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Protein Page:
hnRNP E1 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
hnRNP E1 Single-stranded nucleic acid binding protein that binds preferentially to oligo dC. Abundantly expressed in skeletal muscle, thymus and peripheral blood leukocytes while a lower expression is observed in prostate, spleen, testis, ovary, small intestine, heart, liver, adrenal and thyroid glands. Note: This description may include information from UniProtKB.
Protein type: RNA binding protein; Translation; RNA splicing
Cellular Component: nucleoplasm; cytoplasm; ribonucleoprotein complex
Molecular Function: protein binding; RNA binding; single-stranded DNA binding
Biological Process: nuclear mRNA splicing, via spliceosome; RNA splicing; gene expression
Reference #:  Q15365 (UniProtKB)
Alt. Names/Synonyms: Alpha-CP1; Heterogeneous nuclear ribonucleoprotein E1; heterogenous nuclear ribonucleoprotein E1; heterogenous nuclear ribonucleoprotein X; hnRNP E1; hnRNP-E1; hnRNP-X; HNRPE1; HNRPX; nucleic acid binding protein sub 2.3; Nucleic acid-binding protein SUB2.3; PCBP1; poly(rC) binding protein 1; Poly(rC)-binding protein 1
Gene Symbols: PCBP1
Molecular weight: 37,498 Da
Basal Isoelectric point: 6.66  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

hnRNP E1

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 8 K23-ac IRLLMHGkEVGSIIG
0 51 K23-ub IRLLMHGkEVGSIIG
0 9 K31-ub EVGSIIGkkGEsVkR
0 2 K32-ub VGSIIGkkGEsVkRI
0 1 S35-p IIGkkGEsVkRIREE
0 1 K37-ac GkkGEsVkRIREEsG
3 0 S43-p VkRIREEsGARINIS
1 0 T60-p NCPERIItLTGPTNA
0 1 T107-p LRLVVPAtQCGsLIG
0 1 S111-p VPAtQCGsLIGkGGC
0 5 K115-ub QCGsLIGkGGCkIKE
0 3 K119-ub LIGkGGCkIKEIRES
1 0 T127-p IKEIREStGAQVQVA
0 1 S154-p TIAGVPQsVTECVKQ
0 1 T169-p ICLVMLEtLsQsPQG
0 1 S171-p LVMLEtLsQsPQGRV
0 42 S173-p MLEtLsQsPQGRVMt
0 4 T180-p sPQGRVMtIPyQPMP
0 53 Y183-p GRVMtIPyQPMPAss
0 8 S189-p PyQPMPAssPVICAG
0 36 S190-p yQPMPAssPVICAGG
0 7 Y207-p RCSDAAGyPHAtHDL
0 1 T211-p AAGyPHAtHDLEGPP
0 34 Y222-p EGPPLDAysIQGQHt
0 12 S223-p GPPLDAysIQGQHtI
0 5 T229-p ysIQGQHtIsPLDLA
0 12 S231-p IQGQHtIsPLDLAKL
0 1 K237 IsPLDLAKLNQVARQ
0 26 S246-p NQVARQQsHFAMMHG
0 4 T255-p FAMMHGGtGFAGIds
0 1 D261-ca GtGFAGIdsssPEVK
0 1 S262-p tGFAGIdsssPEVKG
0 1 S263-p GFAGIdsssPEVKGy
0 11 S264-p FAGIdsssPEVKGyW
0 40 Y270-p ssPEVKGyWAsLDAS
0 3 S273-p EVKGyWAsLDASTQt
0 1 T280-p sLDASTQtTHELTIP
0 78 K314-ub QMSGAQIkIANPVEG
0 1 S323-p ANPVEGSsGRQVTIT
0 1 S337-p TGSAASIsLAQyLIN
0 5 Y341-p ASIsLAQyLINARLS
0 91 K351-ub NARLSSEkGMGCS__
  mouse

