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Protein Page:
DATF1 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
DATF1 Putative transcription factor, weakly pro-apoptotic when overexpressed. Tumor suppressor. Ubiquitous. 4 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Transcription factor
Chromosomal Location of Human Ortholog: 20q13.33
Cellular Component: cytoplasm; spindle; nucleus
Molecular Function: zinc ion binding
Biological Process: transcription, DNA-dependent
Reference #:  Q9BTC0 (UniProtKB)
Alt. Names/Synonyms: BYE1; C20orf158; DATF-1; DATF1; death associated transcription factor 1; death inducer-obliterator 1; Death-associated transcription factor 1; Death-inducer obliterator 1; DIDO1; DIDO2; DIDO3; DIO-1; DIO1; dJ885L7.8; DKFZp434P1115; FLJ11265; hDido1; KIAA0333; MGC16140
Gene Symbols: DIDO1
Molecular weight: 243,873 Da
Basal Isoelectric point: 8.09  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

DATF1

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

► Hide Isoforms
 
0 6 S8-p MDDKGDPsNEEAPKA
0 1 - gap
0 1 - gap
0 5 S60-p PQQQLGLsLRRSGRQ
0 1 S88-p ARRRGRRsMPVsLED
0 1 S92-p GRRsMPVsLEDSGEP
0 1 S101-p EDSGEPTsCPATDAE
0 1 S111 ATDAETASEGSVESA
0 1 S114 AETASEGSVESASET
0 1 S117 ASEGSVESASETRSG
0 1 A118 SEGSVESASETRSGP
0 15 T151-p GGDDHDDtsDsDsDG
0 17 S152-p GDDHDDtsDsDsDGL
0 14 S154-p DHDDtsDsDsDGLTL
0 1 S156-p DDtsDsDsDGLTLKE
0 1 S203-p GPAETVGsEASDTVE
0 2 S377-p IEKAANPsGKKKLkI
0 1 K383-ub PsGKKKLkIFQPVIE
0 1 K427-ac KHAAATMkFLSSGKE
0 1 S464-p AQAGIKIssVHKRPA
0 1 S465-p QAGIKIssVHKRPAP
0 4 K474-ac HKRPAPEkKETTVKK
0 2 S501-p KEAACESstPsWAsD
0 7 T502-p EAACESstPsWAsDH
0 2 S504-p ACESstPsWAsDHNY
0 1 S507-p SstPsWAsDHNYNAV
0 1 T519-p NAVKPEKtAAPsPsL
0 12 S523-p PEKtAAPsPsLLYKS
0 1 S525-p KtAAPsPsLLYKSTK
0 1 S555-p KKTAPPGsAVGKQPA
0 2 T603-p KRPWLSAtPSSGASA
0 29 K626-ac AAATAASkkFPGSAA
0 1 K627-ac AATAASkkFPGSAAL
0 1 S645-p VRKPVVPsVPMAsPA
0 2 S650-p VPsVPMAsPAPGRLG
0 3 S660-p PGRLGAMsAAPSQPN
0 1 S677-p IRQNIRRsLkEILWK
0 1 K679-ub QNIRRsLkEILWKRV
0 1 T695 DSDDLIMTENEVGKI
0 1 Y721-p FQVTDNRyKsKYRSI
0 1 S723-p VTDNRyKsKYRSIMF
0 1 S781-p PARSVMEsRTKLHNE
0 34 S805-p AIPDLEDsPPVsDsE
0 27 S809-p LEDsPPVsDsEEQQE
0 7 S811-p DsPPVsDsEEQQESA
0 1 S817 DsEEQQESARAVPEK
