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Protein Page:
EGFR (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
EGFR a receptor tyrosine kinase. This is a receptor for epidermal growth factor (EGF) and related growth factors including TGF-alpha, amphiregulin, betacellulin, heparin-binding EGF-like growth factor, GP30, and vaccinia virus growth factor. EGFR is involved in the control of cell growth and differentiation. It is a single-pass transmembrane tyrosine kinase. Ligand binding to this receptor results in receptor dimerization, autophosphorylation (in trans), activation of various downstream signaling molecules and lysosomal degradation. It can be phosphorylated and activated by Src. Activated EGFR binds the SH2 domain of phospholipase C-gamma (PLC-gamma), activating PLC-gamma-mediated downstream signaling. Phosphorylated EGFR binds Cbl, leading to its ubiquitination and degradation. Grb2 and SHC bind to phospho-EGFR and are involved in the activation of MAP kinase signaling pathways. Phosphorylation on Ser and Thr residues is thought to represent a mechanism for attenuation of EGFR kinase activity. EGFR is overexpressed in breast, head and neck cancers, correlating with poor survival. Activating somatic mutations are seen in lung cancer, corresponding to the minority of patients with strong responses to the EGFR inhibitor Iressa (gefitinib). Mutations and amplifications are also seen in glioblastoma, and upregulation is seen in colon cancer and neoplasms. In xenografts, inhibitors synergize with cytotoxic drugs in the inhibition of many tumor types. Inhibitors include: Iressa/ZD1839, Erbitux, Tarceva, and lapatinib. Four alternatively spliced isoforms have been described. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral; Protein kinase, tyrosine (receptor); Protein kinase, TK; Kinase, protein; EC 2.7.10.1; TK group; EGFR family
Cellular Component: extracellular space; endoplasmic reticulum membrane; nuclear membrane; cell surface; basolateral plasma membrane; integral to membrane; lipid raft; Golgi membrane; membrane; perinuclear region of cytoplasm; cytoplasm; apical plasma membrane; plasma membrane; AP-2 adaptor complex; endosome membrane; nucleus; receptor complex; endosome
Molecular Function: identical protein binding; epidermal growth factor receptor activity; epidermal growth factor binding; nitric-oxide synthase regulator activity; transmembrane receptor protein tyrosine kinase activity; receptor signaling protein tyrosine kinase activity; protein kinase binding; protein phosphatase binding; integrin binding; actin filament binding; protein binding; transmembrane receptor activity; enzyme binding; MAP kinase kinase kinase activity; protein heterodimerization activity; protein-tyrosine kinase activity; double-stranded DNA binding; chromatin binding; glycoprotein binding; ATP binding
Biological Process: circadian rhythm; diterpenoid metabolic process; positive regulation of nitric oxide biosynthetic process; activation of MAPKK activity; nerve growth factor receptor signaling pathway; alkanesulfonate metabolic process; positive regulation of vasodilation; protein insertion into membrane; G1/S-specific positive regulation of cyclin-dependent protein kinase activity; positive regulation of MAP kinase activity; cell-cell adhesion; positive regulation of fibroblast proliferation; ovulation cycle; cell surface receptor linked signal transduction; hair follicle development; positive regulation of superoxide release; negative regulation of mitotic cell cycle; polysaccharide metabolic process; fibroblast growth factor receptor signaling pathway; positive regulation of DNA repair; digestive tract morphogenesis; response to osmotic stress; phospholipase C activation; response to hydroxyisoflavone; hydrogen peroxide metabolic process; positive regulation of transcription from RNA polymerase II promoter; response to oxidative stress; regulation of nitric-oxide synthase activity; negative regulation of protein catabolic process; response to calcium ion; positive regulation of epithelial cell proliferation; negative regulation of apoptosis; negative regulation of epidermal growth factor receptor signaling pathway; tongue development; axon guidance; embryonic placenta development; peptidyl-tyrosine phosphorylation; translation; positive regulation of smooth muscle cell proliferation; protein amino acid autophosphorylation; signal transduction; positive regulation of synaptic transmission, glutamatergic; learning and/or memory; salivary gland morphogenesis; positive regulation of cell proliferation; response to stress; regulation of peptidyl-tyrosine phosphorylation; epidermal growth factor receptor signaling pathway; ossification; phosphoinositide-mediated signaling; MAPKKK cascade; liver development; cell proliferation; positive regulation of protein kinase B signaling cascade; cerebral cortex cell migration; positive regulation of vasoconstriction; calcium-dependent phospholipase A2 activation; innate immune response; positive regulation of protein amino acid phosphorylation; astrocyte activation; positive regulation of phosphorylation; positive regulation of DNA replication; response to cobalamin; positive regulation of cell migration; positive regulation of inflammatory response; lung development
Reference #:  P00533 (UniProtKB)
Alt. Names/Synonyms: avian erythroblastic leukemia viral (v-erb-b) oncogene homolog; cell growth inhibiting protein 40; cell proliferation-inducing protein 61; EGFR; Epidermal growth factor receptor; epidermal growth factor receptor (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian); ERBB; ERBB1; HER1; mENA; PIG61; Proto-oncogene c-ErbB-1; Receptor tyrosine-protein kinase erbB-1
Gene Symbols: EGFR
Molecular weight: 134,277 Da
Basal Isoelectric point: 6.26  Predict pI for various phosphorylation states
CST Pathways:  Angiogenesis  |  ErbB/HER Signaling  |  IL6 Signaling  |  Phospholipase Signaling  |  Tyrosine Kinases & Substrates
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

EGFR

Protein Structure Not Found.

