|
Kit
a receptor tyrosine kinase and a member of the subfamily that includes PDGF, CSF-1 and FLT-3/flk-2 receptors. Receptor for stem cell factor. Plays a critical role in hematopoietic stem cell, mast cell, melanocyte and germ cell development. Ligand binding induces autophosphorylation, dimerization and activation, leading to the recruitment and phosphorylation of downstream SH2-containing signaling components including PLC-gamma, PI3 kinase p85, SHP2 and CrkL, linking c-Kit to various cell signaling pathways. Molecular lesions that impair the kinase activity of c-Kit are associated with a variety of developmental disorders, while mutations that constitutively activate c-Kit can lead to hyperplasia and tumorigenesis. Activating mutations cause >90% of gastrointestinal stromal tumors (GIST); successfully treated with inhibitors Gleevec (imatinib, Glivec) and Sutent (Sutinib, SU11248). Activating mutations also induce mastocytosis. Autocrine/paracrine stimulation may drive some lung and other tumors. Loss of expression associated with melanoma progression. Familial loss of function mutations cause piebaldism, with defects in hair and skin pigmentation due to lack of melanocytes. Note: This description may include information from UniProtKB.
|
| Protein type: Membrane protein, integral; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (receptor); EC 2.7.10.1; TK group; PDGFR family |
|
Cellular Component: extracellular space; cytoplasm; integral to membrane; plasma membrane; nucleus; external side of plasma membrane
|
|
Molecular Function: protein binding; protein homodimerization activity; protease binding; metal ion binding; cytokine binding; protein-tyrosine kinase activity; stem cell factor receptor activity; transmembrane receptor protein tyrosine kinase activity; receptor signaling protein tyrosine kinase activity; ATP binding
|
|
Biological Process: peptidyl-tyrosine phosphorylation; activation of MAPK activity; protein amino acid autophosphorylation; germ cell programmed cell death; protein kinase cascade; positive regulation of JAK-STAT cascade; lymphoid progenitor cell differentiation; signal transduction; positive regulation of tyrosine phosphorylation of Stat3 protein; regulation of cell shape; response to radiation; ovarian follicle development; myeloid progenitor cell differentiation; positive regulation of MAPKKK cascade; positive regulation of cell proliferation; melanocyte differentiation; negative regulation of programmed cell death; erythrocyte differentiation; hemopoiesis; inflammatory response; T cell differentiation; lamellipodium biogenesis; embryonic hemopoiesis; mast cell chemotaxis; dendritic cell cytokine production; cytokine and chemokine mediated signaling pathway; male gonad development; stem cell maintenance; positive regulation of phosphoinositide 3-kinase activity; mast cell degranulation; stem cell differentiation; detection of mechanical stimulus involved in sensory perception of sound; regulation of cell proliferation; positive regulation of phosphoinositide 3-kinase cascade; positive regulation of tyrosine phosphorylation of Stat1 protein; gut development; positive regulation of tyrosine phosphorylation of Stat5 protein; pigmentation; actin cytoskeleton reorganization; immature B cell differentiation; spermatogenesis; glycosphingolipid metabolic process; regulation of pigmentation during development; positive regulation of transcription factor activity; mast cell cytokine production; spermatid development
|
|
Reference #:
P10721 (UniProtKB)
|
| Alt. Names/Synonyms: C-Kit; CD117; KIT; Mast/stem cell growth factor receptor; PBT; Proto-oncogene c-Kit; proto-oncogene tyrosine-protein kinase Kit; SCFR; soluble KIT variant 1; Tyrosine-protein kinase Kit; v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog |
| Gene Symbols: KIT |
|
Molecular weight: 109,865 Da
|
|
Basal Isoelectric point: 6.54
Predict pI for various phosphorylation states
|
|
CST Pathways:
Tyrosine Kinases
|
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®
|