0 1 S862-p ICTGQVPsAEDEPAP
0 1 S889 DLKSKHDSSAPDPAP
0 2 S890 LKSKHDSSAPDPAPD
0 6 S898-p APDPAPDsADEVMPE
0 1 S918-p ASEPGLEsAsHPNVD
0 1 S920-p EPGLEsAsHPNVDRT
0 1 S1011-p TSVMVPKsILAkPss
0 1 K1015-ac VPKsILAkPsssPDP
0 2 S1017-p KsILAkPsssPDPRY
0 4 S1018-p sILAkPsssPDPRYL
0 6 S1019-p ILAkPsssPDPRYLS
0 11 S1030-p RYLSVPPsPNIstsE
0 3 S1034-p VPPsPNIstsESRsP
0 3 T1035-p PPsPNIstsESRsPP
0 3 S1036-p PsPNIstsESRsPPE
0 1 S1038 PNIstsESRsPPEGD
0 24 S1040-p IstsESRsPPEGDtT
0 1 T1046-p RsPPEGDtTLFLSRL
0 1 T1047 sPPEGDtTLFLSRLS
0 1 S1205-p KIKRPANsGELDKMD
0 1 Y1228-p EEADVPAyPKVATVP
0 1 A1232 VPAyPKVATVPQsEK
0 1 S1237-p KVATVPQsEKKPsKy
0 1 S1242-p PQsEKKPsKyPLCSA
0 1 Y1244-p sEKKPsKyPLCSADA
0 2 V1253 LCSADAAVsttPPGs
0 2 S1254-p CSADAAVsttPPGsP
0 3 T1255-p SADAAVsttPPGsPP
0 13 T1256-p ADAAVsttPPGsPPP
0 33 S1260-p VsttPPGsPPPPPPL
0 1 P1284 SSLKPAAPsPATAAT
0 2 S1285-p SLKPAAPsPATAATT
0 1 T1291 PsPATAATTAAAAST
0 1 T1292 sPATAATTAAAASTA
0 2 T1310-p TASSASKtAsPLEHI
0 5 S1312-p SSASKtAsPLEHILQ
0 2 S1327-p TLFGKKKsFDPsARE
0 1 S1331-p KKKsFDPsAREPPGs
0 1 S1338-p sAREPPGsTAGLPQE
0 1 T1339 AREPPGsTAGLPQEP
0 1 G1341 EPPGsTAGLPQEPKT
0 1 D1352-ca EPKTTAEdGVPAPPL
0 63 S1456-p CADVRRNsVERPAEP
0 5 T1469-p EPVAGAAtPsLVEQQ
0 4 S1471-p VAGAAtPsLVEQQKM
0 1 D1518-ca MAHFSVSdALMsPPP
0 4 S1522-p SVSdALMsPPPKSSL
0 1 S1541-p LFQQEQQsADKPASL
0 1 R1565 RDPRQARRLATETGE
0 1 S1616-p PEEKEPAssPWASGE
0 2 S1617-p EEKEPAssPWASGEK
0 2 T1662-p ARRVLLPtPPCGALQ
0 1 S1697-p SQDKALGsAQyEDPR
0 172 Y1700-p KALGsAQyEDPRNLH
0 1 S1712-p NLHSAGRsssPAGEt
0 1 S1713-p LHSAGRsssPAGEtE
0 7 S1714-p HSAGRsssPAGEtEG
0 1 T1719-p sssPAGEtEGDREPQ
0 5 K1742 PLPPPGQKVGGSQPP
0 1 S1823-p GPPPYGDsrGPsPSY
0 1 R1824-m1 PPPYGDsrGPsPSYL
0 5 S1827-p YGDsrGPsPSYLGGP
0 12 R1835-m1 PSYLGGPrGVAPSQF
0 1 R1845-m1 APSQFEErKDPHGEk
0 1 K1852-ac rKDPHGEkREFQDAP
0 5 R1882-m1 QAPFLGSrGGAPFQF
0 1 R1893-m2 PFQFGGQrrPLLSQL
0 1 R1893-m1 PFQFGGQrrPLLSQL
0 1 R1894-m2 FQFGGQrrPLLSQLk
0 1 R1894-m1 FQFGGQrrPLLSQLk
0 1 K1901-ac rPLLSQLkGPRGGPP
0 1 R1938-m2 PSQFETArGPHPNQF
0 1 R1949-m2 PNQFEGPrGQAPNFM
0 1 R1960-m2 PNFMPGPrGIQPQQF
0 1 S1974-p FEDQRVHsPPrFTNQ
0 1 R1977-m2 QRVHsPPrFTNQrAP
0 1 R1982-m1 PPrFTNQrAPAPLQF
0 3 R1982-m2 PPrFTNQrAPAPLQF
0 1 R1993-m1 PLQFGGLrGSAPFSE
