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PPIG (human)

Overview PPIG an ubiquitous peptidyl-prolyl cis/trans isomerase. Distributed in nuclear speckles, which are rich in splicing factors. Colocalizes with the splicing factor SFRS2. A component of splicing factor complexes that bind the phosphorylated C-terminal domain (CTD) of RNA polymerase II. Interacts with CLK1 and PNN. Two splice variant isoforms of the human protein have been described. Note: This description may include information from UniProtKB. Protein type: Cyclophilin; Isomerase; EC 5.2.1.8 Cellular Component: nucleoplasm; nuclear matrix; cytoplasm; nucleolus; nuclear speck; nucleus Molecular Function: peptidyl-prolyl cis-trans isomerase activity; cyclosporin A binding Biological Process: protein folding; RNA splicing Reference #:  Q13427 (UniProtKB) Alt. Names/Synonyms: CARS-cyclophilin; CARS-Cyp; CASP10; Clk-associating RS-cyclophilin; Cyclophilin G; CYP; MGC133241; Peptidyl-prolyl cis-trans isomerase G; Peptidyl-prolyl isomerase G; peptidyl-prolyl isomerase G (cyclophilin G); peptidylprolyl isomerase G (cyclophilin G); PPIase G; PPIG; Rotamase G; SR-cyclophilin; SR-cyp; SRcyp Gene Symbols: PPIG Molecular weight: 88,617 Da Basal Isoelectric point: 10.29  Predict pI for various phosphorylation states Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below PPIG 2GW2 - A=1-179 (human) 2WFI - A=1-177 (human) 2WFJ - A=1-177 (human)

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	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	1		K180-a	SCGELIPkSkVkKEE
0	1		K182-a	GELIPkSkVkKEEKK
0	1		K182-u	GELIPkSkVkKEEKK
0	1		K184-a	LIPkSkVkKEEKKRH
0	1		S193	EEKKRHKSSSsSsSS
0	2		S196-p	KRHKSSSsSsSSSSD
0	3		S198-p	HKSSSsSsSSSSDSD
0	1		S200	SSSsSsSSSSDSDSs
0	1		S206	SSSSDSDSssDSQsS
0	1		S207-p	SSSDSDSssDSQsSs
0	2		S208-p	SSDSDSssDSQsSsD
0	1		S212-p	DSssDSQsSsDSSDS
0	1		S214-p	ssDSQsSsDSSDSES
0	1		S216	DSQsSsDSSDSESAt
0	1		T223-p	SSDSESAtEEKSKKR
0	10		S254-p	KRKKSKKsAssEsEA
0	9		S256-p	KKSKKsAssEsEAEN
0	8		S257-p	KSKKsAssEsEAENL
0	11		S259-p	KKsAssEsEAENLEA
0	14		S290-p	NRFLMRKsPPKADEK
0	1		S315-p	RECNPPNsQPASyQR
0	1		Y320-p	PNsQPASyQRRLLVT
0	1		S345	PRRYRTPSRsRSRDR
0	2		S347-p	RYRTPSRsRSRDRFR
0	112		S356-p	SRDRFRRsEtPPHWR
0	138		T358-p	DRFRRsEtPPHWRQE
0	254		S375-p	RAQRMRVssGERWIK
0	283		S376-p	AQRMRVssGERWIKG
0	12		S397-p	EIKENQRsPVRVKER
0	11		S413-p	ITDHRNVsEsPNRKN
0	16		S415-p	DHRNVsEsPNRKNEK
0	1		K447-a	RNSEKDDkYkNKVKK
0	1		K449-a	SEKDDkYkNKVKKRA
0	1		K459-u	VKKRAKSkSRSkSKE
0	1		K463-u	AKSkSRSkSKEKSKS
0	2		S487-p	NEEKRMRsRsKGRDH
0	5		S489-p	EKRMRsRsKGRDHEN
0	4		S514-p	KGKDQERsRsKEKSK
0	6		S516-p	KDQERsRsKEKSKQL
0	1		S527-p	SKQLESKsNEHDHSK
0	1		S544-p	EKDRRAQsRsRECDI
0	1		S546-p	DRRAQsRsRECDITK
0	1		Y558-p	ITKGKHSyNsRTRER
0	4		S560-p	KGKHSyNsRTRERSR
0	2		S568-p	RTRERSRsRDRsRRV
0	1		S572-p	RSRsRDRsRRVRSRT
0	5		T611-p	SRSRERRtPPGRSRS
0	2		S628-p	RRRRRRDsRssEREE
0	3		S630-p	RRRRDsRssEREESQ
0	2		S631-p	RRRDsRssEREESQs
0	1		S638-p	sEREESQsRNKDKYR
0	2		S666-p	ESEKRMYsKSRDHNS
0	38		S687-p	KKADRDQsPFsKIKQ
0	4		S690-p	DRDQsPFsKIKQSsQ
0	6		S696-p	FsKIKQSsQDNELKS
0	1		S717-p	EDEKIRSsVEkENQk
0	1		K720-a	KIRSsVEkENQkSKG
0	1		K724-a	sVEkENQkSKGQEND
0	34		S744-p	NKKFDHEssPGtDED
0	37		S745-p	KKFDHEssPGtDEDK
0	36		T748-p	DHEssPGtDEDKsG_
0	22		S753-p	PGtDEDKsG______

