Home

EGFR (human)

Overview EGFR a receptor tyrosine kinase. This is a receptor for epidermal growth factor (EGF) and related growth factors including TGF-alpha, amphiregulin, betacellulin, heparin-binding EGF-like growth factor, GP30, and vaccinia virus growth factor. EGFR is involved in the control of cell growth and differentiation. It is a single-pass transmembrane tyrosine kinase. Ligand binding to this receptor results in receptor dimerization, autophosphorylation (in trans), activation of various downstream signaling molecules and lysosomal degradation. It can be phosphorylated and activated by Src. Activated EGFR binds the SH2 domain of phospholipase C-gamma (PLC-gamma), activating PLC-gamma-mediated downstream signaling. Phosphorylated EGFR binds Cbl, leading to its ubiquitination and degradation. Grb2 and SHC bind to phospho-EGFR and are involved in the activation of MAP kinase signaling pathways. Phosphorylation on Ser and Thr residues is thought to represent a mechanism for attenuation of EGFR kinase activity. EGFR is overexpressed in breast, head and neck cancers, correlating with poor survival. Activating somatic mutations are seen in lung cancer, corresponding to the minority of patients with strong responses to the EGFR inhibitor Iressa (gefitinib). Mutations and amplifications are also seen in glioblastoma, and upregulation is seen in colon cancer and neoplasms. In xenografts, inhibitors synergize with cytotoxic drugs in the inhibition of many tumor types. Inhibitors include: Iressa/ZD1839, Erbitux, Tarceva, and lapatinib. Four alternatively spliced isoforms have been described. Note: This description may include information from UniProtKB. Protein type: Protein kinase, TK; EC 2.7.10.1; Membrane protein, integral; Kinase, protein; Protein kinase, tyrosine (receptor); TK group; EGFR family Cellular Component: extracellular space; endoplasmic reticulum membrane; nuclear membrane; basolateral plasma membrane; integral to membrane; lipid raft; Golgi membrane; membrane; perinuclear region of cytoplasm; cytoplasm; plasma membrane; AP-2 adaptor complex; endosome membrane; nucleus; endosome Molecular Function: identical protein binding; epidermal growth factor receptor activity; nitric-oxide