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Protein Page:
APC1 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
APC1 Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. Belongs to the APC1 family. Note: This description may include information from UniProtKB.
Protein type: Ubiquitin conjugating system; Cell cycle regulation
Cellular Component: nucleoplasm; anaphase-promoting complex; cytosol
Biological Process: positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle; mitosis; negative regulation of ubiquitin-protein ligase activity during mitotic cell cycle; regulation of ubiquitin-protein ligase activity during mitotic cell cycle; anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process; mitotic cell cycle spindle assembly checkpoint; mitotic cell cycle
Reference #:  Q9H1A4 (UniProtKB)
Alt. Names/Synonyms: ANAPC1; anaphase promoting complex subunit 1; anaphase-promoting complex 1 (meiotic checkpoint regulator); Anaphase-promoting complex subunit 1; APC1; Cyclosome subunit 1; MCPR; Mitotic checkpoint regulator; Testis-specific gene 24 protein; TSG24
Gene Symbols: ANAPC1
Molecular weight: 216,500 Da
Basal Isoelectric point: 5.88  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

APC1

Protein Structure Not Found.


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Sites Implicated In
activity, induced: S355‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 3 S46-p LRQLQPAsELWssDG
0 4 S50-p QPAsELWssDGAAGL
0 10 S51-p PAsELWssDGAAGLV
0 17 S60-p GAAGLVGsLQEVtIH
0 2 T65-p VGsLQEVtIHEkQKE
0 1 K69-ub QEVtIHEkQKESWQL
0 1 T118-p LAVYKAFtVDSPVQQ
0 1 K140-ub ISQDKSEkAYSSNEV
0 4 S202-p SHEVPPGsPREPLPT
0 2 S233-p KSGSLFGsSRVQYVV
0 1 K245-ub YVVDHAMkIVFLNTD
0 1 K275-ub VWTLRRVkSEEENVV
0 4 S286-p ENVVLKFsEQGGtPQ
0 8 T291-p KFsEQGGtPQNVATS
0 1 S299-p PQNVATSssLTAHLR
0 2 S300-p QNVATSssLTAHLRs
0 1 S307-p sLTAHLRsLSkGDsP
0 3 K310-ub AHLRsLSkGDsPVts
0 8 S313-p RsLSkGDsPVtsPFQ
0 2 T316-p SkGDsPVtsPFQNYS
0 4 S317-p kGDsPVtsPFQNYSS
0 1 Y322 VtsPFQNYSSIHSQS
0 1 T332-p IHSQSRStssPsLHs
0 5 S333-p HSQSRStssPsLHsR
0 2 S334-p SQSRStssPsLHsRs
0 1 S336-p SRStssPsLHsRsPs
0 3 S339-p tssPsLHsRsPsIsN
0 7 S341-p sPsLHsRsPsIsNMA
0 9 S343-p sLHsRsPsIsNMAAL
0 1 S345-p HsRsPsIsNMAALsR
0 2 S351-p IsNMAALsRAHsPAL
1 18 S355-p AALsRAHsPALGVHs
0 9 S362-p sPALGVHsFsGVQRF
0 2 S364-p ALGVHsFsGVQRFNI
0 8 S372-p GVQRFNIssHNQsPK
0 5 S373-p VQRFNIssHNQsPKR
0 2 N375 RFNIssHNQsPKRHS
0 19 S377-p NIssHNQsPKRHSIS
0 1 S386-p KRHSISHsPNSNSNG
0 1 K429-ub EKNSQASkVFITSDL
0 1 K477-ub SVTNIPAkDAAPVEK
0 7 S518-p IPGLPAPsLtMsNtM
0 2 T520-p GLPAPsLtMsNtMPR
0 2 S522-p PAPsLtMsNtMPRPs
0 2 T524-p PsLtMsNtMPRPstP
0 4 S529-p sNtMPRPstPLDGVs
0 9 T530-p NtMPRPstPLDGVst
0 2 S536-p stPLDGVstPKPLsK
0 4 T537-p tPLDGVstPKPLsKL
0 3 S542-p VstPKPLsKLLGsLD
0 14 S547-p PLsKLLGsLDEVVLL
0 10 S555-p LDEVVLLsPVPELRD
0 1 S564-p VPELRDSsKLHDsLy
0 5 S569-p DSsKLHDsLyNEDCT
0 2 Y571-p sKLHDsLyNEDCTFQ
0 1 T596-p DPVHNRVtLELsNGS
0 1 S600-p NRVtLELsNGSMVRI
0 5 N680 DRLAWTRNFDFEGsL
0 12 S686-p RNFDFEGsLsPVIAP
0 38 S688-p FDFEGsLsPVIAPkK
0 1 K694-ub LsPVIAPkKARPsEt
0 1 S699-p APkKARPsEtGsDDD
0 1 T701-p kKARPsEtGsDDDWE
0 4 S703-p ARPsEtGsDDDWEYL
0 1 Y709 GsDDDWEYLLNSDYH
0 1 S713 DWEYLLNSDYHQNVE
0 2 S727-p ESHLLNRsLCLsPSE
0 5 S731-p LNRsLCLsPSEASQM
0 1 S876-p RSRLVVLsIALYILG
0 1 S886-p LYILGDEsLVSDEsS
0 1 S892-p EsLVSDEsSQYLTRI
0 1 A902 YLTRITIAPQkLQVE
0 1 K905-ub RITIAPQkLQVEQEE
0 3 S916-p EQEENRFsFRHSTSV
0 1 K985 IGRQDLSKQACEGNL
0 1 S1058-p VVQYPELsDHEFIEE
0 2 K1066-ub DHEFIEEkENRLLQL
0 8 S1347-p MHREKHKsPsYQIKE
0 2 S1349-p REKHKsPsYQIKEGD
0 1 Y1552-p KTGGEMNyGFHLAHH
0 2 Y1610-p LQALRHLyVLAAEPR
0 1 Y1638-p YALLEVTyKGTQWYE
0 1 K1693 HLKSILSKDGVLyVK
0 1 Y1698-p LSKDGVLyVKLRAGQ
0 2 S1707-p KLRAGQLsYkEDPMG
0 1 Y1708 LRAGQLsYkEDPMGW
0 2 K1709-ub RAGQLsYkEDPMGWQ
  mouse