Substrate Sequence Logo
Sequence Logo

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Sites Implicated In
apoptosis, inhibited: Y869‑p, Y1092‑p
cell adhesion, altered: Y869‑p, Y1016‑p, Y1092‑p
cell cycle regulation: Y869‑p
cell growth, altered: Y869‑p, Y1092‑p, Y1172‑p, Y1197‑p
cell motility, altered: Y869‑p, Y1016‑p
cell motility, induced: Y1110‑p
cytoskeletal reorganization: T678‑p
endocytosis, altered: Y1016‑p
transcription, altered: Y1092‑p, Y1110‑p
activity, induced: Y869‑p, Y1016‑p, Y1092‑p, Y1197‑p
activity, inhibited: S1026‑p
enzymatic activity, induced: Y869‑p, Y1016‑p, Y1092‑p, Y1110‑p, Y1172‑p, Y1197‑p
enzymatic activity, inhibited: T678‑p
intracellular localization: T678‑p, Y1016‑p, Y1092‑p, Y1110‑p, Y1197‑p
molecular association, regulation: T678‑p, T693‑p, Y869‑p, S991‑p, Y998‑p, Y1016‑p, Y1069‑p, Y1092‑p, Y1110‑p, Y1172‑p, Y1197‑p
phosphorylation: S991‑p, Y998‑p, Y1016‑p, Y1092‑p, Y1172‑p, Y1197‑p
protein conformation: Y1016‑p, Y1092‑p, Y1110‑p
protein degradation: T678‑p, Y1069‑p, Y1092‑p, Y1172‑p, Y1197‑p
receptor desensitization, altered: T678‑p, S1070‑p, S1071‑p
receptor internalization, altered: T678‑p, T693‑p, S695‑p, S991‑p, Y998‑p, Y1016‑p, S1070‑p, S1071‑p, Y1092‑p, Y1110‑p, Y1172‑p, S1190‑p, Y1197‑p
receptor recycling, altered: T678‑p
ubiquitination: Y1069‑p, Y1092‑p, Y1110‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

► Hide Isoforms
 
0 1 S77-p VQRNYDLsFLKTIQE
0 1 Y112-p QIIRGNMyyENSyAL
0 1 Y113-p IIRGNMyyENSyALA
0 1 Y117-p NMyyENSyALAVLSN
0 1 K133-ac DANKTGLkELPMRNL
0 1 S151-p LHGAVRFsNNPALCN
1 0 S229-p RCRGKSPsDCCHNQC
1 0 Y270 TCPPLMLYNPTTYQM
0 1 K284-ac MDVNPEGkYSFGATC
0 1 Y316 RACGADSYEMEEDGV
0 1 K346-ac GIGIGEFkDSLSINA
0 1 K454 SLGLRSLKEISDGDV
0 1 K487 LFGTSGQKTKIISNR
0 1 S511-p QVCHALCsPEGCWGP
0 1 Y585-p NCIQCAHyIDGPHCV
0 2 S645-p TNGPKIPsIAtGMVG
0 2 T648-p PKIPsIAtGMVGALL
19 0 T678-p RHIVRKRtLRRLLQE
13 56 T693-p RELVEPLtPsGEAPN
5 7 S695-p LVEPLtPsGEAPNQA
1 1 K708-ub QALLRILkETEFkkI
2 0 K713-ub ILkETEFkkIkVLGS
2 0 K714-ub LkETEFkkIkVLGSG
3 0 K716-ub ETEFkkIkVLGSGAF
1 4 T725-p LGSGAFGtVykGLWI
2 140 Y727-p SGAFGtVykGLWIPE
1 1 K728-ub GAFGtVykGLWIPEG
3 2 K737-ub LWIPEGEkVkIPVAI
1 1 K739-ub IPEGEkVkIPVAIKE