synthase regulator activity; transmembrane receptor protein tyrosine kinase activity; receptor signaling protein tyrosine kinase activity; protein phosphatase binding; actin filament binding; protein binding; enzyme binding; transmembrane receptor activity; MAP kinase kinase kinase activity; protein heterodimerization activity; protein-tyrosine kinase activity; double-stranded DNA binding; ATP binding Biological Process: negative regulation of epidermal growth factor receptor signaling pathway; axon guidance; embryonic placenta development; positive regulation of nitric oxide biosynthetic process; activation of MAPKK activity; protein amino acid autophosphorylation; signal transduction; protein insertion into membrane; G1/S-specific positive regulation of cyclin-dependent protein kinase activity; positive regulation of MAP kinase activity; cell-cell adhesion; positive regulation of fibroblast proliferation; cell surface receptor linked signal transduction; hair follicle development; positive regulation of cell proliferation; salivary gland morphogenesis; response to stress; regulation of peptidyl-tyrosine phosphorylation; epidermal growth factor receptor signaling pathway; ossification; positive regulation of DNA repair; MAPKKK cascade; digestive tract morphogenesis; cell proliferation; positive regulation of protein kinase B signaling cascade; cerebral cortex cell migration; phospholipase C activation; calcium-dependent phospholipase A2 activation; regulation of nitric-oxide synthase activity; negative regulation of protein catabolic process; positive regulation of DNA replication; positive regulation of epithelial cell proliferation; positive regulation of phosphorylation; negative regulation of apoptosis; positive regulation of cell migration Reference #:  P00533 (UniProtKB) Alt. Names/Synonyms: avian erythroblastic leukemia viral (v-erb-b) oncogene homolog; cell growth inhibiting protein 40; cell proliferation-inducing protein 61; EGFR; Epidermal growth factor receptor; epidermal growth factor receptor (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian); ERBB; ERBB1; HER1; mENA; PIG61; Proto-oncogene c-ErbB-1; Receptor tyrosine-protein kinase erbB-1 Gene Symbols: EGFR Molecular weight: 134,277 Da