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CDK5 (human)

Overview CDK5 a protein kinase of the CDK family. Unlike other members of this family, it is not activated by cyclins but by p35 (CDK5R1) and p39. An important regulator of neuronal positioning during brain development. May also play a role in synaptogenesis and neurotransmission. Substrates include TAU, MAP2, NF-H and -M, Nudel, PDE6, beta-catenin, amphyphysin, dynamin I, synapsin 1, Munc-18, and NMDA receptor 2A. Plays a role in myogenesis, haematopoietic cell differentiation, spermatogenesis, insulin secretion, and lens differentiation. Implicated in the pathology of neurofibrillary tangles and formation of senile plaques, hallmarks of Alzheimer?s disease. Induces tau phosphorylation and aggregation and neurofibrillary tangle deposition and neurodegeneration in in vitro and in vivo animal models. Brain samples from Alzeimer?s pateints show elevated CDK5 activity. Note: This description may include information from UniProtKB. Protein type: Protein kinase, CMGC; EC 2.7.1.37; EC 2.7.11.22; Protein kinase, Ser/Thr (non-receptor); Kinase, protein; CMGC group; CDK family; CDK5 subfamily; CDK/CDK5 subfamily Cellular Component: cyclin-dependent protein kinase 5 activator complex; dendrite; postsynaptic density; perikaryon; cytosol; postsynaptic membrane; growth cone; cell soma; membrane; axon; lamellipodium; cytoplasm; plasma membrane; neuromuscular junction; cell junction; nucleus; filopodium Molecular Function: acetylcholine receptor activator activity; ErbB-2 class receptor binding; protein serine/threonine kinase activity; protein binding; ErbB-3 class receptor binding; p53 binding; cyclin-dependent protein kinase activity; tau-protein kinase activity; kinase activity; ATP binding; protein kinase activity Biological Process: Schwann cell development; negative regulation of synaptic plasticity; axon extension; cerebellar cortex formation; regulation of synaptic plasticity; motor axon guidance; sensory perception of pain; receptor clustering; regulation of cell migration; regulation of apoptosis; corpus callosum development; neuron differentiation; receptor catabolic process; oligodendrocyte differentiation; neurite development; central nervous system neuron development; synaptic transmission, glutamatergic; skeletal muscle development; dendrite morphogenesis; cell division; synaptic vesicle endocytosis; negative regulation of protein ubiquitination; negative regulation of transcription, DNA-dependent; synaptic transmission, dopaminergic; regulated secretory pathway; axon guidance; negative regulation of protein export from nucleus; positive regulation of protein binding; protein amino acid autophosphorylation; cell-matrix adhesion; neuron migration; nucleocytoplasmic transport; negative regulation of cell cycle; synaptic transmission; intracellular protein transport; synaptogenesis; behavioral response to cocaine; positive regulation of neuron apoptosis; visual learning; cortical actin cytoskeleton organization and biogenesis; layer formation in the cerebral cortex; serine phosphorylation of STAT3 protein; hippocampus development; peptidyl-threonine phosphorylation; cell proliferation; positive regulation of calcium ion-dependent exocytosis; embryonic development; neuron apoptosis; peptidyl-serine phosphorylation; synaptic vesicle exocytosis; positive regulation of protein kinase activity; regulation of excitatory postsynaptic membrane potential; blood coagulation; phosphorylation Reference #:  Q00535 (UniProtKB) Alt. Names/Synonyms: CDK5; Cell division protein kinase 5; Cyclin-dependent kinase 5; protein kinase CDK5 splicing; PSSALRE; Serine/threonine-protein kinase PSSALRE; Tau protein kinase II catalytic subunit; TPKII catalytic subunit Gene Symbols: CDK5 Molecular weight: 33,304 Da Basal Isoelectric point: 7.57  Predict pI for various phosphorylation states CST Pathways:  Alzheimer's Disease  |  Parkinson's Disease Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below CDK5 1H4L - A/B=1-292 (human) 1LFR - A=1-292 (human) 1UNG - A/B=1-292 (human) 1UNH - A/B=1-292 (human) 1UNL - A/B=1-292 (human) 3O0G - A/B=1-292 (human) 4AU8 - A/B=2-292 (human) Substrate Sequence Logo

