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Protein Page:
Pumilio-2 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
Pumilio-2 Sequence-specific RNA-binding protein that regulates translation and mRNA stability by binding the 3'-UTR of mRNA targets. Its interactions and tissue specificity suggest that it may be required to support proliferation and self-renewal of stem cells by regulating the translation of key transcripts. 3 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Motility/polarity/chemotaxis; Translation; RNA binding protein
Cellular Component: nuclear membrane; stress granule; perinuclear region of cytoplasm; cytoplasm
Molecular Function: protein binding
Biological Process: regulation of translation; stress granule assembly
Reference #:  Q8TB72 (UniProtKB)
Alt. Names/Synonyms: FLJ36528; KIAA0235; MGC138251; MGC138253; PUM2; PUMH2; Pumilio homolog 2; pumilio homolog 2 (Drosophila); Pumilio-2; PUML2
Gene Symbols: PUM2
Molecular weight: 114,216 Da
Basal Isoelectric point: 6.61  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

Pumilio-2

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 3 S67-p PIMVQRRsGQGFHGN
0 1 S75-p GQGFHGNsEVNAILs
0 16 S82-p sEVNAILsPRSESGG
0 1 S93-p ESGGLGVsMVEyVLS
0 11 Y97-p LGVsMVEyVLSsSPA
0 1 S101-p MVEyVLSsSPADKLD
0 1 S109-p SPADKLDsRFRKGNF
0 70 S136-p GDQKGKAsPFEEDQN
0 8 T175-p DCKDFNRtPGsRQAs
0 14 S178-p DFNRtPGsRQAsPtE
0 47 S182-p tPGsRQAsPtEVVER
0 9 T184-p GsRQAsPtEVVERLG
0 22 T396-p GAGQRPLtPNQGQQG
0 2 R462-m1 TGLGAPVrLMAPTPV
0 12 S587-p SSATRREsLsTSsDL
0 1 S589-p ATRREsLsTSsDLyk
0 1 S592-p REsLsTSsDLykRSS
0 3 Y595-p LsTSsDLykRSSSSL
0 2 K596-ub sTSsDLykRSSSSLA
0 19 K672-ub AAPGAEAkYRSASST
0 1 S685-p STSSLFSsSsQLFPP
0 2 S687-p SSLFSsSsQLFPPSR
0 2 Y697-p FPPSRLRyNRsDIMP
0 4 S700-p SRLRyNRsDIMPSGR
0 1 K792-ub EFGSLDQkLALATRI
0 1 K818 YGCRVIQKALESISS
0 2 K843-ub ELDGHVLkCVkDQNG
0 3 K846-ub GHVLkCVkDQNGNHV
0 6 K964-ub FASNVVEkCVTHASR
0 6 Y1003-p MKDQYANyVVQKMID
0 4 T1030-p KIRPHITtLRKyTyG
0 1 Y1034-p HITtLRKyTyGKHIL
0 1 Y1036-p TtLRKyTyGKHILAK
0 1 Y1048-p LAKLEKYyLKNSPDL
  mouse

► Hide Isoforms
 
S67 PIMVQRRSGQSFHGN
S75-p GQSFHGNsEVNAILs
S82-p sEVNAILsPRSESGG
S93 ESGGLGVSMVEYVLS
Y97 LGVSMVEYVLSSSPA
S101 MVEYVLSSSPADKLD
S109 SPADKLDSRFRKGTF
S136-p GDQKGKAsPFEEDQN
T174-p DCKDFNRtPGsRQAs
S177-p DFNRtPGsRQAsPtE
S181-p tPGsRQAsPtEVVER
T183-p GsRQAsPtEVVERLG
T395 GAGQRPITPSQGQQG
R459 TGLGAPVRLMAPTPV
S587-p SSATRREsLSTSSDL
S589 ATRREsLSTSSDLYK
S592 REsLSTSSDLYKRSS
Y595 LSTSSDLYKRSSSSL
K596 STSSDLYKRSSSSLA
K672-ub AAPGAEAkYRSASST
S685 STSSLFSSSSQLFPP
S687 SSLFSSSSQLFPPSR
Y697 FPPSRLRYNRsDIMP
S700-p SRLRYNRsDIMPSGR
K792 EFGSLDQKLALATRI
K818 YGCRVIQKALESISS
K843 ELDGHVLKCVkDQNG
K846-ub GHVLKCVkDQNGNHV
K964 FASNVVEKCVTHASR
Y1003 MKDQYANYVVQKMID
T1030 KIRPHITTLRKYTYG
Y1034 HITTLRKYTYGKHIL
Y1036 TTLRKYTYGKHILAK
Y1048 LAKLEKYYLKNSPDL
  pumilio 2 iso2  
S67 PIMVQRRSGQSFHGN
S75 GQSFHGNSEVNAILS
S82 SEVNAILSPRSESGG
S93 ESGGLGVSMVEYVLS
Y97 LGVSMVEYVLSSSPA
S101 MVEYVLSSSPADKLD
S109 SPADKLDSRFRKGTF
S136 GDQKGKASPFEEDQN
T174 DCKDFNRTPGSRQAS
S177 DFNRTPGSRQASPTE
S181 TPGSRQASPTEVVER
T183 GSRQASPTEVVERLG
T395 GAGQRPITPSQGQQG
R459 TGLGAPVRLMAPTPV
- gap
- under review  
- under review  
- gap
- gap
K593 AAPGAEAKYRSASST
S606 STSSLFSSSSQLFPP
S608 SSLFSSSSQLFPPSR
Y618 FPPSRLRYNRSDIMP
S621 SRLRYNRSDIMPSGR
K713 EFGSLDQKLALATRI
K739-ub YGCRVIQkALESISS
K762 ELDGHVLKCVKDQNG
K765 GHVLKCVKDQNGNHV
K883 FASNVVEKCVTHASR
Y922 MKDQYANYVVQKMID
T949 KIRPHITTLRKYTYG
Y953 HITTLRKYTYGKHIL
Y955 TTLRKYTYGKHILAK
Y967 LAKLEKYYLKNSPDL
  rat

 
S67 PIMVQRRSGQSFHGN
S75 GQSFHGNSEVNAILS
S82 SEVNAILSPRSESGG
S93 ESGGLGVSMVEYVLS
Y97 LGVSMVEYVLSSSPA
S101 MVEYVLSSSPADKLD
S109 SPADKLDSRFRKGTF
S136-p GDQKGKAsPFEEDQN
T174 DCKDFNRTPGSRQAs
S177 DFNRTPGSRQAsPTE
S181-p TPGSRQAsPTEVVER
T183 GSRQAsPTEVVERLG
T395 GAGQRPITPSQGQQG
R461-m1 TGLGAPVrLMAPTPV
S588 SSATRRESLSTSSDL
S590 ATRRESLSTSSDLYK
S593 RESLSTSSDLYKRSS
Y596 LSTSSDLYKRSSSSL
K597 STSSDLYKRSSSSLA
K669 AAPGAEAKYRSASST
S682 STSSLFSSSSQLFPP
S684 SSLFSSSSQLFPPSR
Y694 FPPSRLRYNRSDIMP
S697 SRLRYNRSDIMPSGR
K789 EFGSLDQKLALANRI
K815 YGCRVIQKALESISS
K838 ELDGHVLKCVKDQNG
K841 GHVLKCVKDQNGNHV
K959 FASNVVEKCVTHASR
Y998 MKDQYANYVVQKMID
T1025 KIRPHITTLRKYTYG
Y1029 HITTLRKYTYGKHIL
Y1031 TTLRKYTYGKHILAK
Y1043 LAKLEKYYLKNSPDL
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