Basal Isoelectric point: 6.26  Predict pI for various phosphorylation states CST Pathways:  Angiogenesis  |  ErbB/HER Signaling  |  Jak/Stat/IL-6 Signaling  |  Phospholipase Signaling  |  Tyrosine Kinases Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below EGFR 1DNQ - A=25-336 (human) 1DNR - A=337-645 (human) 1IVO - A/B=25-646 (human) 1M14 - A=695-1022 (human) 1M17 - A=695-1022 (human) 1MOX - A/B=25-525 (human) 1NQL - A=25-642 (human) 1XKK - A=695-1022 (human) 1YY9 - A=25-642 (human) 1Z9I - A=669-721 (human) 2EB2 - A=695-1022 (human) 2EB3 - A=695-1022 (human) 2EXP - A=311-326 (human) 2EXQ - A=27-536 (human) 2GS2 - A=696-1022 (human) 2GS6 - A=696-1022 (human) 2GS7 - A/B=696-1022 (human) 2ITN - A=696-1022 (human) 2ITO - A=696-1022 (human) 2ITP - A=696-1022 (human) 2ITQ - A=696-1022 (human) 2ITT - A=696-1022 (human) 2ITU - A=696-1022 (human) 2ITV - A=696-1022 (human) 2ITW - A=696-1022 (human) 2ITX - A=696-1022 (human) 2ITY - A=696-1022 (human) 2ITZ - A=696-1022 (human) 2J5E - A=696-1022 (human) 2J5F - A=696-1022 (human) 2J6M - A=696-1022 (human) 2JIT - A/B=696-1022 (human) 2JIU - A/B=695-1022 (human) 2JIV - A/B=695-1022 (human) 2KS1 - B=634-677 (human) 2M20 - A/B=642-697 (human) 2RF9 - A/B=696-1022 (human) 2RFD - A/B=702-1022 (human) 2RFE - A/D/C/B=702-1022 (human) 2RGP - A=702-1016 (human) 3B2U - S/A/M/P/I/E/B/V=335-538 (human) 3B2V - A=25-642 (human) 3BEL - A=702-1016 (human) 3BUO - A/C=1063-1075 (human) 3C09 - A/D=336-538 (human) 3GOP - A=669-1022 (human) 3GT8 - A/D/C/B=696-1022 (human) 3IKA - A/B=694-1022 (human) 3LZB - F/A/E/B/H/C/D/G=696-1022 (human) 3NJP - A/B=25-638 (human) 3OB2 - A=1063-1074 (human) 3OP0 - D/C=1066-1076 (human) 3P0Y - A=334-538 (human) 3PFV - D/C=1066-1076 (human) 3POZ - A=696-1022 (human) 3QWQ - A=1-642 (human) 3UG1 - A=695-1022 (human) 3UG2 - A=695-1022 (human) 3VJN - A=695-1022 (human) 3VJO - A=695-1022 (human) 3VRP - B=1062-1074 (human) 3VRR - C=1062-1074 (human) 3W2O - A=698-1022 (human) 3W2P - A=698-1022 (human) 3W2Q - A=698-1022 (human) 3W2R - A=698-1022 (human) 3W2S - A=696-1022 (human) 3W32 - A=696-1022 (human) 3W33 - A=696-1022 (human) 4G5J - A=696-1025 (human) 4G5P - A/B=696-1022 (human) 4HJO - A=696-1022 (human) 4I1Z - A=695-1022 (human) 4I20 - A=695-1022 (human) 4I21 - D/C=315-374 (human) 4I22 - A=695-1022 (human) 4I23 - A=695-1022 (human) 4I24 - A/B=695-1022 (human) Substrate Sequence Logo

