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Protein Page:
Zyxin (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
Zyxin Adhesion plaque protein. Binds alpha-actinin and the CRP protein. Important for targeting TES and ENA/VASP family members to focal adhesions and for the formation of actin-rich structures. May be a component of a signal transduction pathway that mediates adhesion-stimulated changes in gene expression. Interacts with HPV type 6 protein E6. Does not interact significantly with E6 proteins from HPV types 11, 16, or 18. Interacts, via the Pro-rich regions, with the EVH1 domains of ENAH, EVL and VASP. Interacts with the first LIM domain of TES. Interacts with NEBL (isoform 2). Belongs to the zyxin/ajuba family. Note: This description may include information from UniProtKB.
Protein type: Cell adhesion; Motility/polarity/chemotaxis
Cellular Component: cell-cell adherens junction; focal adhesion; integral to plasma membrane; cytoplasm; stress fiber; plasma membrane; nucleus
Molecular Function: protein binding; zinc ion binding
Biological Process: cell-cell signaling; viral reproduction; regulation of inflammatory response; cell adhesion; signal transduction
Reference #:  Q15942 (UniProtKB)
Alt. Names/Synonyms: ESP-2; HED-2; ZYX; Zyxin; Zyxin-2
Gene Symbols: ZYX
Molecular weight: 61,277 Da
Basal Isoelectric point: 6.22  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

Zyxin

Protein Structure Not Found.


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Sites Implicated In
intracellular localization: S142‑p
molecular association, regulation: S142‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 S7-p _MAAPRPsPAISVSV
0 5 S15-p PAISVSVsAPAFyAP
0 19 Y20-p SVsAPAFyAPQkkFG
0 31 K24-ac PAFyAPQkkFGPVVA
0 5 K25-ac AFyAPQkkFGPVVAP
0 1 K25-m2 AFyAPQkkFGPVVAP
0 1 S116-p LEEEIFPsPPPPPEE
2 8 S142-p PQPREKVssIDLEId
1 22 S143-p QPREKVssIDLEIds
0 1 D149-ca ssIDLEIdsLSSLLD
0 2 S150-p sIDLEIdsLSSLLDD
0 1 T159 SSLLDDMTKNDPFkA
0 1 K165-ac MTKNDPFkARVssGy
0 10 S169-p DPFkARVssGyVPPP
0 3 S170-p PFkARVssGyVPPPV
0 52 Y172-p kARVssGyVPPPVAt
0 10 T179-p yVPPPVAtPFSSKSS
0 1 S202-p APLPPWKsPSSsQPL
0 1 S206-p PWKsPSSsQPLPQVP
0 1 T250-p QPVSLANtQPRGPPA
0 7 R253 SLANtQPRGPPAssP
0 1 R253 SLANtQPRGPPAssP
0 6 S258-p QPRGPPAssPAPAPk
0 29 S259-p PRGPPAssPAPAPkF
0 1 A261 GPPAssPAPAPkFsP
0 1 K265-ac ssPAPAPkFsPVtPk
0 1 K265-ub ssPAPAPkFsPVtPk
0 38 S267-p PAPAPkFsPVtPkFt
0 32 T270-p APkFsPVtPkFtPVA
0 1 K272-ac kFsPVtPkFtPVAsk
0 14 T274-p sPVtPkFtPVAskFs
0 4 S278-p PkFtPVAskFsPGAP
0 15 K279-ac kFtPVAskFsPGAPG
0 3 K279-ub kFtPVAskFsPGAPG
0 31 S281-p tPVAskFsPGAPGGs
0 1 G286 kFsPGAPGGsGsQPN
0 6 S288-p sPGAPGGsGsQPNQK
0 5 S290-p GAPGGsGsQPNQKLG
1 3 S303-p LGHPEALsAGtGsPQ
0 1 G305 HPEALsAGtGsPQPP
1 5 T306-p PEALsAGtGsPQPPs
1 18 S308-p ALsAGtGsPQPPsFt
0 2 S313-p tGsPQPPsFtyAQQR
0 8 T315-p sPQPPsFtyAQQREK
0 203 Y316-p PQPPsFtyAQQREKP
0 2 K328-ub EKPRVQEkQHPVPPP
0 51 S344-p QNQNQVRsPGAPGPL
0 1 T352 PGAPGPLTLKEVEEL
0 1 S505-p KQYAPRCsVCSEPIM
0 2 K528-ac VRVVALDkNFHMKCY
4863 : Phospho-Zyxin (Ser142/143) Antibody
8467 : Phospho-Zyxin (Ser142/143) (D1E8) Rabbit mAb
4863 : Phospho-Zyxin (Ser142/143) Antibody
8467 : Phospho-Zyxin (Ser142/143) (D1E8) Rabbit mAb
  mouse