0 2 R1993-m2 PLQFGGLrGSAPFSE
0 2 R2008-m2 KNEQTPSrFHFQGQA
0 2 R2024-m2 QVMKPGPrPLLELPS
0 7 N2080 GKGHEYRNQTFEGRQ
0 1 S2110-p PDAQGRAsEDRRRER
0 1 S2217 DRKDRSKSKESARDP
0 1 S2220 DRSKSKESARDPKPE
0 1 S2229-p RDPKPEAsRAsDAGT
0 1 S2232-p KPEAsRAsDAGTASQ
  DATF1 iso3  
S8 MDDKGDPSNEEAPKA
- gap
- gap
S60 PQQQLGLSLRRSGRQ
S88 ARRRGRRSMPVSLED
S92 GRRSMPVSLEDSGEP
S101 EDSGEPTSCPATDAE
S111 ATDAETASEGSVESA
S114 AETASEGSVESASET
S117 ASEGSVESASETRSG
A118 SEGSVESASETRSGP
T151 GGDDHDDTSDSDSDG
S152 GDDHDDTSDSDSDGL
S154 DHDDTSDSDSDGLTL
S156 DDTSDSDSDGLTLKE
S203 GPAETVGSEASDTVE
S377 IEKAANPSGKKKLKI
K383 PSGKKKLKIFQPVIE
K427 KHAAATMKFLSSGKE
S464 AQAGIKISSVHKRPA
S465 QAGIKISSVHKRPAP
K474 HKRPAPEKKETTVKK
S501 KEAACESSTPSWASD
T502 EAACESSTPSWASDH
S504 ACESSTPSWASDHNY
S507 SSTPSWASDHNYNAV
T519 NAVKPEKTAAPSPSL
S523 PEKTAAPSPSLLYKC
S525 KTAAPSPSLLYKCMY
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- under review  
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- under review  
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- under review  
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- under review  
- gap
- gap
- gap
- gap
  mouse

 
S8-p MDDKGHLsNEEAPKA
T43-p KREGAGDtEVDPsEQ
S48-p GDtEVDPsEQQPQQH
S58-p QPQQHNLsLRRSGRQ
N86 VRRRGKKNVPVSLED
S90 GKKNVPVSLEDSSEP
S99 EDSSEPTSSTVTDVE
S109-p VTDVETAsEGsVEss
S112-p VETAsEGsVEssSEI
S115-p AsEGsVEssSEIRSG
S116-p sEGsVEssSEIRSGP
T148-p GGEEEEDtsDsDsDG
S149-p GEEEEDtsDsDsDGL
S151-p EEEDtsDsDsDGLTL
S153-p EDtsDsDsDGLTLKE
V200 DSAETGSVQIGSAEQ
S374 IEKAANPSGKKKLKI
K380 PSGKKKLKIFQPVVE
R424 KHAAATMRFLSSGKE
S461 VQVGIKISSVHKRLA
S462 QVGIKISSVHKRLAS
K471 HKRLASEKRENPVKK
S497 KEAACESSTPSWASD
T498 EAACESSTPSWASDH
S500 ACESSTPSWASDHNY
S503 SSTPSWASDHNYNAV
P515 NAVKPEKPEKPTALS
S522 PEKPTALSPTLLSKS
T524 KPTALSPTLLSKSMK
S553 IPKKALPSASLVGRQ
T604 KRPWPSATLSGTSAR
K623-ac TPMTAASkKLPGSAA
K624 PMTAASkKLPGSAAV
- gap
S647 SANVPAASPAPGRLG
S657-p PGRLGPVsPAPSQPN
S674 IRQNIRRSLKEILWK
K676 QNIRRSLKEILWKRV
T692 DSDDLIMTENEVGKI
Y718 FQVTDNRYKSKYRSI
S720 VTDNRYKSKYRSIMF
S778 PTKSVIESRTKLLNE
S802-p TIPDMEDsPPVsDsE
S806-p MEDsPPVsDsEEQQE
S808-p DsPPVsDsEEQQEsV
S814-p DsEEQQEsVRAAPEK
S859 ICTGQVPSSEDEPAP
S886-p DFKPRHDssPPNAVP
S887-p FKPRHDssPPNAVPN
T895 PPNAVPNTADEGIAD
S915 ASEPDPESTSSLNQE
