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Protein Page:
CDK5 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
CDK5 a protein kinase of the CDK family. Unlike other members of this family, it is not activated by cyclins but by p35 (CDK5R1) and p39. An important regulator of neuronal positioning during brain development. May also play a role in synaptogenesis and neurotransmission. Substrates include TAU, MAP2, NF-H and -M, Nudel, PDE6, beta-catenin, amphyphysin, dynamin I, synapsin 1, Munc-18, and NMDA receptor 2A. Plays a role in myogenesis, haematopoietic cell differentiation, spermatogenesis, insulin secretion, and lens differentiation. Implicated in the pathology of neurofibrillary tangles and formation of senile plaques, hallmarks of Alzheimer?s disease. Induces tau phosphorylation and aggregation and neurofibrillary tangle deposition and neurodegeneration in in vitro and in vivo animal models. Brain samples from Alzeimer?s pateints show elevated CDK5 activity. Note: This description may include information from UniProtKB.
Protein type: EC 2.7.1.37; EC 2.7.11.22; Protein kinase, Ser/Thr (non-receptor); Protein kinase, CMGC; Kinase, protein; CMGC group; CDK family; CDK/CDK5 subfamily; CDK5 subfamily
Cellular Component: cyclin-dependent protein kinase 5 activator complex; dendrite; postsynaptic density; perikaryon; cytosol; postsynaptic membrane; growth cone; membrane; cell soma; axon; lamellipodium; cytoplasm; nucleus; cell junction; neuromuscular junction; filopodium
Molecular Function: acetylcholine receptor activator activity; ErbB-2 class receptor binding; protein serine/threonine kinase activity; protein binding; ErbB-3 class receptor binding; ephrin receptor binding; p53 binding; cyclin-dependent protein kinase activity; tau-protein kinase activity; kinase activity; ATP binding; protein kinase activity
Biological Process: Schwann cell development; negative regulation of synaptic plasticity; axon extension; cerebellar cortex formation; rhythmic process; regulation of synaptic plasticity; motor axon guidance; sensory perception of pain; regulation of cell migration; receptor clustering; regulation of apoptosis; neuron differentiation; corpus callosum development; receptor catabolic process; oligodendrocyte differentiation; neurite development; central nervous system neuron development; synaptic transmission, glutamatergic; skeletal muscle development; dendrite morphogenesis; cell division; synaptic vesicle endocytosis; negative regulation of protein ubiquitination; negative regulation of transcription, DNA-dependent; axon guidance; regulated secretory pathway; synaptic transmission, dopaminergic; negative regulation of protein export from nucleus; positive regulation of protein binding; protein amino acid autophosphorylation; cell-matrix adhesion; neuron migration; nucleocytoplasmic transport; negative regulation of axon extension; negative regulation of cell cycle; intracellular protein transport; synaptic transmission; synaptogenesis; behavioral response to cocaine; positive regulation of neuron apoptosis; visual learning; cortical actin cytoskeleton organization and biogenesis; layer formation in the cerebral cortex; serine phosphorylation of STAT3 protein; negative regulation of proteolysis; hippocampus development; peptidyl-threonine phosphorylation; cell cycle; positive regulation of calcium ion-dependent exocytosis; cell proliferation; peptidyl-serine phosphorylation; synaptic vesicle exocytosis; neuron apoptosis; embryonic development; positive regulation of protein kinase activity; blood coagulation; regulation of excitatory postsynaptic membrane potential; phosphorylation
Reference #:  Q00535 (UniProtKB)
Alt. Names/Synonyms: CDK5; Cell division protein kinase 5; Cyclin-dependent kinase 5; protein kinase CDK5 splicing; PSSALRE; Serine/threonine-protein kinase PSSALRE; Tau protein kinase II catalytic subunit; TPKII catalytic subunit
Gene Symbols: CDK5
Molecular weight: 33,304 Da
Basal Isoelectric point: 7.57  Predict pI for various phosphorylation states
CST Pathways:  Alzheimer's Disease  |  Parkinson's Disease
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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CDK5

Protein Structure Not Found.

