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Protein Page:
PHKB (human)
p Phosphorylation
a Acetylation
m Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
u Ubiquitination
s Sumoylation
n Neddylation
gl O-GlcNAc
ga O-GalNAc
h Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage

Overview
PHKB Phosphorylase b kinase catalyzes the phosphorylation of serine in certain substrates, including troponin I. The beta chain acts as a regulatory unit and modulates the activity of the holoenzyme in response to phosphorylation. Defects in PHKB are the cause of glycogen storage disease type 9B (GSD9B); also known as phosphorylase kinase deficiency of liver and muscle (PKD). GSD9B is a metabolic disorder characterized by hepathomegaly, only slightly elevated transaminases and plasma lipids, clinical improvement with increasing age, and remarkably no clinical muscle involvement. Biochemical observations suggest that this mild phenotype is caused by an incomplete holoenzyme that lacks the beta subunit, but that may possess residual activity. Belongs to the phosphorylase b kinase regulatory chain family. 4 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Protein kinase, regulatory subunit
Cellular Component: plasma membrane; phosphorylase kinase complex; cytosol
Molecular Function: calmodulin binding; phosphorylase kinase activity; protein binding; hydrolase activity, hydrolyzing O-glycosyl compounds
Biological Process: glycogen metabolic process; generation of precursor metabolites and energy; glycogen catabolic process; carbohydrate metabolic process; glucose metabolic process
Reference #:  Q93100 (UniProtKB)
Alt. Names/Synonyms: DKFZp781E15103; FLJ41698; KPBB; PHKB; Phosphorylase b kinase regulatory subunit beta; phosphorylase kinase beta-subunit; Phosphorylase kinase subunit beta; phosphorylase kinase, beta
Gene Symbols: PHKB
Molecular weight: 124,884 Da
Basal Isoelectric point: 6.5  Predict pI for various phosphorylation states
Select Structure to View Below

PHKB

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

► Hide Isoforms
 
0 5 - gap
0 1 - gap
2 0 S12 AGLTAEVSWKVLERR
2 15 S27-p ARTKRSGsVyEPLKS
0 75 Y29-p TKRSGsVyEPLKSIN
0 1 - gap
0 1 - gap
0 1 - gap
0 54 Y338-p KRFLRDGyRTSLEDP
0 1 E678 LRISDTEELPEFKSF
0 2 S684 EELPEFKSFEELEPP
0 5 S694-p ELEPPKHsKVKRQss
1 168 S700-p HsKVKRQsstPsAPE
0 156 S701-p sKVKRQsstPsAPEL
0 47 T702-p KVKRQsstPsAPELG
0 9 S704-p KRQsstPsAPELGQQ
0 1 N920 DILQPQQNGRCWLNR
0 1 K1047 SRLKEIEKQDDMTSF
0 1 Y1055-p QDDMTSFyNTPPLGK
0 1 Y1068-p GKRGTCSyLTKAVMN
  PHKB iso2  
S4-p ____MACsPDAVVsP
S10-p CsPDAVVsPSSAFLR
- gap
S20 SAFLRSGSVyEPLKS
Y22-p FLRSGSVyEPLKSIN
- gap
- gap
- gap
Y331 KRFLRDGYRTSLEDP
E671 LRISDTEELPEFKSF
S677 EELPEFKSFEELEPP
S687-p ELEPPKHsKVKRQss
S693-p HsKVKRQsstPSAPE
S694-p sKVKRQsstPSAPEL
T695-p KVKRQsstPSAPELG
S697 KRQsstPSAPELGQQ
N913 DILQPQQNGRCWLNR
K1040 SRLKEIEKQDDMTSF
Y1048 QDDMTSFYNTPPLGK
Y1061 GKRGTCSYLTKAVMN
  PHKB iso3  
- gap
- gap
S12 AGLTAEVSWKVLERR
S27 ARTKRSGSVYEPLKS
Y29 TKRSGSVYEPLKSIN
- gap
- gap
- gap
Y338 KRFLRDGYRTSLEDP
E678 LRISDTEELPEFKSF
S684 EELPEFKSFEELEPP
S694 ELEPPKHSKVKRQSS
S700 HSKVKRQSSTPSAPE
S701 SKVKRQSSTPSAPEL
T702 KVKRQSSTPSAPELG
S704 KRQSSTPSAPELGQQ
N920 DILQPQQNGRCWLNR
K1047 SRLKEIEKQDDMTSF
Y1055 QDDMTSFYNTPPLGK
Y1068 GKRGTCSYLTKAVMN
  mouse

► Hide Isoforms
 
S4-p ____MANsPDAAFSS
S10 NsPDAAFSSPALLRS
- gap
S19-p PALLRSGsVYEPLKS
Y21 LLRSGsVYEPLKSIN
- gap
- gap
- gap
Y330 KRFLRDGYRTPLEDP
K670-u LRISDTEkLPEFKsF
S676-p EkLPEFKsFEELEFP
S686 ELEFPKHSKVKRQss
S692-p HSKVKRQsstADAPE
S693-p SKVKRQsstADAPEA
T694-p KVKRQsstADAPEAQ
D696 KRQsstADAPEAQHE
S912-p DILQPQQsGRCWLNR
K1039-u SRLKEIEkQDDMTSF
Y1047 QDDMTSFYNTPPLGK
Y1060 GKRGTCSYLTKVVMN
  PHKB iso4  
S4 ____MANSPDAAFSS
S10 NSPDAAFSSPALLRS
- gap
S19 PALLRSGSVYEPLKS
Y21 LLRSGSVYEPLKSIN
T138-p FKQDPRPttCLHsVF
T139-p KQDPRPttCLHsVFS
S143-p RPttCLHsVFSVHTG
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
  rat

 
- gap
- gap
S12 EGLMSEVSWKLLERR
S27 ARAKRSGSVYEPLKS
Y29 AKRSGSVYEPLKSIN
- gap
- gap
- gap
Y338 KRFLRDGYRTPLEDP
K678 LRISDTEKLPEFKSF
S684 EKLPEFKSFEELEFP
S694 ELEFPKHSKVKRQSs
S700 HSKVKRQSsTADAPE
S701-p SKVKRQSsTADAPEL
T702 KVKRQSsTADAPELR
D704 KRQSsTADAPELRQE
S920 DILQPQQSGRCWLNR
K1047 SRLKEIEKQVSGEAR
- gap
- gap
  rabbit

 
- gap
- gap
S12-p TGLMAEVsWKVLERR
S27-p ARTKRSGsVYEPLKS
Y29 TKRSGsVYEPLKSIN
- gap
- gap
- gap
Y338 KRFLRDGYRTSLEDP
E678 LRISDTEELPEFKSF
S684 EELPEFKSFEELEPP
S694 ELEPPKHSKVKRQsS
S700-p HSKVKRQsSTSNAPE
S701 SKVKRQsSTSNAPEL
T702 KVKRQsSTSNAPELE
N704 KRQsSTSNAPELEQQ
N920 DILQPQQNGRCWLNK
K1047 SRLKEIEKQDDMTSF
Y1055 QDDMTSFYNTPPLGK
Y1068 GKRGTCSYLTKVVMN
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