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Protein Page:
SIN3A (human)
p Phosphorylation
a Acetylation
m Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
u Ubiquitination
s Sumoylation
n Neddylation
gl O-GlcNAc
ga O-GalNAc
h Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage

Overview
SIN3A Acts as a transcriptional repressor. Corepressor for REST. Interacts with MXI1 to repress MYC responsive genes and antagonize MYC oncogenic activities. Also interacts with MXD1-MAX heterodimers to repress transcription by tethering SIN3A to DNA. Acts cooperatively with OGT to repress transcription in parallel with histone deacetylation. Interacts with BAZ2A, MXD3, MXD4, MBD2, NCOR1, NR4A2, REST, RLIM, SAP30, SETDB1 and SMYD2. Interacts with PHF12 in a complex composed of HDAC1, PHF12 and SAP30. Interacts with ARID4B, BRMS1L, DACH1, HCFC1, HDAC1, HDAC2, MXI1, SAP30L, SAP130, SFPQ, SUDS3 and TOPORS. Interacts with TET1; the interaction recruits SIN3A to gene promoters. Interacts with OGT (via TPRs 1-6); the interaction mediates transcriptional repression in parallel with histone deacetylase. Note: This description may include information from UniProtKB.
Protein type: Nuclear receptor co-regulator; Transcription, coactivator/corepressor
Cellular Component: nucleoplasm; kinetochore; transcription factor complex; transcriptional repressor complex; Sin3 complex; nucleus
Molecular Function: protein binding; DNA binding; protein deacetylase activity; protein complex binding; chromatin binding; transcription corepressor activity; transcription factor activity
Biological Process: positive regulation of chromatin silencing; in utero embryonic development; negative regulation of transcription from RNA polymerase II promoter; cellular lipid metabolic process; response to organic nitrogen; protein amino acid deacetylation; response to methylglyoxal; positive regulation of transcription from RNA polymerase II promoter; blood coagulation; DNA replication; positive regulation of defense response to virus by host; regulation of transcription from RNA polymerase II promoter in response to oxidative stress; negative regulation of transcription, DNA-dependent; activation of innate immune response; negative regulation of apoptosis; aging
Reference #:  Q96ST3 (UniProtKB)
Alt. Names/Synonyms: DKFZp434K2235; FLJ90319; Histone deacetylase complex subunit Sin3a; KIAA0700; Paired amphipathic helix protein Sin3a; SIN3 homolog A, transcription regulator (yeast); SIN3A; transcriptional co-repressor Sin3A; Transcriptional corepressor Sin3a; transcriptional regulator, SIN3A
Gene Symbols: SIN3A
Molecular weight: 145,175 Da
Basal Isoelectric point: 6.82  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

SIN3A

Protein Structure Not Found.


STRING  |  Scansite  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Source  |  NURSA  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene


Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 33 S10-p RRLDDQEsPVyAAQQ
0 57 Y13-p DDQEsPVyAAQQRRI
0 5 Y41-p LAPAPPVyEAVSETM
0 1 K122-u QQQFQRLkVEDALSY
0 1 S166-p IDTPGVIsRVSQLFK
0 1 S251 QPPPAKVSKPSQLQA
0 4 T266-p HTPASQQtPPLPPyA
0 5 Y272-p QtPPLPPyAsPRsPP
0 11 S274-p PPLPPyAsPRsPPVQ
0 12 S277-p PPyAsPRsPPVQPHt
0 5 T284-p sPPVQPHtPVTIsLG
0 1 S289-p PHtPVTIsLGTAPSL
0 1 Y310-p EFNHAINyVNKIKNR
0 2 S421-p NNKPQRPsQNGCQIR
0 4 P431 GCQIRRHPtGttPPV
0 18 T432-p CQIRRHPtGttPPVK
1 1 T434-p IRRHPtGttPPVKKK
0 7 T435-p RRHPtGttPPVKKKP
0 1 K469-a TESLFFDkVRKALRS
0 2 Y524-p WFKNFLGyKESVHLE
0 58 Y558-p CKRLGSSyRALPKSy
0 58 Y565-p yRALPKSyQQPKCTG
0 1 K638 RVLEAIQKKLSRLSA
0 1 Y673-p RKALQRIyADKAADI
0 1 K723-a VWREQNEkYYLkSLD
0 1 K727-a QNEkYYLkSLDHQGI
0 1 K727-u QNEkYYLkSLDHQGI
0 2 K747-u DTKVLRSkSLLNEIE
0 38 S832-p FAQRGDLsDVEEEEE
0 11 S860-p KHNGVGGsPPKSKLL
0 5 K875-a FSNTAAQkLRGMDEV
0 1 K875 FSNTAAQKLRGMDEV
0 1 K934-a EREVLGIkRDKSDsP
0 1 K937 VLGIkRDKSDsPAIQ
0 10 S940-p IkRDKSDsPAIQLRL
0 4 Y1101-p EAERWSDyVERyMNs
0 2 Y1105-p WSDyVERyMNsDtts
0 1 S1108-p yVERyMNsDttsPEL
0 1 T1110-p ERyMNsDttsPELRE
0 5 T1111-p RyMNsDttsPELREH
0 21 S1112-p yMNsDttsPELREHL
0 1 K1122-u LREHLAQkPVFLPRN
0 1 S1161-p KTMENVDsLDKLECR
0 2 K1271-u VKYGTVFkAP_____
  mouse

