabolic process; chromatin modification; protein homooligomerization; chromosome separation
Reference #:  Q9H4L7 (UniProtKB)
Alt. Names/Synonyms: ATP-dependent helicase 1; DKFZp762K2015; ETL1; HEL1; hHEL1; KIAA1122; SMARCAD1; SMRCD; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A containing DEAD/H box 1; SWI/SNF-related, matrix-associated actin-dependent regulator of chromatin, subfamily a, containing DEAD/H box 1
Gene Symbols: SMARCAD1
Molecular weight: 117,402 Da
Basal Isoelectric point: 5.39  Predict pI for various phosphorylation states
Select Structure to View Below

SMARCAD1

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 2 S34-p PSQPGPSsPIsLsAE
0 2 S37-p PGPSsPIsLsAEEEN
0 3 S39-p PSsPIsLsAEEENAE
0 11 T54-p GEVSRANtPDsDItE
0 10 S57-p SRANtPDsDItEKTE
0 1 T60-p NtPDsDItEKTEDss
0 1 S66-p ItEKTEDssVPEtPD
0 2 S67-p tEKTEDssVPEtPDN
0 1 T71-p EDssVPEtPDNERKA
0 20 S79-p PDNERKAsISyFKNQ
0 1 S81 NERKAsISyFKNQRG
0 4 Y82-p ERKAsISyFKNQRGI
0 3 S95-p GIQYIDLssDsEDVV
0 2 S96-p IQYIDLssDsEDVVs
0 3 S98-p YIDLssDsEDVVsPN
0 1 S103-p sDsEDVVsPNCSNTV
0 2 T114-p SNTVQEKtFNKDTVI
0 41 S124-p KDTVIIVsEPsEDEE
0 36 S127-p VIIVsEPsEDEEsQG
0 23 S132-p EPsEDEEsQGLPtMA
0 2 T137-p EEsQGLPtMARRNDD
0 8 I145 MARRNDDIsELEDLs
0 30 S146-p ARRNDDIsELEDLsE
0 22 S152-p IsELEDLsELEDLKD
0 1 S173-p KELFPQRsDNDLLKL
0 91 S211-p GPRKRKLssssEPyE
0 45 S212-p PRKRKLssssEPyEE
0 40 S213-p RKRKLssssEPyEED
0 74 S214-p KRKLssssEPyEEDE
0 11 Y217-p LssssEPyEEDEFND
0 21 S239-p RLDHGEEsNEsAEsS
0 15 S242-p HGEEsNEsAEsSSNW
0 3 S245-p EsNEsAEsSSNWEKQ
0 1 K261-u SIVLKLQkEFPNFDk
0 1 K268-m3 kEFPNFDkQELREVL
0 11 S302-p DQDMQYVsQSEVPNG
0 1 K310-u QSEVPNGkEVSSRSQ
0 4 K352-a KKNVFNPkRVVEDSE
0 1 S408 LTLIPQCSQKKAQKI
0 5 S423-p TELRPFNsWEALFTK
0 1 K705-u DEQSIYEkERIAHAK
0 2 S801-p AEKLKEMsQLMLKEP
0 1 K903-u RYLRLDGkTQISERI
  mouse

 
S34-p PSQARPSsPISLsAE
S37 ARPSsPISLsAEEEN
S39-p PSsPISLsAEEENAE
T54-p GEGSRANtPDsDVTE
S57-p SRANtPDsDVTEKTE
T60 NtPDsDVTEKTEDSS
S66 VTEKTEDSSVPEPPD
S67 TEKTEDSSVPEPPDN
P71 EDSSVPEPPDNERKA
S79-p PDNERKAsLsCFQNQ
S81-p NERKAsLsCFQNQRA
C82 ERKAsLsCFQNQRAI
S96-p IQEYIDLssDtEDVs
S97-p QEYIDLssDtEDVsP
T99-p YIDLssDtEDVsPNC
S103-p ssDtEDVsPNCSSTV
K114 SSTVQEKKFSKDTVI
S124-p KDTVIIVsEPsEDEE
S127-p VIIVsEPsEDEEsHD
S132-p EPsEDEEsHDLPsVT
S137-p EEsHDLPsVTRRNDs
S144-p sVTRRNDssELEDLs
S145-p VTRRNDssELEDLsE
S151-p ssELEDLsELEDLKD
S172 KELFPQRSDSDLLKL
S210-p GPRKRKLssssEEDD
S211-p PRKRKLssssEEDDV
S212-p RKRKLssssEEDDVN
S213-p KRKLssssEEDDVND
- gap
S235-p RGDRGEEsNEsAEAS
S238-p RGEEsNEsAEASSNW
A241 EsNEsAEASSNWEKQ
K257 SIVLKLQKEFPNFDK
K264 KEFPNFDKQELREVL
S298-p DQDVQCAsQSEVTNG
K306 QSEVTNGKEVARNQN
K347 KKNVFNPKKAVEDSE
S403-p LTLIPKCsQKKAQKI
N418 TELRPFNNWEALFTK
K700 DEQSIYEKERIAHAK
S796 PEKLKEMSQLMLKEP
K898 RYLRLDGKTQISERI
  rat

 
S34 PSQPGPSSPISLSAE
S37 PGPSSPISLSAEEEN
S39 PSSPISLSAEEENAE
T54-p GEVSRANtPDsDVTE
S57-p SRANtPDsDVTEKTE
T60 NtPDsDVTEKTEDSS
S66 VTEKTEDSSVPEPPD
S67 TEKTEDSSVPEPPDN
P71 EDSSVPEPPDNESKA
S79 PDNESKASLSCFQNQ
S81 NESKASLSCFQNQRT
C82 ESKASLSCFQNQRTI
S96 IQEYIDLSSDsEDVS
S97 QEYIDLSSDsEDVSP
S99-p YIDLSSDsEDVSPNC
S103 SSDsEDVSPNCSSTV
K114 SSTVQEKKFSKDTVI
S124-p KDTVIIVsEPsEDEE
S127-p VIIVsEPsEDEESHD
S132 EPsEDEESHDLPSAT
S137 EESHDLPSATRRNDI
I144 SATRRNDISELEDLS
S145 ATRRNDISELEDLSE
S151 ISELEDLSELEDLKD
S172 KELFPQRSDSDLLKL
S210 GPRKRKLSssSEAYE
S211-p PRKRKLSssSEAYEE
S212-p RKRKLSssSEAYEED
S213 KRKLSssSEAYEEDE
Y216 LSssSEAYEEDEAND
S238 RGDRREESNESAEAS
S241 RREESNESAEASSNW
A244 ESNESAEASSNWEKQ
K260 SIVLKLQKEFPNFDK
K267 KEFPNFDKQELREVL
S301 DQDVQCASQSEVTNG
K309 QSEVTNGKEVARNQN
K350 KKNVFNPKKAVEDSE
S406 LTLIPKCSQKKAQKI
N421 IELRPFNNWETLFTK
K703 DEQSIYEKERIAHAK
S799 AEKLKEMSQLMLKEP
K901 RYLRLDGKTQISERI
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