STRING  |  Scansite  |  KinBase  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  RCSB PDB 1DNQ 1DNR 1IVO 1M14 1M17 1MOX 1NQL 1XKK 1YY9 1Z9I 2EB2 2EB3 2EXP 2EXQ 2GS2 2GS6 2GS7 2ITN 2ITO 2ITP 2ITQ 2ITT 2ITU 2ITV 2ITW 2ITX 2ITY 2ITZ 2J5E 2J5F 2J6M 2JIT 2JIU 2JIV 2KS1 2M20 2RF9 2RFD 2RFE 2RGP 3B2U 3B2V 3BEL 3BUO 3C09 3GOP 3GT8 3IKA 3LZB 3NJP 3OB2 3OP0 3P0Y 3PFV 3POZ 3QWQ 3UG1 3UG2 3VJN 3VJO 3VRP 3VRR 3W2O 3W2P 3W2Q 3W2R 3W2S 3W32 3W33 4G5J 4G5P 4HJO 4I1Z 4I20 4I21 4I22 4I23 4I24  |  ENZYME  |  Phospho3D  |  DISEASE 131550 211980  |  Source  |  InnateDB  |  UCSD-Nature  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene

	Sites Implicated In
apoptosis, inhibited: Y869‑p, Y1092‑p cell adhesion, altered: Y869‑p, Y1016‑p, Y1092‑p cell cycle regulation: Y869‑p cell growth, altered: Y869‑p, Y1092‑p, Y1172‑p, Y1197‑p cell motility, altered: Y869‑p, Y1016‑p cytoskeletal reorganization: T678‑p endocytosis, altered: Y1016‑p transcription, altered: Y1092‑p, Y1110‑p activation: Y869‑p, Y1016‑p, Y1092‑p, Y1197‑p enzymatic activity, induced: Y869‑p, Y1016‑p, Y1092‑p, Y1110‑p, Y1172‑p, Y1197‑p enzymatic activity, inhibited: T678‑p inhibition: S1026‑p intracellular localization: T678‑p, Y1016‑p, Y1092‑p, Y1110‑p, Y1197‑p molecular association, regulation: T678‑p, T693‑p, Y869‑p, S991‑p, Y998‑p, Y1016‑p, Y1069‑p, Y1092‑p, Y1110‑p, Y1172‑p, Y1197‑p phosphorylation: S991‑p, Y998‑p, Y1016‑p, Y1092‑p, Y1172‑p, Y1197‑p protein conformation: Y1016‑p, Y1092‑p, Y1110‑p protein degradation: T678‑p, Y1069‑p, Y1092‑p, Y1172‑p, Y1197‑p receptor desensitization, altered: T678‑p, S1070‑p, S1071‑p receptor internalization, altered: T678‑p, T693‑p, S695‑p, S991‑p, Y998‑p, Y1016‑p, S1070‑p, S1071‑p, Y1092‑p, Y1110‑p, Y1172‑p, S1190‑p, Y1197‑p receptor recycling, altered: T678‑p ubiquitination: Y1069‑p, Y1092‑p, Y1110‑p

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	1		Y112-p	QIIRGNMyyENSyAL
0	1		Y113-p	IIRGNMyyENSyALA
0	1		Y117-p	NMyyENSyALAVLSN
0	1		K133-a	DANKTGLkELPMRNL
0	1		S151-p	LHGAVRFsNNPALCN
1	0		S229-p	RCRGKSPsDCCHNQC
1	0		Y270	TCPPLMLYNPTTYQM
0	1		K284-a	MDVNPEGkYSFGATC
0	1		Y316	RACGADSYEMEEDGV