0 1 K745 VkIPVAIKELREATs
0 1 S752-p KELREATsPkANkEI
2 0 K754-ub LREATsPkANkEILD
3 1 K757-ub ATsPkANkEILDEAy
2 6 Y764-p kEILDEAyVMAsVDN
3 0 S768-p DEAyVMAsVDNPHVC
0 1 Y801-p PFGCLLDyVREHKDN
1 0 K823-ub NWCVQIAkGMNyLED
0 1 Y827-p QIAkGMNyLEDRRLV
1 1 K846-ub AARNVLVkTPQHVKI
0 1 K852 VkTPQHVKITDFGLA
1 4 K860-ub ITDFGLAkLLGAEEk
3 1 K867-ub kLLGAEEkEyHAEGG
65 157 Y869-p LGAEEkEyHAEGGkV
1 1 K875-ub EyHAEGGkVPIKWMA
1 0 K913-ub ELMTFGSkPYDGIPA
2 1 K929-ub EISSILEkGERLPQP
0 1 Y944-p PICTIDVyMIMVKCW
1 0 K960-ub IDADSRPkFRELIIE
3 1 K970-ub ELIIEFSkMARDPQR
0 5 Y978-p MARDPQRyLVIQGDE
3 23 S991-p DERMHLPsPtDsNFy
0 7 T993-p RMHLPsPtDsNFyRA
1 11 S995-p HLPsPtDsNFyRALM
4 139 Y998-p sPtDsNFyRALMDEE
41 7 Y1016-p DVVDADEyLIPQQGF
1 2 S1025-p IPQQGFFssPSTsRt
2 5 S1026-p PQQGFFssPSTsRtP
0 1 S1030-p FFssPSTsRtPLLSs
0 3 T1032-p ssPSTsRtPLLSsLs
2 4 S1037-p sRtPLLSsLsAtsNN
2 5 S1039-p tPLLSsLsAtsNNst
2 3 T1041-p LLSsLsAtsNNstVA
2 7 S1042-p LSsLsAtsNNstVAC
2 3 S1045-p LsAtsNNstVACIDR
0 2 T1046-p sAtsNNstVACIDRN
1 2 S1057-p IDRNGLQsCPIkEDs
1 1 K1061-ub GLQsCPIkEDsFLQR
1 8 S1064-p sCPIkEDsFLQRyss
32 128 Y1069-p EDsFLQRyssDPtGA
11 9 S1070-p DsFLQRyssDPtGAL
10 8 S1071-p sFLQRyssDPtGALt
0 3 T1074-p QRyssDPtGALtEDs
0 1 T1078-p sDPtGALtEDsIDDt
4 6 S1081-p tGALtEDsIDDtFLP
0 3 T1085-p tEDsIDDtFLPVPEy
93 351 Y1092-p tFLPVPEyINQsVPK
1 4 S1096-p VPEyINQsVPKRPAG
1 10 S1104-p VPKRPAGsVQNPVyH
41 447 Y1110-p GsVQNPVyHNQPLNP
0 9 S1120-p QPLNPAPsRDPHyQD
3 38 Y1125-p APsRDPHyQDPHstA
0 6 S1130-p PHyQDPHstAVGNPE
0 4 T1131-p HyQDPHstAVGNPEy
2 64 Y1138-p tAVGNPEyLNtVQPt
0 2 T1141-p GNPEyLNtVQPtCVN
0 3 T1145-p yLNtVQPtCVNStFD
0 1 T1150-p QPtCVNStFDsPAHW
0 4 S1153-p CVNStFDsPAHWAQK
1 8 S1162-p AHWAQKGsHQIsLDN
4 85 S1166-p QKGsHQIsLDNPDyQ
37 971 Y1172-p IsLDNPDyQQDFFPk
1 0 K1179-ac yQQDFFPkEAkPNGI
0 1 K1179 yQQDFFPKEAkPNGI
1 0 K1182-ac DFFPkEAkPNGIFkG
0 1 K1182 DFFPkEAKPNGIFkG
1 0 K1188-ac AkPNGIFkGstAENA
0 1 K1188 AkPNGIFKGstAENA
2 3 S1190-p PNGIFkGstAENAEy
1 3 T1191-p NGIFkGstAENAEyL
75 1018 Y1197-p stAENAEyLRVAPQS
3056 : Phospho-EGF Receptor (Thr669) Antibody
8808 : Phospho-EGF Receptor (Thr669) (D2F1) Rabbit mAb
2231 : Phospho-EGF Receptor (Tyr845) Antibody
6963 : Phospho-EGF Receptor (Tyr845) (D63B4) Rabbit mAb
