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Protein Page:
PPIG (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
PPIG an ubiquitous peptidyl-prolyl cis/trans isomerase. Distributed in nuclear speckles, which are rich in splicing factors. Colocalizes with the splicing factor SFRS2. A component of splicing factor complexes that bind the phosphorylated C-terminal domain (CTD) of RNA polymerase II. Interacts with CLK1 and PNN. Two splice variant isoforms of the human protein have been described. Note: This description may include information from UniProtKB.
Protein type: EC 5.2.1.8; Isomerase; Cyclophilin
Cellular Component: nucleoplasm; nuclear matrix; cytoplasm; nucleolus; nuclear speck; nucleus
Molecular Function: protein binding; peptidyl-prolyl cis-trans isomerase activity; cyclosporin A binding
Biological Process: protein peptidyl-prolyl isomerization; protein folding; RNA splicing
Reference #:  Q13427 (UniProtKB)
Alt. Names/Synonyms: CARS-cyclophilin; CARS-Cyp; CASP10; Clk-associating RS-cyclophilin; Cyclophilin G; CYP; MGC133241; Peptidyl-prolyl cis-trans isomerase G; Peptidyl-prolyl isomerase G; peptidyl-prolyl isomerase G (cyclophilin G); peptidylprolyl isomerase G (cyclophilin G); PPIase G; PPIG; Rotamase G; SR-cyclophilin; SR-cyp; SRcyp
Gene Symbols: PPIG
Molecular weight: 88,617 Da
Basal Isoelectric point: 10.29  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

PPIG

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 2 S173-p FAEVRILsCGELIPK
0 1 K180 sCGELIPKSkVKKEE
0 1 K182 GELIPKSKVKKEEKK
0 1 K182-ub GELIPKSkVKKEEKK
0 1 K184 LIPKSkVKKEEKKRH
0 2 S193-p EEKKRHKsSssSsss
0 2 S195-p KKRHKsSssSsssss
0 2 S196-p KRHKsSssSsssssD
0 4 S198-p HKsSssSsssssDsD
0 1 S199-p KsSssSsssssDsDs
0 2 S200-p sSssSsssssDsDss
0 1 S201-p SssSsssssDsDsss
0 1 S202-p ssSsssssDsDsssD
0 1 S204-p SsssssDsDsssDSQ
0 2 S206-p ssssDsDsssDSQsS
0 1 S207-p sssDsDsssDSQsSs
0 2 S208-p ssDsDsssDSQsSsD
0 3 S212-p DsssDSQsSsDSsDs
0 2 S214-p ssDSQsSsDSsDsES
0 1 S216 DSQsSsDSsDsESAt
0 1 S217-p SQsSsDSsDsESAtE
0 1 S219-p sSsDSsDsESAtEEK
0 2 T223-p SsDsESAtEEKSKKR
0 11 S254-p KRKKSKKsAssEsEA
0 13 S256-p KKSKKsAssEsEAEN
0 11 S257-p KSKKsAssEsEAENL
0 13 S259-p KKsAssEsEAENLEA
0 20 S290-p NRFLMRKsPPKADEK
0 3 S315-p RECNPPNsQPASyQR
0 1 Y320-p PNsQPASyQRRLLVT
0 1 T343-p RGPRRYRtPsRsRSR
