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TCEB3 (human)

Overview TCEB3 SIII, also known as elongin, is a general transcription elongation factor that increases the RNA polymerase II transcription elongation past template-encoded arresting sites. Subunit A is transcriptionally active and its transcription activity is strongly enhanced by binding to the dimeric complex of the SIII regulatory subunits B and C (elongin BC complex). Heterotrimer of an A (A1, A2 or A3), B and C subunit. The C subunit mediates the binding of the elongin BC complex to subunit A. Note: This description may include information from UniProtKB. Protein type: Transcription factor; DNA binding protein Cellular Component: nucleoplasm; transcription elongation factor complex; integral to membrane Molecular Function: DNA binding Biological Process: transcription from RNA polymerase II promoter; regulation of transcription from RNA polymerase II promoter; viral reproduction; positive regulation of viral transcription; RNA elongation from RNA polymerase II promoter; gene expression Reference #:  Q14241 (UniProtKB) Alt. Names/Synonyms: EloA; ELOA1; Elongin 110 kDa subunit; elongin A; Elongin-A; FLJ38760; FLJ42849; RNA polymerase II transcription factor SIII subunit A1; SIII; SIII p110; TCEB3; TCEB3A; transcription elongation factor B (SIII), polypeptide 3 (110kDa, elongin A); transcription elongation factor B alpha subunit; Transcription elongation factor B polypeptide 3 Gene Symbols: TCEB3 Molecular weight: 89,909 Da Basal Isoelectric point: 9.59  Predict pI for various phosphorylation states Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below TCEB3 4HFX - A/D/C/B=597-682 (human)

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	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	1		S60	LKYLKKLSTLPITVD
0	1		T72-p	TVDILAEtGVGKTVN
0	5		A108	LVPVERNAEPDEQDF
0	16		Y138-p	EEEMEGDyQEtWKAT
0	1		T141-p	MEGDyQEtWKATGsR
0	1		S147-p	EtWKATGsRSYsPDH
0	10		S151-p	ATGsRSYsPDHRQKK
0	4		S163-p	QKKHRKLsELERPHK
0	3		S188-p	RKRCHRMsPTYSsDP
0	2		S193-p	RMsPTYSsDPESSDY
0	1		S208-p	GHVQSPPsCTSPHQM
0	1		Y220-p	HQMYVDHyRsLEEDQ
0	9		S222-p	MYVDHyRsLEEDQEP
0	2		S251-p	FQDRLGAsQERHLGE
0	1		S297	SVVSREKSHKALSKE
0	1		S311-p	EENRRPPsGDNAREK
0	6		L340	SSLKKKCLPPsEAAs
0	1		S343-p	KKKCLPPsEAAsDNH
0	1		S347-p	LPPsEAAsDNHLKKP
0	1		K361	PKHRDPEKAKLDKSK
0	1		K363	HRDPEKAKLDKSKQG
0	1		K366	PEKAKLDKSKQGLDS
0	3		S410-p	KTNLDRKsLGsLPKV
0	5		S413-p	LDRKsLGsLPKVEEt
0	24		T420-p	sLPKVEEtDMEDEFE
0	1		S541-p	QPKRKAFssPQEEEE
0	5		S542-p	PKRKAFssPQEEEEA
0	6		Y563-p	MNSKMQVySGSKCAY

	mouse
S34-p	LKYLKKLsILPITVD
T46	TVDILVETGVGKTVN
S82-p	LVPVERNsEAEDQDF
Y112	EEELEGNYQESWKPS
S115	LEGNYQESWKPSGSR
S121	ESWKPSGSRSYsPEH
S125-p	PSGSRSYsPEHRQKK
S137	QKKHKKLSEPERPHK
S162	RKRCHKVSPPYSSDP
S167	KVSPPYSSDPESSDY
P182	GHVQSPPPSSPHQMY
S193	HQMYTDLSRsPEEDQ
S195-p	MYTDLSRsPEEDQEP
S224	FQDRLGVSHLGEQGK
S266-p	SAVSREKsHKASSKE
S280	EESRRLLSGDSAKEK
S309-p	SSLKKKFsPALDVAS
L312	KKKFsPALDVASDNH
S316	sPALDVASDNHFKKP
K330-a	PKHKDSEkAkSDkNK
K332-a	HKDSEkAkSDkNKQS
K335-a	SEkAkSDkNKQSVDG
S379	RTNADGKSAGPLHPK
P382	ADGKSAGPLHPKAEE
T390-p	LHPKAEEtDVDDEFE
S514	QPKRKAFSsPQEEEE
S515-p	PKRKAFSsPQEEEEA
Y536	MNSKMQVYSGSKCAY

	rat
S34	LKYLKKLSVLPITVD
T46	TVDILVETGVGKTVN
N82	LVPVERNNEAEDQDF
Y112	EEEAEGNYQESWQAS
S115	AEGNYQESWQASGSQ
S121	ESWQASGSQPYSPEH
S125	ASGSQPYSPEHRQKK
P137	QKKHRKLPELERPHK
S162	RKRCHKVSPPYSSDP
S167	KVSPPYSSDPESSDY
P182	GHVQSPPPSSPHQMY
S193	HQMYTDLSRSPEMDQ
S195	MYTDLSRSPEMDQEP
S224	FQDRLGVSHLGEHQG
S267	SVMGREKSHKASSKE
S281	EESRRLLSEDSAKEK
S310-p	NSLKKKLsPALDVAS
L313	KKKLsPALDVASDNH
S317	sPALDVASDNHFKKP
K331	PKHKDSEKIKSDKNK
K333	HKDSEKIKSDKNKQS
K336	SEKIKSDKNKQSVDS
S380-p	RTNSDRKsPGSLPKV
S383	SDRKsPGSLPKVEEM
M390	SLPKVEEMDMDDEFE
S514	QPKRKAFSSPQEEEE
S515	PKRKAFSSPQEEEEA
Y536	MNSKMQVYSGSKCAY

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