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zyxin (human)

Overview zyxin Adhesion plaque protein. Binds alpha-actinin and the CRP protein. Important for targeting TES and ENA/VASP family members to focal adhesions and for the formation of actin-rich structures. May be a component of a signal transduction pathway that mediates adhesion-stimulated changes in gene expression. Interacts with HPV type 6 protein E6. Does not interact significantly with E6 proteins from HPV types 11, 16, or 18. Interacts, via the Pro-rich regions, with the EVH1 domains of ENAH, EVL and VASP. Interacts with the first LIM domain of TES. Interacts with NEBL (isoform 2). Belongs to the zyxin/ajuba family. Note: This description may include information from UniProtKB. Protein type: Cell adhesion; Motility/polarity/chemotaxis Cellular Component: focal adhesion; cell-cell adherens junction; integral to plasma membrane; cytoplasm; plasma membrane; stress fiber; nucleus Molecular Function: protein binding; zinc ion binding Biological Process: cell-cell signaling; virus-host interaction; signal transduction; cell adhesion Reference #:  Q15942 (UniProtKB) Alt. Names/Synonyms: ESP-2; HED-2; ZYX; Zyxin; Zyxin-2 Gene Symbols: ZYX Molecular weight: 61,277 Da Basal Isoelectric point: 6.22  Predict pI for various phosphorylation states Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below zyxin

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	Sites Implicated In
intracellular localization: S142‑p molecular association, regulation: S142‑p

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	4		S15-p	PAISVSVsAPAFyAP
0	17		Y20-p	SVsAPAFyAPQkkFG
0	30		K24-a	PAFyAPQkkFGPVVA
0	5		K25-a	AFyAPQkkFGPVVAP
0	1		K25-m2	AFyAPQkkFGPVVAP
2	6		S142-p	PQPREKVssIDLEId
1	18		S143-p	QPREKVssIDLEIds
0	1		D149-ca	ssIDLEIdsLSSLLD
0	1		S150-p	sIDLEIdsLSSLLDD
0	1		T159	SSLLDDMTKNDPFkA
0	1		K165-a	MTKNDPFkARVssGy
0	5		S169-p	DPFkARVssGyVPPP
0	2		S170-p	PFkARVssGyVPPPV
0	50		Y172-p	kARVssGyVPPPVAt
0	8		T179-p	yVPPPVAtPFSSKSS
0	7		R253	SLANTQPRGPPAssP
0	4		S258-p	QPRGPPAssPAPAPk
0	22		S259-p	PRGPPAssPAPAPkF
0	1		K265-a	ssPAPAPkFsPVtPk
0	1		K265-u	ssPAPAPkFsPVtPk
0	29		S267-p	PAPAPkFsPVtPkFt
0	27		T270-p	APkFsPVtPkFtPVA
0	1		K272-a	kFsPVtPkFtPVAsk
0	12		T274-p	sPVtPkFtPVAskFs
0	1		S278-p	PkFtPVAskFsPGAP
0	14		K279-a	kFtPVAskFsPGAPG
0	3		K279-u	kFtPVAskFsPGAPG
0	21		S281-p	tPVAskFsPGAPGGs
0	1		G286	kFsPGAPGGsGsQPN
0	3		S288-p	sPGAPGGsGsQPNQK
0	3		S290-p	GAPGGsGsQPNQKLG
1	1		S303-p	LGHPEALsAGtGsPQ
1	2		T306-p	PEALsAGtGsPQPPs
1	11		S308-p	ALsAGtGsPQPPsFt
0	2		S313-p	tGsPQPPsFtyAQQR
0	8		T315-p	sPQPPsFtyAQQREK
0	219		Y316-p	PQPPsFtyAQQREKP
0	2		K328-u	EKPRVQEkQHPVPPP
0	34		S344-p	QNQNQVRsPGAPGPL
0	2		K528-a	VRVVALDkNFHMKCY