0	1		K346-a	GIGIGEFkDSLSINA
0	1		K454	SLGLRSLKEISDGDV
0	1		K487	LFGTSGQKTKIISNR
0	1		S511-p	QVCHALCsPEGCWGP
0	1		Y585-p	NCIQCAHyIDGPHCV
0	1		S645-p	TNGPKIPsIAtGMVG
0	1		T648-p	PKIPsIAtGMVGALL
19	0		T678-p	RHIVRKRtLRRLLQE
11	49		T693-p	RELVEPLtPsGEAPN
4	6		S695-p	LVEPLtPsGEAPNQA
1	1		K708-u	QALLRILkETEFkkI
2	0		K713-u	ILkETEFkkIkVLGS
2	0		K714-u	LkETEFkkIkVLGSG
2	0		K716-u	ETEFkkIkVLGSGAF
1	128		Y727-p	SGAFGTVykGLWIPE
1	1		K728-u	GAFGTVykGLWIPEG
2	2		K737-u	LWIPEGEkVkIPVAI
1	1		K739-u	IPEGEkVkIPVAIKE
0	1		K745	VkIPVAIKELREATs
0	1		S752-p	KELREATsPkANkEI
2	0		K754-u	LREATsPkANkEILD
2	1		K757-u	ATsPkANkEILDEAy
2	4		Y764-p	kEILDEAyVMAsVDN
3	0		S768-p	DEAyVMAsVDNPHVC
0	1		Y801-p	PFGCLLDyVREHKDN
1	0		K823-u	NWCVQIAkGMNyLED
0	1		Y827-p	QIAkGMNyLEDRRLV
1	1		K846-u	AARNVLVkTPQHVKI
0	1		K852	VkTPQHVKITDFGLA
1	4		K860-u	ITDFGLAkLLGAEEk
2	1		K867-u	kLLGAEEkEyHAEGG
62	136		Y869-p	LGAEEkEyHAEGGKV
0	1		K875	EyHAEGGKVPIKWMA
1	0		K913-u	ELMTFGSkPYDGIPA
2	1		K929-u	EISSILEkGERLPQP
0	1		Y944-p	PICTIDVyMIMVKCW
1	0		K960-u	IDADSRPkFRELIIE
2	1		K970-u	ELIIEFSkMARDPQR
0	4		Y978-p	MARDPQRyLVIQGDE
2	18		S991-p	DERMHLPsPtDsNFy
0	5		T993-p	RMHLPsPtDsNFyRA
0	10		S995-p	HLPsPtDsNFyRALM
2	124		Y998-p	sPtDsNFyRALMDEE
38	7		Y1016-p	DVVDADEyLIPQQGF
0	2		S1025-p	IPQQGFFssPSTsRT
2	4		S1026-p	PQQGFFssPSTsRTP
0	1		S1030-p	FFssPSTsRTPLLSs
1	3		S1037-p	sRTPLLSsLsAtsNN
1	4		S1039-p	TPLLSsLsAtsNNst
1	2		T1041-p	LLSsLsAtsNNstVA
1	4		S1042-p	LSsLsAtsNNstVAC
1	2		S1045-p	LsAtsNNstVACIDR
0	1		T1046-p	sAtsNNstVACIDRN
0	1		S1057-p	IDRNGLQsCPIKEDs
0	1		K1061	GLQsCPIKEDsFLQR
0	6		S1064-p	sCPIKEDsFLQRyss
31	125		Y1069-p	EDsFLQRyssDPtGA
9	8		S1070-p	DsFLQRyssDPtGAL
8	8		S1071-p	sFLQRyssDPtGALT
0	3		T1074-p	QRyssDPtGALTEDs
3	5		S1081-p	tGALTEDsIDDtFLP
0	2		T1085-p	TEDsIDDtFLPVPEy
82	341		Y1092-p	tFLPVPEyINQsVPK
0	4		S1096-p	VPEyINQsVPKRPAG
0	7		S1104-p	VPKRPAGsVQNPVyH
33	427		Y1110-p	GsVQNPVyHNQPLNP
0	8		S1120-p	QPLNPAPsRDPHyQD
3	32		Y1125-p	APsRDPHyQDPHstA
0	6		S1130-p	PHyQDPHstAVGNPE
0	4		T1131-p	HyQDPHstAVGNPEy
1	59		Y1138-p	tAVGNPEyLNtVQPt
0	2		T1141-p	GNPEyLNtVQPtCVN
0	3		T1145-p	yLNtVQPtCVNStFD
0	1		T1150-p	QPtCVNStFDsPAHW
0	4		S1153-p	CVNStFDsPAHWAQK
1	5		S1162-p	AHWAQKGsHQIsLDN
2	75		S1166-p	QKGsHQIsLDNPDyQ
34	966		Y1172-p	IsLDNPDyQQDFFPk