	mouse
K180-a	SCGELIPkSkVkKEE
K182-a	GELIPkSkVkKEEKK
K182	GELIPkSKVkKEEKK
K184-a	LIPkSkVkKEEKKRH
S193	EEKKRHKSSSSSSSS
S196	KRHKSSSSSSSSDSD
S198	HKSSSSSSSSDSDSS
S200	SSSSSSSSDSDSSSD
S204	SSSSDSDSSSDSQSS
S205	SSSDSDSSSDSQSSS
S206	SSDSDSSSDSQSSSE
S210	DSSSDSQSSSEsSDS
S212	SSDSQSSSEsSDSES
S214-p	DSQSSSEsSDSESAS
S221	sSDSESASEEKSRKR
S252-p	KRKKSKKsPssEsEA
S254-p	KKSKKsPssEsEAEN
S255-p	KSKKsPssEsEAENV
S257-p	KKsPssEsEAENVDA
S288-p	NRFLMRKsPPKADDK
S313	RECNPPNSQPASYQR
Y318	PNSQPASYQRRFLVT
S343-p	PRRYRTPsRsRSRDR
S345-p	RYRTPsRsRSRDRFR
S354-p	SRDRFRRsEtPPHWR
T356-p	DRFRRsEtPPHWRQE
S373-p	RAQRMRVssGERWIK
S374-p	AQRMRVssGERWIKG
S395-p	EIKENQRsPVRVKEK
S411-p	ITDHRHMsEsPNRKV
S413-p	DHRHMsEsPNRKVEK
K445	RNSEKDDKYNKNKVK
K448	EKDDKYNKNKVKKRG
K458	VKKRGKSKSRSKSKE
K462	GKSKSRSKSKERSKS
S486	HEDKRVRSRSKERDH
S488	DKRVRSRSKERDHET
S513-p	KGKDQERsRsKENSK
S515-p	KDQERsRsKENSKQV
S526	SKQVESKSNEHDHSK
S543	EKDRRAQSRSRERDL
S545	DRRAQSRSRERDLTK
Y557	LTKSKHSYNSRTRER
S559	KSKHSYNSRTRERSR
S567	RTRERSRSRDRSRRV
S571	RSRSRDRSRRVRSRS
T610	SRSRDRRTPGRSRSK
S626	RRRRRRDSRSSEREE
S628	RRRRDSRSSEREESQ
S629	RRRDSRSSEREESQS
S636	SEREESQSRNKDKYR
S664	EGEKRTYSKSRDHNS
S685-p	KKADREQsPVsKTKQ
S688-p	DREQsPVsKTKQSsQ
S694-p	VsKTKQSsQDNEVKS
P715	EDEKTRSPVEKENQK
K718	KTRSPVEKENQKSKG
K722	PVEKENQKSKGQEND
S742-p	NKKCDHEssPGtDED
S743-p	KKCDHEssPGtDEDK
T746-p	DHEssPGtDEDKsG_
S751-p	PGtDEDKsG______

	rat
K180	SCGELVPKSKVKKEE
K182	GELVPKSKVKKEEKK
K182	GELVPKSKVKKEEKK
K184	LVPKSKVKKEEKKRH
S193-p	EEKKRHKsSSSSsSs
S196	KRHKsSSSSsSsDSD
S198-p	HKsSSSSsSsDSDsS
S200-p	sSSSSsSsDSDsSsD
S204-p	SsSsDSDsSsDSQSS
S205	sSsDSDsSsDSQSSS
S206-p	SsDSDsSsDSQSSSD
S210	DsSsDSQSSSDSSDS
S212	SsDSQSSSDSSDSES
S214	DSQSSSDSSDSESAS
S221	SSDSESASEEKSRKR
S252	KRKKSKKSPSSESEA
S254	KKSKKSPSSESEADN
S255	KSKKSPSSESEADNV
S257	KKSPSSESEADNVDA
S288	NRFLMRKSPPKADDK
S313	RECNPPNSQPASYQR
Y318	PNSQPASYQRRFLVT
S343	PRRYRTPSRSRSRDR
S345	RYRTPSRSRSRDRFR
S354-p	SRDRFRRsEtPPHWR
T356-p	DRFRRsEtPPHWRQE
S373	RAQRMRVSSGERWIK
S374	AQRMRVSSGERWIKG
S395	EIKENQRSPVRVKEK
S411	ITDHRHMSESPNRKI
S413	DHRHMSESPNRKIEK
K445	RNSEKDDKYNKNKVK
K448	EKDDKYNKNKVKKRG
K458	VKKRGKSKSRSKSKE
K462	GKSKSRSKSKERSKS
S486	HEDKRVRSRSKERDH
S488	DKRVRSRSKERDHET
S513	KGKDQERSRSKENSK
S515	KDQERSRSKENSKQV
S526	SKQVESKSNEHDHSK
S543	EKDRRAQSRSRERDL
S545	DRRAQSRSRERDLTK
Y557	LTKSKHSYNSRTRER
S559	KSKHSYNSRTRERSR
S567	RTRERSRSRDRSRRV
S571	RSRSRDRSRRVRSRS
T610	SRSRDRRTPGRSRSK
S626	RRRRRRDSRSSEREE
S628	RRRRDSRSSEREESQ
S629	RRRDSRSSEREESQS
S636	SEREESQSRNKEKYR
S664	EGEKRMYSKSRDHSS
S685-p	KKADIDQsPVSKTKQ
S688	DIDQsPVSKTKQSSQ
S694	VSKTKQSSQDNEVKS
P715	EDEKTRSPVEKENQK
K718	KTRSPVEKENQKSKG
K722	PVEKENQKSKGQEND
S742	NKKCDHESSPGTDED
S743	KKCDHESSPGTDEDK
T746	DHESSPGTDEDKSG_
S751	PGTDEDKSG______

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