S917 EPDPESTSSLNQERK
S1008 TSAVVPKSILAKPss
K1012 VPKSILAKPsssPDP
S1014-p KSILAKPsssPDPRY
S1015-p SILAKPsssPDPRYL
S1016-p ILAKPsssPDPRYLS
S1027-p RYLSVPPsPsIsEsR
S1029-p LSVPPsPsIsEsRsP
- gap
S1031-p VPPsPsIsEsRsPPE
S1033-p PsPsIsEsRsPPEGD
S1035-p PsIsEsRsPPEGDtt
T1041-p RsPPEGDttLFLSRL
T1042-p sPPEGDttLFLSRLN
A1200 KVKRPSSAGELDKTD
Y1223 EELETSVYPKVtAAL
T1227-p TSVYPKVtAALPSEK
S1232 KVtAALPSEKKPPKy
P1237 LPSEKKPPKySVHSI
Y1239-p SEKKPPKySVHSIDT
T1249-p HSIDTAAtsttPPGs
S1250-p SIDTAAtsttPPGsP
T1251-p IDTAAtsttPPGsPP
T1252-p DTAAtsttPPGsPPP
S1256-p tsttPPGsPPPPPPL
T1280-gl SSLKPGStSTVTAPt
S1281 SLKPGStSTVTAPtt
T1287-gl tSTVTAPttAAITTT
T1288-gl STVTAPttAAITTTA
T1305 VTAATSKTAsPLEHI
S1307-p AATSKTAsPLEHILQ
S1322 TLFGKKKSFEPSGKE
S1326 KKKSFEPSGKESVGS
S1333 SGKESVGStLsPHQD
T1334-p GKESVGStLsPHQDS
S1336-p ESVGStLsPHQDSKA
D1347 DSKAKGEDTMSAAPL
A1448 RMCMKVSATERPADF
S1461 DFTTDASSASLVEQQ
S1463 TTDASSASLVEQQKM
D1510 MAHFSVSDALMsPPP
S1514-p SVSDALMsPPPKSSL
A1533 LFSQEQQAPDPSQGA
R1560-m1 RDPRQARrLAAENTE
- gap
V1613 EAKESMAVPWAPGEN
T1668 PRRVLLPTPPSTTFP
S1709 SQETSLGSSQYEDPR
Y1712 TSLGSSQYEDPRGAQ
- gap
- gap
S1726-p QSAGKNDsPVADMED
- gap
R1754-m1 SFPQPGQrGGGPQPQ
N1836 GPPPYGDNRGLsPSY
R1837 PPPYGDNRGLsPSYL
S1840-p YGDNRGLsPSYLGGP
R1848-m1 PSYLGGPrGGAPAQF
R1858 APAQFEDRKDPHGEK
K1865 RKDPHGEKREFQDTP
R1895 QAQFMGNRAPFQFGG
R1904 PFQFGGQRRPLLTQM
R1904 PFQFGGQRRPLLTQM
R1905 FQFGGQRRPLLTQMK
R1905 FQFGGQRRPLLTQMK
K1912 RPLLTQMKGPRGGPP
R1949 PSQFENSRGTHPGQF
R1960 PGQFEGARGQAPGFM
R1971 PGFMPGPRGIQPQQF
S1985 FEEQRVNSPPrFAGQ
R1988-m2 QRVNSPPrFAGQrAS
R1993 PPrFAGQRASAPLPY
R1993-m2 PPrFAGQrASAPLPY
R2004 PLPYGGPRGPAPFPE
R2004-m2 PLPYGGPrGPAPFPE
R2019-m2 KNEQPPSrFHFQGPS
R2035 QPVKPPPRPLLELPS
S2092-p GKGHEYRsPAFEGRQ
F2128 ESRQGRAFEDRRRER
S2233-p DRKDRSKsREsPRDQ
S2236-p DRSKsREsPRDQKPE
- gap
- gap
  rat

 
S8-p MDDKGDLsNEEAPKA
T43 KREGAGDTEVDPSEQ
S48 GDTEVDPSEQQPQQH
S58 QPQQHNLSLRRSGRQ
N86 VRRRGRKNVPVSLED
S90 GRKNVPVSLEDSSEP
S99 EDSSEPTSSTVTDVE
S109 VTDVETASEGSVESS
S112 VETASEGSVESSSEI
S115 ASEGSVESSSEIRSG
S116 SEGSVESSSEIRSGP
T148-p GGDEEEDtsDSDSDG
S149-p GDEEEDtsDSDSDGL
S151 EEEDtsDSDSDGLTL
S153 EDtsDSDSDGLTLKE
- under review  
S374 IEKAANPSGKKKLKI
K380 PSGKKKLKIFQPVVE
K424 KHAAATMKILSSGKE