	mouse
S15	PAISVSVSAPAFYAP
Y20	SVSAPAFYAPQKKFA
K24	PAFYAPQKKFAPVVA
K25	AFYAPQKKFAPVVAP
K25	AFYAPQKKFAPVVAP
C143	PQPREKVCsIDLEID
S144-p	QPREKVCsIDLEIDS
D150	CsIDLEIDSLSSLLD
S151	sIDLEIDSLSSLLDD
T160-p	SSLLDDMtKNDPFKA
K166	MtKNDPFKARVSSGY
S170	DPFKARVSSGYVPPP
S171	PFKARVSSGYVPPPV
Y173	KARVSSGYVPPPVAT
T180	YVPPPVATPFVPKPS
R244-m1	SSANTQPrGPLSQAP
Q249	QPrGPLSQAPTPAPK
A250	PrGPLSQAPTPAPKF
K256	QAPTPAPKFAPVAPK
K256	QAPTPAPKFAPVAPK
A258	PTPAPKFAPVAPKFT
A261	APKFAPVAPKFTPVV
K263	KFAPVAPKFTPVVSK
T265	APVAPKFTPVVSKFs
S269	PKFTPVVSKFsPGAP
K270	KFTPVVSKFsPGAPs
K270	KFTPVVSKFsPGAPs
S272-p	TPVVSKFsPGAPsGP
S277-p	KFsPGAPsGPGPQPN
P279	sPGAPsGPGPQPNQK
P281	GAPsGPGPQPNQKMV
S294	MVPPDAPSSVSTGsP
T298	DAPSSVSTGsPQPPS
S300-p	PSSVSTGsPQPPSFT
S305	TGsPQPPSFTYAQQK
T307	sPQPPSFTYAQQKEK
Y308	PQPPSFTYAQQKEKP
K320	EKPLVQEKQHPQPPP
S336-p	QNQNQVRsPGGPGPL
K520	VRVVALDKNFHMKCY

	rat
S15	PAISVSVSAPAFYAP
Y20	SVSAPAFYAPQKKFA
K24	PAFYAPQKKFAPVVA
K25	AFYAPQKKFAPVVAP
K25	AFYAPQKKFAPVVAP
S143-p	PQPREKVssIDLEID
S144-p	QPREKVssIDLEIDS
D150	ssIDLEIDSLSSLLD
S151	sIDLEIDSLSSLLDD
T160	SSLLDDMTKNDPFKA
K166	MTKNDPFKARVSSGY
S170	DPFKARVSSGYVPPP
S171	PFKARVSSGYVPPPV
Y173	KARVSSGYVPPPVAT
T180	YVPPPVATPFVPKPS
R244-m1	SSANTQPrGPLSQAP
Q249	QPrGPLSQAPTPAPK
A250	PrGPLSQAPTPAPKF
K256	QAPTPAPKFAPVAPK
K256	QAPTPAPKFAPVAPK
A258	PTPAPKFAPVAPKFT
A261	APKFAPVAPKFTPVA
K263	KFAPVAPKFTPVASK
T265	APVAPKFTPVASKFS
S269	PKFTPVASKFSPGAP
K270	KFTPVASKFSPGAPS
K270	KFTPVASKFSPGAPS
S272	TPVASKFSPGAPSGP
S277	KFSPGAPSGPGPQPS
P279	SPGAPSGPGPQPSQK
P281	GAPSGPGPQPSQKSV
S294	SVPLEAPSSVGTGSP
T298	EAPSSVGTGSPQPPS
S300	PSSVGTGSPQPPSFT
S305	TGSPQPPSFTYAQQK
T307	SPQPPSFTYAQQKEK
Y308	PQPPSFTYAQQKEKP
K320	EKPLVQEKQHPLPPP
S336-p	QNQNQVRsPGGPGPL
K520	VRVVALDKNFHMKCY

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