2641 : Phospho-EGF Receptor (Tyr998) (C24A5) Rabbit mAb
2235 : Phospho-EGF Receptor (Tyr992) Antibody
2237 : Phospho-EGF Receptor (Tyr1045) Antibody
2238 : Phospho-EGF Receptor (Ser1046/1047) Antibody
2238 : Phospho-EGF Receptor (Ser1046/1047) Antibody
2234 : Phospho-EGF Receptor (Tyr1068) Antibody
2236 : Phospho-EGF Receptor (Tyr1068) (1H12) Mouse mAb
3777 : Phospho-EGF Receptor (Tyr1068) (D7A5) XP(R) Rabbit mAb
4031 : Phospho-EGF Receptor (Tyr1068) (1H12) Mouse mAb (Biotinylated)
6625 : Phospho-EGF Receptor (Tyr1068) (1H12) Mouse mAb (Sepharose Bead Conjugate)
8543 : Phospho-EGF Receptor (Tyr1068) (D7A5) XP(R) Rabbit mAb (Biotinylated)
2220 : Phospho-EGF Receptor (Tyr1086) Antibody
4404 : Phospho-EGF Receptor (Tyr1148) Antibody
2244 : Phospho-HER2/ErbB2 (Tyr1248)/EGFR (Tyr1173) Antibody
4407 : Phospho-EGF Receptor (Tyr1173) (53A5) Rabbit mAb
  EGFR iso5  
S77 VQRNYDLSFLKTIQE
Y112 QIIRGNMYYENSYAL
Y113 IIRGNMYYENSYALA
Y117 NMYYENSYALAVLSN
K133 DANKTGLKELPMRNL
S151 LHGAVRFSNNPALCN
S229 RCRGKSPSDCCHNQC
Y270 TCPPLMLYNPTTYQM
K284 MDVNPEGKYSFGATC
Y316 RACGADSYEMEEDGV
K346 GIGIGEFKDSLSINA
K454 SLGLRSLKEISDGDV
K487 LFGTSGQKTKIISNR
S511 QVCHALCSPEGCWGP
Y585 NCIQCAHYIDGPHCV
S645 TNGPKIPSIATGMVG
T648 PKIPSIATGMVGALL
T678 RHIVRKRTLRRLLQE
T693 RELVEPLTPSGEAPN
S695 LVEPLTPSGEAPNQA
K708 QALLRILKETEFKKI
K713 ILKETEFKKIKVLGS
K714 LKETEFKKIKVLGSG
K716 ETEFKKIKVLGSGAF
T725 LGSGAFGTVYKGLWI
Y727 SGAFGTVYKGLWIPE
K728 GAFGTVYKGLWIPEG
K737 LWIPEGEKVKIPVAI
K739 IPEGEKVKIPVAIKE
K745 VKIPVAIKELREATS
S752 KELREATSPKANKEI
K754 LREATSPKANKEILD
K757 ATSPKANKEILDEAY
Y764 KEILDEAYVMASVDN
S768 DEAYVMASVDNPHVC
Y801 PFGCLLDYVREHKDN
K823 NWCVQIAKGMNYLED
Y827 QIAKGMNYLEDRRLV
K846 AARNVLVKTPQHVKI
K852 VKTPQHVKITDFGLA
K860 ITDFGLAKLLGAEEK
K867 KLLGAEEKEYHAEGG
Y869 LGAEEKEYHAEGGKV
K875 EYHAEGGKVPIKWMA
K913 ELMTFGSKPYDGIPA
K929 EISSILEKGERLPQP
Y944 PICTIDVYMIMVKCW
K960 IDADSRPKFRELIIE
K970 ELIIEFSKMARDPQR
Y978 MARDPQRYLVIQGDE
S991 DERMHLPSPTDSNFY
T993 RMHLPSPTDSNFYRA
S995 HLPSPTDSNFYRALM
Y998 SPTDSNFYRALMDEE
Y1016 DVVDADEYLIPQQGF
S1025 IPQQGFFSSPSTSRT
S1026 PQQGFFSSPSTSRTP
S1030 FFSSPSTSRTPLLSS
T1032 SSPSTSRTPLLSSLS
S1037 SRTPLLSSLSATSNN
S1039 TPLLSSLSATSNNST
