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pumilio 2 (human)

Overview pumilio 2 Sequence-specific RNA-binding protein that regulates translation and mRNA stability by binding the 3'-UTR of mRNA targets. Its interactions and tissue specificity suggest that it may be required to support proliferation and self-renewal of stem cells by regulating the translation of key transcripts. 3 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB. Protein type: Motility/polarity/chemotaxis; Translation; RNA binding protein Cellular Component: stress granule; perinuclear region of cytoplasm; cytoplasm Molecular Function: protein binding; RNA binding Biological Process: regulation of translation; stress granule assembly Reference #:  Q8TB72 (UniProtKB) Alt. Names/Synonyms: FLJ36528; KIAA0235; MGC138251; MGC138253; PUM2; PUMH2; Pumilio homolog 2; pumilio homolog 2 (Drosophila); Pumilio-2; PUML2 Gene Symbols: PUM2 Molecular weight: 114,216 Da Basal Isoelectric point: 6.61  Predict pI for various phosphorylation states Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below pumilio 2 3Q0Q - A=706-1056 (human) 3Q0R - A=706-1056 (human) 3Q0S - A=706-1056 (human) 3GVO - A=706-1056 (mouse) 3GVT - A/B=706-1056 (mouse)

STRING  |  Scansite  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  RCSB PDB 3Q0Q 3Q0R 3Q0S  |  DISEASE  |  Source  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	1		S67-p	PIMVQRRsGQGFHGN
0	12		S82-p	SEVNAILsPRSESGG
0	10		Y97-p	LGVSMVEyVLSSSPA
0	60		S136-p	GDQKGKAsPFEEDQN
0	6		T175-p	DCKDFNRtPGsRQAs
0	10		S178-p	DFNRtPGsRQAsPtE
0	37		S182-p	tPGsRQAsPtEVVER
0	5		T184-p	GsRQAsPtEVVERLG
0	21		T396-p	GAGQRPLtPNQGQQG
0	1		R462	TGLGAPVRLMAPTPV
0	9		S587-p	SSATRREsLSTSSDL
0	3		Y595-p	LSTSSDLykRSSSSL
0	2		K596-u	STSSDLykRSSSSLA
0	19		K672-u	AAPGAEAkYRSASST
0	1		S687-p	SSLFSSSsQLFPPSR
0	1		Y697-p	FPPSRLRyNRsDIMP
0	2		S700-p	SRLRyNRsDIMPSGR
0	1		K792-u	EFGSLDQkLALATRI
0	1		K818	YGCRVIQKALESISS
0	2		K843-u	ELDGHVLkCVkDQNG
0	3		K846-u	GHVLkCVkDQNGNHV
0	6		K964-u	FASNVVEkCVTHASR
0	6		Y1003-p	MKDQYANyVVQKMID
0	4		T1030-p	KIRPHITtLRKyTyG
0	1		Y1034-p	HITtLRKyTyGKHIL
0	1		Y1036-p	TtLRKyTyGKHILAK
0	1		Y1048-p	LAKLEKYyLKNSPDL

	mouse ► Hide Isoforms
S67	PIMVQRRSGQSFHGN
S82-p	SEVNAILsPRSESGG
Y97	LGVSMVEYVLSSSPA
S136-p	GDQKGKAsPFEEDQN
T174-p	DCKDFNRtPGsRQAs
S177-p	DFNRtPGsRQAsPtE
S181-p	tPGsRQAsPtEVVER
T183-p	GsRQAsPtEVVERLG
T395	GAGQRPITPSQGQQG
R459	TGLGAPVRLMAPTPV
S587-p	SSATRREsLSTSSDL
Y595	LSTSSDLYKRSSSSL
K596	STSSDLYKRSSSSLA
K672-u	AAPGAEAkYRSASST
S687	SSLFSSSSQLFPPSR
Y697	FPPSRLRYNRsDIMP
S700-p	SRLRYNRsDIMPSGR
K792	EFGSLDQKLALATRI
K818	YGCRVIQKALESISS
K843	ELDGHVLKCVkDQNG
K846-u	GHVLKCVkDQNGNHV
K964	FASNVVEKCVTHASR
Y1003	MKDQYANYVVQKMID
T1030	KIRPHITTLRKYTYG
Y1034	HITTLRKYTYGKHIL
Y1036	TTLRKYTYGKHILAK
Y1048	LAKLEKYYLKNSPDL

	pumilio 2 iso2
S67	PIMVQRRSGQSFHGN
S82	SEVNAILSPRSESGG
Y97	LGVSMVEYVLSSSPA
S136	GDQKGKASPFEEDQN
T174	DCKDFNRTPGSRQAS
S177	DFNRTPGSRQASPTE
S181	TPGSRQASPTEVVER
T183	GSRQASPTEVVERLG
T395	GAGQRPITPSQGQQG
R459	TGLGAPVRLMAPTPV
-	under review
-	under review
-	under review
K593	AAPGAEAKYRSASST
S608	SSLFSSSSQLFPPSR
Y618	FPPSRLRYNRSDIMP
S621	SRLRYNRSDIMPSGR
K713	EFGSLDQKLALATRI
K739-u	YGCRVIQkALESISS
K762	ELDGHVLKCVKDQNG
K765	GHVLKCVKDQNGNHV
K883	FASNVVEKCVTHASR
Y922	MKDQYANYVVQKMID
T949	KIRPHITTLRKYTYG
Y953	HITTLRKYTYGKHIL
Y955	TTLRKYTYGKHILAK
Y967	LAKLEKYYLKNSPDL

	rat
S67	PIMVQRRSGQSFHGN
S82	SEVNAILSPRSESGG
Y97	LGVSMVEYVLSSSPA
S136-p	GDQKGKAsPFEEDQN
T174	DCKDFNRTPGSRQAs
S177	DFNRTPGSRQAsPTE
S181-p	TPGSRQAsPTEVVER
T183	GSRQAsPTEVVERLG
T395	GAGQRPITPSQGQQG
R461-m1	TGLGAPVrLMAPTPV
S588	SSATRRESLSTSSDL
Y596	LSTSSDLYKRSSSSL
K597	STSSDLYKRSSSSLA
K669	AAPGAEAKYRSASST
S684	SSLFSSSSQLFPPSR
Y694	FPPSRLRYNRSDIMP
S697	SRLRYNRSDIMPSGR
K789	EFGSLDQKLALANRI
K815	YGCRVIQKALESISS
K838	ELDGHVLKCVKDQNG
K841	GHVLKCVKDQNGNHV
K959	FASNVVEKCVTHASR
Y998	MKDQYANYVVQKMID
T1025	KIRPHITTLRKYTYG
Y1029	HITTLRKYTYGKHIL
Y1031	TTLRKYTYGKHILAK
Y1043	LAKLEKYYLKNSPDL

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