0 2 S345-p PRRYRtPsRsRSRDR
0 3 S347-p RYRtPsRsRSRDRFR
0 128 S356-p SRDRFRRsEtPPHWR
0 167 T358-p DRFRRsEtPPHWRQE
0 254 S375-p RAQRMRVssGERWIK
0 283 S376-p AQRMRVssGERWIKG
0 2 S386-p RWIKGDKsELNEIKE
0 19 S397-p EIKENQRsPVRVKER
0 18 S413-p ITDHRNVsEsPNRKN
0 23 S415-p DHRNVsEsPNRKNEK
0 1 K447-ac RNSEKDDkYkNKVKK
0 1 K449-ac SEKDDkYkNKVKKRA
0 1 K459-ub VKKRAKSkSRSkSKE
0 1 K463-ub AKSkSRSkSKEKSKS
0 2 S487-p NEEKRMRsRsKGRDH
0 5 S489-p EKRMRsRsKGRDHEN
0 4 S514 KGKDQERSRSKEKSK
0 6 S516 KDQERSRSKEKSKQL
0 1 S527-p SKQLESKsNEHDHSK
0 3 S544-p EKDRRAQsRsRECDI
0 2 S546-p DRRAQsRsRECDITK
0 1 Y558-p ITKGKHSyNsRTRER
0 4 S560-p KGKHSyNsRTRERSR
0 2 S568-p RTRERSRsRDRsRRV
0 1 S572-p RSRsRDRsRRVRSRT
0 6 T611-p SRSRERRtPPGRSRS
0 3 S628-p RRRRRRDsRssEREE
0 4 S630-p RRRRDsRssEREESQ
0 3 S631-p RRRDsRssEREESQs
0 1 S638-p sEREESQsRNKDKYR
0 2 S666-p ESEKRMYsKSRDHNs
0 1 S673-p sKSRDHNssNNsREK
0 1 S674-p KSRDHNssNNsREKK
0 1 S677-p DHNssNNsREKKADR
0 45 S687-p KKADRDQsPFsKIKQ
0 5 S690-p DRDQsPFsKIKQSsQ
0 7 S696-p FsKIKQSsQDNELKS
0 2 S716-p KEDEKIRssVEkENQ
0 2 S717-p EDEKIRssVEkENQk
0 1 K720-ac KIRssVEkENQkSKG
0 1 K724-ac sVEkENQkSKGQEND
0 43 S744-p NKKFDHEssPGtDED
0 46 S745-p KKFDHEssPGtDEDK
0 44 T748-p DHEssPGtDEDKsG_
0 25 S753-p PGtDEDKsG______
3804 : Phospho-PPIG (Ser376) Antibody
  mouse

 
S173 FAEVRILSCGELIPk
K180-ac SCGELIPkSkVkKEE
K182-ac GELIPkSkVkKEEKK
K182 GELIPkSKVkKEEKK
K184-ac LIPkSkVkKEEKKRH
S193 EEKKRHKSSSSSSSS
S195 KKRHKSSSSSSSSDS
S196 KRHKSSSSSSSSDSD
S198 HKSSSSSSSSDSDSS
S199 KSSSSSSSSDSDSSS
S200 SSSSSSSSDSDSSSD
- gap
- gap
S202 SSSSSSDSDSSSDSQ
S204 SSSSDSDSSSDSQSS
S205 SSSDSDSSSDSQSSS
S206 SSDSDSSSDSQSSSE
S210 DSSSDSQSSSEsSDS
S212 SSDSQSSSEsSDSES
S214-p DSQSSSEsSDSESAS
S215 SQSSSEsSDSESASE
S217 SSSEsSDSESASEEK
S221 sSDSESASEEKSRKR
S252-p KRKKSKKsPssEsEA
S254-p KKSKKsPssEsEAEN
S255-p KSKKsPssEsEAENV
S257-p KKsPssEsEAENVDA
S288-p NRFLMRKsPPKADDK
S313 RECNPPNSQPASYQR
Y318 PNSQPASYQRRFLVT
T341 RGPRRYRTPsRsRSR
S343-p PRRYRTPsRsRSRDR
S345-p RYRTPsRsRSRDRFR
S354-p SRDRFRRsEtPPHWR
T356-p DRFRRsEtPPHWRQE
S373-p RAQRMRVssGERWIK
S374-p AQRMRVssGERWIKG
S384 RWIKGDKSELNEIKE
S395-p EIKENQRsPVRVKEK
S411-p ITDHRHMsEsPNRKV
S413-p DHRHMsEsPNRKVEK
K445 RNSEKDDKYNKNKVK
K448 EKDDKYNKNKVKKRG
K458 VKKRGKSKSRSKSKE
K462 GKSKSRSKSKERSKS
S486 HEDKRVRSRSKERDH
S488 DKRVRSRSKERDHET
S513-p KGKDQERsRsKENSK
S515-p KDQERsRsKENSKQV