 
S10-p RRLDDQEsPVYAAQQ
Y13 DDQEsPVYAAQQRRI
Y41 LAPAPPVYEAVSETM
K122 QQQFQRLKVEDALSY
S166 IDTPGVISRVSQLFK
S251-gl QPTAAKVsKPSQLQA
T266 HTPASQQTPPLPPYA
Y272 QTPPLPPYAsPRsPP
S274-p PPLPPYAsPRsPPVQ
S277-p PPYAsPRsPPVQPHt
T284-p sPPVQPHtPVTISLG
S289 PHtPVTISLGTAPSL
Y310 EFNHAINYVNKIKNR
S421 NNKPQRPSQNGCQIR
S431-p GCQIRRHsGtGAtPP
T433-p QIRRHsGtGAtPPVK
A435 RRHsGtGAtPPVKKK
T436-p RHsGtGAtPPVKKKP
K470 TESLFFDKVRKALRS
Y525 WFKNFLGYKESVHLE
Y559-p CKRLGSSyRALPKSy
Y566-p yRALPKSyQQPKCTG
K639-a RVLEAIQkKLSRLSA
Y674 RKALQRIYADKAADI
K724 VWREQNEKYYLKSLD
K728 QNEKYYLKSLDHQGI
K728 QNEKYYLKSLDHQGI
K748 DTKVLRSKSLLNEIE
S833-p FAQRGDLsDVEEEEE
S861-p KHNGVGGsPPKSKLL
K876 FSNTAAQKLRGMDEV
K876-u FSNTAAQkLRGMDEV
K935 EREVLGIKRDkSDsP
K938-u VLGIKRDkSDsPAIQ
S941-p IKRDkSDsPAIQLRL
Y1102 EAERWSDYVERyMSs
Y1106-p WSDYVERyMSsDtts
S1109-p YVERyMSsDttsPEL
T1111-p ERyMSsDttsPELRE
T1112-p RyMSsDttsPELREH
S1113-p yMSsDttsPELREHL
K1123 LREHLAQKPVFLPRN
S1162 KTMENVESLDKLECR
K1272 VKYGTVFKAP_____
  rat

 
S10 RRLDDQESPVYAAQQ
Y13 DDQESPVYAAQQRRI
Y41 LAPAPPVYEAVSETM
K122 QQQFQRLKVEDALSY
S166 IDTPGVISRVSQLFK
S251 QPTPAKVSKPSQLQA
T266 HTPASQQTPPLPPYA
Y272 QTPPLPPYASPRSPP
S274 PPLPPYASPRSPPVQ
S277 PPYASPRSPPVQPHT
T284 SPPVQPHTPVTISLG
S289 PHTPVTISLGTAPSL
Y310 EFNHAINYVNKIKNR
S421 NNKPQRPSQNGCQIR
S431 GCQIRRHSGTGATPP
T433 QIRRHSGTGATPPVK
A435 RRHSGTGATPPVKKK
T436 RHSGTGATPPVKKKP
K470 TESLFFDKVRKALRS
Y525 WFKNFLGYKESVHLE
Y559 CKRLGSSYRALPKSY
Y566 YRALPKSYQQPKCTG
K639 RVLEAIQKKLSRLSA
Y674 RKALQRIYADKAADI
K724 VWREQNEKYYLKSLD
K728 QNEKYYLKSLDHQGI
K728 QNEKYYLKSLDHQGI
K748 DTKVLRSKSLLNEIE
S833-p FAQRGDLsDVEEEEE
S861 KHNGVGGSPPKSKLL
K876 FSNTAAQKLRGMDEV
K876 FSNTAAQKLRGMDEV
K935 EREVLGIKRDKSDsP
K938 VLGIKRDKSDsPAIQ
S941-p IKRDKSDsPAIQLRL
Y1102 EAERWSDYVERYMSS
Y1106 WSDYVERYMSSDTTS
S1109 YVERYMSSDTTSPEL
T1111 ERYMSSDTTSPELRE
T1112 RYMSSDTTSPELREH
S1113 YMSSDTTSPELREHL
K1123 LREHLAQKPVFLPR_
- gap
- gap
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