T1041 LLSSLSATSNNSTVA
S1042 LSSLSATSNNSTVAC
S1045 LSATSNNSTVACIDR
T1046 SATSNNSTVACIDRN
S1057 IDRNGLQSCPIKEDS
K1061 GLQSCPIKEDSFLQR
S1064 SCPIKEDSFLQRYSS
Y1069 EDSFLQRYSSDPTGA
S1070 DSFLQRYSSDPTGAL
S1071 SFLQRYSSDPTGALT
T1074 QRYSSDPTGALTEDS
T1078 SDPTGALTEDSIDDT
S1081 TGALTEDSIDDTFLP
T1085 TEDSIDDTFLPVPGE
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  mouse

 
S77 VQRNYDLSFLKTIQE
L112 QIIRGNALYENTYAL
Y113 IIRGNALYENTYALA
Y117 NALYENTYALAILSN
R133 GTNRTGLRELPMRNL
S151 LIGAVRFSNNPILCN
S229 RCRGRSPSDCCHNQC
Y270-p TCPPLMLyNPTTYQM
K284 MDVNPEGKYSFGATC
Y316-p RACGPDYyEVEEDGI
K346 GIGIGEFKDTLSINA
K454-ub SLGLRSLkEISDGDV
K487-ub LFGTPNQkTKIMNNR
S511 HVCNPLCSSEGCWGP
Y585 NCIQCAHYIDGPHCV
S647 PSGPKIPSIATGIVG
T650 PKIPSIATGIVGGLL
T680 RHIVRKRTLRRLLQE
T695-p RELVEPLtPSGEAPN
S697 LVEPLtPSGEAPNQA
K710-ub QAHLRILkETEFKKI
K715 ILkETEFKKIKVLGS
K716 LkETEFKKIKVLGSG
K718 ETEFKKIKVLGSGAF
T727 LGSGAFGTVykGLWI
Y729-p SGAFGTVykGLWIPE
K730-ub GAFGTVykGLWIPEG
K739-ub LWIPEGEkVkIPVAI
K741-ub IPEGEkVkIPVAIkE
K747-ub VkIPVAIkELREATS
S754 kELREATSPKANkEI
K756 LREATSPKANkEILD
K759-ub ATSPKANkEILDEAY
Y766 kEILDEAYVMASVDN
S770 DEAYVMASVDNPHVC
Y803 PYGCLLDYVREHKDN
K825 NWCVQIAKGMNYLED
Y829 QIAKGMNYLEDRRLV
K848-ub AARNVLVkTPQHVkI
K854-ub VkTPQHVkITDFGLA
K862-ub ITDFGLAkLLGAEEk
K869-ub kLLGAEEkEyHAEGG
Y871-p LGAEEkEyHAEGGkV
K877-ub EyHAEGGkVPIKWMA
K915 ELMTFGSKPYDGIPA
K931-ub DISSILEkGERLPQP
Y946 PICTIDVYMIMVKCW
K962 IDADSRPKFRELILE
K972-ub ELILEFSkMARDPQR
Y980 MARDPQRYLVIQGDE
S993-p DERMHLPsPtDsNFy
T995-p RMHLPsPtDsNFyRA
S997-p HLPsPtDsNFyRALM
Y1000-p sPtDsNFyRALMDEE
Y1018-p DVVDADEyLIPQQGF
N1027 IPQQGFFNSPSTSRt
S1028 PQQGFFNSPSTSRtP
S1032 FFNSPSTSRtPLLSS
T1034-p NSPSTSRtPLLSSLs
S1039 SRtPLLSSLsAtsNN
S1041-p tPLLSSLsAtsNNST
T1043-p LLSSLsAtsNNSTVA
S1044-p LSSLsAtsNNSTVAC
S1047 LsAtsNNSTVACINR
T1048 sAtsNNSTVACINRN
S1057-p ACINRNGsCRVkEDA
K1061-ub RNGsCRVkEDAFLQR
A1064 sCRVkEDAFLQRyss
Y1069-p EDAFLQRyssDPtGA
S1070-p DAFLQRyssDPtGAV
S1071-p AFLQRyssDPtGAVT
T1074-p QRyssDPtGAVTEDN
T1078 sDPtGAVTEDNIDDA
N1081 tGAVTEDNIDDAFLP
A1085 TEDNIDDAFLPVPEy
Y1092-p AFLPVPEyVNQSVPK
S1096 VPEyVNQSVPKRPAG
S1104-p VPKRPAGsVQNPVyH
Y1110-p GsVQNPVyHNQPLHP
G1120 QPLHPAPGRDLHYQN
Y1125 APGRDLHYQNPHSNA
