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Protein Page:
SIN3A (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
SIN3A Acts as a transcriptional repressor. Corepressor for REST. Interacts with MXI1 to repress MYC responsive genes and antagonize MYC oncogenic activities. Also interacts with MXD1-MAX heterodimers to repress transcription by tethering SIN3A to DNA. Acts cooperatively with OGT to repress transcription in parallel with histone deacetylation. Interacts with BAZ2A, MXD3, MXD4, MBD2, NCOR1, NR4A2, REST, RLIM, SAP30, SETDB1 and SMYD2. Interacts with PHF12 in a complex composed of HDAC1, PHF12 and SAP30. Interacts with ARID4B, BRMS1L, DACH1, HCFC1, HDAC1, HDAC2, MXI1, SAP30L, SAP130, SFPQ, SUDS3 and TOPORS. Interacts with TET1; the interaction recruits SIN3A to gene promoters. Interacts with OGT (via TPRs 1-6); the interaction mediates transcriptional repression in parallel with histone deacetylase. Note: This description may include information from UniProtKB.
Protein type: Transcription, coactivator/corepressor; Nuclear receptor co-regulator
Cellular Component: kinetochore; nucleoplasm; transcription factor complex; intercellular bridge; Sin3 complex; transcriptional repressor complex; cytoplasm; nucleolus; nucleus
Molecular Function: protein binding; protein deacetylase activity; protein complex binding; chromatin binding; transcription corepressor activity; transcription factor activity
Biological Process: positive regulation of chromatin silencing; transcription, DNA-dependent; in utero embryonic development; cellular lipid metabolic process; negative regulation of transcription from RNA polymerase II promoter; response to organic nitrogen; protein amino acid deacetylation; response to methylglyoxal; positive regulation of transcription from RNA polymerase II promoter; negative regulation of circadian rhythm; negative regulation of transcription, DNA-dependent; blood coagulation; DNA replication; positive regulation of defense response to virus by host; regulation of transcription from RNA polymerase II promoter in response to oxidative stress; activation of innate immune response; aging; negative regulation of apoptosis
Reference #:  Q96ST3 (UniProtKB)
