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Protein Page:
CDK5 (human)
p Phosphorylation
a Acetylation
m Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
u Ubiquitination
s Sumoylation
n Neddylation
gl O-GlcNAc
ga O-GalNAc
h Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage

Overview
CDK5 a protein kinase of the CDK family. Unlike other members of this family, it is not activated by cyclins but by p35 (CDK5R1) and p39. An important regulator of neuronal positioning during brain development. May also play a role in synaptogenesis and neurotransmission. Substrates include TAU, MAP2, NF-H and -M, Nudel, PDE6, beta-catenin, amphyphysin, dynamin I, synapsin 1, Munc-18, and NMDA receptor 2A. Plays a role in myogenesis, haematopoietic cell differentiation, spermatogenesis, insulin secretion, and lens differentiation. Implicated in the pathology of neurofibrillary tangles and formation of senile plaques, hallmarks of Alzheimer?s disease. Induces tau phosphorylation and aggregation and neurofibrillary tangle deposition and neurodegeneration in in vitro and in vivo animal models. Brain samples from Alzeimer?s pateints show elevated CDK5 activity. Note: This description may include information from UniProtKB.
Protein type: Kinase, protein; Protein kinase, CMGC; EC 2.7.11.22; Protein kinase, Ser/Thr (non-receptor); EC 2.7.1.37; CMGC group; CDK family; CDK5 subfamily; CDK/CDK5 subfamily
Cellular Component: cyclin-dependent protein kinase 5 activator complex; dendrite; postsynaptic density; perikaryon; cytosol; postsynaptic membrane; growth cone; membrane; cell soma; axon; lamellipodium; cytoplasm; neuromuscular junction; cell junction; nucleus; filopodium
Molecular Function: acetylcholine receptor activator activity; protein serine/threonine kinase activity; ErbB-2 class receptor binding; protein binding; ErbB-3 class receptor binding; ephrin receptor binding; cyclin-dependent protein kinase activity; p53 binding; tau-protein kinase activity; kinase activity; ATP binding; protein kinase activity
Biological Process: Schwann cell development; negative regulation of synaptic plasticity; axon extension; cerebellar cortex formation; regulation of synaptic plasticity; motor axon guidance; sensory perception of pain; receptor clustering; regulation of cell migration; corpus callosum development; regulation of apoptosis; neuron differentiation; receptor catabolic process; oligodendrocyte differentiation; neurite development; central nervous system neuron development; synaptic transmission, glutamatergic; skeletal muscle development; dendrite morphogenesis; cell division; synaptic vesicle endocytosis; negative regulation of protein ubiquitination; negative regulation of transcription, DNA-dependent; regulated secretory pathway; axon guidance; synaptic transmission, dopaminergic; negative regulation of protein export from nucleus; positive regulation of protein binding; cell-matrix adhesion; protein amino acid autophosphorylation; neuron migration; nucleocytoplasmic transport; negative regulation of axon extension; negative regulation of cell cycle; synaptic transmission; intracellular protein transport; synaptogenesis; behavioral response to cocaine; positive regulation of neuron apoptosis; visual learning; cortical actin cytoskeleton organization and biogenesis; layer formation in the cerebral cortex; serine phosphorylation of STAT3 protein; hippocampus development; peptidyl-threonine phosphorylation; cell proliferation; positive regulation of calcium ion-dependent exocytosis; synaptic vesicle exocytosis; peptidyl-serine phosphorylation; embryonic development; neuron apoptosis; positive regulation of protein kinase activity; regulation of excitatory postsynaptic membrane potential; blood coagulation; phosphorylation
Reference #:  Q00535 (UniProtKB)
Alt. Names/Synonyms: CDK5; Cell division protein kinase 5; Cyclin-dependent kinase 5; protein kinase CDK5 splicing; PSSALRE; Serine/threonine-protein kinase PSSALRE; Tau protein kinase II catalytic subunit; TPKII catalytic subunit
Gene Symbols: CDK5
Molecular weight: 33,304 Da
Basal Isoelectric point: 7.57  Predict pI for various phosphorylation states
CST Pathways:  Alzheimer's Disease  |  Parkinson's Disease
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

CDK5

Protein Structure Not Found.

