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Protein Page:
FKBP5 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
FKBP5 Interacts with functionally mature heterooligomeric progesterone receptor complexes along with HSP90 and TEBP. Part of a heteromultimeric cytoplasmic complex with HSP90, HSP70 and steroid receptors. Dissociates from the complex when NR3C1 binds glucocorticoid. By androgen. Widely expressed, enriched in testis compared to other tissues. Inhibited by FK506 but not cyclosporin. Note: This description may include information from UniProtKB.
Protein type: Isomerase; Chaperone; EC 5.2.1.8
Cellular Component: endoplasmic reticulum membrane; membrane; nucleolus; nucleus
Molecular Function: FK506 binding; peptidyl-prolyl cis-trans isomerase activity; heat shock protein binding
Biological Process: protein peptidyl-prolyl isomerization; protein folding
Reference #:  Q13451 (UniProtKB)
Alt. Names/Synonyms: 51 kDa FK506-binding protein; 51 kDa FK506-binding protein 5; 51 kDa FKBP; 54 kDa progesterone receptor-associated immunophilin; AIG6; Androgen-regulated protein 6; FF1 antigen; FK506 binding protein 5; FK506-binding protein 5; FKBP-5; FKBP-51; FKBP5; FKBP51; FKBP54; HSP90-binding immunophilin; MGC111006; p54; Peptidyl-prolyl cis-trans isomerase FKBP5; peptidylprolyl cis-trans isomerase; PPIase FKBP5; Ptg-10; T-cell FK506-binding protein
Gene Symbols: FKBP5
Molecular weight: 51,212 Da
Basal Isoelectric point: 5.71  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

FKBP5

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 6 S13-p GAKNNEEsPTATVAE
0 1 K28-ub QGEDITSkKDRGVLK
0 12 Y54-p PMIGDKVyVHYKGKL
0 1 E75 DSSHDRNEPFVFSLG
0 1 K155 IIRRTKRKGEGYSNP
0 1 K208-ub GIDKALEkMQREEQC
0 6 Y243-p EPNAELIyEVTLkSF
0 1 K248-ub LIyEVTLkSFEKAKE
0 1 Y327-p FLNLAMCyLKLREYT
0 2 K352-ub GLDSANEkGLYRRGE
0 1 K376-ub SAKGDFEkVLEVNPQ
0 1 K385-ub LEVNPQNkAARLQIS
0 17 Y409-p NERDRRIyANMFkkF
0 11 K414-ac RIyANMFkkFAEQDA
0 1 K415-ac IyANMFkkFAEQDAK
0 1 T433-p NKAMGKKtsEGVTNE
0 1 S434-p KAMGKKtsEGVTNEk
0 1 K441-ac sEGVTNEkGtDsQAM
0 1 K441-ub sEGVTNEkGtDsQAM
0 4 T443-p GVTNEkGtDsQAMEE
0 18 S445-p TNEkGtDsQAMEEEK
  mouse

 
N13 GTSNNGENPAATMTE
K28 QGEDITTKKDRGVLK
Y54-p PMFGDKVyVHYKGML
K75-ub DSSHDRKkPFAFSLG
K155-ub VIRRIKRkGEGYSNP
K208 GIDKALVKMQREEQC
Y243 DPNAELMYEVTLKSF
K248 LMYEVTLKSFEKAKE
Y327 FLNLAMCYLKLREYN
K352-ub GLDSANEkGLYRRGE
K376 SAKGDFEKVLAVNPQ
R385 LAVNPQNRAARLQIS
Y409 NERDRRVYANMFKKF
K414 RVYANMFKKFAERDA
K415 VYANMFKKFAERDAK
A433 SKAGSKKAVEGAAGK
V434 KAGSKKAVEGAAGKQ
K440 AVEGAAGKQHESQAM
K440 AVEGAAGKQHESQAM
H442 EGAAGKQHESQAMEE
S444 AAGKQHESQAMEEGK
  rat

 
N13 GTSNNEENPAATVVE
K28 QGEDITTKKDRGVLK
Y54 PMIGDKVYVHYKGKL
E75 DSSRDRNEPFVFSLG
K155 IIRRIKRKGEGYSNP
K208 GIDKALEKMQREEQC
Y243 EPNAELMYEVTLKSF
K248 LMYEVTLKSFEKAKE
Y327 FLNLAMCYLKLREYT
K352 GLDSANEKGLYRRGE
K376 SAKGDFEKVLEVNPQ
K385 LEVNPQNKAARLQIS
Y409 NERDRRVYANMFKKF
K414 RVYANMFKKFAEQDA
K415 VYANMFKKFAEQDAK
A433 SKALSKKAVEGAAGK
V434 KALSKKAVEGAAGKK
- under review  
K440 AVEGAAGKKHESQTM
H442 EGAAGKKHESQTMGE
S444 AAGKKHESQTMGEGK
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