1	0		K1179-a	yQQDFFPkEAkPNGI
0	1		K1179	yQQDFFPKEAkPNGI
1	0		K1182-a	DFFPkEAkPNGIFkG
0	1		K1182	DFFPkEAKPNGIFkG
1	0		K1188-a	AkPNGIFkGstAENA
0	1		K1188	AkPNGIFKGstAENA
1	3		S1190-p	PNGIFkGstAENAEy
0	3		T1191-p	NGIFkGstAENAEyL
66	1003		Y1197-p	stAENAEyLRVAPQS

	mouse
L112	QIIRGNALYENTYAL
Y113	IIRGNALYENTYALA
Y117	NALYENTYALAILSN
R133	GTNRTGLRELPMRNL
S151	LIGAVRFSNNPILCN
S229	RCRGRSPSDCCHNQC
Y270-p	TCPPLMLyNPTTYQM
K284	MDVNPEGKYSFGATC
Y316-p	RACGPDYyEVEEDGI
K346	GIGIGEFKDTLSINA
K454-u	SLGLRSLkEISDGDV
K487-u	LFGTPNQkTKIMNNR
S511	HVCNPLCSSEGCWGP
Y585	NCIQCAHYIDGPHCV
S647	PSGPKIPSIATGIVG
T650	PKIPSIATGIVGGLL
T680	RHIVRKRTLRRLLQE
T695-p	RELVEPLtPSGEAPN
S697	LVEPLtPSGEAPNQA
K710-u	QAHLRILkETEFKKI
K715	ILkETEFKKIKVLGS
K716	LkETEFKKIKVLGSG
K718	ETEFKKIKVLGSGAF
Y729-p	SGAFGTVykGLWIPE
K730-u	GAFGTVykGLWIPEG
K739-u	LWIPEGEkVkIPVAI
K741-u	IPEGEkVkIPVAIkE
K747-u	VkIPVAIkELREATS
S754	kELREATSPKANkEI
K756	LREATSPKANkEILD
K759-u	ATSPKANkEILDEAY
Y766	kEILDEAYVMASVDN
S770	DEAYVMASVDNPHVC
Y803	PYGCLLDYVREHKDN
K825	NWCVQIAKGMNYLED
Y829	QIAKGMNYLEDRRLV
K848-u	AARNVLVkTPQHVkI
K854-u	VkTPQHVkITDFGLA
K862-u	ITDFGLAkLLGAEEk
K869-u	kLLGAEEkEyHAEGG
Y871-p	LGAEEkEyHAEGGkV
K877-u	EyHAEGGkVPIKWMA
K915	ELMTFGSKPYDGIPA
K931-u	DISSILEkGERLPQP
Y946	PICTIDVYMIMVKCW
K962	IDADSRPKFRELILE
K972-u	ELILEFSkMARDPQR
Y980	MARDPQRYLVIQGDE
S993-p	DERMHLPsPtDsNFy
T995-p	RMHLPsPtDsNFyRA
S997-p	HLPsPtDsNFyRALM
Y1000-p	sPtDsNFyRALMDEE
Y1018-p	DVVDADEyLIPQQGF
N1027	IPQQGFFNSPSTSRT
S1028	PQQGFFNSPSTSRTP
S1032	FFNSPSTSRTPLLSS
S1039	SRTPLLSSLSATSNN
S1041	TPLLSSLSATSNNST
T1043	LLSSLSATSNNSTVA
S1044	LSSLSATSNNSTVAC
S1047	LSATSNNSTVACINR
T1048	SATSNNSTVACINRN
S1057	ACINRNGSCRVkEDA
K1061-u	RNGSCRVkEDAFLQR
A1064	SCRVkEDAFLQRyss
Y1069-p	EDAFLQRyssDPtGA
S1070-p	DAFLQRyssDPtGAV
S1071-p	AFLQRyssDPtGAVT
T1074-p	QRyssDPtGAVTEDN
N1081	tGAVTEDNIDDAFLP
A1085	TEDNIDDAFLPVPEy
Y1092-p	AFLPVPEyVNQSVPK
S1096	VPEyVNQSVPKRPAG
S1104-p	VPKRPAGsVQNPVyH
Y1110-p	GsVQNPVyHNQPLHP
G1120	QPLHPAPGRDLHYQN
Y1125	APGRDLHYQNPHSNA
S1130	LHYQNPHSNAVGNPE
N1131	HYQNPHSNAVGNPEy
Y1138-p	NAVGNPEyLNTAQPT
T1141	GNPEyLNTAQPTCLS
T1145	yLNTAQPTCLSSGFN
G1150	QPTCLSSGFNSPALW
S1153	CLSSGFNSPALWIQK
S1162-p	ALWIQKGsHQMsLDN
S1166-p	QKGsHQMsLDNPDyQ
Y1172-p	MsLDNPDyQQDFFPk
K1179	yQQDFFPKETkPNGI
K1179-u	yQQDFFPkETkPNGI
