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Protein Page:
AKAP1 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
AKAP1 Binds to type I and II regulatory subunits of protein kinase A and anchors them to the cytoplasmic face of the mitochondrial outer membrane. AKAP149 is highly expressed in prostate and small intestine whereas S-AKAP84 is expressed in kidney, pancreas, liver, lung and brain. AKAP149 is also expressed in colon carcinoma. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral; Adaptor/scaffold; Mitochondrial
Cellular Component: mitochondrial outer membrane; membrane; mitochondrion; integral to membrane; cytosol
Molecular Function: protein binding; RNA binding
Biological Process: blood coagulation
Reference #:  Q92667 (UniProtKB)
Alt. Names/Synonyms: A kinase (PRKA) anchor protein 1; A kinase anchor protein 1, mitochondrial; A-kinase anchor protein 149 kDa; A-kinase anchor protein, 149kD; AKAP; AKAP 149; AKAP1; AKAP121; AKAP149; AKAP84; D-AKAP-1; D-AKAP1; Dual specificity A-kinase-anchoring protein 1; dual-specificity A-kinase anchoring protein 1; MGC1807; PRKA1; protein kinase A anchoring protein 1; Protein kinase A-anchoring protein 1; protein kinase A1; S-AKAP84; SAKAP84; Spermatid A-kinase anchor protein 84
Gene Symbols: AKAP1
Molecular weight: 97,342 Da
Basal Isoelectric point: 4.84  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

AKAP1

Protein Structure Not Found.


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Sites Implicated In
molecular association, regulation: S151‑p, S159‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

► Hide Isoforms
 
0 48 V60 AIKEPLPVEDVCPKV
0 3 S69-p DVCPKVVstPPsVTE
0 13 T70-p VCPKVVstPPsVTEP
0 3 S73-p KVVstPPsVTEPPEK
0 38 S105-p THPPCRRsEssGILP
0 46 S107-p PPCRRsEssGILPNT
0 10 S108-p PCRRsEssGILPNTT
0 2 N113 EssGILPNTTDMRLR
0 4 L119 PNTTDMRLRPGTRRD
0 1 S128-p PGTRRDDsTKLELAL
0 1 E139 ELALTGGEAKsIPLE
0 1 S142-p LTGGEAKsIPLECPL
0 2 S150-p IPLECPLssPKGVLF
1 7 S151-p PLECPLssPKGVLFs
0 1 - gap
0 2 S158-p sPKGVLFssKsAEVC
1 2 S159-p PKGVLFssKsAEVCK
0 1 S161-p GVLFssKsAEVCKQD
0 6 S169-p AEVCKQDsPFSRVPR
0 1 S231-p HVLELENsKGPSLAs
0 1 S238-p sKGPSLAsLEGEEDK
0 1 S309-p GELGNEEsLDRNEEG
0 1 S330-p GLDRNEEsLDRNEEG
0 8 S353-p RAAFQIIsQVIsEAt
0 8 S357-p QIIsQVIsEAtEQVL
0 7 T360-p sQVIsEAtEQVLAtT
0 2 T366-p AtEQVLAtTVGKVAG
0 1 V371 LAtTVGKVAGRVCQA
0 2 - gap
0 4 S429-p PGLPAEGsPPPKTYV
0 3 S441-p TYVSCLKsLLssPtK
0 2 S444-p SCLKsLLssPtKDSK
0 7 S445-p CLKsLLssPtKDSKP
0 1 T447-p KsLLssPtKDSKPNI
0 29 T533-p SPRDKAItPPLPEST
0 1 A565 EDGWTMDAEADHSGG
0 1 S570 MDAEADHSGGsDRNs
0 2 S573-p EADHSGGsDRNsMDs
0 2 S577-p SGGsDRNsMDsVDsC
0 1 S580-p sDRNsMDsVDsCCsL
0 1 S583-p NsMDsVDsCCsLKKt
0 2 S586-p DsVDsCCsLKKtEsF
0 1 T590-p sCCsLKKtEsFQNAQ
0 6 S592-p CsLKKtEsFQNAQAG
0 2 S600-p FQNAQAGsNPKKVDL
0 2 K634-ub GRYVSFLkQTSGAKI
0 1 K673 KALNLIGKKFKELNL
0 1 K800-ub YVDYGGYkRVKVDVL
0 4 Y900-p AQWVDSYyTsL____
0 3 S902-p WVDSYyTsL______
  AKAP1 iso3  
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- under review  
- gap
- gap
- gap
- gap
- gap
- gap
- gap
S107 HVLELENSKAPSLAS
S114 SKAPSLASLEGEEDK
- under review  
- under review  
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
  mouse