 
S46-p LRQLQPAsELWssDG
S50-p QPAsELWssDGAAGL
S51-p PAsELWssDGAAGLV
S60-p GAAGLVGsLQEVTIH
T65 VGsLQEVTIHEKQKE
K69 QEVTIHEKQKESWQL
T118 LAVYKAFTVDSTVQQ
K140 ISQDKSEKIYKSHEL
L202 SHEVPPSLPREPLPT
S233 KSGSLFGSSRVQYVV
K245 YVVDPAVKIVFLNID
K275 VWTLRRVKPEEENAV
P286 ENAVLKFPEQAGTLQ
T291 KFPEQAGTLQNATTS
S299 LQNATTSSSLTAHLR
S300 QNATTSSSLTAHLRS
S307 SLTAHLRSLSkGEsP
K310-ub AHLRSLSkGEsPVAs
S313-p RSLSkGEsPVAsPFQ
A316 SkGEsPVAsPFQNyS
S317-p kGEsPVAsPFQNySS
Y322-p VAsPFQNySSIHSQS
T332 IHSQSRSTSSPSLHS
S333 HSQSRSTSSPSLHSR
S334 SQSRSTSSPSLHSRS
S336 SRSTSSPSLHSRSPs
S339 TSSPSLHSRSPsISN
S341 SPSLHSRSPsISNMA
S343-p SLHSRSPsISNMAAL
S345 HSRSPsISNMAALSR
S351 ISNMAALSRAHsPAL
S355-p AALSRAHsPALGVHs
S362-p sPALGVHsFSGAQRF
S364 ALGVHsFSGAQRFNL
S372-p GAQRFNLssHsQsPK
S373-p AQRFNLssHsQsPKR
S375-p RFNLssHsQsPKRHS
S377-p NLssHsQsPKRHSIS
S386 KRHSISHSPSGSFND
K429 EKNSQASKVFITTDL
K477 SVTNIHAKDAAPVEK
S518 IPGLPAPSLTMSNMM
T520 GLPAPSLTMSNMMPR
S522 PAPSLTMSNMMPRPS
M524 PSLTMSNMMPRPSTP
S529 SNMMPRPSTPLDGVG
T530 NMMPRPSTPLDGVGT
G536 STPLDGVGTPKPLSK
T537 TPLDGVGTPKPLSKL
S542 VGTPKPLSKLLGsMD
S547-p PLSKLLGsMDEVVLL
S555-p MDEVVLLsPVPELRD
S564 VPELRDSSKLNDSLY
S569 DSSKLNDSLYNEDCT
Y571 SKLNDSLYNEDCTFQ
T596 DPVHNRVTLELSNGS
S600 NRVTLELSNGSMVRI
S680-p DRLAWTRsFDFEGsL
S686-p RsFDFEGsLsPVIAP
S688-p FDFEGsLsPVIAPKK
K694 LsPVIAPKKARPsDT
S699-p APKKARPsDTGSDED
T701 KKARPsDTGSDEDWE
S703 ARPsDTGSDEDWEyL
Y709-p GSDEDWEyLLNsEYH
S713-p DWEyLLNsEYHRNVE
S727 ESHLLNKSLCLTALE
T731 LNKSLCLTALEVSNA
S876 RSRLVVLSIALYTLG
S886 LYTLGDESCVSDETC
T892 ESCVSDETCQYLSKV
T902-p YLSKVTStPQKPQAE
K905 KVTStPQKPQAEQEE
T916 EQEENRFTFRHSASV
K985-ub IGRQDLSkQACEGNL
S1058 VVQYPELSDHEFIEE
K1066-ub DHEFIEEkENRLLQL
S1347-p MHREKHKsPSYQIKE
S1349 REKHKsPSYQIKEGD
Y1552 KTGGEMNYGFHLAHH
Y1610 LQALRHLYVLAAEPR
Y1638 YALIEVTYKGTQWYE
K1693-ub HLRSILSkDGVLYVK
Y1698 LSkDGVLYVKLRAGQ
S1707-p KLRAGQLsykEDPMG
Y1708-p LRAGQLsykEDPMGW
K1709-ub RAGQLsykEDPMGWQ
  rat