Alt. Names/Synonyms: DKFZp434K2235; FLJ90319; Histone deacetylase complex subunit Sin3a; KIAA0700; Paired amphipathic helix protein Sin3a; SIN3 homolog A, transcription regulator (yeast); SIN3A; transcriptional co-repressor Sin3A; Transcriptional corepressor Sin3a; transcriptional regulator, SIN3A
Gene Symbols: SIN3A
Molecular weight: 145,175 Da
Basal Isoelectric point: 6.82  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

SIN3A

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 34 S10-p RRLDDQEsPVyAAQQ
0 51 Y13-p DDQEsPVyAAQQRRI
0 5 Y41-p LAPAPPVyEAVSETM
0 1 K122-ub QQQFQRLkVEDALSY
0 1 S166-p IDTPGVIsRVsQLFK
0 1 S169-p PGVIsRVsQLFKGHP
0 1 S251 QPPPAKVSKPSQLQA
0 4 T266-p HTPASQQtPPLPPyA
0 5 Y272-p QtPPLPPyAsPRsPP
0 11 S274-p PPLPPyAsPRsPPVQ
0 13 S277-p PPyAsPRsPPVQPHt
0 5 T284-p sPPVQPHtPVTIsLG
0 1 S289-p PHtPVTIsLGTAPSL
0 1 Y310-p EFNHAINyVNKIKNR
0 2 S421-p NNKPQRPsQNGCQIR
0 5 P431 GCQIRRHPtGttPPV
0 18 T432-p CQIRRHPtGttPPVK
1 2 T434-p IRRHPtGttPPVKKK
0 7 T435-p RRHPtGttPPVKKKP
0 1 S450-p KLLNLKDssMADASK
0 1 S451-p LLNLKDssMADASKH
0 1 K469-ac TESLFFDkVRKALRS
0 2 Y524-p WFKNFLGyKESVHLE
0 1 T539-p TYPKERAtEGIAMEI
0 55 Y558-p CKRLGSSyRALPKSy
0 55 Y565-p yRALPKSyQQPKCTG
0 1 T574-p QPKCTGRtPLCKEVL
0 1 T584-p CKEVLNDtWVSFPSW
0 1 K601-ac DSTFVSSkKTQYEEH
0 1 K638 RVLEAIQKKLsRLSA
0 1 S641-p EAIQKKLsRLSAEEQ
0 1 Y673-p RKALQRIyADKAADI
0 1 K723-ac VWREQNEkYYLkSLD
0 1 K727-ac QNEkYYLkSLDHQGI
0 1 K727-ub QNEkYYLkSLDHQGI
0 1 S728 NEkYYLkSLDHQGIN
0 1 T741 INFKQNDTKVLRSkS
0 2 K747-ub DTKVLRSkSLLNEIE
0 1 T802-p IHHVKRQtGIQKEDK
0 41 S832-p FAQRGDLsDVEEEEE
0 13 S860-p KHNGVGGsPPKSkLL
0 1 K865-ac GGsPPKSkLLFSNTA
0 6 K875-ac FSNTAAQkLRGMDEV
0 1 K875 FSNTAAQKLRGMDEV
0 1 K934-ac EREVLGIkRDKsDsP
0 1 K937 VLGIkRDKsDsPAIQ
0 1 S938-p LGIkRDKsDsPAIQL
0 12 S940-p IkRDKsDsPAIQLRL
0 1 Y958-p MDVDVEDyyPAFLDM
0 1 Y959-p DVDVEDyyPAFLDMV
0 2 S1089-p LDTEEENsDDPVEAE
0 4 Y1101-p EAERWSDyVERyMNs
0 3 Y1105-p WSDyVERyMNsDtts
0 2 S1108-p yVERyMNsDttsPEL
0 1 T1110-p ERyMNsDttsPELRE
0 6 T1111-p RyMNsDttsPELREH
0 24 S1112-p yMNsDttsPELREHL
0 1 K1122-ub LREHLAQkPVFLPRN
0 2 S1161-p KTMENVDsLDKLECR
0 1 S1231-p REMAAETsKWLMGEG
0 2 K1271-ub VKYGTVFkAP_____
  mouse

 
S10-p RRLDDQEsPVYAAQQ
Y13 DDQEsPVYAAQQRRI
Y41 LAPAPPVYEAVSETM
K122 QQQFQRLKVEDALSY
S166 IDTPGVISRVSQLFK
S169 PGVISRVSQLFKGHP
S251-gl QPTAAKVsKPSQLQA
T266 HTPASQQTPPLPPYA
Y272 QTPPLPPYAsPRsPP
S274-p PPLPPYAsPRsPPVQ
S277-p PPYAsPRsPPVQPHt
T284-p sPPVQPHtPVTISLG
S289 PHtPVTISLGTAPSL
Y310 EFNHAINYVNKIKNR