Substrate Sequence Logo
Sequence Logo

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Sites Implicated In
enzymatic activity, induced: S159‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 K9-ac QKYEKLEkIGEGtyG
0 1 K9 QKYEKLEKIGEGtyG
1 9 T14-p LEkIGEGtyGtVFKA
14 900 Y15-p EkIGEGtyGtVFKAK
0 9 T17-p IGEGtyGtVFKAKNR
0 6 K33-ac THEIVALkRVRLDDD
0 1 S46-p DDDEGVPsSALREIC
0 3 K56-ac LREICLLkELKHKNI
0 1 K56 LREICLLKELKHKNI
0 2 S72-p RLHDVLHsDKKLTLV
0 1 S105-p LDPEIVKsFLFQLLK
0 7 K128-ub NVLHRDLkPQNLLIN
0 4 K141-ub INRNGELkLADFGLA
0 1 Y158-p FGIPVRCysAEVVTL
5 0 S159-p GIPVRCysAEVVTLW
0 1 Y167-p AEVVTLWyRPPDVLF
0 1 T231-p EEQWPSMtKLPDYkP
0 2 K232 EQWPSMtKLPDYkPy
0 3 K237-ub MtKLPDYkPyPMYPA
0 1 Y239-p KLPDYkPyPMYPATT
0 1 K254 SLVNVVPKLNATGRD
0 7 K268 DLLQNLLKCNPVQRI
0 2 Y285 EEALQHPYFSDFCPP
  mouse

 
K9 QKYEKLEKIGEGtyG
K9-ub QKYEKLEkIGEGtyG
T14-p LEkIGEGtyGtVFKA
Y15-p EkIGEGtyGtVFKAK
T17-p IGEGtyGtVFKAKNR
K33 THEIVALKRVRLDDD
S46 DDDEGVPSSALREIC
K56 LREICLLKELKHKNI
K56-ub LREICLLkELKHKNI
S72 RLHDVLHSDKKLTLV
S105 LDPEIVKSFLFQLLK
K128-ub NVLHRDLkPQNLLIN
K141-ub INRNGELkLADFGLA
Y158 FGIPVRCYsAEVVTL
S159-p GIPVRCYsAEVVTLW
Y167 AEVVTLWYRPPDVLF
T231 EEQWPAMTKLPDYkP
K232 EQWPAMTKLPDYkPY
K237-ub MTKLPDYkPYPMYPA
Y239 KLPDYkPYPMYPATT
K254-ub SLVNVVPkLNATGRD
K268-ub DLLQNLLkCNPVQRI
Y285 EEALQHPYFSDFCPP
  rat

 
K9 QKYEKLEKIGEGTyG
K9 QKYEKLEKIGEGTyG
T14 LEKIGEGTyGTVFKA
Y15-p EKIGEGTyGTVFKAK
T17 IGEGTyGTVFKAKNR
K33 THEIVALKRVRLDDD
S46 DDDEGVPSSALREIC
K56 LREICLLKELKHKNI
K56 LREICLLKELKHKNI
S72 RLHDVLHSDKKLTLV
S105 LDPEIVKSLLFQLLK
K128-ub NVLHRDLkPQNLLIN
K141-ub INRNGELkLADFGLA
Y158 FGIPVRCYSAEVVTL
S159 GIPVRCYSAEVVTLW
Y167 AEVVTLWYRPPDVLF
T231 EEQWPAMTkLPDYkP
K232-ub EQWPAMTkLPDYkPY
K237-ub MTkLPDYkPYPMYPA
Y239 kLPDYkPYPMYPATT
K254 SLVNVVPKLNATGRD
K268-ub DLLQNLLkCNPVQRI
Y285-p EEALQHPyFSDFCPP
  cow

 
K9 QKYEKLEKIGEGtYG
K9 QKYEKLEKIGEGtYG
T14-p LEKIGEGtYGTVFKA
Y15 EKIGEGtYGTVFKAK
T17 IGEGtYGTVFKAKNR
K33 THEIVALKRVRLDDD
S46 DDDEGVPSSALREIC
K56 LREICLLKELKHKNI
K56 LREICLLKELKHKNI
S72 RLHDVLHSDKKLTLV
S105 LDPEIVKSFLFQLLK
K128 NVLHRDLKPQNLLIN
K141 INRNGELKLADFGLA
Y158 FGIPVRCYSAEVVTL
S159 GIPVRCYSAEVVTLW
Y167 AEVVTLWYRPPDVLF
T231 EEQWPAMTKLPDYKP
K232 EQWPAMTKLPDYKPY
K237 MTKLPDYKPYPMYPA
Y239 KLPDYKPYPMYPATT
K254 SLVNVVPKLNATGRD
K268 DLLQNLLKCNPVQRI
Y285 EEALQHPYFSDFCPP
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