S1130 LHYQNPHSNAVGNPE
N1131 HYQNPHSNAVGNPEy
Y1138-p NAVGNPEyLNTAQPT
T1141 GNPEyLNTAQPTCLS
T1145 yLNTAQPTCLSSGFN
G1150 QPTCLSSGFNSPALW
S1153 CLSSGFNSPALWIQK
S1162-p ALWIQKGsHQMsLDN
S1166-p QKGsHQMsLDNPDyQ
Y1172-p MsLDNPDyQQDFFPk
K1179 yQQDFFPKETkPNGI
K1179-ub yQQDFFPkETkPNGI
K1182 DFFPkETKPNGIFkG
K1182-ub DFFPkETkPNGIFkG
K1188 TkPNGIFKGPTAENA
K1188-ub TkPNGIFkGPTAENA
P1190 PNGIFkGPTAENAEy
T1191 NGIFkGPTAENAEyL
Y1197-p PTAENAEyLRVAPPS
3056 : Phospho-EGF Receptor (Thr669) Antibody
8808 : Phospho-EGF Receptor (Thr669) (D2F1) Rabbit mAb
2231 : Phospho-EGF Receptor (Tyr845) Antibody
6963 : Phospho-EGF Receptor (Tyr845) (D63B4) Rabbit mAb
2641 : Phospho-EGF Receptor (Tyr998) (C24A5) Rabbit mAb
2235 : Phospho-EGF Receptor (Tyr992) Antibody
2234 : Phospho-EGF Receptor (Tyr1068) Antibody
2236 : Phospho-EGF Receptor (Tyr1068) (1H12) Mouse mAb
3777 : Phospho-EGF Receptor (Tyr1068) (D7A5) XP(R) Rabbit mAb
4031 : Phospho-EGF Receptor (Tyr1068) (1H12) Mouse mAb (Biotinylated)
8543 : Phospho-EGF Receptor (Tyr1068) (D7A5) XP(R) Rabbit mAb (Biotinylated)
2220 : Phospho-EGF Receptor (Tyr1086) Antibody
4407 : Phospho-EGF Receptor (Tyr1173) (53A5) Rabbit mAb
  rat

 
S77 VQRNYDLSFLKTIQE
L112 QIIRGNALYENTYAL
Y113 IIRGNALYENTYALA
Y117 NALYENTYALAVLSN
R133 GTNKTGLRELPMRNL
S151 LIGAVRFSNNPILCN
S229 RCRGRSPSDCCHNQC
Y270 TCPPLMLYNPTTYQM
K284 MDVNPEGKYSFGATC
Y316 RACGPDYYEVEEDGV
K346 GIGIGEFKDTLSINA
K454 SLGLRSLKEISDGDV
K487 LFGTPNQKTKIMNNR
S511 HVCNPLCSSEGCWGP
Y585 NCIKCAHYVDGPHCV
S646 PEGPKIPSIATGIVG
T649 PKIPSIATGIVGGLL
T679-p RQLVRKRtLRRLLQE
T694 RELVEPLTPSGEAPN
S696 LVEPLTPSGEAPNQA
K709 QAHLRILKETEFKKI
K714 ILKETEFKKIKVLGS
K715 LKETEFKKIKVLGSG
K717 ETEFKKIKVLGSGAF
T726 LGSGAFGTVYKGLWI
Y728 SGAFGTVYKGLWIPE
K729 GAFGTVYKGLWIPEG
K738 LWIPEGEKVKIPVAI
K740 IPEGEKVKIPVAIKE
K746 VKIPVAIKELREATS
S753 KELREATSPKANKEI
K755 LREATSPKANKEILD
K758 ATSPKANKEILDEAY
Y765 KEILDEAYVMASVDN
S769 DEAYVMASVDNPHVC
Y802 PYGCLLDYVREHKDN
K824 NWCVQIAKGMNYLED
Y828 QIAKGMNYLEDRRLV
K847 AARNVLVKTPQHVKI
K853 VKTPQHVKITDFGLA
K861 ITDFGLAKLLGAEEK
K868 KLLGAEEKEyHAEGG
Y870-p LGAEEKEyHAEGGKV
K876 EyHAEGGKVPIKWMA
K914 ELMTFGSKPYDGIPA
K930 EISSILEKGERLPQP
Y945 PICTIDVYMIMVKCW
K961 IDADSRPKFRELILE