 
S55-p AIKDRRLsEEACPGV
S64-p EACPGVLsVAPTVTQ
V65 ACPGVLsVAPTVTQP
T68 GVLsVAPTVTQPPGR
S101-p TRQVRRRsEssGNLP
S103-p QVRRRsEssGNLPsV
S104-p VRRRsEssGNLPsVA
S109-p EssGNLPsVADTRsQ
S115-p PsVADTRsQPGPCRD
I124 PGPCRDEIAKVELSL
K135-ub ELSLMGDkAKSIPLG
S138 LMGDkAKSIPLGCPL
L146 IPLGCPLLPKDAsFP
- gap
S151-p PLLPKDAsFPYEAVE
- gap
- gap
- gap
S164 VERCKQESALGKTPG
S220 CVSEVEKSEFPILAP
- gap
S282 LEPQVKGSSNTSDRD
T299 GELDKDETVPENDQI
S315 QAAFQLISQVILEAT
L319 QLISQVILEATEEFR
T322 SQVILEATEEFRATT
T328 ATEEFRATTVGKtVA
T333-p RATTVGKtVAQVHPT
S378-p TRTGATAsPSAEALP
- gap
S395-p TYVSCLSsPLSGPTK
S398 SCLSsPLSGPTKDQK
- gap
T401 SsPLSGPTKDQKPKN
T487-p SSGDKAMtPPLPVST
T519-p EDGWTMDtEADHsGG
S524-p MDtEADHsGGsDGNs
S527-p EADHsGGsDGNsMDS
S531-p sGGsDGNsMDSVDSC
S534 sDGNsMDSVDSCCGL
S537 NsMDSVDSCCGLTKP
C539 MDSVDSCCGLTKPDS
T542 VDSCCGLTKPDSPQS
S546 CGLTKPDSPQSVQAG
S554 PQSVQAGSNPKKVDL
K588-ub GRYVSFLkQTSGAKI
K627-ub KALNLIGkKFKELNL
K754 YVDYGGYKRVKVDVL
Y854 AQWVDSYYASL____
S856 WVDSYYASL______
  rat

 
T55 AIEDRLPTEEACPGV
S64 EACPGVLSVTPSVTQ
V65 ACPGVLSVTPSVTQP
S68 GVLSVTPSVTQPPGK
S101-p TRQVRRRsEssGNLP
S103-p QVRRRsEssGNLPSI
S104-p VRRRsEssGNLPSIV
S109 EssGNLPSIVDTRLQ
L115 PSIVDTRLQAGQCSD
N124 AGQCSDENSKVVLSL
E135 VLSLMGDEAKSIPLG
S138 LMGDEAKSIPLGRPL
F146 IPLGRPLFPKDLSFP
- gap
S151 PLFPKDLSFPYEAVE
- gap
- gap
- gap
S164 VEGCKQESALGRTPG
- under review  
- gap
- under review  
- under review  
S312 QTAFQIISQVILEAT
L316 QIISQVILEATEEIR
T319 SQVILEATEEIRATT
T325 ATEEIRATTVGKTVA
T330 RATTVGKTVAQVHPT
S375-p TRTGATAsPSAGAPP
- gap
S392 TYVSCLSSPLSGPTK
S395 SCLSSPLSGPTKDQK
- gap
T398 SSPLSGPTKDQKPKN
T484-p SSGDKAVtPPLPDST
T516 EDGWTMDTEADHSGG
S521 MDTEADHSGGSDGNS
S524 EADHSGGSDGNSMDS
S528 SGGSDGNSMDSVDSC
S531 SDGNSMDSVDSCCGL
S534 NSMDSVDSCCGLTKP
C536 MDSVDSCCGLTKPDS
T539 VDSCCGLTKPDSPQT
S543 CGLTKPDSPQTVQAG
S551 PQTVQAGSNPKKVDL
K585 GRYVSFLKQTSGAKI
K624 KALNLIGKKFKELNL
K751 YVDYGGYKRVKVDVL
Y851 AQWVDSCYASL____
S853 WVDSCYASL______
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