K1182	DFFPkETKPNGIFkG
K1182-u	DFFPkETkPNGIFkG
K1188	TkPNGIFKGPTAENA
K1188-u	TkPNGIFkGPTAENA
P1190	PNGIFkGPTAENAEy
T1191	NGIFkGPTAENAEyL
Y1197-p	PTAENAEyLRVAPPS

	rat
L112	QIIRGNALYENTYAL
Y113	IIRGNALYENTYALA
Y117	NALYENTYALAVLSN
R133	GTNKTGLRELPMRNL
S151	LIGAVRFSNNPILCN
S229	RCRGRSPSDCCHNQC
Y270	TCPPLMLYNPTTYQM
K284	MDVNPEGKYSFGATC
Y316	RACGPDYYEVEEDGV
K346	GIGIGEFKDTLSINA
K454	SLGLRSLKEISDGDV
K487	LFGTPNQKTKIMNNR
S511	HVCNPLCSSEGCWGP
Y585	NCIKCAHYVDGPHCV
S646	PEGPKIPSIATGIVG
T649	PKIPSIATGIVGGLL
T679-p	RQLVRKRtLRRLLQE
T694	RELVEPLTPSGEAPN
S696	LVEPLTPSGEAPNQA
K709	QAHLRILKETEFKKI
K714	ILKETEFKKIKVLGS
K715	LKETEFKKIKVLGSG
K717	ETEFKKIKVLGSGAF
Y728	SGAFGTVYKGLWIPE
K729	GAFGTVYKGLWIPEG
K738	LWIPEGEKVKIPVAI
K740	IPEGEKVKIPVAIKE
K746	VKIPVAIKELREATS
S753	KELREATSPKANKEI
K755	LREATSPKANKEILD
K758	ATSPKANKEILDEAY
Y765	KEILDEAYVMASVDN
S769	DEAYVMASVDNPHVC
Y802	PYGCLLDYVREHKDN
K824	NWCVQIAKGMNYLED
Y828	QIAKGMNYLEDRRLV
K847	AARNVLVKTPQHVKI
K853	VKTPQHVKITDFGLA
K861	ITDFGLAKLLGAEEK
K868	KLLGAEEKEyHAEGG
Y870-p	LGAEEKEyHAEGGKV
K876	EyHAEGGKVPIKWMA
K914	ELMTFGSKPYDGIPA
K930	EISSILEKGERLPQP
Y945	PICTIDVYMIMVKCW
K961	IDADSRPKFRELILE
K971	ELILEFSKMARDPQR
Y979	MARDPQRYLVIQGDE
S992	DERMHLPSPTDSNFY
T994	RMHLPSPTDSNFYRA
S996	HLPSPTDSNFYRALM
Y999	SPTDSNFYRALMEEE
Y1017-p	DVVDADEyLIPQQGF
N1026	IPQQGFFNSPSTSRT
S1027	PQQGFFNSPSTSRTP
S1031	FFNSPSTSRTPLLSS
S1038	SRTPLLSSLSANSNS
S1040	TPLLSSLSANSNSST
N1042	LLSSLSANSNSSTVA
S1043	LSSLSANSNSSTVAC
S1046	LSANSNSSTVACINR
T1047	SANSNSSTVACINRN
S1056	ACINRNGSCRVKEDA
K1060	RNGSCRVKEDAFLQR
A1063	SCRVKEDAFLQRySS
Y1068-p	EDAFLQRySSDPTSV
S1069	DAFLQRySSDPTSVL
S1070	AFLQRySSDPTSVLT
T1073	QRySSDPTSVLTEDN
N1080	TSVLTEDNIDDTFLP
T1084	TEDNIDDTFLPVPEy
Y1091-p	TFLPVPEyINQSVPK
S1095	VPEyINQSVPKRPAG
S1103	VPKRPAGSVQNPVyH
Y1109-p	GSVQNPVyHNQPLHP
G1119	QPLHPAPGRDLHYQN
Y1124	APGRDLHYQNPHSNA
S1129	LHYQNPHSNAVSNPE
N1130	HYQNPHSNAVSNPEy
Y1137-p	NAVSNPEyLNTAQPT
T1140	SNPEyLNTAQPTCLS
T1144	yLNTAQPTCLSSGFD
G1149	QPTCLSSGFDSSALW
S1152	CLSSGFDSSALWIQK
S1161	ALWIQKGSHQMSLDN
S1165	QKGSHQMSLDNPDyQ
Y1171-p	MSLDNPDyQQDFFPK
K1178	yQQDFFPKEAKPNGI
K1178	yQQDFFPKEAKPNGI
K1181	DFFPKEAKPNGIFKG
K1181	DFFPKEAKPNGIFKG
K1187	AKPNGIFKGPTAENA
K1187	AKPNGIFKGPTAENA
P1189	PNGIFKGPTAENAEy
T1190	NGIFKGPTAENAEyL
Y1196-p	PTAENAEyLRVAPPS

