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AKAP1 (human)

Overview AKAP1 Binds to type I and II regulatory subunits of protein kinase A and anchors them to the cytoplasmic face of the mitochondrial outer membrane. AKAP149 is highly expressed in prostate and small intestine whereas S-AKAP84 is expressed in kidney, pancreas, liver, lung and brain. AKAP149 is also expressed in colon carcinoma. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB. Protein type: Adaptor/scaffold; Mitochondrial; Membrane protein, integral Cellular Component: postsynaptic membrane; mitochondrial crista; mitochondrial outer membrane; mitochondrion; mitochondrial matrix; integral to membrane; lipid particle; neuromuscular junction; cytosol Molecular Function: protein domain specific binding; protein binding; RNA binding; microtubule binding; beta-tubulin binding; protein complex scaffold; protein kinase binding; protein phosphatase 2B binding Biological Process: negative regulation of protein amino acid dephosphorylation; cellular response to insulin stimulus; negative regulation of NFAT protein import into nucleus; blood coagulation Reference #:  Q92667 (UniProtKB) Alt. Names/Synonyms: A kinase (PRKA) anchor protein 1; A kinase anchor protein 1, mitochondrial; A-kinase anchor protein 149 kDa; A-kinase anchor protein, 149kD; AKAP; AKAP 149; AKAP1; AKAP121; AKAP149; AKAP84; D-AKAP-1; D-AKAP1; Dual specificity A-kinase-anchoring protein 1; dual-specificity A-kinase anchoring protein 1; MGC1807; PRKA1; protein kinase A anchoring protein 1; Protein kinase A-anchoring protein 1; protein kinase A1; S-AKAP84; SAKAP84; Spermatid A-kinase anchor protein 84 Gene Symbols: AKAP1 Molecular weight: 97,342 Da Basal Isoelectric point: 4.84  Predict pI for various phosphorylation states Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below AKAP1

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	Sites Implicated In
molecular association, regulation: S151‑p, S159‑p

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human ► Hide Isoforms
0	45		V60	AIKEPLPVEDVCPKV
0	3		S69-p	DVCPKVVstPPSVTE
0	8		T70-p	VCPKVVstPPSVTEP
0	36		S105-p	THPPCRRsEssGILP
0	40		S107-p	PPCRRsEssGILPNT
0	8		S108-p	PCRRsEssGILPNTT
0	4		L119	PNTTDMRLRPGTRRD
0	1		S128-p	PGTRRDDsTKLELAL
0	1		E139	ELALTGGEAKSIPLE
1	2		S151-p	PLECPLSsPKGVLFs
0	1		L156	LSsPKGVLFssKsAE
0	2		S158-p	sPKGVLFssKsAEVC
1	2		S159-p	PKGVLFssKsAEVCK
0	1		S161-p	GVLFssKsAEVCKQD
0	3		S169-p	AEVCKQDsPFSRVPR
0	8		S353-p	RAAFQIIsQVIsEAt
0	8		S357-p	QIIsQVIsEAtEQVL
0	7		T360-p	sQVIsEAtEQVLAtT
0	2		T366-p	AtEQVLAtTVGKVAG
0	1		V371	LAtTVGKVAGRVCQA
0	1		-	gap
0	2		S429-p	PGLPAEGsPPPKTYV
0	1		S441	TYVSCLKSLLssPtK
0	1		S444-p	SCLKSLLssPtKDSK
0	3		S445-p	CLKSLLssPtKDSKP
0	1		T447-p	KSLLssPtKDSKPNI
0	23		T533-p	SPRDKAItPPLPEST
0	1		A565	EDGWTMDAEADHSGG
0	1		S570	MDAEADHSGGSDRNs
0	1		S573	EADHSGGSDRNsMDs
0	2		S577-p	SGGSDRNsMDsVDsC
0	1		S580-p	SDRNsMDsVDsCCsL
0	1		S583-p	NsMDsVDsCCsLKKT
0	1		S586-p	DsVDsCCsLKKTEsF
0	2		S592-p	CsLKKTEsFQNAQAG
0	1		S600-p	FQNAQAGsNPKKVDL
0	2		K634-u	GRYVSFLkQTSGAKI
0	1		K673	KALNLIGKKFKELNL
0	1		K800-u	YVDYGGYkRVKVDVL
0	4		Y900-p	AQWVDSYyTsL____
0	2		S902-p	WVDSYyTsL______