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
K466 TPVIAASKKLPGSAA
K467 PVIAASKKLPGSAAV
- gap
S490 SANVPAASPVPGRLG
S500 PGRLGPVSPAPSQPN
S517 IRQNIRRSLKEILWK
K519 QNIRRSLKEILWKRV
T535-p DSDDLIMtENEVGKI
Y561 FQVTDNRYKSKYRSI
S563 VTDNRYKSKYRSIMF
S621 PTKSVIESRTKLLNE
S645-p TIPDMEDsPPVsDSE
S649-p MEDsPPVsDSEEQES
S651 DsPPVsDSEEQESVR
S656 sDSEEQESVRAAPEK
S701 ICTGQVPSSEDEPAP
S728 DLKARHDSSPPDAVP
S729 LKARHDSSPPDAVPS
T737 PPDAVPSTADEGIAE
T756 TCDPDLETVSSLNQE
S758 DPDLETVSSLNQERK
S849 TSAVVPKSILAKPSS
K853 VPKSILAKPSSSPDP
S855 KSILAKPSSSPDPRY
S856 SILAKPSSSPDPRYL
S857 ILAKPSSSPDPRYLS
S868 RYLSVPPSPNTSISE
S872 VPPSPNTSISESRsP
- gap
S874 PSPNTSISESRsPPE
S876 PNTSISESRsPPEGD
S878-p TSISESRsPPEGDTT
T884 RsPPEGDTTLFLSRL
T885 sPPEGDTTLFLSRLS
A1043 KVKRPSSAGELDKTD
Y1066 EETETSVYPKVTAAL
T1070 TSVYPKVTAALPSEK
S1075 KVTAALPSEKKPPKY
P1080 LPSEKKPPKYSVHSA
Y1082 SEKKPPKYSVHSADT
S1092 HSADTTASSTTPPGs
S1093 SADTTASSTTPPGsP
T1094 ADTTASSTTPPGsPP
T1095 DTTASSTTPPGsPPP
S1099-p SSTTPPGsPPPPPPL
T1123 SSLKPGSTSTVTAPT
S1124 SLKPGSTSTVTAPTT
T1130 TSTVTAPTTSAVITT
T1131 STVTAPTTSAVITTT
T1149 VTAATSKTASPLEHI
S1151 AATSKTASPLEHILQ
S1166 TLFGKKKSFEPSGKE
S1170 KKKSFEPSGKESVGS
S1177 SGKESVGSTLAPHHD
T1178 GKESVGSTLAPHHDS
A1180 ESVGSTLAPHHDSKA
D1191 DSKAKGEDTMSAAPL
S1292-p RMCVKVSsTERPADF
S1305 DFSTDASSASLVEQQ
S1307 STDASSASLVEQQKM
D1354 MAHFSVSDALMSPPP
S1358 SVSDALMSPPPKSSL
- under review  
R1404 RDPRQARRLAAENTE
- gap
S1457 EAKESMASPWAPGEN
T1512 PRRVLLPTPPSTTFP
S1553 SQETSLGSSQYEDPR
Y1556 TSLGSSQYEDPRGAQ
S1568 GAQSAGRSDsPVADM
- gap
S1570-p QSAGRSDsPVADMED
- gap
R1598-m1 SFPSPAQrGGGPQPQ
N1680 GPPPYGDNRGLsPSY
R1681 PPPYGDNRGLsPSYL
S1684-p YGDNRGLsPSYLGGP
R1692-m1 PSYLGGPrGGAPAQF
R1702 APAQFEDRKDPHGEK
K1709 RKDPHGEKREFQDTP
R1738 QAQFMGNRAPFQFGG
R1747 PFQFGGQRRPLLTQI
R1747 PFQFGGQRRPLLTQI
R1748 FQFGGQRRPLLTQIK
R1748 FQFGGQRRPLLTQIK
K1755 RPLLTQIKGPRGGPP
R1792 PSQFETSRGTHPGQF
R1803 PGQFEGARGQAPGFM
R1814 PGFMPGPRGVQPQQF
S1828 FEEQRVNSPPRFAGQ
R1831 QRVNSPPRFAGQRAS
R1836 PPRFAGQRASAPLPY
R1836 PPRFAGQRASAPLPY
R1847 PLPYGGPRGPAPFPE
R1847 PLPYGGPRGPAPFPE
R1862 KNEQPPSRFHFQGPS
R1878 QPVKPPPRPLLELPS
S1935 GKGHEYRSPAFEGRQ
F1971 ESRQGRAFEDRRRER
S2076 DRKDRSKSRESPRDL
S2079 DRSKSRESPRDLKPE
- gap
- gap
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