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Protein Page:
PHKB (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
PHKB Phosphorylase b kinase catalyzes the phosphorylation of serine in certain substrates, including troponin I. The beta chain acts as a regulatory unit and modulates the activity of the holoenzyme in response to phosphorylation. Defects in PHKB are the cause of glycogen storage disease type 9B (GSD9B); also known as phosphorylase kinase deficiency of liver and muscle (PKD). GSD9B is a metabolic disorder characterized by hepathomegaly, only slightly elevated transaminases and plasma lipids, clinical improvement with increasing age, and remarkably no clinical muscle involvement. Biochemical observations suggest that this mild phenotype is caused by an incomplete holoenzyme that lacks the beta subunit, but that may possess residual activity. Belongs to the phosphorylase b kinase regulatory chain family. 4 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Protein kinase, regulatory subunit
Cellular Component: plasma membrane; phosphorylase kinase complex; cytosol
Molecular Function: calmodulin binding; phosphorylase kinase activity; protein binding; hydrolase activity, hydrolyzing O-glycosyl compounds
Biological Process: glycogen metabolic process; generation of precursor metabolites and energy; glycogen catabolic process; carbohydrate metabolic process; glucose metabolic process; protein amino acid phosphorylation
Reference #:  Q93100 (UniProtKB)
Alt. Names/Synonyms: DKFZp781E15103; FLJ41698; KPBB; PHKB; Phosphorylase b kinase regulatory subunit beta; phosphorylase kinase beta-subunit; Phosphorylase kinase subunit beta; phosphorylase kinase, beta
Gene Symbols: PHKB
Molecular weight: 124,884 Da
Basal Isoelectric point: 6.5  Predict pI for various phosphorylation states
Select Structure to View Below

PHKB

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

► Hide Isoforms
 
0 5 - gap
0 1 - gap
0 1 - gap
2 0 S12 AGLTAEVSWKVLERR
2 17 S27-p ARTKRSGsVyEPLKS
0 75 Y29-p TKRSGsVyEPLKSIN
0 1 K226 GVWERGSKYNNGSTE
0 1 - gap
0 1 - gap
0 1 - gap
0 1 S314-p LDDEVLFsQtLDKVV
0 1 T316-p DEVLFsQtLDKVVRK
0 56 Y338-p KRFLRDGyRTSLEDP
0 1 S460-p LLADELIsPKDIDPV
0 1 E678 LRISDTEELPEFKSF
0 2 S684 EELPEFKSFEELEPP
0 5 S694-p ELEPPKHsKVKRQss
1 167 S700-p HsKVKRQsstPsAPE
0 155 S701-p sKVKRQsstPsAPEL
0 48 T702-p KVKRQsstPsAPELG
0 9 S704-p KRQsstPsAPELGQQ
0 1 N920 DILQPQQNGRCWLNR
0 1 K1037 EAFNEFQKDQSRLkE
0 1 K1043-ac QKDQSRLkEIEKQDD
0 1 K1047 SRLkEIEKQDDMTSF
0 1 Y1055-p QDDMTSFyNTPPLGK
0 1 Y1068-p GKRGTCSyLTKAVMN
  PHKB iso2  
S5-p ___MMACsPDAVVsP
S11-p CsPDAVVsPSsAFLR
S14-p DAVVsPSsAFLRSGS
- gap
S21 sAFLRSGSVyEPLKS
Y23-p FLRSGSVyEPLKSIN
K220 GVWERGSKYNNGSTE
- gap
- gap
- gap
S308 LDDEVLFSQTLDKVV
T310 DEVLFSQTLDKVVRK
Y332 KRFLRDGYRTSLEDP
S454 LLADELISPKDIDPV
E672 LRISDTEELPEFKSF
S678 EELPEFKSFEELEPP
S688-p ELEPPKHsKVKRQss
S694-p HsKVKRQsstPSAPE
S695-p sKVKRQsstPSAPEL
T696-p KVKRQsstPSAPELG
S698 KRQsstPSAPELGQQ
N914 DILQPQQNGRCWLNR
K1031 EAFNEFQKDQSRLKE
K1037 QKDQSRLKEIEKQDD
K1041 SRLKEIEKQDDMTSF
Y1049 QDDMTSFYNTPPLGK
Y1062 GKRGTCSYLTKAVMN
  PHKB iso3  
- gap
- gap
- gap
S12 AGLTAEVSWKVLERR
S27 ARTKRSGSVYEPLKS
Y29 TKRSGSVYEPLKSIN
K226 GVWERGSKYNNGSTE
- gap
- gap
- gap
S314 LDDEVLFSQTLDKVV
T316 DEVLFSQTLDKVVRK
Y338 KRFLRDGYRTSLEDP
S460 LLADELISPKDIDPV
E678 LRISDTEELPEFKSF
S684 EELPEFKSFEELEPP
S694 ELEPPKHSKVKRQSS
S700 HSKVKRQSSTPSAPE
S701 SKVKRQSSTPSAPEL
T702 KVKRQSSTPSAPELG
S704 KRQSSTPSAPELGQQ
N920 DILQPQQNGRCWLNR
K1037 EAFNEFQKDQSRLKE
K1043 QKDQSRLKEIEKQDD
K1047 SRLKEIEKQDDMTSF
Y1055 QDDMTSFYNTPPLGK
Y1068 GKRGTCSYLTKAVMN
  mouse

