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ERK1 (human)

Overview ERK1 p42 MAP kinase plays a critical role in the regulation of cell growth and differentiation. Activated by a wide variety of extracellular signals including growth and neurotrophic factors, cytokines, hormones and neurotransmitters. Activation of MAP kinases occurs through phosphorylation of threonine and tyrosine residues at the sequence T*EY* by a single upstream MAP kinase kinase, MEK. Note: This description may include information from UniProtKB. Protein type: Protein kinase, Ser/Thr (non-receptor); Protein kinase, CMGC; EC 2.7.1.123; EC 2.7.11.24; Kinase, protein; CMGC group; MAPK family; MAPK/ERK subfamily; ERK subfamily Cellular Component: Golgi apparatus; focal adhesion; mitochondrion; early endosome; pseudopodium; caveola; cytosol; microtubule cytoskeleton; nucleoplasm; cytoskeleton; late endosome; nucleolus; nucleus Molecular Function: MAP kinase activity; protein binding; phosphotyrosine binding; ATP binding; phosphatase binding Biological Process: axon guidance; nerve growth factor receptor signaling pathway; positive regulation of histone phosphorylation; activation of MAPKK activity; activation of MAPK activity; apoptosis; stress-activated MAPK cascade; toll-like receptor 3 signaling pathway; sensory perception of pain; protein amino acid phosphorylation; BMP signaling pathway; response to exogenous dsRNA; regulation of transcription factor activity; small GTPase mediated signal transduction; lipopolysaccharide-mediated signaling pathway; toll-like receptor 4 signaling pathway; epidermal growth factor receptor signaling pathway; platelet activation; fibroblast growth factor receptor signaling pathway; MyD88-independent toll-like receptor signaling pathway; cytokine and chemokine mediated signaling pathway; MAPKKK cascade; transcription from RNA polymerase I promoter; cell cycle; Toll signaling pathway; toll-like receptor 2 signaling pathway; toll-like receptor 1 signaling pathway; MyD88-dependent toll-like receptor signaling pathway; regulation of stress-activated MAPK cascade; organ morphogenesis; cartilage development; virus-host interaction; Ras protein signal transduction; insulin receptor signaling pathway; toll-like receptor signaling pathway; innate immune response; positive regulation of histone acetylation; gene expression; positive regulation of transcription from RNA polymerase II promoter; positive regulation of protein amino acid phosphorylation; transcription initiation from RNA polymerase I promoter; blood coagulation; response to DNA damage stimulus; regulation of cytoskeleton organization and biogenesis Reference #:  P27361 (UniProtKB) Alt. Names/Synonyms: ERK-1; ERK1; ERT2; Extracellular signal-regulated kinase 1; extracellular signal-related kinase 1; HS44KDAP; HUMKER1A; Insulin-stimulated MAP2 kinase; MAP kinase 1; MAP kinase 3; MAP kinase isoform p44; MAPK 1; MAPK 3; MAPK3; MGC20180; Microtubule-associated protein 2 kinase; Mitogen-activated protein kinase 1; Mitogen-activated protein kinase 3; MK03; p44-ERK1; p44-MAPK; P44ERK1; P44MAPK; PRKM3 Gene Symbols: MAPK3 Molecular weight: 43,136 Da Basal Isoelectric point: 6.28  Predict pI for various phosphorylation states CST Pathways:  Angiogenesis  |  Apoptosis  |  B Cell Receptor Signaling  |  ErbB/HER Signaling  |  ESC Pluripotency and Differentiation  |  GPCRs Signaling to MAPK/Erk  |  Inhibition of Apoptosis  |  Insulin Receptor Signaling  |  Jak/Stat/IL-6 Signaling  |  MAPK/Erk in Growth and Differentiation  |  Mitochondrial Control of Apoptosis  |  mTOR Signaling  |  Regulation of Microtubule Dynamics  |  T Cell Receptor Signaling  |  TGF-ß Signaling  |  Translation: eIF4E and p70S6K  |  Warburg Effect Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below ERK1 2ZOQ - A/B=1-379 (human) Substrate Sequence Logo