	pig
L112	QIIRGNVLYENTHAL
Y113	IIRGNVLYENTHALA
H117	NVLYENTHALAVLSN
R133	GANKTGLRELPMRNL
S151	LQGAVRFSNNPALCH
S229	RCRGRSPSDCCHNQC
Y270	TCPPLMLYNPTTYQM
K284	MDVNPLGKYSFGATC
Y316	RACSSDSYEVEEDGV
K346	GIGIGEFKDTLSINA
K454	SLGLRSLKEISDGDV
K487	LFGTASQKTKIINNR
S511	HICNPLCSSEGCWGP
Y585	SCVRCAHYIDGPHCV
S645	VDRPKIPSIATGIVG
T648	PKIPSIATGIVGGLL
T678	RHIVRKRTLRRLLQE
T693	RELVEPLTPSGEAPN
S695	LVEPLTPSGEAPNQA
K708	QALLRILKETEFKKV
K713	ILKETEFKKVKVLGS
K714	LKETEFKKVKVLGSG
K716	ETEFKKVKVLGSGAF
Y727	SGAFGTVYKGLWIPE
K728	GAFGTVYKGLWIPEG
K737	LWIPEGEKVKIPVAI
K739	IPEGEKVKIPVAIKE
K745	VKIPVAIKELREATS
S752	KELREATSPKANKEI
K754	LREATSPKANKEILD
K757	ATSPKANKEILDEAY
Y764	KEILDEAYVMASVDN
S768	DEAYVMASVDNPHVC
Y801	PFGCLLDYVREHKDN
K823	NWCVQIAKGMNYLED
Y827	QIAKGMNYLEDRRLV
K846	AARNVLVKTPQHVKI
K852	VKTPQHVKITDFGLA
K860	ITDFGLAKLLGAEEK
K867	KLLGAEEKEYHAEGG
Y869	LGAEEKEYHAEGGKV
K875	EYHAEGGKVPIKWLA
K913	ELMTFGSKPYDGIPA
K929	EISTVLEKGERLPQP
Y944	PICTIDVYMIMVKCW
K960	IDADSRPKFRELIIE
K970	ELIIEFSKMARDPQR
Y978	MARDPQRYLVIQGDE
S991	DERMHLPSPTDSNFY
T993	RMHLPSPTDSNFYRA
S995	HLPSPTDSNFYRALM
Y998	SPTDSNFYRALMDEE
Y1016	DVVDADEYLVPQQGF
H1025	VPQQGFFHSPATSRT
S1026	PQQGFFHSPATSRTP
S1030	FFHSPATSRTPLLSS
S1037	SRTPLLSSLSATSST
S1039	TPLLSSLSATSSTPA
T1041	LLSSLSATSSTPAVA
S1042	LSSLSATSSTPAVAC
P1045	LSATSSTPAVACVDR
A1046	SATSSTPAVACVDRN
S1056	CVDRNGQSYPLKEDS
K1060	NGQSYPLKEDSFLQR
S1063	SYPLKEDSFLQRYsS
Y1068	EDSFLQRYsSDPTGA
S1069-p	DSFLQRYsSDPTGAL
S1070	SFLQRYsSDPTGALT
T1073	QRYsSDPTGALTEDS
S1080	TGALTEDSLDDTFLP
T1084	TEDSLDDTFLPAPEY
Y1091	TFLPAPEYVNQSVPK
S1095	APEYVNQSVPKRPAG
S1103	VPKRPAGSVQNPVYH
Y1109	GSVQNPVYHNQPLSA
G1119	QPLSAAPGRDPHYQN
Y1124	APGRDPHYQNSHSNA
S1129	PHYQNSHSNAVGNPE
N1130	HYQNSHSNAVGNPEY
Y1137	NAVGNPEYLNTPRPA
T1140	GNPEYLNTPRPACIN
A1144	YLNTPRPACINGGLD
G1149	RPACINGGLDGPAFW
G1152	CINGGLDGPAFWAQT
S1161-p	AFWAQTGsHQINLDN
N1165	QTGsHQINLDNPDYQ
Y1171	INLDNPDYQQAFFPK
K1178	YQQAFFPKEAKSNGI
K1178	YQQAFFPKEAKSNGI
K1181	AFFPKEAKSNGICKG
K1181	AFFPKEAKSNGICKG
K1187	AKSNGICKGPAAENA
K1187	AKSNGICKGPAAENA
P1189	SNGICKGPAAENAEY
A1190	NGICKGPAAENAEYL
Y1196	PAAENAEYLRAAPAS

Home  |  Curator Login With enhanced literature mining using Linguamatics I2E Produced by 3rd Millennium  |  Design by Digizyme ©2003-2013 Cell Signaling Technology, Inc.