Substrate Sequence Logo
Sequence Logo

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Sites Implicated In
enzymatic activity, induced: S159‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 K9 QKYEKLEKIGEGtyG
1 9 T14-p LEKIGEGtyGtVFKA
14 898 Y15-p EKIGEGtyGtVFKAK
0 7 T17-p IGEGtyGtVFKAKNR
0 6 K33-a THEIVALkRVRLDDD
0 1 S46-p DDDEGVPsSALREIC
0 2 K56-a LREICLLkELKHKNI
0 1 K56 LREICLLKELKHKNI
0 2 S72-p RLHDVLHsDKKLTLV
0 7 K128-u NVLHRDLkPQNLLIN
0 4 K141-u INRNGELkLADFGLA
0 1 Y158-p FGIPVRCysAEVVTL
5 0 S159-p GIPVRCysAEVVTLW
0 1 Y167-p AEVVTLWyRPPDVLF
0 1 T231-p EEQWPSMtKLPDYkP
0 2 K232 EQWPSMtKLPDYkPy
0 3 K237-u MtKLPDYkPyPMYPA
0 1 Y239-p KLPDYkPyPMYPATT
0 1 K254 SLVNVVPKLNATGRD
0 7 K268 DLLQNLLKCNPVQRI
0 2 Y285 EEALQHPYFSDFCPP
  mouse

 
K9-u QKYEKLEkIGEGtyG
T14-p LEkIGEGtyGtVFKA
Y15-p EkIGEGtyGtVFKAK
T17-p IGEGtyGtVFKAKNR
K33 THEIVALKRVRLDDD
S46 DDDEGVPSSALREIC
K56 LREICLLKELKHKNI
K56-u LREICLLkELKHKNI
S72 RLHDVLHSDKKLTLV
K128-u NVLHRDLkPQNLLIN
K141-u INRNGELkLADFGLA
Y158 FGIPVRCYsAEVVTL
S159-p GIPVRCYsAEVVTLW
Y167 AEVVTLWYRPPDVLF
T231 EEQWPAMTKLPDYkP
K232 EQWPAMTKLPDYkPY
K237-u MTKLPDYkPYPMYPA
Y239 KLPDYkPYPMYPATT
K254-u SLVNVVPkLNATGRD
K268-u DLLQNLLkCNPVQRI
Y285 EEALQHPYFSDFCPP
  rat

 
K9 QKYEKLEKIGEGTyG
T14 LEKIGEGTyGTVFKA
Y15-p EKIGEGTyGTVFKAK
T17 IGEGTyGTVFKAKNR
K33 THEIVALKRVRLDDD
S46 DDDEGVPSSALREIC
K56 LREICLLKELKHKNI
K56 LREICLLKELKHKNI
S72 RLHDVLHSDKKLTLV
K128-u NVLHRDLkPQNLLIN
K141-u INRNGELkLADFGLA
Y158 FGIPVRCYSAEVVTL
S159 GIPVRCYSAEVVTLW
Y167 AEVVTLWYRPPDVLF
T231 EEQWPAMTkLPDYkP
K232-u EQWPAMTkLPDYkPY
K237-u MTkLPDYkPYPMYPA
Y239 kLPDYkPYPMYPATT
K254 SLVNVVPKLNATGRD
K268-u DLLQNLLkCNPVQRI
Y285-p EEALQHPyFSDFCPP
  cow

 
K9 QKYEKLEKIGEGtYG
T14-p LEKIGEGtYGTVFKA
Y15 EKIGEGtYGTVFKAK
T17 IGEGtYGTVFKAKNR
K33 THEIVALKRVRLDDD
S46 DDDEGVPSSALREIC
K56 LREICLLKELKHKNI
K56 LREICLLKELKHKNI
S72 RLHDVLHSDKKLTLV
K128 NVLHRDLKPQNLLIN
K141 INRNGELKLADFGLA
Y158 FGIPVRCYSAEVVTL
S159 GIPVRCYSAEVVTLW
Y167 AEVVTLWYRPPDVLF
T231 EEQWPAMTKLPDYKP
K232 EQWPAMTKLPDYKPY
K237 MTKLPDYKPYPMYPA
Y239 KLPDYKPYPMYPATT
K254 SLVNVVPKLNATGRD
K268 DLLQNLLKCNPVQRI
Y285 EEALQHPYFSDFCPP
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