 
K23-ac IRLLMHGkEVGSIIG
K23-ub IRLLMHGkEVGSIIG
K31 EVGSIIGKKGESVKR
K32 VGSIIGKKGESVKRI
S35 IIGKKGESVKRIREE
K37 GKKGESVKRIREEsG
S43-p VKRIREEsGARINIS
T60 NCPERIITLTGPTNA
T107 LRLVVPATQCGSLIG
S111 VPATQCGSLIGkGGC
K115-ub QCGSLIGkGGCKIKE
K119 LIGkGGCKIKEIRES
T127 IKEIRESTGAQVQVA
S154 TIAGVPQSVTECVKQ
T169-p ICLVMLEtLsQsPQG
S171-p LVMLEtLsQsPQGRV
S173-p MLEtLsQsPQGRVMt
T180-p sPQGRVMtIPyQPMP
Y183-p GRVMtIPyQPMPAss
S189-p PyQPMPAssPVICAG
S190-p yQPMPAssPVICAGG
Y207 RCSDAAGYPHATHDL
T211 AAGYPHATHDLEGPP
Y222 EGPPLDAYSIQGQHt
S223 GPPLDAYSIQGQHtI
T229-p YSIQGQHtIsPLDLA
S231-p IQGQHtIsPLDLAkL
K237-ub IsPLDLAkLNQVARQ
S246-p NQVARQQsHFAMMHG
T255-p FAMMHGGtGFAGIDS
D261 GtGFAGIDSSsPEVK
S262 tGFAGIDSSsPEVKG
S263 GFAGIDSSsPEVKGY
S264-p FAGIDSSsPEVKGYW
Y270 SsPEVKGYWASLDAS
S273 EVKGYWASLDASTQT
T280 SLDASTQTTHELTIP
K314-ub QMSGAQIkIANPVEG
S323 ANPVEGSSGRQVTIT
S337 TGSAASISLAQYLIN
Y341 ASISLAQYLINARLS
K351-ub NARLSSEkGMGCS__
  rat

 
K180 IRLLMHGKEVGSIIG
K180 IRLLMHGKEVGSIIG
K188 EVGSIIGKKGESVKR
K189 VGSIIGKKGESVKRI
S192 IIGKKGESVKRIREE
K194 GKKGESVKRIREESG
S200 VKRIREESGARINIS
T217 NCPERIITLTGPTNA
T264 LRLVVPATQCGSLIG
S268 VPATQCGSLIGKGGC
K272 QCGSLIGKGGCKIKE
K276 LIGKGGCKIKEIRES
T284 IKEIRESTGAQVQVA
S311 TIAGVPQSVTECVKQ
T326 ICLVMLETLSQsPQG
S328 LVMLETLSQsPQGRV
S330-p MLETLSQsPQGRVMT
T337 sPQGRVMTIPYQPMP
Y340 GRVMTIPYQPMPAss
S346-p PYQPMPAssPVICAG
S347-p YQPMPAssPVICAGG
Y364 RCSDAAGYPHATHDL
T368 AAGYPHATHDLEGPP
Y379 EGPPLDAYSIQGQHT
S380 GPPLDAYSIQGQHTI
T386 YSIQGQHTISPLDLA
S388 IQGQHTISPLDLAKL
K394 ISPLDLAKLNQVARQ
S403 NQVARQQSHFAMMHG
T412 FAMMHGGTGFAGIDS
D418 GTGFAGIDSSsPEVK
S419 TGFAGIDSSsPEVKG
S420 GFAGIDSSsPEVKGY
S421-p FAGIDSSsPEVKGYW
Y427 SsPEVKGYWASLDAS
S430 EVKGYWASLDASTQT
T437 SLDASTQTTHELTIP
K471-ub QMSGAQIkIANPVEG
S480 ANPVEGSSGRQVTIT
S494 TGSAASISLAQYLIN
Y498 ASISLAQYLINARLS
K508-ub NARLSSEkGMGCS__
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