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SFRS9 (human)

Overview SFRS9 Plays a role in constitutive splicing and can modulate the selection of alternative splice sites. Represses the splicing of MAPT/Tau exon 10. Belongs to the splicing factor SR family. Note: This description may include information from UniProtKB. Protein type: RNA binding protein; RNA splicing Cellular Component: nucleoplasm; nucleolus; nucleus Molecular Function: RNA binding; nucleotide binding Biological Process: nuclear mRNA splicing, via spliceosome; transcription from RNA polymerase II promoter; mRNA splice site selection; mRNA export from nucleus; negative regulation of nuclear mRNA splicing, via spliceosome; RNA splicing; gene expression; mRNA 3'-end processing; mRNA processing; termination of RNA polymerase II transcription Reference #:  Q13242 (UniProtKB) Alt. Names/Synonyms: Pre-mRNA-splicing factor SRp30C; SFRS9; Splicing factor, arginine/serine-rich 9; SRP30C Gene Symbols: SRSF9 Molecular weight: 25,542 Da Basal Isoelectric point: 8.74  Predict pI for various phosphorylation states

Select Structure to View Below SFRS9 1WG4 - A=104-188 (mouse)

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	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	2		S2-p	______MsGWADERG
0	3		Y17-p	GEGDGRIyVGNLPTD
0	2		K28-u	LPTDVREkDLEDLFy
0	2		Y35-p	kDLEDLFykYGRIRE
0	10		K36-u	DLEDLFykYGRIREI
0	109		Y70-p	RDAEDAIyGRNGyDY
0	19		Y75-p	AIyGRNGyDYGQCRL
0	3		R93-m1	FPRTYGGrGGWPrGG
0	1		R98-m1	GGrGGWPrGGRNGPP
0	3		K128-u	SGSWQDLkDHMREAG
0	3		Y139-p	REAGDVCyADVQkDG
0	1		K144-u	VCyADVQkDGVGMVE
0	1		K155-u	GMVEYLRkEDMEyAL
0	2		Y160-p	LRkEDMEyALRKLDD
0	1		T168-p	ALRKLDDtkFRSHEG
0	3		K169-u	LRKLDDtkFRSHEGE
0	3		S178-p	RSHEGETsyIRVYPE
0	51		Y179-p	SHEGETsyIRVYPER
0	2		S187-p	IRVYPERstsyGysR
0	1		T188-p	RVYPERstsyGysRs
0	31		S189-p	VYPERstsyGysRsR
0	1		Y190-p	YPERstsyGysRsRs
0	4		Y192-p	ERstsyGysRsRsGs
0	8		S193-p	RstsyGysRsRsGsR
0	3		S195-p	tsyGysRsRsGsRGR
0	7		S197-p	yGysRsRsGsRGRDs
0	9		S199-p	ysRsRsGsRGRDsPy
0	152		S204-p	sGsRGRDsPyQsRGs
0	2		Y206-p	sRGRDsPyQsRGsPH
0	12		S208-p	GRDsPyQsRGsPHyF
0	339		S211-p	sPyQsRGsPHyFsPF
0	130		Y214-p	QsRGsPHyFsPFRPy
1	105		S216-p	RGsPHyFsPFRPy__
0	5		Y221-p	yFsPFRPy_______

	mouse
S3-p	_____MSsGWADERG
Y18	GEGDGRIYVGNLPSD
K29	LPSDVREKDLEDLFY
Y36	KDLEDLFYkYGRIRE
K37-u	DLEDLFYkYGRIREI
Y71-p	RDAEDAIyGRNGYDY
Y76	AIyGRNGYDYGQCRL
R94	FPRTYGGRGGWPRGA
R99	GGRGGWPRGARNGPP
K129	SGSWQDLKDHMREAG
Y140	REAGDVCYADVQKDG
K145	VCYADVQKDGMGMVE
K156	GMVEYLRKEDMEYAL
Y161	LRKEDMEYALRKLDD
T169	ALRKLDDTKFRSHEG
K170	LRKLDDTKFRSHEGE
S179	RSHEGETSyIRVYPE
Y180-p	SHEGETSyIRVYPER
S188	IRVYPERSTsYGysR
T189	RVYPERSTsYGysRs
S190-p	VYPERSTsYGysRsR
Y191	YPERSTsYGysRsRs
Y193-p	ERSTsYGysRsRsGs
S194-p	RSTsYGysRsRsGsR
S196-p	TsYGysRsRsGsRGR
S198-p	YGysRsRsGsRGRDs
S200-p	ysRsRsGsRGRDsPY
S205-p	sGsRGRDsPYQsRGs
Y207	sRGRDsPYQsRGsPH
S209-p	GRDsPYQsRGsPHyF
S212-p	sPYQsRGsPHyFsPF
Y215-p	QsRGsPHyFsPFRPY
S217-p	RGsPHyFsPFRPY__
Y222	yFsPFRPY_______

	rat
S2	______MSGWADERG
Y17	GEGDGRIYVGNLPTD
K28	LPTDVREKDLEDLFY
Y35	KDLEDLFYKYGRIRE
K36	DLEDLFYKYGRIREI
Y70	RDAEDAIYGRNGYDY
Y75	AIYGRNGYDYGQCRL
R93	FPRAYGGRGGWPRAS
R98	GGRGGWPRASRNGPP
K128	SGSWQDLKDHMREAG
Y139	REAGDVCYADVQKDG
K144	VCYADVQKDGMGMVE
K155	GMVEYLRKEDMEYAL
Y160	LRKEDMEYALRKLDD
T168	ALRKLDDTKFRSHEG
K169	LRKLDDTKFRSHEGE
S178	RSHEGETSYIRVYPE
Y179	SHEGETSYIRVYPER
G187	IRVYPERGTSYGCSR
T188	RVYPERGTSYGCSRS
S189	VYPERGTSYGCSRSR
Y190	YPERGTSYGCSRSRS
C192	ERGTSYGCSRSRSGS
S193	RGTSYGCSRSRSGSR
S195	TSYGCSRSRSGSRGR
S197	YGCSRSRSGSRGRDs
S199	CSRSRSGSRGRDsPY
S204-p	SGSRGRDsPYQSRGs
Y206	SRGRDsPYQSRGsPH
S208	GRDsPYQSRGsPHYF
S211-p	sPYQSRGsPHYFsPF
Y214	QSRGsPHYFsPFRPY
S216-p	RGsPHYFsPFRPY__
Y221	YFsPFRPY_______

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