K971 ELILEFSKMARDPQR
Y979 MARDPQRYLVIQGDE
S992 DERMHLPSPTDSNFY
T994 RMHLPSPTDSNFYRA
S996 HLPSPTDSNFYRALM
Y999 SPTDSNFYRALMEEE
Y1017-p DVVDADEyLIPQQGF
N1026 IPQQGFFNSPSTSRT
S1027 PQQGFFNSPSTSRTP
S1031 FFNSPSTSRTPLLSS
T1033 NSPSTSRTPLLSSLS
S1038 SRTPLLSSLSANSNS
S1040 TPLLSSLSANSNSST
N1042 LLSSLSANSNSSTVA
S1043 LSSLSANSNSSTVAC
S1046 LSANSNSSTVACINR
T1047 SANSNSSTVACINRN
S1056 ACINRNGSCRVKEDA
K1060 RNGSCRVKEDAFLQR
A1063 SCRVKEDAFLQRySS
Y1068-p EDAFLQRySSDPTSV
S1069 DAFLQRySSDPTSVL
S1070 AFLQRySSDPTSVLT
T1073 QRySSDPTSVLTEDN
T1077 SDPTSVLTEDNIDDT
N1080 TSVLTEDNIDDTFLP
T1084 TEDNIDDTFLPVPEy
Y1091-p TFLPVPEyINQSVPK
S1095 VPEyINQSVPKRPAG
S1103-p VPKRPAGsVQNPVyH
Y1109-p GsVQNPVyHNQPLHP
G1119 QPLHPAPGRDLHyQN
Y1124-p APGRDLHyQNPHSNA
S1129 LHyQNPHSNAVSNPE
N1130 HyQNPHSNAVSNPEy
Y1137-p NAVSNPEyLNTAQPT
T1140 SNPEyLNTAQPTCLS
T1144 yLNTAQPTCLSSGFD
G1149 QPTCLSSGFDSSALW
S1152 CLSSGFDSSALWIQK
S1161 ALWIQKGSHQMSLDN
S1165 QKGSHQMSLDNPDyQ
Y1171-p MSLDNPDyQQDFFPK
K1178 yQQDFFPKEAKPNGI
K1178 yQQDFFPKEAKPNGI
K1181 DFFPKEAKPNGIFKG
K1181 DFFPKEAKPNGIFKG
K1187 AKPNGIFKGPTAENA
K1187 AKPNGIFKGPTAENA
P1189 PNGIFKGPTAENAEy
T1190 NGIFKGPTAENAEyL
Y1196-p PTAENAEyLRVAPPS
3056 : Phospho-EGF Receptor (Thr669) Antibody
8808 : Phospho-EGF Receptor (Thr669) (D2F1) Rabbit mAb
2231 : Phospho-EGF Receptor (Tyr845) Antibody
6963 : Phospho-EGF Receptor (Tyr845) (D63B4) Rabbit mAb
2641 : Phospho-EGF Receptor (Tyr998) (C24A5) Rabbit mAb
2235 : Phospho-EGF Receptor (Tyr992) Antibody
2237 : Phospho-EGF Receptor (Tyr1045) Antibody
2234 : Phospho-EGF Receptor (Tyr1068) Antibody
2236 : Phospho-EGF Receptor (Tyr1068) (1H12) Mouse mAb
3777 : Phospho-EGF Receptor (Tyr1068) (D7A5) XP(R) Rabbit mAb
4031 : Phospho-EGF Receptor (Tyr1068) (1H12) Mouse mAb (Biotinylated)
6625 : Phospho-EGF Receptor (Tyr1068) (1H12) Mouse mAb (Sepharose Bead Conjugate)
8543 : Phospho-EGF Receptor (Tyr1068) (D7A5) XP(R) Rabbit mAb (Biotinylated)
2220 : Phospho-EGF Receptor (Tyr1086) Antibody
4407 : Phospho-EGF Receptor (Tyr1173) (53A5) Rabbit mAb
  pig

 
S77 MQNSYNLSFLKTIQE
L112 QIIRGNVLYENTHAL
Y113 IIRGNVLYENTHALA
H117 NVLYENTHALAVLSN
R133 GANKTGLRELPMRNL
S151 LQGAVRFSNNPALCH
S229 RCRGRSPSDCCHNQC
Y270 TCPPLMLYNPTTYQM