STRING  |  Scansite  |  KinBase  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho3D  |  DISEASE  |  Source  |  UCSD-Nature A000874 A003852 A004160  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene

	Sites Implicated In
cell differentiation, induced: T202‑p, Y204‑p cell growth, altered: T202‑p, Y204‑p cell motility, altered: T202‑p, Y204‑p cytoskeletal reorganization: T202‑p, Y204‑p transcription, altered: T202‑p, Y204‑p activation: T202‑p, Y204‑p enzymatic activity, induced: T202‑p, Y204‑p intracellular localization: T202‑p, Y204‑p molecular association, regulation: T202‑p, Y204‑p phosphorylation: T202‑p, Y204‑p protein conformation: T202‑p, Y204‑p protein degradation: T202‑p, Y204‑p

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	1		Y60	YGMVSSAYDHVRKTR
0	1		K72-u	KTRVAIKkISPFEHQ
0	1		T127	IVQDLMETDLyKLLK
0	3		Y130-p	DLMETDLyKLLKSQQ
0	1		S170-p	LHRDLKPsNLLINTT
0	2		K181-a	INTTCDLkICDFGLA
0	2		K181-u	INTTCDLkICDFGLA
0	12		T198-p	ADPEHDHtGFLtEyV
962	1994		T202-p	HDHtGFLtEyVAtRW
982	3563		Y204-p	HtGFLtEyVAtRWyR
0	38		T207-p	FLtEyVAtRWyRAPE
1	0		Y210-p	EyVAtRWyRAPEIML
0	3		K220-u	PEIMLNSkGYTKSID
0	1		K287-u	YLQSLPSkTKVAWAk
0	1		K294-u	kTKVAWAkLFPKSDS

	mouse
Y61	YGMVSSAYDHVRKTR
K73	KTRVAIKKISPFEHQ
T128-p	IVQDLMEtDLyKLLK
Y131-p	DLMEtDLyKLLKSQQ
S171	LHRDLKPSNLLINTT
K182	INTTCDLKICDFGLA
K182	INTTCDLKICDFGLA
T199-p	ADPEHDHtGFLtEyV
T203-p	HDHtGFLtEyVAtRW
Y205-p	HtGFLtEyVAtRWyR
T208-p	FLtEyVAtRWyRAPE
Y211-p	EyVAtRWyRAPEIML
K221-u	PEIMLNSkGYTKSID
K288	YLQSLPSKTKVAWAK
K295	KTKVAWAKLFPKSDS

	rat
Y61-p	YGMVSSAyDHVRKTR
K73	KTRVAIKKISPFEHQ
T128	IVQDLMETDLYKLLK
Y131	DLMETDLYKLLKSQQ
S171	LHRDLKPSNLLINTT
K182	INTTCDLKICDFGLA
K182	INTTCDLKICDFGLA
T199	ADPEHDHTGFLtEyV
T203-p	HDHTGFLtEyVATRW
Y205-p	HTGFLtEyVATRWYR
T208	FLtEyVATRWYRAPE
Y211	EyVATRWYRAPEIML
K221	PEIMLNSKGYTKSID
K288	YLQSLPSKTKVAWAK
K295	KTKVAWAKLFPKSDS

	hamster
Y50	YGMVSSAYDHVRKTR
K62	KTRVAIKKISPFEHQ
T117	IVQDLMETDLYKLLK
Y120	DLMETDLYKLLKSQQ
S160	LHRDLKPSNLLINTT
K171	INTTCDLKICDFGLA
K171	INTTCDLKICDFGLA
T188	ADPEHDHTGFLtEyV
T192-p	HDHTGFLtEyVATRW
Y194-p	HTGFLtEyVATRWYR
T197	FLtEyVATRWYRAPE
Y200	EyVATRWYRAPEIML
K210	PEIMLNSKGYTKSID
K277	YLQSLPSKTKVAWAK
K284	KTKVAWAKLFPKSDS

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