► Hide Isoforms
 
S4-p ____MANsPDAAFSS
S10 NsPDAAFSSPALLRS
S11 sPDAAFSSPALLRSG
- gap
S19-p PALLRSGsVYEPLKS
Y21 LLRSGsVYEPLKSIN
K218-ac GVWERGSkYNNGSTE
- gap
- gap
- gap
S306 LDDEALFSQTLDKVI
T308 DEALFSQTLDKVIRK
Y330 KRFLRDGYRTPLEDP
S452 LLADELISPKDIDPV
K670-ub LRISDTEkLPEFKsF
S676-p EkLPEFKsFEELEFP
S686 ELEFPKHSKVKRQss
S692-p HSKVKRQsstADAPE
S693-p SKVKRQsstADAPEA
T694-p KVKRQsstADAPEAQ
D696 KRQsstADAPEAQHE
S912-p DILQPQQsGRCWLNR
K1029-ac EAFHEFQkDESRLKE
K1035 QkDESRLKEIEkQDD
K1039-ub SRLKEIEkQDDMTSF
Y1047 QDDMTSFYNTPPLGK
Y1060 GKRGTCSYLTKVVMN
  PHKB iso4  
S4 ____MANSPDAAFSS
S10 NSPDAAFSSPALLRS
S11 SPDAAFSSPALLRSG
- gap
S19 PALLRSGSVYEPLKS
Y21 LLRSGSVYEPLKSIN
- under review  
T138-p FKQDPRPttCLHsVF
T139-p KQDPRPttCLHsVFS
S143-p RPttCLHsVFSVHTG
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- under review  
- gap
- gap
- gap
- gap
  rat

 
- gap
- gap
- gap
S12 EGLMSEVSWKLLERR
S27 ARAKRSGSVYEPLKS
Y29 AKRSGSVYEPLKSIN
K226 GVWERGSKYNNGSTE
- gap
- gap
- gap
S314 LDDEALFSQTLDKVI
T316 DEALFSQTLDKVIRK
Y338 KRFLRDGYRTPLEDP
S460 LLADELISPKDIDPV
K678 LRISDTEKLPEFKSF
S684 EKLPEFKSFEELEFP
S694 ELEFPKHSKVKRQSs
S700 HSKVKRQSsTADAPE
S701-p SKVKRQSsTADAPEL
T702 KVKRQSsTADAPELR
D704 KRQSsTADAPELRQE
S920 DILQPQQSGRCWLNR
K1037 EAFHEFQKDESRLKE
K1043 QKDESRLKEIEKQVS
K1047 SRLKEIEKQVSGEAR
- gap
- gap
  rabbit

 
- gap
- gap
- gap
S12-p TGLMAEVsWKVLERR
S27-p ARTKRSGsVYEPLKS
Y29 TKRSGsVYEPLKSIN
K226 GVWERGSKYNNGSTE
- gap
- gap
- gap
N314 LDDDVLYNQTLDKVI
T316 DDVLYNQTLDKVIRK
Y338 KRFLRDGYRTSLEDP
S460 LLADELISPKDIDPV
E678 LRISDTEELPEFKSF
S684 EELPEFKSFEELEPP
S694 ELEPPKHSKVKRQsS
S700-p HSKVKRQsSTSNAPE
S701 SKVKRQsSTSNAPEL
T702 KVKRQsSTSNAPELE
N704 KRQsSTSNAPELEQQ
N920 DILQPQQNGRCWLNK
K1037 EAFHEFQKDESRLKE
K1043 QKDESRLKEIEKQDD
K1047 SRLKEIEKQDDMTSF
Y1055 QDDMTSFYNTPPLGK
Y1068 GKRGTCSYLTKVVMN
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