S421 NNKPQRPSQNGCQIR
S431-p GCQIRRHsGtGAtPP
T433-p QIRRHsGtGAtPPVK
A435 RRHsGtGAtPPVKKK
T436-p RHsGtGAtPPVKKKP
S451 KLMSLKESSMADASK
S452 LMSLKESSMADASKH
K470 TESLFFDKVRKALRS
Y525 WFKNFLGYKESVHLE
T540 SFPKERATEGIAMEI
Y559-p CKRLGSSyRALPKSy
Y566-p yRALPKSyQQPKCTG
T575 QPKCTGRTPLCKEVL
T585 CKEVLNDTWVSFPSW
K602 DSTFVSSKKTQYEEH
K639-ac RVLEAIQkKLSRLSA
S642 EAIQkKLSRLSAEEQ
Y674 RKALQRIYADKAADI
K724 VWREQNEKYYLKsLD
K728 QNEKYYLKsLDHQGI
K728 QNEKYYLKsLDHQGI
S729-p NEKYYLKsLDHQGIN
T742-p INFKQNDtKVLRSKS
K748 DtKVLRSKSLLNEIE
T803 IHHVKRQTGIQKEDK
S833-p FAQRGDLsDVEEEEE
S861-p KHNGVGGsPPKSKLL
K866 GGsPPKSKLLFSNTA
K876 FSNTAAQKLRGMDEV
K876-ub FSNTAAQkLRGMDEV
K935 EREVLGIKRDkSDsP
K938-ub VLGIKRDkSDsPAIQ
S939 LGIKRDkSDsPAIQL
S941-p IKRDkSDsPAIQLRL
Y959 MDVDVEDYYPAFLDM
Y960 DVDVEDYYPAFLDMV
S1090 LDTEEENSDDPVEAE
Y1102 EAERWSDYVERyMSs
Y1106-p WSDYVERyMSsDtts
S1109-p YVERyMSsDttsPEL
T1111-p ERyMSsDttsPELRE
T1112-p RyMSsDttsPELREH
S1113-p yMSsDttsPELREHL
K1123 LREHLAQKPVFLPRN
S1162 KTMENVESLDKLECR
S1232 REMAAETSKWLMGEG
K1272 VKYGTVFKAP_____
  rat

 
S10 RRLDDQESPVYAAQQ
Y13 DDQESPVYAAQQRRI
Y41 LAPAPPVYEAVSETM
K122 QQQFQRLKVEDALSY
S166 IDTPGVISRVSQLFK
S169 PGVISRVSQLFKGHP
S251 QPTPAKVSKPSQLQA
T266 HTPASQQTPPLPPYA
Y272 QTPPLPPYASPRSPP
S274 PPLPPYASPRSPPVQ
S277 PPYASPRSPPVQPHT
T284 SPPVQPHTPVTISLG
S289 PHTPVTISLGTAPSL
Y310 EFNHAINYVNKIKNR
S421 NNKPQRPSQNGCQIR
S431 GCQIRRHSGTGATPP
T433 QIRRHSGTGATPPVK
A435 RRHSGTGATPPVKKK
T436 RHSGTGATPPVKKKP
S451 KLISLKESSMADASK
S452 LISLKESSMADASKH
K470 TESLFFDKVRKALRS
Y525 WFKNFLGYKESVHLE
T540 SFPKERATEGIAMEI
Y559 CKRLGSSYRALPKSY
Y566 YRALPKSYQQPKCTG
T575 QPKCTGRTPLCKEVL
T585 CKEVLNDTWVSFPSW
K602 DSTFVSSKKTQYEEH
K639 RVLEAIQKKLSRLSA
S642 EAIQKKLSRLSAEEQ
Y674 RKALQRIYADKAADI
K724 VWREQNEKYYLKSLD
K728 QNEKYYLKSLDHQGI
K728 QNEKYYLKSLDHQGI
S729 NEKYYLKSLDHQGIN
T742 INFKQNDTKVLRSKS
K748 DTKVLRSKSLLNEIE
T803 IHHVKRQTGIQKEDK
S833-p FAQRGDLsDVEEEEE
S861 KHNGVGGSPPKSKLL
K866 GGSPPKSKLLFSNTA
K876 FSNTAAQKLRGMDEV
K876 FSNTAAQKLRGMDEV
K935 EREVLGIKRDKSDsP
K938 VLGIKRDKSDsPAIQ
S939 LGIKRDKSDsPAIQL
S941-p IKRDKSDsPAIQLRL
Y959 MDVDVEDYYPAFLDM
Y960 DVDVEDYYPAFLDMV
S1090 LDTEEENSDDPVEAE
Y1102 EAERWSDYVERYMSS
Y1106 WSDYVERYMSSDTTS
S1109 YVERYMSSDTTSPEL
T1111 ERYMSSDTTSPELRE
T1112 RYMSSDTTSPELREH
S1113 YMSSDTTSPELREHL
K1123 LREHLAQKPVFLPR_
- gap
- gap
- gap
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