 
P7 _MAAPRPPPAISVSV
S15 PAISVSVSAPAFYAP
Y20 SVSAPAFYAPQKKFA
K24 PAFYAPQKKFAPVVA
K25 AFYAPQKKFAPVVAP
K25 AFYAPQKKFAPVVAP
S117 LEEDIFPSPPPPLEE
C143 PQPREKVCsIDLEID
S144-p QPREKVCsIDLEIDS
D150 CsIDLEIDSLSSLLD
S151 sIDLEIDSLSSLLDD
T160-p SSLLDDMtKNDPFKA
K166 MtKNDPFKARVSSGY
S170 DPFKARVSSGYVPPP
S171 PFKARVSSGYVPPPV
Y173 KARVSSGYVPPPVAT
T180 YVPPPVATPFVPKPS
T203 APLPPWKTPSSSQPP
S207 PWKTPSSSQPPPQPQ
T241 QPVSSANTQPrGPLS
R244-m1 SSANTQPrGPLSQAP
R244-m2 SSANTQPrGPLSQAP
Q249 QPrGPLSQAPtPAPK
A250 PrGPLSQAPtPAPKF
T252-p GPLSQAPtPAPKFAP
K256 QAPtPAPKFAPVAPK
K256 QAPtPAPKFAPVAPK
A258 PtPAPKFAPVAPKFT
A261 APKFAPVAPKFTPVV
K263 KFAPVAPKFTPVVsK
T265 APVAPKFTPVVsKFs
S269-p PKFTPVVsKFsPGAP
K270 KFTPVVsKFsPGAPs
K270 KFTPVVsKFsPGAPs
S272-p TPVVsKFsPGAPsGP
S277-p KFsPGAPsGPGPQPN
P279 sPGAPsGPGPQPNQK
P281 GAPsGPGPQPNQKMV
S294 MVPPDAPSSVsTGsP
S297-p PDAPSSVsTGsPQPP
T298 DAPSSVsTGsPQPPS
S300-p PSSVsTGsPQPPSFT
S305 TGsPQPPSFTYAQQK
T307 sPQPPSFTYAQQKEK
Y308 PQPPSFTYAQQKEKP
K320 EKPLVQEKQHPQPPP
S336-p QNQNQVRsPGGPGPL
T344-p PGGPGPLtLKEVEEL
S497 KQYAPRCSVCSEPIM
K520 VRVVALDKNFHMKCY
  rat

 
P7 _MAAPRPPPAISVSV
S15 PAISVSVSAPAFYAP
Y20 SVSAPAFYAPQKkFA
K24 PAFYAPQKkFAPVVA
K25-ac AFYAPQKkFAPVVAP
K25 AFYAPQKKFAPVVAP
S117 LEEDIFPSPPPPLEE
S143-p PQPREKVssIDLEID
S144-p QPREKVssIDLEIDS
D150 ssIDLEIDSLSSLLD
S151 sIDLEIDSLSSLLDD
T160 SSLLDDMTKNDPFKA
K166 MTKNDPFKARVSSGY
S170 DPFKARVSSGYVPPP
S171 PFKARVSSGYVPPPV
Y173 KARVSSGYVPPPVAT
T180 YVPPPVATPFVPKPS
A203 APLPPWKAPSSSQPP
S207 PWKAPSSSQPPPQPQ
T241 QSVSSANTQPrGPLS
R244-m1 SSANTQPrGPLSQAP
R244 SSANTQPRGPLSQAP
Q249 QPrGPLSQAPTPAPK
A250 PrGPLSQAPTPAPKF
T252 GPLSQAPTPAPKFAP
K256 QAPTPAPKFAPVAPK
K256 QAPTPAPKFAPVAPK
A258 PTPAPKFAPVAPKFT
A261 APKFAPVAPKFTPVA
K263 KFAPVAPKFTPVASk
T265 APVAPKFTPVASkFs
S269 PKFTPVASkFsPGAP
K270-ac KFTPVASkFsPGAPS
K270 KFTPVASKFsPGAPS
S272-p TPVASkFsPGAPSGP
S277 kFsPGAPSGPGPQPS
P279 sPGAPSGPGPQPSQK
P281 GAPSGPGPQPSQKSV
S294 SVPLEAPSSVGTGSP
G297 LEAPSSVGTGSPQPP
T298 EAPSSVGTGSPQPPS
S300 PSSVGTGSPQPPSFT
S305 TGSPQPPSFTYAQQK
T307 SPQPPSFTYAQQKEK
Y308 PQPPSFTYAQQKEKP
K320 EKPLVQEKQHPLPPP
S336-p QNQNQVRsPGGPGPL
T344 PGGPGPLTLKEVEEL
S497 KQYAPRCSVCSEPIM
K520 VRVVALDKNFHMKCY
4863 : Phospho-Zyxin (Ser142/143) Antibody
8467 : Phospho-Zyxin (Ser142/143) (D1E8) Rabbit mAb
4863 : Phospho-Zyxin (Ser142/143) Antibody
8467 : Phospho-Zyxin (Ser142/143) (D1E8) Rabbit mAb
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