Sequence-specific RNA-binding protein that regulates translation and mRNA stability by binding the 3'-UTR of mRNA targets. Its interactions and tissue specificity suggest that it may be required to support proliferation and self-renewal of stem cells by regulating the translation of key transcripts. 3 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: RNA binding protein; Motility/polarity/chemotaxis; Translation
Chromosomal Location of Human Ortholog: 2p22-p21
Cellular Component: nuclear membrane; stress granule; perinuclear region of cytoplasm; cytoplasm
Molecular Function: protein binding
Biological Process: regulation of translation; stress granule assembly
SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.