S526 SKQVESKSNEHDHSK
S543-p EKDRRAQsRSRERDL
S545 DRRAQsRSRERDLTK
Y557 LTKSKHSYNSRTRER
S559 KSKHSYNSRTRERSR
S567 RTRERSRSRDRSRRV
S571 RSRSRDRSRRVRSRS
T610 SRSRDRRTPGRSRSK
S626 RRRRRRDSRSSEREE
S628 RRRRDSRSSEREESQ
S629 RRRDSRSSEREESQS
S636 SEREESQSRNKDKYR
S664 EGEKRTYSKSRDHNS
S671 SKSRDHNSSSNNREK
S672 KSRDHNSSSNNREKK
N675 DHNSSSNNREKKADR
S685-p KKADREQsPVsKTKQ
S688-p DREQsPVsKTKQSsQ
S694-p VsKTKQSsQDNEVKS
S714-p QEDEKTRsPVEKENQ
P715 EDEKTRsPVEKENQK
K718 KTRsPVEKENQKSKG
K722 PVEKENQKSKGQEND
S742-p NKKCDHEssPGtDED
S743-p KKCDHEssPGtDEDK
T746-p DHEssPGtDEDKsG_
S751-p PGtDEDKsG______
3804 : Phospho-PPIG (Ser376) Antibody
  rat

 
S173 FAEVRILSCGELVPK
K180 SCGELVPKSKVKKEE
K182 GELVPKSKVKKEEKK
K182 GELVPKSKVKKEEKK
K184 LVPKSKVKKEEKKRH
S193-p EEKKRHKsSSSSsSs
S195 KKRHKsSSSSsSsDS
S196 KRHKsSSSSsSsDSD
S198-p HKsSSSSsSsDSDsS
S199 KsSSSSsSsDSDsSs
S200-p sSSSSsSsDSDsSsD
- gap
- gap
S202 SSSsSsDSDsSsDSQ
S204-p SsSsDSDsSsDSQSS
S205 sSsDSDsSsDSQSSS
S206-p SsDSDsSsDSQSSSD
S210 DsSsDSQSSSDSSDS
S212 SsDSQSSSDSSDSES
S214 DSQSSSDSSDSESAS
S215 SQSSSDSSDSESASE
S217 SSSDSSDSESASEEK
S221 SSDSESASEEKSRKR
S252 KRKKSKKSPssEsEA
S254-p KKSKKSPssEsEADN
S255-p KSKKSPssEsEADNV
S257-p KKSPssEsEADNVDA
S288-p NRFLMRKsPPKADDK
S313 RECNPPNSQPASYQR
Y318 PNSQPASYQRRFLVT
T341-p RGPRRYRtPsRSRSR
S343-p PRRYRtPsRSRSRDR
S345 RYRtPsRSRSRDRFR
S354-p SRDRFRRsEtPPHWR
T356-p DRFRRsEtPPHWRQE
S373 RAQRMRVSSGERWIK
S374 AQRMRVSSGERWIKG
S384 RWIKGDKSELNEIKE
S395-p EIKENQRsPVRVKEK
S411-p ITDHRHMsEsPNRKI
S413-p DHRHMsEsPNRKIEK
K445 RNSEKDDKYNKNKVK
K448 EKDDKYNKNKVKKRG
K458 VKKRGKSKSRSKSKE
K462 GKSKSRSKSKERSKS
S486 HEDKRVRSRSKERDH
S488 DKRVRSRSKERDHET
S513 KGKDQERSRSKENSK
S515 KDQERSRSKENSKQV
S526 SKQVESKSNEHDHSK
S543 EKDRRAQSRSRERDL
S545 DRRAQSRSRERDLTK
Y557 LTKSKHSYNSRTRER
S559 KSKHSYNSRTRERSR
S567 RTRERSRSRDRSRRV
S571 RSRSRDRSRRVRSRS
T610 SRSRDRRTPGRSRSK
S626 RRRRRRDSRSSEREE
S628 RRRRDSRSSEREESQ
S629 RRRDSRSSEREESQS
S636 SEREESQSRNKEKYR
S664 EGEKRMYSKSRDHSS
S671 SKSRDHSSSNNNREK
S672 KSRDHSSSNNNREKK
N675 DHSSSNNNREKKADI
S685-p KKADIDQsPVSKTKQ
S688 DIDQsPVSKTKQSSQ
S694 VSKTKQSSQDNEVKS
S714-p QEDEKTRsPVEKENQ
P715 EDEKTRsPVEKENQK
K718 KTRsPVEKENQKSKG
K722 PVEKENQKSKGQEND
S742 NKKCDHESSPGTDED
S743 KKCDHESSPGTDEDK
T746 DHESSPGTDEDKSG_
S751 PGTDEDKSG______
3804 : Phospho-PPIG (Ser376) Antibody
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