STRING  |  Scansite  |  KinBase  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  RCSB PDB 1H4L 1LFR 1UNG 1UNH 1UNL 3O0G 4AU8  |  ENZYME  |  Phospho3D  |  DISEASE  |  Source  |  UCSD-Nature  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene

	Sites Implicated In
enzymatic activity, induced: S159‑p

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	1		K9	QKYEKLEKIGEGtyG
1	7		T14-p	LEKIGEGtyGtVFKA
14	894		Y15-p	EKIGEGtyGtVFKAK
0	5		T17-p	IGEGtyGtVFKAKNR
0	6		K33-a	THEIVALkRVRLDDD
0	1		S46-p	DDDEGVPsSALREIC
0	2		K56-a	LREICLLkELKHKNI
0	1		K56	LREICLLKELKHKNI
0	2		S72-p	RLHDVLHsDKKLTLV
0	7		K128-u	NVLHRDLkPQNLLIN
0	4		K141-u	INRNGELkLADFGLA
0	1		Y158-p	FGIPVRCysAEVVTL
5	0		S159-p	GIPVRCysAEVVTLW
0	1		Y167-p	AEVVTLWyRPPDVLF
0	2		K232	EQWPSMTKLPDYkPy
0	3		K237-u	MTKLPDYkPyPMYPA
0	1		Y239-p	KLPDYkPyPMYPATT
0	1		K254	SLVNVVPKLNATGRD
0	7		K268	DLLQNLLKCNPVQRI
0	2		Y285	EEALQHPYFSDFCPP

	mouse
K9-u	QKYEKLEkIGEGtyG
T14-p	LEkIGEGtyGtVFKA
Y15-p	EkIGEGtyGtVFKAK
T17-p	IGEGtyGtVFKAKNR
K33	THEIVALKRVRLDDD
S46	DDDEGVPSSALREIC
K56	LREICLLKELKHKNI
K56-u	LREICLLkELKHKNI
S72	RLHDVLHSDKKLTLV
K128-u	NVLHRDLkPQNLLIN
K141-u	INRNGELkLADFGLA
Y158	FGIPVRCYsAEVVTL
S159-p	GIPVRCYsAEVVTLW
Y167	AEVVTLWYRPPDVLF
K232	EQWPAMTKLPDYkPY
K237-u	MTKLPDYkPYPMYPA
Y239	KLPDYkPYPMYPATT
K254-u	SLVNVVPkLNATGRD
K268-u	DLLQNLLkCNPVQRI
Y285	EEALQHPYFSDFCPP

	rat
K9	QKYEKLEKIGEGTyG
T14	LEKIGEGTyGTVFKA
Y15-p	EKIGEGTyGTVFKAK
T17	IGEGTyGTVFKAKNR
K33	THEIVALKRVRLDDD
S46	DDDEGVPSSALREIC
K56	LREICLLKELKHKNI
K56	LREICLLKELKHKNI
S72	RLHDVLHSDKKLTLV
K128-u	NVLHRDLkPQNLLIN
K141-u	INRNGELkLADFGLA
Y158	FGIPVRCYSAEVVTL
S159	GIPVRCYSAEVVTLW
Y167	AEVVTLWYRPPDVLF
K232-u	EQWPAMTkLPDYkPY
K237-u	MTkLPDYkPYPMYPA
Y239	kLPDYkPYPMYPATT
K254	SLVNVVPKLNATGRD
K268-u	DLLQNLLkCNPVQRI
Y285-p	EEALQHPyFSDFCPP

	cow
K9	QKYEKLEKIGEGtYG
T14-p	LEKIGEGtYGTVFKA
Y15	EKIGEGtYGTVFKAK
T17	IGEGtYGTVFKAKNR
K33	THEIVALKRVRLDDD
S46	DDDEGVPSSALREIC
K56	LREICLLKELKHKNI
K56	LREICLLKELKHKNI
S72	RLHDVLHSDKKLTLV
K128	NVLHRDLKPQNLLIN
K141	INRNGELKLADFGLA
Y158	FGIPVRCYSAEVVTL
S159	GIPVRCYSAEVVTLW
Y167	AEVVTLWYRPPDVLF
K232	EQWPAMTKLPDYKPY
K237	MTKLPDYKPYPMYPA
Y239	KLPDYKPYPMYPATT
K254	SLVNVVPKLNATGRD
K268	DLLQNLLKCNPVQRI
Y285	EEALQHPYFSDFCPP

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