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Protein Page:
MTAP (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
MTAP Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S- adenosylmethionine. Has broad substrate specificity with 6- aminopurine nucleosides as preferred substrates. Homotrimer. Ubiquitously expressed. Inhibited by 5'-methylthiotubercin and 5'- chloroformycin. Belongs to the PNP/MTAP phosphorylase family. MTAP subfamily. Note: This description may include information from UniProtKB.
Protein type: Amino Acid Metabolism - cysteine and methionine; EC 2.4.2.28; Transferase; Phosphorylase
Cellular Component: cytoplasm; cytosol; nucleus
Molecular Function: phosphorylase activity; S-methyl-5-thioadenosine phosphorylase activity
Biological Process: methionine salvage; sulfur amino acid metabolic process; nicotinamide riboside catabolic process; nucleobase, nucleoside, nucleotide and nucleic acid metabolic process; purine ribonucleoside salvage; polyamine metabolic process
Reference #:  Q13126 (UniProtKB)
Alt. Names/Synonyms: 5'-methylthioadenosine phosphorylase; c86fus; MeSAdo phosphorylase; methylthioadenosine phosphorylase; MSAP; MTA phosphorylase; MTAP; MTAPase; S-methyl-5'-thioadenosine phosphorylase
Gene Symbols: MTAP
Molecular weight: 31,236 Da
Basal Isoelectric point: 6.75  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

MTAP

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 T5-p ___MASGttttAVKI
0 1 T6-p __MASGttttAVKIG
0 1 T7-p _MASGttttAVKIGI
0 1 T8-p MASGttttAVKIGII
0 1 K32 ILEGRTEKYVDTPFG
0 1 K32-ub ILEGRTEkYVDTPFG
0 1 K40 YVDTPFGKPSDALIL
0 4 K40-ub YVDTPFGkPSDALIL
0 1 K49-ub SDALILGkIKNVDCV
0 2 K71-ub QHTIMPSkVNYQANI
0 1 K157 EVLIETAKKLGLRCH
0 1 K157-ub EVLIETAkKLGLRCH
0 1 S183-p RFSSRAEsFMFRtWG
0 1 T188-p AEsFMFRtWGADVIN
0 1 K248-ub KENANKAkSLLLTTI
  mouse

 
S5 ___MASGSACTAVKI
A6 __MASGSACTAVKIG
C7 _MASGSACTAVKIGI
T8 MASGSACTAVKIGII
K32-ac ILEGRTEkYVDTPFG
K32 ILEGRTEKYVDTPFG
K40-ac YVDTPFGkPSDALIL
K40-ub YVDTPFGkPSDALIL
K49 SDALILGKIKNVDCV
K71-ub QHTIMPSkVNYQANI
K157-ac EVLIETAkKLGLRCH
K157 EVLIETAKKLGLRCH
S183 RFSSRAESLIFRTWG
T188 AESLIFRTWGADVVN
K248 KENANKAKSLLLTTI
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