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Protein Page:
TCEB3 (human)
p Phosphorylation
a Acetylation
m Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
u Ubiquitination
s Sumoylation
n Neddylation
gl O-GlcNAc
ga O-GalNAc
h Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage

Overview
TCEB3 SIII, also known as elongin, is a general transcription elongation factor that increases the RNA polymerase II transcription elongation past template-encoded arresting sites. Subunit A is transcriptionally active and its transcription activity is strongly enhanced by binding to the dimeric complex of the SIII regulatory subunits B and C (elongin BC complex). Heterotrimer of an A (A1, A2 or A3), B and C subunit. The C subunit mediates the binding of the elongin BC complex to subunit A. Note: This description may include information from UniProtKB.
Protein type: Transcription factor; DNA binding protein
Cellular Component: nucleoplasm; extracellular space; integral to membrane
Molecular Function: DNA binding
Biological Process: transcription from RNA polymerase II promoter; regulation of transcription from RNA polymerase II promoter; viral reproduction; positive regulation of viral transcription; RNA elongation from RNA polymerase II promoter; gene expression
Reference #:  Q14241 (UniProtKB)
Alt. Names/Synonyms: EloA; ELOA1; Elongin 110 kDa subunit; elongin A; Elongin-A; FLJ38760; FLJ42849; RNA polymerase II transcription factor SIII subunit A1; SIII; SIII p110; TCEB3; TCEB3A; transcription elongation factor B (SIII), polypeptide 3 (110kDa, elongin A); transcription elongation factor B alpha subunit; Transcription elongation factor B polypeptide 3
Gene Symbols: TCEB3
Molecular weight: 89,909 Da
Basal Isoelectric point: 9.59  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

TCEB3

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 K38-m1 SALQVVEkLQARLAA
0 6 A108 LVPVERNAEPDEQDF
0 16 Y138-p EEEMEGDyQETWKAT
0 11 S151-p ATGSRSYsPDHRQKK
0 5 S163-p QKKHRKLsELERPHK
0 3 S188-p RKRCHRMsPTYSsDP
0 2 S193-p RMsPTYSsDPESSDY
0 11 S222-p MYVDHYRsLEEDQEP
0 2 S251-p FQDRLGAsQERHLGE
0 1 S311-p EENRRPPsGDNAREK
0 7 L340 SSLKKKCLPPsEAAs
0 1 S343-p KKKCLPPsEAAsDNH
0 1 S347-p LPPsEAAsDNHLKKP
0 1 T397-p KGSNNLKtPEGKVKT
0 4 S410-p KTNLDRKsLGsLPKV
0 5 S413-p LDRKsLGsLPKVEEt
0 25 T420-p sLPKVEEtDMEDEFE
0 1 S541-p QPKRKAFssPQEEEE
0 6 S542-p PKRKAFssPQEEEEA
0 6 Y563-p MNSKMQVySGSKCAY
  mouse

 
K12 SALQVVEKLQARLAA
S82-p LVPVERNsEAEDQDF
Y112 EEELEGNYQESWKPS
S125-p PSGSRSYsPEHRQKK
S137 QKKHKKLSEPERPHK
S162 RKRCHKVSPPYSSDP
S167 KVSPPYSSDPESSDY
S195-p MYTDLSRsPEEDQEP
S224 FQDRLGVSHLGEQGK
S280-p EESRRLLsGDSAKEK
S309-p SSLKKKFsPALDVAS
L312 KKKFsPALDVASDNH
S316 sPALDVASDNHFKKP
A366 KVPNHLKAQEGKVRT
S379 RTNADGKSAGPLHPK
P382 ADGKSAGPLHPKAEE
T390-p LHPKAEEtDVDDEFE
S514 QPKRKAFSsPQEEEE
S515-p PKRKAFSsPQEEEEA
Y536 MNSKMQVYSGSKCAY
  rat

 
K12 SALQVVEKLQARLAA
N82 LVPVERNNEAEDQDF
Y112 EEEAEGNYQESWQAS
S125 ASGSQPYSPEHRQKK
P137 QKKHRKLPELERPHK
S162 RKRCHKVSPPYSSDP
S167 KVSPPYSSDPESSDY
S195-p MYTDLSRsPEMDQEP
S224 FQDRLGVSHLGEHQG
S281 EESRRLLSEDSAKEK
S310-p NSLKKKLsPALDVAS
L313 KKKLsPALDVASDNH
S317 sPALDVASDNHFKKP
A367 KVPNNLKAQEGKVRT
S380-p RTNSDRKsPGSLPKV
S383 SDRKsPGSLPKVEEM
M390 SLPKVEEMDMDDEFE
S514 QPKRKAFSSPQEEEE
S515 PKRKAFSSPQEEEEA
Y536 MNSKMQVYSGSKCAY
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