K284 MDVNPLGKYSFGATC
Y316 RACSSDSYEVEEDGV
K346 GIGIGEFKDTLSINA
K454 SLGLRSLKEISDGDV
K487 LFGTASQKTKIINNR
S511 HICNPLCSSEGCWGP
Y585 SCVRCAHYIDGPHCV
S645 VDRPKIPSIATGIVG
T648 PKIPSIATGIVGGLL
T678 RHIVRKRTLRRLLQE
T693 RELVEPLTPSGEAPN
S695 LVEPLTPSGEAPNQA
K708 QALLRILKETEFKKV
K713 ILKETEFKKVKVLGS
K714 LKETEFKKVKVLGSG
K716 ETEFKKVKVLGSGAF
T725 LGSGAFGTVYKGLWI
Y727 SGAFGTVYKGLWIPE
K728 GAFGTVYKGLWIPEG
K737 LWIPEGEKVKIPVAI
K739 IPEGEKVKIPVAIKE
K745 VKIPVAIKELREATS
S752 KELREATSPKANKEI
K754 LREATSPKANKEILD
K757 ATSPKANKEILDEAY
Y764 KEILDEAYVMASVDN
S768 DEAYVMASVDNPHVC
Y801 PFGCLLDYVREHKDN
K823 NWCVQIAKGMNYLED
Y827 QIAKGMNYLEDRRLV
K846 AARNVLVKTPQHVKI
K852 VKTPQHVKITDFGLA
K860 ITDFGLAKLLGAEEK
K867 KLLGAEEKEYHAEGG
Y869 LGAEEKEYHAEGGKV
K875 EYHAEGGKVPIKWLA
K913 ELMTFGSKPYDGIPA
K929 EISTVLEKGERLPQP
Y944 PICTIDVYMIMVKCW
K960 IDADSRPKFRELIIE
K970 ELIIEFSKMARDPQR
Y978 MARDPQRYLVIQGDE
S991 DERMHLPSPTDSNFY
T993 RMHLPSPTDSNFYRA
S995 HLPSPTDSNFYRALM
Y998 SPTDSNFYRALMDEE
Y1016 DVVDADEYLVPQQGF
H1025 VPQQGFFHSPATSRT
S1026 PQQGFFHSPATSRTP
S1030 FFHSPATSRTPLLSS
T1032 HSPATSRTPLLSSLS
S1037 SRTPLLSSLSATSST
S1039 TPLLSSLSATSSTPA
T1041 LLSSLSATSSTPAVA
S1042 LSSLSATSSTPAVAC
P1045 LSATSSTPAVACVDR
A1046 SATSSTPAVACVDRN
S1056 CVDRNGQSYPLKEDS
K1060 NGQSYPLKEDSFLQR
S1063 SYPLKEDSFLQRYsS
Y1068 EDSFLQRYsSDPTGA
S1069-p DSFLQRYsSDPTGAL
S1070 SFLQRYsSDPTGALT
T1073 QRYsSDPTGALTEDS
T1077 SDPTGALTEDSLDDT
S1080 TGALTEDSLDDTFLP
T1084 TEDSLDDTFLPAPEY
Y1091 TFLPAPEYVNQSVPK
S1095 APEYVNQSVPKRPAG
S1103 VPKRPAGSVQNPVYH
Y1109 GSVQNPVYHNQPLSA
G1119 QPLSAAPGRDPHYQN
Y1124 APGRDPHYQNSHSNA
S1129 PHYQNSHSNAVGNPE
N1130 HYQNSHSNAVGNPEY
Y1137 NAVGNPEYLNTPRPA
T1140 GNPEYLNTPRPACIN
A1144 YLNTPRPACINGGLD
G1149 RPACINGGLDGPAFW
G1152 CINGGLDGPAFWAQT
S1161-p AFWAQTGsHQINLDN
N1165 QTGsHQINLDNPDYQ
Y1171 INLDNPDYQQAFFPK
K1178 YQQAFFPKEAKSNGI
K1178 YQQAFFPKEAKSNGI
K1181 AFFPKEAKSNGICKG
K1181 AFFPKEAKSNGICKG
K1187 AKSNGICKGPAAENA
K1187 AKSNGICKGPAAENA
P1189 SNGICKGPAAENAEY
A1190 NGICKGPAAENAEYL
Y1196 PAAENAEYLRAAPAS
3056 : Phospho-EGF Receptor (Thr669) Antibody
8808 : Phospho-EGF Receptor (Thr669) (D2F1) Rabbit mAb
2641 : Phospho-EGF Receptor (Tyr998) (C24A5) Rabbit mAb
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