 
S46 LRQLQPASELWSSDG
S50 QPASELWSSDGAAGL
S51 PASELWSSDGAAGLV
S60 GAAGLVGSLQEVTIH
T65 VGSLQEVTIHEKQKE
K69 QEVTIHEKQKESWQL
T118 LAVYKAFTVDSTVQQ
K140 ISQDKSEKIYKSHEL
L202 SHEVPPSLPREPLPT
S233 KSGSLFGSSRVQYVV
K245 YVVDPAVKIVFLNID
K275 VWTLRRVKPEEETAV
P286 ETAVLKFPEQAGTLQ
T291 KFPEQAGTLQNAATS
S299 LQNAATSSSLTAHLR
S300 QNAATSSSLTAHLRS
S307 SLTAHLRSLSKGESP
K310 AHLRSLSKGESPVAS
S313 RSLSKGESPVASPFQ
A316 SKGESPVASPFQNYS
S317 KGESPVASPFQNYSS
Y322 VASPFQNYSSIHSQS
A332 IHSQSRSASSPSLHS
S333 HSQSRSASSPSLHSR
S334 SQSRSASSPSLHSRS
S336 SRSASSPSLHSRSPS
S339 ASSPSLHSRSPSISN
S341 SPSLHSRSPSISNMA
S343 SLHSRSPSISNMAAL
S345 HSRSPSISNMAALSR
S351 ISNMAALSRAHSPAL
S355 AALSRAHSPALGVHS
S362 SPALGVHSFSGVQRF
S364 ALGVHSFSGVQRFNL
S372 GVQRFNLSSHNQSPK
S373 VQRFNLSSHNQSPKR
N375 RFNLSSHNQSPKRHS
S377 NLSSHNQSPKRHSIS
S386 KRHSISHSPSGSFND
K429 EKNSQASKVFITTDL
K477 SVTNIHAKDAAPVEK
S518 IPGLPAPSLTMSNMM
T520 GLPAPSLTMSNMMPR
S522 PAPSLTMSNMMPRPS
M524 PSLTMSNMMPRPSTP
S529 SNMMPRPSTPLDGVS
T530 NMMPRPSTPLDGVST
S536 STPLDGVSTPKPLSK
T537 TPLDGVSTPKPLSKL
S542 VSTPKPLSKLLGSMD
S547 PLSKLLGSMDEVVLL
S555 MDEVVLLSPVPELRD
S564 VPELRDSSKLNDSLY
S569 DSSKLNDSLYNEDCT
Y571 SKLNDSLYNEDCTFQ
T596 DPVHNRVTLELSNGS
S600 NRVTLELSNGSMVRI
S680 DRLAWTRSFDFEGSL
S686 RSFDFEGSLsPVIAP
S688-p FDFEGSLsPVIAPKK
K694 LsPVIAPKKARPSDT
S699 APKKARPSDTGSDDD
T701 KKARPSDTGSDDDWE
S703 ARPSDTGSDDDWEYL
Y709 GSDDDWEYLLNSEYH
S713 DWEYLLNSEYHHNVE
S727 ESHLLNKSLCLNALE
N731 LNKSLCLNALEVTKT
S876 RSRLVVLSIALYTLG
S886 LYTLGDESCVSDETS
T892 ESCVSDETSQYLSKV
T902 YLSKVTLTPQKPQAE
K905 KVTLTPQKPQAEQEE
T916 EQEENRFTFRQSASV
K985 IGRQDLSKQACEGNL
S1058 VVQYPELSDHEFIEE
K1066 DHEFIEEKENRLLQL
S1347 MHREKHKSPSYQIKE
S1349 REKHKSPSYQIKEGD
Y1552 KTGGEMNYGFHLAHH
Y1610 LQALRHLYVLAAEPR
Y1638 YALIEVTYKGTQWYE
K1693 HLRSILSKDGVLYVK
Y1698 LSKDGVLYVKLRAGQ
S1707 KLRAGQLSYKEDPMG
Y1708 LRAGQLSYKEDPMGW
K1709 RAGQLSYKEDPMGWQ
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