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HER4
a receptor tyrosine kinase of the EGFR family. Specifically binds and is activated by neuregulins, NRG- 2, NRG-3, heparin-binding EGF-like growth factor, betacellulin and NTAK. Heterodimerizes and signals with other EGF receptors. Interaction with these factors induces cell differentiation. Not activated by EGF, TGF-A, and amphiregulin. Interacts with PDZ domains of DLG2, DLG3, DLG4 and the syntrophin SNTB2. Interacts with WWOX. May act as a tumor suppressor: overexpressed in head and neck cancer , but downregulated in renal cancer, papillary carcinoma, high-grade gliomas and invasive breast cancer. 3 alternatively-spliced isoforms of the human protein have been reported. Note: This description may include information from UniProtKB.
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| Protein type: EC 2.7.10.1; Protein kinase, tyrosine (receptor); Kinase, protein; Membrane protein, integral; Protein kinase, TK; TK group; EGFR family |
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Cellular Component: mitochondrion; basolateral plasma membrane; postsynaptic density; extracellular region; integral to membrane; caveola; cytosol; nucleoplasm; mitochondrial matrix; cytoplasm; nucleolus; plasma membrane; nucleus
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Molecular Function: protein binding; protein homodimerization activity; protein-tyrosine kinase activity; transmembrane receptor protein tyrosine kinase activity; receptor signaling protein tyrosine kinase activity; ATP binding; epidermal growth factor receptor binding
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Biological Process: lactation; synapse maturation; peptidyl-tyrosine phosphorylation; apoptosis; protein amino acid autophosphorylation; positive regulation of transcription, DNA-dependent; heart development; embryonic pattern specification; signal transduction; regulation of cell migration; olfactory bulb interneuron differentiation; negative regulation of cell proliferation; positive regulation of glucose import; positive regulation of cell proliferation; neural crest cell migration; positive regulation of cardiac muscle cell proliferation; response to drug; nervous system development; cell migration; cell fate commitment; transcription, DNA-dependent; positive regulation of synaptic transmission, GABAergic; positive regulation of phosphoinositide 3-kinase activity; cell proliferation; central nervous system morphogenesis; response to hydrogen peroxide; positive regulation of tyrosine phosphorylation of Stat5 protein; positive regulation of protein amino acid phosphorylation; response to progesterone stimulus; surfactant homeostasis; positive regulation of epithelial cell proliferation; transmembrane receptor protein tyrosine kinase signaling pathway; negative regulation of apoptosis; positive regulation of cell migration
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Reference #:
Q15303 (UniProtKB)
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| Alt. Names/Synonyms: avian erythroblastic leukemia viral (v-erb-b2) oncogene homolog 4; ERBB4; HER4; MGC138404; p180erbB4; Proto-oncogene-like protein c-ErbB-4; Receptor tyrosine-protein kinase erbB-4; Tyrosine kinase-type cell surface receptor HER4; v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian) |
| Gene Symbols: ERBB4 |
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Molecular weight: 146,808 Da
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Basal Isoelectric point: 5.98
Predict pI for various phosphorylation states
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CST Pathways:
ErbB/HER Signaling
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Tyrosine Kinases
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Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®
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