	AKAP1 iso3
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	mouse
S55-p	AIKDRRLsEEACPGV
S64	EACPGVLSVAPTVTQ
V65	ACPGVLSVAPTVTQP
S101-p	TRQVRRRsEssGNLP
S103-p	QVRRRsEssGNLPSV
S104-p	VRRRsEssGNLPSVA
S115-p	PSVADTRsQPGPCRD
-	gap
K135-u	ELSLMGDkAKSIPLG
-	gap
S151-p	PLLPKDAsFPYEAVE
-	gap
Y154	PKDAsFPYEAVERCK
-	gap
S164	VERCKQESALGKTPG
S315	QAAFQLISQVILEAT
L319	QLISQVILEATEEFR
T322	SQVILEATEEFRATT
T328	ATEEFRATTVGKtVA
T333-p	RATTVGKtVAQVHPT
S378-p	TRTGATAsPSAEALP
A383	TAsPSAEALPPKTYV
S395-p	TYVSCLSsPLSGPTK
S398	SCLSsPLSGPTKDQK
G399	CLSsPLSGPTKDQKP
T401	SsPLSGPTKDQKPKN
T487-p	SSGDKAMtPPLPVST
T519-p	EDGWTMDtEADHsGG
S524-p	MDtEADHsGGsDGNs
S527-p	EADHsGGsDGNsMDS
S531-p	sGGsDGNsMDSVDSC
S534	sDGNsMDSVDSCCGL
S537	NsMDSVDSCCGLTKP
G540	DSVDSCCGLTKPDSP
S546	CGLTKPDSPQSVQAG
S554	PQSVQAGSNPKKVDL
K588-u	GRYVSFLkQTSGAKI
K627-u	KALNLIGkKFKELNL
K754	YVDYGGYKRVKVDVL
Y854	AQWVDSYYASL____
S856	WVDSYYASL______

	rat
T55	AIEDRLPTEEACPGV
S64	EACPGVLSVTPSVTQ
V65	ACPGVLSVTPSVTQP
S101-p	TRQVRRRsEssGNLP
S103-p	QVRRRsEssGNLPSI
S104-p	VRRRsEssGNLPSIV
L115	PSIVDTRLQAGQCSD
-	gap
E135	VLSLMGDEAKSIPLG
-	gap
S151	PLFPKDLSFPYEAVE
-	gap
Y154	PKDLSFPYEAVEGCK
-	gap
S164	VEGCKQESALGRTPG
S312	QTAFQIISQVILEAT
L316	QIISQVILEATEEIR
T319	SQVILEATEEIRATT
T325	ATEEIRATTVGKTVA
T330	RATTVGKTVAQVHPT
S375-p	TRTGATAsPSAGAPP
A380	TAsPSAGAPPPKTYV
S392	TYVSCLSSPLSGPTK
S395	SCLSSPLSGPTKDQK
G396	CLSSPLSGPTKDQKP
T398	SSPLSGPTKDQKPKN
T484	SSGDKAVTPPLPDST
T516	EDGWTMDTEADHSGG
S521	MDTEADHSGGSDGNS
S524	EADHSGGSDGNSMDS
S528	SGGSDGNSMDSVDSC
S531	SDGNSMDSVDSCCGL
S534	NSMDSVDSCCGLTKP
G537	DSVDSCCGLTKPDSP
S543	CGLTKPDSPQTVQAG
S551	PQTVQAGSNPKKVDL
K585	GRYVSFLKQTSGAKI
K624	KALNLIGKKFKELNL
K751	YVDYGGYKRVKVDVL
Y851	AQWVDSCYASL____
S853	WVDSCYASL______

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