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Protein Page:
ERK3 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
ERK3 a protein kinase of the MAPK family. Plays a critical role in the regulation of cell growth and differentiation. Localized in the nucleus, and has been reported to be activated in fibroblasts upon treatment with serum or phorbol esters. Note: This description may include information from UniProtKB.
Protein type: Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor); Kinase, protein; EC 2.7.11.24; CMGC group; MAPK family; MAPK/ERK subfamily; ERK subfamily
Cellular Component: cytoplasm; nucleus
Molecular Function: MAP kinase activity; protein serine/threonine kinase activity; protein binding; protein heterodimerization activity; protein kinase binding; ATP binding
Biological Process: MAPKKK cascade; cell cycle; signal transduction; protein amino acid phosphorylation
Reference #:  Q16659 (UniProtKB)
Alt. Names/Synonyms: DKFZp686F03189; ERK-3; ERK3; Extracellular signal-regulated kinase 3; extracellular signal-regulated kinase, p97; HsT17250; MAP kinase 6; MAP kinase isoform p97; MAPK 6; MAPK6; Mitogen-activated protein kinase 6; MK06; p97-MAPK; p97MAPK; PRKM6; protein kinase, mitogen-activated 5; protein kinase, mitogen-activated 6
Gene Symbols: MAPK6
Molecular weight: 82,681 Da
Basal Isoelectric point: 4.91  Predict pI for various phosphorylation states
CST Pathways:  ErbB/HER Signaling  |  GPCR Signaling to MAPKs  |  IL6 Signaling  |  Microtubule Dynamics  |  mTOR Signaling  |  Translation: eIF4E and p70S6K
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

ERK3

Protein Structure Not Found.


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Sites Implicated In
intracellular localization: S189‑p
molecular association, regulation: S189‑p
protein stabilization: S684‑p, S688‑p, T698‑p, S705‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 K4-ub ____MAEkFESLMNI
0 1 T54-p AIKKIVLtDPQSVKH
0 1 K154-ub NVLHRDLkPANLFIN
0 1 Y182-p ARIMDPHySHKGHLs
5 16 S189-p ySHKGHLsEGLVTKW
0 1 Y209-p LLLSPNNyTKAIDMW
0 1 K276-ub NDMTEPHkPLTQLLP
0 1 Y357-p HIYNWERyHDCQFsE
0 13 S363-p RyHDCQFsEHDWPVH
1 13 S386-p QLDPRALsDVtDEEE
0 12 T389-p PRALsDVtDEEEVQV
0 1 S450-p TCNYKTRsSsyLDNL
0 3 S452-p NYKTRsSsyLDNLVW
0 1 Y453-p YKTRsSsyLDNLVWR
0 4 Y467-p RESEVNHyyEPkLII
0 1 Y468-p ESEVNHyyEPkLIID
0 1 K471-ub VNHyyEPkLIIDLSN
0 2 K480-ub IIDLSNWkEQsKEKS
0 1 S483-p LSNWkEQsKEKSDKK
0 1 K502-ub CERNGLVkAQIALEE
0 1 K517-ub ASQQLAGkEREKNQG
0 1 S556-p KLNDLNSsVsQLELk
0 1 S558-p NDLNSsVsQLELkSL
0 2 K563-ub sVsQLELkSLISkSV
0 1 K568-ub ELkSLISkSVSQEKQ
0 2 K631-ub TYTSYLDkFFSRkED
0 1 K636-ub LDkFFSRkEDTEMLE
0 1 T644-p EDTEMLEtEPVEDGk
0 1 K651-ub tEPVEDGkLGERGHE
0 4 S665-p EEGFLNNsGEFLFNK
1 4 S684-p IGIPQFHsPVGsPLK
1 3 S688-p QFHsPVGsPLKSIQA
1 1 T698-p KSIQATLtPSAMKss
0 1 S704-p LtPSAMKssPQIPHQ
1 1 S705-p tPSAMKssPQIPHQT
  mouse

 
K4 ____MAEKFESLMNI
T54 AIKKIVLTDPQSVKH
K154 NVLHRDLKPANLFIN
Y182 ARIMDPHYSHKGHLs
S189-p YSHKGHLsEGLVTKW
Y209 LLLSPNNYTKAIDMW
R276 NDMTEPHRPLTQLLP
Y357 HIYNWERYHDCQFsE
S363-p RYHDCQFsEHDWPIH
S386-p QLDPRALsDVtDEEE
T389-p PRALsDVtDEEEVQV
S450 TCNYKTRSSPYLDNL
P452 NYKTRSSPYLDNLVW
Y453 YKTRSSPYLDNLVWR
Y467 RESEVNHYYEPKLII
Y468 ESEVNHYYEPKLIID
K471 VNHYYEPKLIIDLSN
K480 IIDLSNWKEQSKEKS
S483 LSNWKEQSKEKSDKR
K502 CERNGLVKAQIALEE
- gap
S554 KLNDLNSSVSQLELK
S556 NDLNSSVSQLELKSL
K561 SVSQLELKSLISKSV
K566 ELKSLISKSVSREKQ
K630 TYTSYLDKFFSRKED
K635 LDKFFSRKEDSEMLE
T643 EDSEMLETEPVEEGK
K650 TEPVEEGKRGERGRE
G664 EAGLLSGGGEFLLSK
S683-p IGTPQFHsPVGsPLK
S687-p QFHsPVGsPLKSIQA
T697 KSIQATLTPSAMKSS
S703 LTPSAMKSSPQIPHK
S704 TPSAMKSSPQIPHKT
  rat

 
K4 ____MAEKFESLMNI
T54 AIKKIVLTDPQSVKH
K154 NVLHRDLKPANLFIN
Y182 ARIMDPHYSHKGHLS
S189 YSHKGHLSEGLVTKW
Y209 LLLSPNNYTKAIDMW
K276 NDMTEPHKPLTQLLP
Y357 HIYNWERYHDCQFSE
S363 RYHDCQFSEHDWPIH
S386 QLDPRALSDVTDEEE
T389 PRALSDVTDEEEVQV
S450 TCNYKTRSPSYLDNL
S452 NYKTRSPSYLDNLVW
Y453 YKTRSPSYLDNLVWR
Y467 RESEVNHYYEPKLII
Y468 ESEVNHYYEPKLIID
K471 VNHYYEPKLIIDLSN
K480 IIDLSNWKEQSKDKS
S483 LSNWKEQSKDKSDKR
K502 CERNGLVKAQIALEE
- gap
S554 KLNDLNSSVSQLEMK
S556 NDLNSSVSQLEMKSL
K561 SVSQLEMKSLISKSV
K566 EMKSLISKSVSREKQ
K630 TYTSYLDKFFSRKED
K635 LDKFFSRKEDSEMLE
T643 EDSEMLETEPVEEGK
K650 TEPVEEGKRGERGRE
G664 EAGLLSSGGEFLLSR
S683 IGTPQFHSPGGSPLK
S687 QFHSPGGSPLKSIQA
T697 KSIQATLTPSAMKSS
S703 LTPSAMKSSPQIPHK
S704 TPSAMKSSPQIPHKT
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