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Protein Page:
AKAP1 (human)
p Phosphorylation
a Acetylation
m Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
u Ubiquitination
s Sumoylation
n Neddylation
gl O-GlcNAc
ga O-GalNAc
h Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage

Overview
AKAP1 Binds to type I and II regulatory subunits of protein kinase A and anchors them to the cytoplasmic face of the mitochondrial outer membrane. AKAP149 is highly expressed in prostate and small intestine whereas S-AKAP84 is expressed in kidney, pancreas, liver, lung and brain. AKAP149 is also expressed in colon carcinoma. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Mitochondrial; Adaptor/scaffold; Membrane protein, integral
Cellular Component: mitochondrial outer membrane; mitochondrion; integral to membrane; cytosol
Molecular Function: protein binding; RNA binding
Biological Process: blood coagulation
Reference #:  Q92667 (UniProtKB)
Alt. Names/Synonyms: A kinase (PRKA) anchor protein 1; A kinase anchor protein 1, mitochondrial; A-kinase anchor protein 149 kDa; A-kinase anchor protein, 149kD; AKAP; AKAP 149; AKAP1; AKAP121; AKAP149; AKAP84; D-AKAP-1; D-AKAP1; Dual specificity A-kinase-anchoring protein 1; dual-specificity A-kinase anchoring protein 1; MGC1807; PRKA1; protein kinase A anchoring protein 1; Protein kinase A-anchoring protein 1; protein kinase A1; S-AKAP84; SAKAP84; Spermatid A-kinase anchor protein 84
Gene Symbols: AKAP1
Molecular weight: 97,342 Da
Basal Isoelectric point: 4.84  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

AKAP1

Protein Structure Not Found.


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Sites Implicated In
molecular association, regulation: S151‑p, S159‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

► Hide Isoforms
 
0 47 - gap
0 3 S69-p DVCPKVVstPPSVTE
0 9 T70-p VCPKVVstPPSVTEP
0 37 S105-p THPPCRRsEssGILP
0 42 S107-p PPCRRsEssGILPNT
0 9 S108-p PCRRsEssGILPNTT
0 2 - gap
0 4 - gap
0 1 - gap
1 3 S151-p PLECPLSsPKGVLFs
0 1 - gap
0 2 S158-p sPKGVLFssKSAEVC
1 2 S159-p PKGVLFssKSAEVCK
0 4 S169-p AEVCKQDsPFSRVPR
0 8 S353-p RAAFQIIsQVIsEAt
0 8 S357-p QIIsQVIsEAtEQVL
0 7 T360-p sQVIsEAtEQVLAtT
0 2 T366-p AtEQVLAtTVGKVAG
0 1 - gap
0 2 S429-p PGLPAEGsPPPKTYV
0 1 S441 TYVSCLKSLLssPtK
0 1 S444-p SCLKSLLssPtKDSK
0 4 S445-p CLKSLLssPtKDSKP
0 1 T447-p KSLLssPtKDSKPNI
0 25 T533-p SPRDKAItPPLPEST
0 2 S577-p SGGSDRNsMDSVDSC
0 3 S592-p CSLKKTEsFQNAQAG
0 2 K634-u GRYVSFLkQTSGAKI
0 1 K673 KALNLIGKKFKELNL
0 1 K800-u YVDYGGYkRVKVDVL
0 4 Y900-p AQWVDSYyTsL____
0 2 S902-p WVDSYyTsL______
  AKAP1 iso3  
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
  mouse

 
S55-p AIKDRRLsEEACPGV
S64-p EACPGVLsVAPTVTQ
- gap
S101-p TRQVRRRsEssGNLP
S103-p QVRRRsEssGNLPsV
S104-p VRRRsEssGNLPsVA
S109-p EssGNLPsVADTRsQ
S115-p PsVADTRsQPGPCRD
K135-u ELSLMGDkAKSIPLG
- gap
S151-p PLLPKDAsFPYEAVE
- gap
Y154 PKDAsFPYEAVERCK
S164 VERCKQESALGKTPG
S315 QAAFQLISQVILEAT
- gap
T322 SQVILEATEEFRATT
T328 ATEEFRATTVGKTVA
S378-p TRTGATAsPSAEALP
- gap
S395-p TYVSCLSsPLSGPTK
S398 SCLSsPLSGPTKDQK
- gap
T401 SsPLSGPTKDQKPKN
T487-p SSGDKAMtPPLPVST
S531-p SGGSDGNsMDSVDSC
S546 CGLTKPDSPQSVQAG
K588-u GRYVSFLkQTSGAKI
K627-u KALNLIGkKFKELNL
K754 YVDYGGYKRVKVDVL
Y854 AQWVDSYYASL____
S856 WVDSYYASL______
  rat

 
T55 AIEDRLPTEEACPGV
S64 EACPGVLSVTPSVTQ
- gap
S101-p TRQVRRRsEssGNLP
S103-p QVRRRsEssGNLPSI
S104-p VRRRsEssGNLPSIV
S109 EssGNLPSIVDTRLQ
- gap
- gap
- gap
S151 PLFPKDLSFPYEAVE
- gap
Y154 PKDLSFPYEAVEGCK
S164 VEGCKQESALGRTPG
S312 QTAFQIISQVILEAT
- gap
T319 SQVILEATEEIRATT
T325 ATEEIRATTVGKTVA
S375-p TRTGATAsPSAGAPP
- gap
S392 TYVSCLSSPLSGPTK
S395 SCLSSPLSGPTKDQK
- gap
T398 SSPLSGPTKDQKPKN
T484 SSGDKAVTPPLPDST
S528 SGGSDGNSMDSVDSC
S543 CGLTKPDSPQTVQAG
K585 GRYVSFLKQTSGAKI
K624 KALNLIGKKFKELNL
K751 YVDYGGYKRVKVDVL
Y851 AQWVDSCYASL____
S853 WVDSCYASL______
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